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Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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Precision clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline Proszynski Braden Tierney caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox christopher chin Deena Najjar Irina Matei Irenaeus chan carlos cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian c.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu duane c.hassane Susan M.Bailey Kelly Bolton Jaime Mateus christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced Pattern Analysis&Human Performance Group BoulderCO 80302USA children's cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer cancer center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative Physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA cell and Molecular Biology Program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative PcR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(cHIP)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of cHIP in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

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Jacobson's Lemma for Generalized Drazin–Riesz Inverses

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Acta Mathematica Sinica,English Series 2023年第3期39卷 481-496页

作者： Soufiane HADJI hassane ZGUITTI Department of Mathematics Dhar El Mahraz Faculty of ScienceSidi Mohamed Ben Abdellah UniversityP.O.Box 1796 Fes-Atlas30003 Fez Morocco

For bounded linear operators A,B,c and D on a Banach space X,we show that if BAc=BDB and cDB=cAc then I-Ac is generalized Drazin-Riesz invertible if and only if I-BD is generalized Drazin-Riesz invertible,which gives a positive answer to Question 4.9 in Yan,Zeng and Zhu[complex *** 14,Paper No.12(2020)].In particular,we show that Jacobson’s lemma holds for generalized Drazin-Riesz inverses.

关键词： Jacobson's lemma Drazin inverse generalized Drazin-Riesz inverse

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Entropy and Renormalized Solutions for Nonlinear Elliptic Problem Involving Variable Exponent and Measure Data

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Acta Mathematica Sinica,English Series 2015年第1期31卷 151-169页

作者： Mohamed Badr BENBOUBKER Houssam cHRAYTEH Mostafa EL MOUMNI hassane HJIAJ National School of Applied Sciences Abdelmalek Essaadi University Beirut Arab University Faculty of ScienceDepartment of Mathematics and Computer Science Laboratory LAMA Faculty of Sciences Dhar El MahrazSidi Mohamed Ben Abdellah University

We give an existence result of entropy and renormalized solutions for strongly nonlinear elliptic equations in the framework of Sobolev spaces with variable exponents of the type： -div （a（x, u,▽u）＋φ（u））＋g（x, u,▽u）=μ, where the right-hand side belongs to L^1（Ω）＋W^-1,p＇（x）（Ω）, -div（a（x, u,▽u）） is a Leray-Lions operator defined from W^-1,p＇（x）（Ω） into its dual and φ∈c^0（R,R^N）. The function g（x, u,▽u） is a non linear lower order term with natural growth with respect to ｜▽u｜ satisfying the sign condition, that is, g（x, u,▽u）u ≥ 0.

关键词： Nonlinear elliptic problem Sobolev spaces variable exponent entropy solution renormalized solution measure data

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Association between AcTN3 R577X genotype and risk of non-contact injury in trained athletes:A systematic review

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Journal of Sport and Health Science 2023年第3期12卷 359-368页

作者： hassane Zouhal Juan Del coso Ayyappan Jayavel claire Toumy Guillaume Ravé Nidhal Jebabli cain c.T.clark Benjamin Barthélémy Anthony c.Hackney Abderraouf Ben Abderrahman M2S(Laboratoire Mouvement SportSanté)-EA 1274Department of Sport SciencesUniversity of RennesRennes F-35000France Rey Juan carlos University Centre for Sport StudiesMadrid 28032Spain SRM college of Physiotherapy SRM Institute of Science and TechnologySRM NagarKattankulathur 603203India Department of Sport Sciences University of RouenMont Saint AignanCETAPS EA 3832F-76821France Toulouse Football club Toulouse 31000France Higher Institute of Sport and Physical Education Ksar-SaidUniversity of ManoubaTunis 2010Tunisia centre for Intelligent Healthcare Coventry UniversityCoventry CV15FBUK Department of Exercise&Sport Science Department of NutritionUniversity of North CarolinaChapel HillNC 27514USA

Purpose:The aim of this study was to review,systematically,evidence concerning the link between the AcTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training ***:A computerized literature search was performed in the electronic databases PubMed,Web of Science,and SPORTDiscus,from inception until November *** included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the AcTN3 R577X ***:Our search identified 492 *** the screening of titles,abstracts,and full texts,13 studies examining the association between the AcTN3 genotypes and the rate and severity of non-contact injury were included in the *** studies were performed in 6 different countries(Spain,Japan,Brazil,china,the Republic of Korea,and Italy)and involved a total participant pool of 1093 *** the studies,2 studies involved only women,5 studies involved only men,and 6 studies involved both men and *** the studies included were classified as highquality studies(≥6 points in the Physiotherapy Evidence Database(PEDro)scale score).Overall,evidence suggests there is an association between the AcTN3 R577X genotype and non-contact injury in 12 *** studies observed a significant association between A cTN3 R577X polymorphism and exercise induced muscle damage:2 with non-contact ankle injury,3 with non-contact muscle injury,and 1 with overall non-contact ***:The present findings support the premise that possessing the AcTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries,such as muscle injury,ankle sprains,and higher levels of exercise-induced muscle damage.

关键词： α-actinin-3 deficiency Athletic performance Exercise-related injury Muscle injury Single nucleotide polymorphism

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Fifth-degree elastic energy for predictive continuum stress-strain relations and elastic instabilities under large strain and complex loading in silicon

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npj computational Materials 2020年第1期6卷 697-704页

作者： Hao chen Nikolai A.Zarkevich Valery I.Levitas duane D.Johnson Xiancheng Zhang Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China Ames Laboratory U.S.Department of EnergyIowa State UniversityAmesIA 50011-3020USA Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Department of Mechanical Engineering Iowa State UniversityAmesIA 50011USA Department of Materials Science&Engineering Iowa State UniversityAmesIA 50011USA

Materials under complex loading develop large strains and often phase transformation via an elastic instability,as observed in both simple and complex ***,we represent a material(exemplified for Si I)under large Lagrangian strains within a continuum description by a 5^(th)-order elastic energy found by minimizing error relative to density functional theory(DFT)results.

关键词： continuum energy minimizing

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chenopodium ambrosioides induces an endothelium-dependent relaxation of rat isolated aorta

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Journal of Integrative Medicine 2019年第2期17卷 115-124页

作者： Asmae Assaidi Ikram Dib Monique Tits Luc Angenot Said Bellahcen Nourelhouda Bouanani Abdelkhaleq Legssyer Mohammed Aziz hassane Mekhfi Mohammed Bnouham Michel Frederich Abderrahim Ziyyat Laboratory of Physiology Genetics and Ethnopharmacology Department of Biology Faculty of Sciences Mohammed I University Laboratory of Pharmacognosy Center for Interdisciplinary Research on the Medicines (CIRM) University of Liège

Objective: This study aims to evaluate the vasodilatory effect of chenopodium ambrosioides on the isolated rat aorta, and to explore its mechanism of ***: The vasorelaxant effect and the mode of action of various extracts from the leaves of c. ambrosioides were evaluated on thoracic aortic rings isolated from Wistar rats. In addition, ethyl acetate and methanol fractions were analyzed, using thin-layer chromatography and high-performance liquid chromatography techniques, for their polyphenolic ***: The various active extracts of c. ambrosioides at four concentrations(10^(-3), 10^(-2), 10^(-1) and 1 mg/mL) relaxed the contraction elicited by phenylephrine, in a concentration-dependent *** effect seems to be endothelium-dependent, since the vasodilatory effect was entirely absent in denuded aortic rings. The vasorelaxant effect of the methanol fraction(MF) of c. ambrosioides at 1 mg/mL was also inhibited by atropine and tetraethylammonium. This effect remained unchanged by Nx-nitro-L-arginine methyl ester hydrochloride and glibenclamide. The preliminary phytochemical analysis showed that the leaves of c. ambrosioides are rich in phenolic and flavonoid ***: These results suggest that the MF of c. ambrosioides produces an endothelium-dependent relaxation of the isolated rat aorta, which is thought to be mediated mainly through stimulation of the muscarinic receptors, and probably involving the opening of ca^(2+)-activated potassium channels.

关键词： chenopodium ambrosioides chenopodiaceae Vasorelaxation ca^2+-activated potassium channels Thin-layer chromatography High-performance liquid chromatography Plant complementary and alternative medicine

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Phosphorus availability in two soils amended with poultry litter

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Journal of Environmental Sciences 1996年第4期8卷 483-490页

作者： Han Xingguo (Institute of Botany,chinese Academy of Sciences,Beijing 100093,china)duane c.Wolf (Department of Agronomy,University of Arkansas,Fayetteville, AR 72701,USA) Institute of Botany Chinese Academy of Sciences Beijing 100093 China Department of Agronomy University of Arkansas Fayetteville AR 72701 United States

Understanding P transformation in soils amended with poultry litter is important if water quality is to be *** objectives were to determine the influence of method of litter application and temperature on P availability. Poultry litter containing 20. 8g P/kg (dry weight) was either surface-applied or incorporated into captina (fine-silty, siliceous, mesic Typic Fragiudult) and Nixa (loamy-skeletal,siliceous,Glossic Fragiudult) silt loams at rates of 0 or 10g/kg and incubated at 20℃ or 35℃ at a water potential of -40 kpa. Water soluble and available P (0.03 mol/L NH4F+0. 025mol/L Hcl extraction) were determined during a 60d laboratory study. Results indicated that water soluble and available P levels in the soils initially decreased, then rapidly increased,and approached a steady state phase after approximately 20d. After 60d, water soluble P levels were significantly higher when litter was surface applied than when litter was incor porated. When the incubation was terminated, the net increase in available P in both soils was>100 mg P/*** efficient recycling of P and protection of water quality, application method and temperature should be considered when amending soils with poultry litter,

关键词： nutrient cycling phosphorus availability poultry litter water quality.

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Geothermobarometry of Askaoun Pluton in Ouzellarh-Sirwa Promontory (central Anti-Atlas;Morocco)

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Open Journal of Geology 2012年第3期2卷 136-147页

作者： Abdeslam Toummite Moha Ikenne El hassane Beraaouz Applied Geology and Environmental Geology Laboratory Faculty of Sciences Ibn Zohr University Agadir Morocco

Rocks of the late Neoproterozoic Askaoun pluton (558 ± 2 Ma) located in the Ouzellarh-Sirwa promontory (Anti-Atlas) include magmatic microgranular enclaves (MMEs) ranging from rounded to ovoid in shape, dark and fine grained and generally 5 to 10 cm in size, some reaching a size of 50 cm. They are composed of microdiorite, quartz microdiorite and micromonzodiorite, whereas the felsic host rocks comprise mainly quartz-diorite and amphibole-biotite granodiorite based on mineralogical compositions. The mineral assemblage is similar to those described in their hosting granitoids but with different proportions. In this study composition of minerals is used to describe the nature of the magma and estimate the pressure, temperature and oxygen fugacity at which Askaoun pluton is emplaced. Based on chemistry of biotite Askaoun pluton formed from calc-alkaline magma. compositions of plagioclase (An5 - An29);hornblende (Mg ≠= 0.59 - 0.65) and biotite (Mg ≠= 0.49 - 0.55) of MMEs are slightly distinct or similar to those of host rocks (An7-40;hbl Mg ≠= 0.64 - 0.69;Bi Mg ≠= 0.49 - 0.50) which suggest partial to complete equilibration during mafic-felsic magma interaction. The coexisting hornblende and plagioclase (hornblende-plagioclase thermometry), Al content in hornblende (aluminum-in-hornblende barometry) and the assemblage titanite-magnetite-quartz were used to constrain the P, T and fO2 during the crystallization of the parent magmas. The Askaoun pluton was emplaced at temperature ca. 504°c - 633°c and at pressure ca. 0.9 - 4.66 ± 0.6 Kbars (average depth = 6.5 km) from a highly oxidized magma (log fO2 = ?24.8 to ?19.2).

关键词： Askaoun Pluton MMEs Hornblende Thermobarometry Ouzellargh-Sirwa Promontory Anti-Atlas Morocco

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comparative Study of Thermal comfort Induced from Masonry Made of Stabilized compressed Earth Block vs conventional cementitious Material

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Journal of Minerals and Materials characterization and Engineering 2019年第6期7卷 385-403页

作者： hassane Seini Moussa Philbert Nshimiyimana césaire Hema Ousmane Zoungrana Adamah Messan Luc courard Institut International d’Ingénierie de l’Eau et de l’Environnement (2iE) Laboratoire Eco-Matériaux et Habitats Durables (LEMHaD) Rue de la Science Ouagadougou Burkina Faso Université de Liège (ULiège) Urban and Environmental Engineering (UEE) Liège Belgium Université catholique de Louvain (UcLouvain) Architecture et Climat Louvain-La-Neuve Belgium Université de Liège (ULiège) Service socio-anthropologie du développement Liège Belgium

This paper investigates the stabilization effect on compressed earth blocks (cEB) produced from quartz-kaolinite rich earthen material stabilized with 0% - 25% calcium carbide residue (ccR). The paper evaluated various physico-thermal properties of the stabilized cEB and thermal comfort in the model building made of cEB masonry. The optical properties of cEB were evaluated from the mineral composition of the earthen material and ccR and apparent density of the cEB. A simulation was carried out on naturally ventilated model building whose masonry is made of ccR stabilized cEB comparing to the so-called conventional cementitious materials such as cement blocks and concrete. The results showed a decrease of the apparent density of the cEB from 2100 kg·m–3 for unstabilized cEB (0% ccR) to 1600 kg·m–3 for 25% ccR stabilized cEB. The thermal conductivity and depth of penetration of the heat flux on a 24 hours period of cEB respectively decreased from 1 W·m–1·K–1 and 12.7 cm for 0% ccR-cEB to 0.5 W·m–1·K–1 and 10.2 cm for 25% ccR-cEB. The emissivity, solar absorptivity and visible absorptivity of the cEB respectively decreased from 0.82, 0.82 and 0.82 for 0% ccR-cEB to 0.80, 0.64 and 0.64 for 25% ccR-cEB. The number of hours of warm and humid thermal discomfort was impacted for stabilized cEB based masonry in comparison with cement based masonry. The warm discomfort in building made of 20% ccR-cEB masonry was 400 hours lesser than that in building made of hollow cement blocks masonry. If air conditioning system is used to keep the indoor temperature below 28°c, the economy of 310,000 cFA francs (535 USD) is made every year on energy consumption for cooling in the model building made of 20% ccR-cEB masonry, corresponding to 9.6% less, with respect to that made of hollow cement blocks masonry.

关键词： calcium carbide Residue compressed Earth Block cementitious Materials Energy Plus Software Thermal comfort

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Influence of Synthesis Parameters on the Structure, Pore Morphology and Bioactivity of a New Mesoporous Glass

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Journal of Biosciences and Medicines 2014年第2期2卷 57-63页

作者： Nouha Letaief Anita Lucas-Girot hassane Oudadesse Rachida Dorbez-Sridi 1Université de Rennes 1 ISCR UMR CNRS 6226 Rennes France 2Université de Monastir Faculté des Sciences Monastir Tunisie Université de Monastir Faculté des Sciences Monastir Tunisie Université de Rennes 1 ISCR UMR CNRS 6226 Rennes France

The main objective of the present work was to investigate the effect of surfactant type and synthesis temperature on the structure, porosity and the bioactivity of 92S6 (92% SiO2, 6% caO, and 2% P2O5 mol %) mesoporous sol-gel glasses. The aim was to provide a basis for controlling the bioactive behavior of the different 92S6 samples used for tissue regeneration and for biomedical engineering in order to obtain sufficient performances by controlling the porosity of the glass. In this paper, a series of mesoporous bioactive glasses were synthesized using three different surfactants (c10H20BrN, c19H42BrN, c22H48BrN) at different aging temperatures (20°c, 40°c and 60°c). The surfactant was removed by calcination, which was carried out by increasing the temperature to 650°c for 6 h. A comparison among these synthesized glasses was conducted and the research emphasis was placed on the synthesis temperature and the surfactant type dependence on the textural properties and particularly porosity that were ultimately responsible for glass bioactivity.

关键词： Mesoporous Glass Sol-Gel Bioactive Glass Hydroxyapatite

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