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Effects of marine collagen peptides on glucose and lipid metabolism and markers of metabolic nuclear receptors in hypertensive patients with type 2 diabetes

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Effects of marine collagen peptides on glucose and lipid met...

基于CiteSpace的中医药防治难治性肾病综合征可视化分析

中国食品科学技术学会第八届年会暨第六届东西方食品业高层论坛

作者： Zhu Cui-Feng~(a,b) Li Guan-zhi~b Peng Hong-Bin~1 zhang Fan~2 Chen Yun~2 Lu Hong~2 LI Yong~(1*) (a Department of Nutrition and Food Hygiene,school of Public Health,{3. university,beijing 10083. china b Department of Nutrition,Shenzhen Hospital of peking university,Shenzhen 51803.,china.)

Objective:This study was attempted to determine the effects of marine collagen peptides(MCPs) on glucose and lipid metabolism and markers of three metabolic nuclear receptors,peroxisome proliferator -activated receptor(PPARs),liver X receptor(LXRs)and farnesoid X receptor(FXRs),in hypertensive patients with type 2 ***:The study population consisted of one hundred hypertensive patients with type 2 diabetes and fifty healthy subjects recruited from local communities in Shenzhen,*** patients with hypertension were randomized into intervention group(n=50,group A)and non-intervention group(n=50,group B)whereas fifty healthy subjects were assigned to control *** or placebo (water-soluble starch)were respetively given to group A and group B before breakfast and bedtime at a dose of 6.5g over a period of three *** serum samples were analyzed for levels of blood glucose, insulin,serum lipid,uric acid,glycosylated hemoglobin(GHbA1c),high sensitivity C-Reactive protein (hs-CRP),serum creatinine and markers of metabolic nuclear receptor,including free fatty acid,cytochrome P450,leptin,resistin,adiponectin,bradykinin,NO and prostacyclin before intervention,1.5 months,and 3.months after *** occurrence of acute or chronic complications developed during the study such as hypoglycemia and diabetic ketoacidosis were recorded and compared among different ***:Before intervention,the levels of fasting blood glucose,insulin,triglyceride in group A and B were higher than those of healthy controls while levels of HDLc in group A and group B were much lower than that of healthy *** the study,the concentrations of free fatty acid,cytochrome P450,resistin and bradykinin in group A and B were much higher than those in controls,yet no statistical differences were noted between group A and *** of prostacyclin in group A and B were higher than those of normal controls either before or after *** t

关键词： marine collagen peptide glucose and lipid metabolism peroxisome proliferator-activated receptor(PPAR) liver X receptor farnesoid X receptor metabolic nuclear receptor

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世界中西医结合杂志 2024年第5期19卷 864-870,878页

作者：张一凡潘知玉张琪柳菁段行宇张昱北京中医药大学研究生院北京100029 中国中医科学院西苑医院肾病科北京100091

目的运用CiteSpace软件分析中医药防治难治性肾病综合征(Refractory nephrotic syndrome,RNS)的研究现状、热点及趋势。方法检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)自2000年1月1日—2022年12... 详细信息

目的运用CiteSpace软件分析中医药防治难治性肾病综合征(Refractory nephrotic syndrome,RNS)的研究现状、热点及趋势。方法检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)自2000年1月1日—2022年12月3.日期间收录的关于中医药防治RNS的相关文献,统计发文量,利用CiteSpace 6.1.R6软件对作者合作、机构合作及关键词等信息进行可视化分析,绘制知识图谱。结果共纳入694篇文献,自2000年开始到2018年发文量呈上升趋势,总体趋于平稳。知识图谱中共涉及563.作者,戴恩来是发文量最多的作者;共涉及413.研究机构,甘肃中医药大学是发文量最多的机构;共纳入3.1个关键词,形成了10个聚类;近年来突现的关键词有免疫功能、炎症因子等。结论中医药防治RNS研究仍然有很大发展空间,研究作者及机构之间合作亟待加强;目前的研究热点主要以中药及中成药的临床干预效果、作用机制为主,标准化治疗方案有待建立,同时中医药防治RNS作用机制也需进一步深入探索。

关键词：难治性肾病综合征中医药 CiteSpace 知识图谱文献计量学

High spin structures in A～110 mass region

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High spin structures in A～110 mass region

基于低频射电偏振特征的极高能宇宙线背景剔除

第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： S.Y.Wang~(1 1)),B.Qi~1,D.P.Sun~1,C.J.Xu~1,C.Liu~1,X.L.Ren~1,L.Liu~1,B.T.duan~1, X.X.Zhu~1,J.Xi~1,X.L.Yang~1,F.Z,Lv~1,H.Hua~2,Z.Y.Li~2,S.Q.zhang~2,J.M.Yao~2, L.H.Zhu~3.X.G.Wu~3.G.S.Li~3.Y.Liu~3.X.Q.Li~3.Y.Zheng~3.L.L.Wang~3.L.Wang~3.1(school of Space Science and Physics,Shandong {3. at Weihai,Weihai 264209,china) 2(school of Physicsand SK Lab.of Nucl.Phys.& Tech.,peking {3.,beijing 100871,china) 3.china Institute of Atomic Energy,beijing 102413.china)

Using the techniques of in-beamγ—ray spectroscopy,the high-spin states of the neutron-rich nuclei Sb, Sn,and In were studied via the Cd（Li,5n）Sb,Cd（Li,3.）Sb,Cd（Li,4n1p）Sn and Cd（Li,α3.）In fusion-evaporation *** DCO ratios andγ—γcoincidences were *** a result of these experiments the level schemes of Sb,Sn,and In were significantly extended. Excited states of these neutron-rich nuclei were discussed within the framework of the particle-rotor model （PRM） and the triaxial relativistic mean-field（RMF） approaches.

关键词： neutron-rich nuclei high spin states fusion-evaporation reaction

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天文学报 2024年第4期65卷 148-160页

作者：孙志豪马鹏雄张克文张超许鑫中国科学院紫金山天文台南京210023 中国科学技术大学天文与空间科学学院合肥230026 北京大学物理学院北京100871 西安电子科技大学电子工程学院西安710071

自触发射电阵列的设计是宇宙线大气簇射的射电探测所面临的机遇和难题之一,例如由背景源产生高振幅的瞬时噪声会导致射电阵列的误触发,而阵列设计需要避免由噪声导致的误触发.大气簇射射电信号独有的偏振特征为解决阵列的误触发问题提... 详细信息

自触发射电阵列的设计是宇宙线大气簇射的射电探测所面临的机遇和难题之一,例如由背景源产生高振幅的瞬时噪声会导致射电阵列的误触发,而阵列设计需要避免由噪声导致的误触发.大气簇射射电信号独有的偏振特征为解决阵列的误触发问题提供了解决方案,而利用信号偏振特征解决阵列误触发的方法的前提是射电信号的电场重建.由于背景噪声也会通过天线响应耦合到最终的观测数据中,这对正确重建射电信号的电场构成不可忽视的挑战.基于GRAND(Giant Radio Array for Neutrino Detection)验证阵列GP3.0(GRAND-Proto 3.0)的样机,结合模拟软件ZHAireS(ZHS AIR-shower Extended Simulations)模拟大气簇射产生的射电信号,耦合三极化天线的真实响应并使用最小二乘法重建电场,研究了射电信号的偏振特性,最终统计了以偏振为基础的天线的触发效率.

关键词：星际介质:宇宙线星际介质:射电探测辐射:偏振星际介质:大气簇射

Distribution patterns and industry planning of commonly used traditional Chinese medicinal plants in china

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Plant Diversity 2022年第3期44卷 255-261页

作者： zhang-Jian Shan Jian-Fei Ye Da-Cheng Hao Pei-Gen Xiao zhi-duan Chen An-Ming Lu State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China university of Chinese Academy of Sciences Beijing 100049China china National Botanical Garden Beijing 100093China Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Medicinal plants are the primary material basis for disease prevention and treatment in traditional Chinese medicine(TCM).The conservation and sustainable utilization of these medicinal plants is critical for the development of the TCM ***,wild medicinal plant resources have sharply declined in recent *** ameliorate the shortage of medicinal plant resources,it is essential to explore the development potential of the TCM industry in different geographical *** this purpose,we examined the spatial distribution of commonly used medicinal plants in china,the number of Chinese medicinal material markets,and the number of TCM decoction piece ***,multispecies superimposition analysis and Thiessen polygons were used to reveal the optimal range for planting bulk medicinal plants and the ideal regions for building Chinese medicinal material markets,***,we quantitatively analyzed mismatches between the spatial distribution of commonly used medicinal plant richness,Chinese medicinal material markets,and TCM decoction piece *** found that the areas suitable for growing commonly used medicinal plants in china were mainly distributed in Hengduan Mountain,Nanling Mountain,Wuling Mountain,and Daba Mountain *** Thiessen polygon network based on Chinese medicinal material market localities showed there are currently fewer markets in southwestern,northwestern,and northeastern china than in central and southern *** decoction piece enterprises are concentrated in a few provinces,such as Hebei and *** found that the distribution of commonly used medicinal plants,Chinese medicinal material markets and TCM decoction piece enterprises are mismatched in Henan,Shaanxi,Hunan,Hubei,Zhejiang,Fujian,Chongqing,and *** recommend strengthening development of the TCM industry in Henan,Hunan,Zhejiang,Shaanxi,Hubei,Chongqing,Fujian,and Xizang;building more Chinese medicinal material markets in southw

关键词： Medicinal plant Distribution pattern Traditional Chinese medicine industry Thiessen polygon

A Simplifed and Efficient Synthesis of 7-Hydroxymethyl-6,7-Dihydropyrro-[1,2-c]-Pyrimidine-1,3.Dione as a Potent Anti-HIV-1 Agent

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A Simplifed and Efficient Synthesis of 7-Hydroxymethyl-6,7-D...

铜氧超导材料电荷密度波和元激发的共振非弹性X射线散射研究

第三届全国有机化学学术会议

作者： WANG, Xiao-Wei zhang, zhi-Li HAN, Peng MA, Xiao-Yan LIU, Jun-Yi ( Department of Chemical Biology, school of Pharmaceutical Sciences ,{3., beijing 100083.

＜正＞ The reverse transcriptase of HIV provides a key target for the development of anti-AIDS drugs. The discovery of l-[（2-hydroxyethoxy）methyl]-6-（phenylthio）-thymine （HEPT） as a compound with potent and selective in vivo activity against HIV-1 has led to the synthesis many new non-nucleoside reverse transcriptase inhibitors. To investigate the new anti-HIV-1 agents, we have designed and synthesized 7-hydroxy-methyl-6,7-dihydropyrro-[ 1,2-c ]-pyrimidine-1,3.dione （Scheme 1）.

关键词：

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物理学报 2024年第19期73卷 122-139页

作者：李齐治张世龙彭莹莹北京大学物理学院量子材料科学中心北京100871 深圳平湖实验室深圳518111

铜氧超导材料问世以来,其高温超导的理论机制仍有待解决.近年来,铜氧超导领域的实验进展主要集中在利用新型表征手段探索微观机理,其中同步辐射的建设推进了先进谱学技术的发展.基于同步辐射的共振非弹性X射线散射技术,因具有体测量、... 详细信息

铜氧超导材料问世以来,其高温超导的理论机制仍有待解决.近年来,铜氧超导领域的实验进展主要集中在利用新型表征手段探索微观机理,其中同步辐射的建设推进了先进谱学技术的发展.基于同步辐射的共振非弹性X射线散射技术,因具有体测量、能量动量分辨及直接探测不同元激发色散关系的能力,在铜氧超导材料研究中得到了广泛应用.无论是B ardeen-Cooper-Schrieffer理论框架下粘合库珀对的声子,还是强关联体系中Hubbard模型预测的磁涨落和竞争序,都可以用共振非弹性X射线散射实验测量,并研究它们之间的关联.本文介绍了利用共振非弹性X射线散射测量铜氧超导材料电荷密度波及相关低能激发,包括声子异常现象的研究进展,还介绍了磁激发和超导最高转变温度的关系,最后对未来的研究方向和面临的挑战进行展望.

关键词：共振非弹性X射线散射铜氧超导电荷密度波声子磁激发

Population Size Estimation with Covariate Values Missing Non-ignorable

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Acta Mathematicae Applicatae Sinica 2016年第3期32卷 659-668页

作者： Li-ping LIU zhi-chao GUO Xiao-gang duan LMAM and CSS School of Mathematical Sciences Peking University Beijing 100871 China beijing Normal university Beijing 100875 China

The main purpose of this paper is using capture-recapture data to estimate the population size when some covariate values are missing, possibly non-ignorable. Conditional likelihood method is adopted, with a sub-model describing various missing mechanisms. The derived estimate is proved to be asymptotically normal, and simulation studies via a version of EM algorithm show that it is approximately unbiased. The proposed method is applied to a real example, and the result is compared with previous ones.

关键词： capture-recapture conditional likelihood EM algorithm missing non-ignorable

Global Well-posedness for gKdV-3.in Sobolev Spaces of Negative Index

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Acta Mathematica Sinica,English Series 2008年第5期24卷 857-866页

作者： zhi Fei zhang school of Mathematical Science Peking University Beijing 100871 P. R. China

The initial value problem for the generalized Korteweg-deVries equation of order three on the line is shown to be globally well posed for rough data. Our proof is based on the multilinear estimate and the I-method int... 详细信息

关键词： KdV equation Global well posedness I-method Multilinear estimate