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A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks

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Microsystems & Nanoengineering 2021年第1期7卷 63-75页

作者： tao Yue Da Zhao duc t.t.phan Xiaolin Wang Joshua Jonghyun Park Zayn Biviji Christopher C.W.Hughes Abraham P.Lee Department of Biomedical Engineering University of CaliforniaIrvineCAUSA School of Mechatronic Engineering and Automation Shanghai UniversityShanghaiChina Department of Molecular Biology and Biochemistry University of CaliforniaIrvineCAUSA Department of Micro/Nano Electronics Shanghai Jiao Tong UniversityShanghaiChina National Key Laboratory of Science and technology for Micro/Nano Fabrication Shanghai Jiao Tong UniversityShanghaiChina Key Laboratory for thin Film and Micro Fabrication of the Ministry of Education Shanghai Jiao Tong UniversityShanghaiChina Department of Electrical Engineering and Computer Science University of CaliforniaIrvineCAUSA. Department of Applied Mathematics-Biology Brown UniversityProvidenceRIUSA. Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCAUSA

the vascular network of the circulatory system plays a vital role in maintaining homeostasis in the human *** this paper,a novel modular microfluidic system with a vertical two-layered configuration is developed to generate largescale perfused microvascular networks in *** two-layer polydimethylsiloxane(PDMS)configuration allows the tissue chambers and medium channels not only to be designed and fabricated independently but also to be aligned and bonded *** method can produce a modular microfluidic system that has high flexibility and scalability to design an integrated platform with multiple perfused vascularized tissues with high *** medium channel was designed with a rhombic shape and fabricated to be semiclosed to form a capillary burst valve in the vertical direction,serving as the interface between the medium channels and tissue *** and anastomosis at the vertical interface were successfully achieved by using different combinations of tissue chambers and medium *** large-scale microvascular networks were generated and quantified in terms of vessel length and *** leakage of the perfused 70-kDa FItC-dextran confirmed the lumenization of the microvascular networks and the formation of tight vertical interconnections between the microvascular networks and medium channels in different structural *** platform enables the culturing of interconnected,large-scale perfused vascularized tissue networks with high density and scalability for a wide range of multiorgan-on-a-chip applications,including basic biological studies and drug screening.

关键词： interconnection networks configuration

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A hierarchical system to predict behavior of soil and cantilever sheet wall by data-driven models

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Frontiers of Structural and Civil Engineering 2022年第6期16卷 667-684页

作者： Nang duc BUI Hieu Chi phan tiep duc PHAM Ashutosh Sutra DHAR Institute of techniques for Special Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Faculty of Engineering and Applied Science Memorial University of NewfoundlandSt.John’sNL A1B 3X5Canada

the study proposes a framework combining machine learning(ML)models into a logical hierarchical system which evaluates the stability of the sheet wall before other *** study uses the hardening soil(HS)model to develop a 200-sample finite element analysis(FEA)database,to develop the ML ***,a system containing three trained ML models is proposed to first predict the stability status(random forest classification,RFC)followed by 1)the cantilever top horizontal displacement of sheet wall(artificial neural network regression models,RANN1)and 2)vertical settlement of soil(RANN2).the uncertainty of this data-driven system is partially investigated by developing 1000 RFC models,based on the application of random sampling technique in the data splitting *** on the distribution of the evaluation metrics reveals negative skewed data toward the 1.0000 *** implies a high performance of RFC on the database with medians of accuracy,precision,and recall,on test set are 1.0000,1.0000,and 0.92857,*** regression ANN models have coefficient of determinations on test set,as high as 0.9521 for RANN1,and 0.9988 for RANN2,*** parametric study for these regressions is also provided to evaluate the relative insight influence of inputs to output.

关键词： finite element analysis cantilever sheet wall machine learning artificial neural network random forest

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Poroelastodynamic responses and elastic moduli of a transversely isotropic porous cylinder under forced deformation test

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International Journal of Mining Science and technology 2023年第7期33卷 793-800页

作者： Chao Liu Dung t.phan Aramco Research Center-Houston Houston TX 77084USA

Existing transversely isotropic poroelastodynamics solutions are limited to infinite domains and without experimental validation. Furthermore, there is a lack of analytical simulations for the elastic moduli dispersion of fluid-saturated porous cylinders. to address these three limitations and investigate the mechanisms of moduli dispersion, we present the analytical solutions of the poromechanical responses and the elastic moduli dispersion of a transversely isotropic, fluid-saturated, finite porous cylinder subjected to a forced deformation test. through an example, we demonstrate the effects of loading frequency, boundary conditions, and material's anisotropy, dimension, and permeability on the responses of pore pressure,force, displacement, and dynamic elastic moduli of the cylinder. the specimen's responses are significantly influenced by the frequency of the applied load, resulting in a drained state at low frequencies and an undrained state at high frequencies. At high frequencies, the sample behaves identically for an open or a closed lateral boundary, and permeability has insignificant effects. the dynamic elastic moduli are mainly controlled by the loading frequency and the ratio of the sample's radius to its height. Lastly,we show excellent matches between the newly derived analytical solution and laboratory measurements on one clay and two shale samples from Mont terri.

关键词： Poroelastodynamics Dynamic moduli transversely isotropic Porous cylinder Forced deformation test

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Digital Earth:A platform for the SDGs and green transformation at the global and local level,employing essential SDGs variables

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Big Earth Data 2021年第4期5卷 476-496页

作者： Hiromichi Fukui duc Chuc Man Anh phan Chubu Institute for Advanced Studies and International Digital Earth Applied Science Research Center(IDEAS) Chubu UniversityKasugaiJapan Graduate School of Engineering Chubu UniversityKasugaiJapan

the 17 Sustainable Development Goals present clear directions toward the green transformation being sought by the global *** SDGs are an integrated framework,with a complex network of interlinkages between the goals,targets and indicators,and they pose wicked problems to ***,measur-ing progress and achievements with the SDGs requires the integra-tion of various spatio-temporal datasets from different domains and the synthesis of disciplines to describe a system of *** Group on Earth Observations has developed the concept of Essential Variables to describe systems across Societal Benefit Areas that are applicable for this *** Earth is a virtual representation of the planet,potentially encompassing all its sys-tems and life forms,including human *** as a multidimensional,multi-scale,multi-temporal,and multi-layer informa-tion facility,Digital Earth is a valuable platform that can contribute to the achievement of the SDGs and a green *** that end,a set of Essential SDGs Variables(ESDGVs)for the platform are proposed and cases of implementation and use are introduced.

关键词： Digital Earth SDGs Earth Observation interoperability Essential Variables

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Suzuki Reaction of Aryl Bromides Using a Phosphine-Free Magnetic Nanoparticle-Supported Palladium Catalyst

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催化学报 2011年第11期32卷 1667-1676页

作者： Nghia t. BUI trung B. DANG Ha V. LE Nam t. S. phan Department of Chemical Engineering HCMC University of Technology VNU-HCM 268 Ly Thuong Kiet Distriet 10 Ho Chi Minh City Viet Nam

A palladium catalyst immobilized on superparaganetic nanoparticles was prepared with a palladium loading of 0.30 mmol/g. the catalyst was characterized using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometry, thermogravimetric analysis, Fourier transform infrared, atomic absorption spectrophotometry, and nitrogen adsorption. the immobilized palladium catalyst was an efficient catalyst without added phosphine ligands for the Suzuki cross-coupling reaction of several aryl bromides with phenylboronic acid. the recovery of catalyst was simply by magnetic decantation in the presence of a magnet. the immobilized palladium catalyst can be reused many times without significant degradation in catalytic activity. No leaching of active palladium species into the reaction solution was detected.

关键词： superparamagnetic nanoparticle Suzuki reaction palladium aryl bromide

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Stem cell-based therapy for human diseases

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Signal transduction and targeted therapy 2022年第9期7卷 3242-3282页

作者： duc M.Hoang Phuong t.Pham trung Q.Bach Anh t.L.Ngo Quyen t.Nguyen trang t.K.phan Giang H.Nguyen Phuong t.t.Le Van t.Hoang Nicholas R.Forsyth Michael Heke Liem thanh Nguyen Department of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Department of Cellular therapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Institute for Science&technology in Medicine Keele UniversityKeeleUK a Department of Biology Stanford UniversityStanfordCAUSA

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be *** cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative *** are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ *** are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene therapy(ISCt).this review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(At),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular ***,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical *** mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,At-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment.

关键词： diseases distress treatment

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Robust exponential stability and stabilization of linear uncertain polytopic time-delay systems

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控制理论与应用（英文版） 2008年第2期6卷 163-170页

作者： Nam phan t. Phat VU N. Department of Mathematics Quynhon UniversityQuynhonBinhdinhVietnam Institute of Mathematics 18 Hoang Quoc Viet RoadHanoiVietnam

this paper proposes new sufficient conditions for the exponential stability and *** linear uncertain polytopic time-delay systems. the conditions for exponential stability are expressed in terms of Kharitonov-type linear matrix inequalities （LMIs） and we develop control design methods based on LMIs for solving stabilization problem. Our method consists of a combination of the LMI approach and the use of parameter-dependent Lyapunov functionals, which allows to compute simultaneously the two bounds that characterize the exponetial stability rate of the solution. Numerical examples illustrating the conditions are given.

关键词： Polytopic time-delay system Exponential stability Stabilization Parameter-dependent Lyapunov function Linear matrix inequalities

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Determination of fuel burnup distribution of a research reactor based on measurements at subcritical conditions

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Nuclear Science and techniques 2018年第12期29卷 30-38页

作者： Quang Binh Do Hoai-Nam tran Quang Huy Ngo Giang t. t. phan Ho Chi Minh City University of technology and Education 1 Vo Van Ngan Thu Duc HCMC Vietnam Institute of Fundamental and Applied Sciences Duy Tan University Ho Chi Minh city Vietnam

this paper presents the determination of the fuel burnup distribution of the Dalat nuclear research reactor(DNRR) using a method of measurements at subcritical conditions. the method is based on the assumption of linear dependence of the reactivity on the burnup of fuel bundles and the measurements at subcritical *** measurements were taken for seven selected fuel bundles in two different measuring sequences. the measured burnup values have also been compared with the calculations for verifying the method and the measurement procedure. the results obtained with the three detectors have a good agreement with each other with a discrepancy less than 1.0%. the errors of the measured burnup values are within 6%. Comparison between the calculated and measured burnup values shows that the discrepancy of the C/E ratio is within 9% compared to unity. the results indicate that the method of measurements at subcritical conditions could be well applied to determine the relative burnup distribution of the DNRR.

关键词：研究反应堆燃料分发测量过程验证方法方法论价值计算

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Saving Our Planet's Flora,the Contribution of the French National Natural History Museum to the Implementation of the Global Strategy for Plant Conservation

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植物分类与资源学报 2011年第1期33卷 46-52页

作者： Maté DELMAS Jean-Patrick LE duc International Relations Department of Botanical and Zoological GardensMuséum National d'Histoire NaturelleParis International Affairs Officer Muséum National d'Histoire NaturelleParis

the National Natural History Museum plays a key role in the implementation of the GSPC through its botanical gardens,the Conservatoire Botanique National du Bassin Parisien,the Herbarium,and also by providing expertise on all areas of the Strategy(botany,conservation,ethonobotany,article 8j,substainable use),*** 2 of the goals of GSPC(conserving plant diversity,Understanding and Documenting Plant Diversity),the Muséum has developed activities all over the world,including compilation of various flora and description of new species,as well as establishment of plant conservation schemes and habitat protection *** also conserves endangered species in the botanical garden.

关键词： Global Strategy for Plant Conservation Conservation Botanical expertise

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Detection and localization of the hemoglobin and collagen distribution of the uterine cervix

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Journal of Innovative Optical Health Sciences 2019年第4期12卷 116-126页

作者： tran Van tien Nguyen Ngoc Quynh Le Huynh duc phan Ngoc Khuong Cat Huynh Quang Linh Department of Applied Physics Faculty of Applied Science Ho Chi Minh City University of Technology700000 Vietnam DCSELAB—National key Laboratory of Digital Control and System Engineering 700000 Vietnam Department of Biomedical Engineering Faculty of Medicine Nguyen Tat Thanh University700000 Vietnam Department of Engineering Physics Faculty of Applied Science Ho Chi Minh City University of Technology700000 Vietnam

Changes of the blood vessels and collagen are associated with the development of abnormal cervical ***,optical coberence tomography and Mueller polarization images were 1used to provide information regarding the presence of collagen fibers in the cervical ***,most of these methods need a lot of time for image recording and are *** addition,the general survey on the absorption and distribution characteristics of collagen and blood in the cervical is still *** this study,we developed a colposcopy combining cross-polarized inage and image procssing algorithm with an fficient analytical model to map the distribution of blood and collagen in the *** this system's proof of concept,we captured and processed the case of cervical ectopy and Nabothian *** results show that the distribution of blood and collagen maps matched with anatomical and physiological when compared with Lugol's iodline *** technology has some advantages,such as low cost,real time,and can replace the 11se of acetic acid or Lugol's iodine in the future.

关键词： Hemoglobin collagen cross polarized image uterine cervix

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