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Comparative genome analysis between Southeast Asian and South American Zika viruses

Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1026-1032页

作者： Theerarat Kochakarn Namfon Kotanan Krittikorn Kümpornsin duangkamon loesbanluechai Monta Thammasatta Prasert Auewarakul Prapon Wilairat Thanat Chookajorn Genomics and Evolutionary Medicine Unit Centre of Excellence in Malaria ResearchFaculty of Tropical MedicineMahidol University Department of Biochemistry Faculty of ScienceMahidol University Department of Clinical Microscopy Faculty of Allied Health SciencesChulalongkorn University National Science and Technology Development Agency Pathum Thani Department of Microbiology Faculty of Medicine Siriraj HospitalMahidol University

Objective:To understand the cause for the differences between potentially mild Southeast Asian and the more pathogenic ZIKV in South ***:A comparative genomic analysis was performed to determine putative causations stemming from ***:Phylogcnctic analyses integrating geographical and time factors revealed that Southeast Asian ZIKV might not be the direct source of South American outbreaks as previously *** acid residues unique to South American ZIKV isolates at the envelope,pr and NS1 proteins are listed and shown in the structural *** unique residues on external viral proteins are not found in Southeast Asian ZIKV and could be responsible for the ongoing outbreak either via an intrinsic property of the virus or interactions with human *** a selected few primer/probe sets currently in clinical use were identified of being capable of detecting ZIKV strains *** envelope proteins of dengue virus(DENV) and ZIKV also showed a remarkable degree of similarity especially at the surface ***:findings that may help explain the cross-reactivity of DENV antibodies to ***,major caveats must be exercised in using existing diagnostic tools for ZIKV.

关键词： Phylogenetic analysis Protein structure Southeast Asia Dengue virus Zika virus

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