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Profiling and identification of chemical components of Shenshao Tablet and its absorbed components in rats by comprehensive HPLC/DAD/ESI-MS^n analysis

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Chinese Journal of Natural Medicines 2018年第10期16卷 791-800页

作者： MIAO Wen-Juan HU Ying JIA Li zhang Chun-Xia YANG Wen-zhi zhang Ping GUO De-An Department of Pharmacy Institute of Hematology and Blood Disease HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

Shenshao Tablet(SST),prepared from Paeoniae Radix Alba(PRA)and total ginsenoside of Ginseng Stems and Leaves(GSL),is a traditional Chinese medicine(TCM)preparation prescribed to treat coronary heart ***,its chemical composition and the components that can migrate into blood potentially exerting the therapeutic effects have rarely been *** developed an HPLC/DAD/ESI-MS^n approach aiming to comprehensively profile and identify both the chemical components of SST and its absorbed ingredients(and metabolites)in rat plasma and *** separation was performed on an Agilent Eclipse XDB C_(18) column using acetonitrile/0.1% formic acid as the mobile *** detection was conducted in both negative and positive ESI modes to yield more structure *** with reference compounds(t_R,MS^n),interpretation of the fragmentation pathways,and searching of in-house database,were utilized for more reliable structure elucidation.A total of 82 components,including 21monoterpene glycosides,four galloyl glucoses,two phenols from PRA,and 55 ginsenosides from GSL,were identified or tentatively characterized from the 70% ethanolic extract of *** them,seven and 24 prototype compounds could be detectable in the plasma and urine samples,respectively,after oral administration of an SST extract(4 g×kg^(–1))in *** metabolites were observed in the rat *** findings of this work first unveiled the chemical complexity of SST and its absorbed components,which would be beneficial to understanding the therapeutic basis and quality control of SST.

关键词： Shenshao Tablet Paeoniae Radix Alba Total ginsenoside of Ginseng Stems and Leaves Chemical component

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咸水湖泊细粒重力流沉积及油气意义:以柴达木盆地英西地区下干柴沟组上段为例

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古地理学报 2024年第4期26卷 985-1004页

作者：王小妮杨智冯有良蒋文琦龙国徽伍坤宇张洪侯鸣秋邢浩婷张天舒刘畅魏琪钊中国石油勘探开发研究院北京100083 中国石油青海油田分公司勘探开发研究院甘肃敦煌736200 北京大学地球与空间科学学院北京100871

细粒重力流可以将滨浅湖的碎屑物质和有机质搬运至半深湖—深湖,形成沉积粒度小于0.0625 mm的细粒重力流沉积物,是深湖环境的重要搬运和沉积作用之一。柴达木盆地英雄岭地区西部下干柴沟组上段(E3.2)为咸水的半深湖—深湖环境,发育了湖... 详细信息

细粒重力流可以将滨浅湖的碎屑物质和有机质搬运至半深湖—深湖,形成沉积粒度小于0.0625 mm的细粒重力流沉积物,是深湖环境的重要搬运和沉积作用之一。柴达木盆地英雄岭地区西部下干柴沟组上段(E3.2)为咸水的半深湖—深湖环境,发育了湖底扇—深湖化学沉淀碳酸盐岩沉积体系。研究表明下干柴沟组上段发育有7大类岩相:云/灰质泥岩、粉砂质泥岩、白云岩、泥质白云岩、泥质粉砂岩、细粉砂岩以及粗粉砂岩岩相,形成了7类细粒沉积岩相组合:(1)泥流—泥质湍流—安静水体沉积岩相组合(LA1);(2)半深湖化学沉淀与事件沉积互层岩相组合(LA2);(3.滑塌—细粒碎屑流—泥流沉积岩相组合(LA3.;(4)细粒异重流沉积岩相组合(LA4);(5)细粒浓缩密度流沉积岩相组合(LA5);(6)细粒碎屑流—细粒过渡流—细粒浊流沉积岩相组合(LA6);(7)细粒浓缩密度流—细粒湍流—细粒过渡流—泥流沉积岩相组合(LA7)。细粒重力流作用及其相互转化,形成了多样的岩相组合,反映了复杂的沉积作用过程。湖盆细粒沉积物的形成和分布受古气候、盆地构造及湖平面变化的影响。在整体干旱的气候背景下,气候湿润湖平面上升有利于优质烃源岩和细粒异重流的发育;气候干热湖平面下降则有利于发育化学沉积的碳酸盐岩层和滑塌引起的细粒重力流沉积。咸水湖盆半深湖—深湖环境发育的代表泥流—泥质湍流—安静水体沉积的岩相组合(LA1)和化学沉淀碳酸盐岩与事件沉积碳酸盐岩互层的岩相组合(LA2)是优质的“甜点段”。

关键词：细粒重力流沉积咸化湖泊页岩油下干柴沟组上段英雄岭地区柴达木盆地

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Reconstruction of fission events in heavy ion reactions with the compact spectrometer for heavy ion experiment

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Nuclear Science and Techniques 2022年第4期33卷 1-9页

作者： Xin-Yue Diao Fen-Hai Guan Yi-Jie Wang Yu-Hao Qin zhi Qin Dong Guo Qiang-Hua Wu Da-Wei Si Xuan Zhao Sheng Xiao Yao-Peng zhang Xiang-Lun Wei Hai-Chuan Zou He-Run Yang Peng Ma Rong-Jiang Hu Li-Min duan Artur Dobrowolski Krzysztof Pomorski zhi-Gang Xiao Department of Physics Tsinghua UniversityBeijing 100084China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China school of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Physics Maria Curie Skłodowska UniversityLublin 20031Poland

We report a reconstruction method for fast-fission events in 25 MeV/u^(86)Kr +^(208)Pb reactions at the Compact Spectrometer for Heavy Ion Experiment(CSHINE). The fission fragments(FFs) are measured using three large-area parallel-plate avalanche counters, which can deliver the position and arrival timing information of the fragments. The start timing information is provided by the radio frequency of the cyclotron. Fission events were reconstructed using the velocities of the two FFs. The broadening of both the velocity distribution and azimuthal difference of the FFs decreases with the folding angle, in accordance with the picture that fast fission occurs. The anisotropic angular distribution of the fission axis also consistently reveals the dynamic features of fission events.

关键词： Fast fission Heavy ion reactions Parallelplate avalanche counter CSHINE

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SURFACE STRESS EFFECT IN MECHANICS OF NANOSTRUCTURED MATERIALS

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Acta Mechanica Solida Sinica 2011年第1期24卷 52-82页

作者： Jianxiang Wang Zhuping Huang Huiling duan Shouwen Yu Xiqiao Feng Gangfeng Wang Weixu zhang Tiejun Wang LTCS and Department of Mechanics and Aerospace Engineering College of Engineering Peking University Beijing 100871 China AML Department of Engineering Mechanics Tsinghua University Beijing 100084 China SV Lab Deparment of Engineering Mechanics School of Aerospace Engineering Xi＇an Jiaotong University Xi＇an 710049 China

This review article summarizes the advances in the surface stress effect in mechanics of nanostructured elements, including nanoparticles, nanowires, nanobeams, and nanofilms, and heterogeneous materials containing nanoscale inhomogeneities. It begins with the fundamental formulations of surface mechanics of solids, including the definition of surface stress as a surface excess quantity, the surface constitutive relations, and the surface equilibrium equations. Then, it depicts some theoretical and experimental studies of the mechanical properties of nanostructured elements, as well as the static and dynamic behaviour of cantilever sensors caused by the surface stress which is influenced by adsorption. Afterwards, the article gives a summary of the analytical elasto-static and dynamic solutions of a single as well as multiple inhomogeneities embedded in a matrix with the interface stress prevailing. The effect of surface elasticity on the diffraction of elastic waves is elucidated. Due to the difficulties in the analytical solution of inhomogeneities of complex shapes and configurations, finite element approaches have been developed for heterogeneous materials with the surface stress. Surface stress and surface energy are inherently related to crack propagation and the stress field in the vicinity of crack tips. The solutions of crack prob- lems taking into account surface stress effects are also included. Predicting the effective elastic and plastic responses of heterogeneous materials while taking into account surface and interface stresses has received much attention. The advances in this topic are inevitably delineated. Mechanics of rough surfaces appears to deserve special attention due to its theoretical and practical implications. Some most recent work is reviewed. Finally, some challenges are pointed out. They include the characterization of surfaces and interfaces of real nanomaterials, experimental mea- surements and verification of mechanical parameters o

关键词： surface/interface stress size-effect nanowires nanobeams nanofilms nanoinhomogeneities cantilevers elastic wave crack elastic constants rough surface effective surface stress

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基于PLS-DA的盘龙七及其易混品大盘龙七差异性成分分析

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中国现代中药 2024年第9期26卷 1520-1527页

作者：何姬刘妍如段金廒唐志书宋忠兴赵艳婷游雪莲张德柱杨国伟张丽权伟陕西中医药大学/陕西中药资源产业化省部共建协同创新中心陕西咸阳712083 南京中医药大学/江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室江苏南京210023 北京中医药大学中药学院北京100700 陕西盘龙药业集团股份有限公司陕西商洛711400 山西省检验检测中心/山西省标准计量技术研究院山西太原030002 陕西中医药大学附属医院药剂科陕西咸阳712000

目的:确定盘龙七及其同名异物药材大盘龙七的差异性成分并建立其含量测定方法。方法:采用偏最小二乘法-判别分析(PLS-DA)结合超高效液相色谱-四极杆-飞行时间质谱法(UPLC-Q-TOF-MS)分析盘龙七和大盘龙七差异性成分,并建立差异性成分定... 详细信息

目的:确定盘龙七及其同名异物药材大盘龙七的差异性成分并建立其含量测定方法。方法:采用偏最小二乘法-判别分析(PLS-DA)结合超高效液相色谱-四极杆-飞行时间质谱法(UPLC-Q-TOF-MS)分析盘龙七和大盘龙七差异性成分,并建立差异性成分定性、定量分析方法。结果:PLS-DA结果显示以t检验(P1.0)为标准,筛选出盘龙七和大盘龙七差异性成分共296个。对排名靠前的差异性成分进行表征分析,进一步筛选出符合碎片裂解规律及文献记载的差异性成分共8个,其中绿原酸、没食子酸、岩白菜素3.成分含量差异最显著。结论:该方法能有效分析盘龙七和大盘龙七的差异性,为盘龙七及大盘龙七的质量评价及定性、定量分析提供参考。

关键词：盘龙七大盘龙七偏最小二乘法-判别分析超高效液相色谱-四极杆-飞行时间质谱法绿原酸没食子酸岩白菜素

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3.0 MPa grade highly ductile biodegradable Zn-2Cu-(0.2-0.8)Li alloys with novel ternary phases

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Journal of Materials Science & Technology 2023年第26期157卷 234-245页

作者： Meng Cao Zhe Xue Zhao-Yong Lv Jin-Ling Sun zhang-zhi Shi Lu-Ning Wang beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Orthopedics Department Peking University ShouGang HospitalBeijing 100144China Advanced Technology and Materials Co. Ltd.(AT&M)Beijing 100081China Liaocheng People’s Hospital Liaocheng Hospital Affiliated to Shandong First Medical UniversityLiaocheng 252000China

Although a few high-strength biodegradable Zn alloys with yield strengths(YSs)over 3.0 MPa in rolled state have been developed,their elongations(ELs)are generally less than 3.%.This study developed rolled Zn-2Cu-x Li(x=0.2 wt.%,0.5 wt.%,0.8 wt.%)alloys with YSs of 3.6-3.5 MPa and ELs of 44%-61%.Three-dimensional atom probe(3.AP)and time of flight secondary ion mass spectrometry(TOF-SIMS)were employed to characterize Li *** kinds of Zn-Cu-Li ternary phases are identified,which are blockyε′-(Cu_(0.5),Li_(0.5))Zn 4,blockyβ′-(Li_(0.9),Cu_(0.1))Zn 4,and small roundγparticles with high Li content in the annealed *** identified phases are Zn,β-LiZn 4,andε-CuZn 4 *** the increase of Li content in the alloys,ε′phase with 6.50 at.%Cu transforms intoβ′phase with 2.12 at.%Cu,i.e.,the average level in the ***ε′phase,there exist nano-scale Li clusters andεphase,resulting inε′/ε*** Zn laths precipitate fromβ′phase,resulting inβ′/Zn lamellar *** lamel-lar structure is the matrix of Zn-2Cu-0.8Li and leads to near-isotropic *** tests show that degradation rates fall in the range of 153.196μm/year,which decrease with Li *** the alloys exert positive effects on the growth of MC3.3.E1 cells with 10%*** research reveals how microstructure evolves in Zn-2Cu-x Li alloys,which lays the foundation for their future applications.

关键词： Biodegradable Zn alloys Zn-Cu-Li ternary phase Microstructure

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Power-law scalings in weakly-interacting Bose gases at quantum criticality

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Frontiers of physics 2022年第6期17卷 235-241页

作者： Ming-Cheng Liang zhi-Xing Lin Yang-Yang Chen Xi-Wen Guan Xibo zhang International Center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Institute of Modern Physics Northwest UniversityXi'an 710127China Department of Theoretical Physics Research School of Physics and EngineeringAustralian National UniversityCanberra ACT 0200Australia beijing Academy of Quantum Information Sciences Beijing 100193China

Weakly interacting quantum systems in low dimensions have been investigated for a long time,but there still remain a number of open questions and a lack of explicit expressions of physical properties of such *** this work,we find power-law scalings of thermodynamic observables in low-dimensional interacting Bose gases at quantum *** present a physical picture for these systems with the repulsive interaction strength approaching zero;namely,the competition between the kinetic and interaction energy scales gives rise to power-law scalings with respect to the interaction strength in characteristic thermodynamic *** prediction is supported by exact Bethe ansatz solutions in one dimension,demonstrating a simple 1/3.power-law scaling of the critical entropy per *** method also yields results in agreement with a non-perturbative renormalization-group computation in two *** results provide a new perspective for understanding many-body phenomena induced by weak interactions in quantum gases.

关键词： power-law scaling quantum criticality Bose gases weak interaction non-perturbative methods

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Synthesis and activity of novel indole derivatives as inhibitors of CD3.

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Acta Pharmaceutica Sinica B 2013年第4期3卷 245-253页

作者： Dongying Wu Kaiyiu Ting Yaokai duan Na Li Jianguo Li Liangren zhang Honcheung Lee Lihe zhang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Physiology University of Hong KongHong KongChina

CD3. is a multifunctional enzyme/receptor expressed in a variety of mammalian tissues,regulating a wide range of physiological *** with the previously reported compound 1,an inhibitor of human CD3. NADase,we synthesized a series of indole-based NH-substituted derivatives with modifications on alkyl chains,changes in substituent groups on aromatic rings,and differences in carbon chain *** 10,13.16 and 3. exhibited moderate inhibition of human CD3. *** of the structure-activity relationships showed that the phenylpropionyl moiety was very important for the inhibitory *** study provides information for the rational design of CD3. inhibitors.

关键词： CD3. Inhibitors Synthesis Structure-activity relationship

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Machine learning(ML)-assisted optimization doping of KI in MAPbI_(3. solar cells

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Rare Metals 2021年第7期40卷 1698-1707页

作者： Sheng Jiang Cun-Cun Wu Fan Li Yu-Qing zhang Ze-Hao zhang Qiao-Hui zhang {3.-Jian Chen Bo Qu Li-Xin Xiao Min-Lin Jiang Institute for Advanced Study Nanchang UniversityJiangxi 330031China school of Materials Science and Engineering Nanchang UniversityJiangxi 330031China State Key Laboratory for Artificial Microstructures and Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871China

Perovskite solar cells have drawn extensive attention in the photovoltaic(PV)field due to their rapidly increasing ***,additives have become necessary for the fabrication of highly efficient perovskite solar cells(PSCs).Additionally,alkali metal doping has been an effective method to decrease the defect density in the perovskite ***,the traditional trial-and-error method to find the optimal doping concentration is timeconsuming and needs a significant amount of raw *** this work,in order to explore new ways of facilitating the process of finding the optimal doping concentration in perovskite solar cells,we applied a machine learning(ML)approach to assist the optimization of KI doping in MAPbI_(3. solar *** the aid of ML technique,we quickly found that 3.KI doping could further improve the efficiency of MAPbI_(3. solar *** a result,a highest efficiency of 20.91%has been obtained for MAPbI_(3. solar cells.

关键词： Perovskite solar cell Machine learning KI Doping

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Ti_(3.AICN MAX for tailoring MgH_(2) hydrogen storage material:from performance to mechanism

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Rare Metals 2023年第6期42卷 1923-1934页

作者： Xing-Qing duan Guang-Xu Li Wen-Hui zhang Hui Luo Hai-Mei Tang Li Xu Peng Sheng Xin-Hua Wang Xian-Tun Huang Cun-Ke Huang zhi-Qiang Lan Wen-Zheng Zhou Jin Guo Mohammd Bin Ismail Hai-Zhen Liu Guangxi Novel Battery Materials Research Center of Engineering Technology Guangxi Colleges and Universities Key Laboratory of Novel Energy Materials and Related TechnologySchool of Physical Science and TechnologyGuangxi UniversityNanning530004China State Key Laboratory of Advanced Power Transmission Technology State Grid Smart Grid Research Institute Co.Ltd.Beijing102209China Department of Materials Science and Engineering Zhejiang UniversityHangzhou310027China Department of Materials Science and Engineering Baise CollegeBaise533000China Energy Storage Research Group Faculty of Ocean Engineering Technology and InformaticsUniversiti Malaysia TerengganuKuala Nerus21030Malaysia

Many MXenes are efficient catalysts for MgH_(2)hydrogen storage ***,the synthesis of MXenes should consume a large amount of corrosive HF to etch out the Al layers from the transition metal aluminum carbides or nitrides(MAX) phases,which is environmentally *** this work,Ti_(3.AlCN MAX without HFetching was employed directly to observably enhance the kinetics and the cycling stability of MgH_(2).With addition of10 wt% Ti_(3.AlCN,the onset dehydrogenation temperature of MgH2 was dropped from 3.0 to 205℃,and the rehydrogenation of MgH2 under 6 MPa H2 began at as low as50℃.Furthermore,at 3.0℃,it could provide 6.2 wt% of hydrogen in 10 *** cycling,the composite underwent an activation process during the initial 40 cycles,with the reversible capacity increased from 4.7 wt% to 6.5 wt%.After that,the capacity showed almost no attenuation for up to 100 *** enhancing effect of Ti_(3.AICN on MgH_(2) was comparable to many *** was demonstrated that Ti_(3.AICN did not destabilize MgH_(2) but acted as an efficient catalyst for MgH_(2).Ti_(3.AICN was observed to be the active sites for the nucleation and growth of MgH_(2)and might also help in dissociation and recombination of hydrogen *** two factors are believed to contribute to the improvement of MgH_(2).This study not only provides a promising strategy for improving the hydrogen storage performances of MgH_(2) by using noncorrosive MAX materials,but also adds evidence of nucleation and growth of MgH_(2) on a catalyst.

关键词： Hydrogen storage Magnesium hydride MAX MXene Titanium aluminum carbonitride

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