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In vitro interference of cefotaxime at subinhibitory concentrations on biofilm formation by nontypeable Haemophilus influenzae

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 745-750页

作者： Sudarat Baothong Sutthirat Sitthisak duangkamol kunthalert Department of Microbiology and Parasitology Faculty of Medical ScienceNaresuan University Centre of Excellence in Medical Biotechnology Faculty of Medical ScienceNaresuan University

Objective:To investigate the in vitro interference of cefotaxime at subinhibitory concentrations [sub-minimal inhibitory concentrations(MIC)] on biofilm formation by nontypeable Haemophilus influenzae(NTHi).Methods:The interference of subinhibitory concentrations of cefotaxime on biofilm formation of the clinical strong-biofilm forming isolates of NTHi was evaluated by a microtiter plate biofilm formation *** effect of sub-MIC cefotaxime on bacterial cell-surface hydrophobicity was determined using a standard microbial adhesion to n-hexadecane ***,the effects on bacterial adherence to human fibronectin and expression of bacterial adhesins were also ***:Subinhibitory concentrations of cefotaxime,both at 0.1× and 0.5× MIC levels,efficiently reduced the NTHi biofilm formation,and this effect was independent of decreasing bacterial ***-MIC cefotaxime also decreased bacterial cell-surface hydrophobicity and reduced adherence to human *** in the P2 and P6 gene expressions upon exposure to sub-MIC cefotaxime was also ***:Taken together,our results indicate that sub-MIC cefotaxime interferes with the formation of NTHi biofilm,and this effect is feasibly related to the interference with cell-surface hydrophobicity,fibronectin-binding activity as well as alteration of the P2 and P6 gene *** findings of the present study therefore provide a rationale for the use of subinhibitory concentrations of cefotaxime for treatment of NTHi-related diseases.

关键词： Biofilm formation Cefotaxime Nontypeable Haemophilus influenzae Subinhibitory concentration Sub-MIC

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