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Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice

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Neural Regeneration Research 2024年第4期19卷 863-871页

作者： Chenlu Zhu Xiao ren Chen Liu Yawei Liu Yonggang Wang Department of Neurology Lanzhou University Second Hospital Department of Neurology The First Affiliated Hospital of Nanchang University Department of Neurology Xiaogan City Central Hospital Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China Headache Center Department of NeurologyBeijing Tiantan HospitalCapital Medical University

Alzheimer’s disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient’s daily functioning with progressive cognitive decline,which can be partly attributed to impaired hippocampal *** in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging,especially in Alzheimer’s *** evidence indicated that RNA-binding protein 8A(Rbm8a)promotes the proliferation of neural progenitor cells,with lower expression levels observed in Alzheimer’s disease patients compared with healthy *** study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer’s ***,Rbm8a overexpression was induced in the dentate gyrus of 5×FAD mice to validate this *** Rbm8a levels in the dentate gyrus triggered neurogenesis and abated pathological phenotypes(such as plaque formation,gliosis reaction,and dystrophic neurites),leading to ameliorated memory performance in 5×FAD *** sequencing data further substantiated these findings,showing the enrichment of differentially expressed genes involved in biological processes including neurogenesis,cell proliferation,and amyloid protein *** conclusion,overexpressing Rbm8a in the dentate gyrus of 5×FAD mouse brains improved cognitive function by ameliorating amyloid-beta-associated pathological phenotypes and enhancing neurogenesis.

关键词： Adora2a Alzheimer’s disease astrocyte cAMP signaling pathway dentate gyrus dystrophic neurites microglia neurogenesis plaque Rbm8a

Wireless semantic communication based on semantic matching multiple access and intent bias multiplexing

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 26-36页

作者： ren Chao He Zongrui Sun Chen Li Haojin Zhang Haijun University of Science and Technology Beijing Beijing 100083China Research and Development Center Sony(China)LimitedBeijing 100027China

This paper proposes a multi-access and multi-user semantic communication scheme based on semantic matching and intent deviation to address the increasing demand for wireless users and *** scheme enables flexible management of long frames,allowing each unit of bandwidth to support a higher number of *** leveraging semantic classification,different users can independently access the network through the transmission of long concatenated sequences without modifying the existing wireless communication *** overcome the potential disadvantage of incomplete semantic database matching leading to semantic intent misunderstanding,the scheme proposes using intent deviation as an *** allows different receivers to interpret the same semantic information differently,enabling multiplexing where one piece of information can serve multiple users with distinct *** results show that at a bit error rate(BER)of 0.1,it is possible to reduce the transmission by approximately 20 semantic basic units.

关键词： semantic communication multiple access multiplexing multimodal communication

Engineered stem cells by emerging biomedical stratagems

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Science Bulletin 2024年第2期69卷 248-279页

作者： Jinglin Wang Xiaoxuan Zhang Hanxu Chen Haozhen ren Min Zhou Yuanjin Zhao Department of Vascular Surgery.Nanjing Drum Tower Hospital Affliated Hospital of Medical SchoolNanjing UniversityNanjing 210008China Division of Hepatobiliary Surgery and Transplantation Surgery Department of General SurgeryNanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shenzhen Research Institute Southeast UniversityShenzhen 518038China

Stem cell therapy holds immense potential as a viable treatment for a widespread range of intractable *** the safety of stem cell transplantation having been demonstrated in numerous clinical trials,various kinds of stem cells are currently utilized in medical *** the achievements,the therapeutic benefits of stem cells for diseases are limited,and the data of clinical researches are *** optimize tthe effectiveness of stem cells,engineering approaches have been developed to enhance their inherent abilities and impart them with new functionalities,paving the way for the next generation of stem cell *** review offers a detailed analysis of engineered stem cells,including their clinical applications and potential for future *** begin by briefly introducing the recent advances in the production of stem cells(induced pluripotent stem cells(ipsCs),embryonic stem cells(ESCs),mesenchymal stem cells(MSCs)and hematopoietic stem cells(HSCs).Furthermore,we present the latest developments of engineered strategies in stem cells,including engineered methods in molecular biology and biomaterial fields,and their application in biomedical ***,we summarize the current obstacles and suggest future prospects for engineered stem cells in clinical translations and biomedical applications.

关键词： Stem cells Genetic modification Biomaterials Microfluidics Organ-on-a-chip Bioprinting

Observing eddy dye patches induced by shear instabilities in the surf zone on a plane beach

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Acta Oceanologica Sinica 2024年第3期43卷 15-29页

作者： Chunping ren Nannan Fu Chong Yu Yuchuan Bai Kezhao Fang State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China College of Water Resource Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

The effects of surf zone eddy generated by alongshore currents on the deformation and transport of dye are still poorly understood,and related tracer release experiments are ***,a tracer release laboratory experiment was conducted under monochromatic,unidirectional incident waves with a large incident angle(30°)on a plane beach with a 1:100 slope in a large wave basin.A charge-coupled device suspended above the basin recorded the dye patch *** evolution of eddy dye patch was observed and the transport and diffusion were analyzed based on the collected ***,a linear instability numerical model was adopted to calculate the perturbation velocity field at the initial *** observation and image processing results show that surf zone eddy patches occurred and were separated from the original dye *** numerical analysis results demonstrate that the structure of the perturbation velocity field is consistent with the experimental observations,and that the ejection of eddy patches shoreward or offshore may be ascribed to the double vortex.

关键词： surf zone tracer release experiment evolution of eddy patch shear instability of alongshore currents

Particle agglomeration and inhibition method in the fluidized pyrolysis reaction of waste resin

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Chinese Journal of Chemical Engineering 2024年第3期67卷 135-147页

作者： Congjing ren Peng Zhang Qi Song Zhengliang Huang Yao Yang Yongrong Yang Ningbo Innovation Center Zhejiang UniversityNingbo 315100China College of Chemical and Biological Engineering Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture TechnologyZhejiang UniversityHangzhou 310027China

This work investigated the pyrolysis reaction of waste resin in a fluidized bed *** was found that the pyrolysis-generated ash would adhere to the surface of ceramic particles,causing particle agglomeration and *** kaolin could effectively inhibit the particle agglomeration during the fluidized pyrolysis reaction through physical isolation and chemical *** the one hand,kaolin could form a coating layer on the surface of ceramic particles to prevent the adhesion of organic ash generated by the pyrolysis of *** the other hand,when a sufficient amount of kaolin(-0.2%(mass))was added,the activated kaolin could fully contact with the Na+ ions generated by the pyrolysis of resin and react to form a high-melting aluminosilicate mineral(nepheline),which could reduce the formation of low-melting-point sodium sulfate and thereby avoid the agglomeration of ceramic particles.

关键词： Pyrolysis reaction of waste resin Fluidization Particle agglomeration Kaolin

Reactive molecular dynamics insight into the thermal decomposition mechanism of 2,6-Bis(picrylamino)-3,5-dinitropyridine

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Defence Technology（防务技术） 2024年第3期33卷 134-146页

作者： Jianbo Fu Hui ren Xinzhou Wu Yongjin Chen Mi Zhang Yazhi Cheng State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

2,6-bis(picrylamino)-3,5-dinitropyridine(PYX)has excellent thermostability,which makes its thermal decomposition mechanism receive much *** this paper,the mechanism of PYX thermal decomposition was investigated thoroughly by the ReaxFF-lg force field combined with DFT-B3LYP(6-311++G)*** detailed decomposition mechanism,small-molecule product evolution,and cluster evolution of PYX were mainly *** the initial stage of decomposition,the intramolecular hydrogen transfer reaction and the formation of dimerized clusters are earlier than the denitration *** the progress of the reaction,one side of the bitter amino group is removed from the pyridine ring,and then the pyridine ring is *** final products produced in the thermal decomposition process are CO_(2),H_(2)O,N_(2),and H_(2).Among them,H_(2)O has the earliest generation time,and the reaction rate constant(k_(3))is the *** clusters are formed during the decomposition of PYX,and the formation,aggregation,and decomposition of these clusters are strongly affected by *** low temperatures(2500 K-2750 K),many clusters are *** high temperatures(2750 K-3250 K),the clusters aggregate to form larger *** 3500 K,the large clusters decompose and become *** the late stage of the reaction,H and N in the clusters escaped almost entirely,but more O was trapped in the clusters,which affected the auto-oxidation process of ***'s initial decomposition activation energy(E_(a))was calculated to be 126.58 kJ/*** work contributes to a theoretical understanding of PYX's entire thermal decomposition process.

关键词： PYX Thermal decomposition ReaxFF-lg MD simulations Excellent thermostable explosives

Influence of Repetitive Impulse Waveforms on Surface Discharge Characteristics and Insulation Life for Polyimide Film

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 746-755页

作者： Zhiyun Han Qingmin Li Yujin Guo Tao Liu Guojing Dong Hanwen ren State Key Laboratory of Alternate Electrical Power System with renewable Energy Sources North China Electric Power UniversityBeijing 102206China Electric Power Research Institute Beijing 100085China Inner Mongolia Electric Economy and Technology Academy Hohhot 010020China

Accelerated insulation aging problems under high frequency repetitive impulses in power electronic transformers are drawing more and more attention in modern power systems. Partial discharge (PD) characteristics including discharge inception voltage, phase distribution and statistical characteristics on polyimide (PI) surface under different impulse waveforms and the insulation life of PI films are studied in this paper. We carry out experiments based on PD and insulation lifetime test systems, using five different types of repetitive impulses, including three bipolar waves and two unipolar waves. The experimental results show that there is little variation in discharge inception voltage under different waveforms, but great variation in phase distribution and statistical characteristics of PD. In addition, insulation life is approximately the same under different waveforms with the same polarity, and the aging rate under bipolar waveforms is larger than that under unipolar waveforms. We explain the differences between the bipolar and unipolar waveforms on insulation life, which can be concluded that the surface charge under unipolar waveform accumulates more significnatly compared with bipolar waveform and decreases the electric filed strength in discharging the air gap and inhibits surface discharge from occurring.

关键词： Insulation life polyimide film power electronic transformer repetitive impulse surface discharge characteristics

A new calibration method for radon detector in seismic systems

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Earthquake Science 2024年第5期37卷 445-458页

作者： Hongwei ren Yaowei Liu Institute of Geophysics China Earthquake AdministrationBeijing 100081China National Institute of Natural Hazards Ministry of Emergency ManagementBeijing 100085China

Radon observation is an important measurement item of seismic precursor network *** radon detector calibration is a key technical link for ensuring radon observation *** present,the radon detector calibration in seismic systems in China is faced with a series of bottleneck problems,such as aging and scrap,acquisition difficulties,high supervision costs,and transportation limitations of radon *** a result,a large number of radon detectors cannot be accurately calibrated regularly,seriously affecting the accuracy and reliability of radon observation data in *** solve this problem,a new calibration method for radon detectors was *** advantage of this method is that the dangerous radioactive substance,i.e.,the radon source,can be avoided,but only“standard instruments”and water samples with certain dissolved radon concentrations can be used to realize radon detector *** method avoids the risk of radioactive leakage and solves the current widespread difficulties and bottleneck of radon detector calibration in seismic systems in *** comparison experiment with the traditional calibration method shows that the error of the calibration coefficient obtained by the new method is less than 5%compared with that by the traditional method,which meets the requirements of seismic observation systems,confirming the reliability of the new *** new method can completely replace the traditional calibration method of using a radon source in seismic systems.

关键词： radon detector calibration “standard instrument” scintillation chamber radon source

Multiscale control of MnO_(2) growth via[WO_(6)]-perturbed[MnO_(6)]assembly toward a favorable balance between capacitance and rate performance

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Rare Metals 2024年第4期43卷 1658-1671页

作者： Jin-Kang Liu Tian-Shuo Yang Zhi-Bin ren Adekunle-Adedapo Obisanya Xin-Yi Tan Yan-Di Rao Jun-Shuang Zhou Fa-Ming Gao Jian-ren Wang Hebei Key Laboratory of Applied Chemistry Yanshan UniversityQinhuangdao066004China

Although pseudocapacitive manganese dioxide(MnO_(2))integrates the high-power merit of carbonaceous materials with the high-energy merit of battery-type materials,it still has a long way to go in achieving a more satisfactory balance of higher energy and power density,and in decoupling the relationship of structural characteristics with energy storage *** realize such goals,a bottom-up[WO_(6)]-perturbed[MnO_(6)]assembly strategy has been developed here due to their similar structure,yet mismatched lattice *** facile protocol is capable of finely controlling the morphology and crystal structure of MnO_(2)by adjusting its internal[WO_(6)]***,the as-prepared W_xMnO_(2)is treated as an ideal platform to scrutinize the correlations of the structure with the energy storage *** operando Raman spectra and finite element analysis have fully demonstrated the superiority of the locally ordered defects-enriched structure of W_(0.02)-MnO_(2),which could reach a favorable balance between the ion diffusion equilibrium time and the number of active *** a result,the W_(0.02)-MnO_(2)is able to deliver a high capacitance of 292 F·g^(-1)at a current density of 1 A·g^(-1)and a remarkable rate performance with a 60%capacity retention at a current density of 50 A·g^(-1).The further unveiled structure-performance relationship provides a guideline for the design of better pseudocapacitive energy storage devices.

关键词： Supercapacitors Pseudocapacitive materials MnO_(2) Tungsten doping Crystal structure regulation