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图模驱动的在线医疗健康智慧问答服务研究

现代情报 2025年第1期45卷 164-176页

作者：张君冬刘江峰邓景鹏刘艳华黄奇南京大学信息管理学院江苏南京210023 南京大学数据智能与交叉创新实验室江苏南京210023 武汉大学信息管理学院湖北武汉430064 南京中医药大学卫生经济管理学院江苏南京210023

[目的/意义]学者们重视追求医疗智慧问答相关技术本身的前沿性,对基础理论的探讨研究较少,两者未能融合发展。[方法/过程]在辨析相关概念的基础上,首先阐述在线医疗健康领域智慧问答服务的内涵及特征,之后剖析知识图谱与大语言模型的联... 详细信息

[目的/意义]学者们重视追求医疗智慧问答相关技术本身的前沿性,对基础理论的探讨研究较少,两者未能融合发展。[方法/过程]在辨析相关概念的基础上,首先阐述在线医疗健康领域智慧问答服务的内涵及特征,之后剖析知识图谱与大语言模型的联系及两者的互补融合思路,最后提出图模驱动的在线医疗健康智慧问答服务。[结果/结论]文章将医疗智慧问答服务理论特征贯穿智慧问答服务的全过程,创新性地提出其智慧问答服务应包含大语言模型驱动的医疗知识图谱构建、知识图谱增强的医疗大模型训练、图模驱动的智慧问答服务流程三部分。本研究实现了理论与技术的有机结合,研究成果可用于后续医疗智慧问答的实践性工作。

关键词：知识图谱大语言模型在线医疗健康智慧问答服务

Nanostructured lubricant additives for titanium alloy:Lubrication by the solid-liquid interface with Coulomb repulsion

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Friction 2024年第7期12卷 1564-1579页

作者： Linlin duan Dan JIA Jian LI Jianfang liu Haitao duan State Key Laboratory of Special Surface Protection Materials and Application Technology Wuhan Research Institute of Materials ProtectionWuhan 430030China Hubei Longzhong Laboratory Xiangyang 441000China College of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430030China

In this work,the advantage of Coulomb repulsion in the intermolecular forces experienced by molecules on the solid–liquid nanosized contact interface is taken,and the superior friction-reducing property of Cu_(3)(PO_(4))2·3H_(2)O(CuP)oil-based additives has been confirmed for titanium ***-dimensional(3D)CuP nanoflowers(CuP-Fs)with a strong capillary absorption effect are prepared to achieve the homogeneous mixing of solid CuP and lubricating *** by CuP-Fs additives for titanium alloy,friction coefficient(COF)can be reduced by 73.68%,and wear rate(WR)reduced by 99.69%.It is demonstrated that the extraordinary friction-reducing property is due to the repulsive solid–liquid interface with low viscous shear force originating from Coulomb repulsion between polar water molecules in CuP and non-polar oil ***,any steric hindrance or connection between this repulsive solid–liquid interface will trigger the adhesion and increase the viscous shear force,for example,dispersant,hydrogen bondings,and shaky adsorbed water ***,the lamellar thickness of CuP and the molecular size of lubricant both have a great influence on tribological *** the lubrication mechanism based on interface Coulomb repulsion is proposed that may help broaden the scope of the exploration in low-friction nanomaterial design and new lubricant systems.

关键词： lubrication nanomaterial additive solid-liquid interface wear

Molecular dynamics simulations of microscopicstructure of ultra strong shock waves in dense helium

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Frontiers of physics 2016年第6期11卷 197-207页

作者： Hao liu Wei Kang qi Zhang Yin Zhang Huilin duan X. T. He HEDPS Center for Applied Physics and Technology Peking University Beijing 100871 China College of Engineering Peking University Beijing 100871 China Department of Mechanics and Engineering Science College of Engineering Peking University Beijing 100871 China Center for Applied Physics and Technology HEDPS and IFSA Collaborative Innovation Center of MoE Peking University Beijing 100871 China Institute of Applied Physics and Computational Mathematics Beijing 100088 China

Hydrodynamic properties and structure of strong shock waves in classical dense helium are simulated using non-equilibrium molecular dynamics methods. The shock speed in the simulation reaches 100 km/s and the Mach number is over 250, which are close to the parameters of shock waves in the implosion process of inertial confinement fusion. The simulations show that the high-Mach-number shock waves in dense media have notable differences from weak shock waves or those in dilute gases. These results will provide useful information on the implosion process, especially the structure of strong shock wave front, which remains an open question in hydrodynamic simulations.

关键词： shock structure high Mach number dense media

Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway

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Chinese Journal of Natural Medicines 2020年第12期18卷 898-906页

作者： qi You-Chao duan Guo-Zhen MAO Wei liu qian ZHANG Yong-Liang LI Pei-Feng College of Veterinary Medicine Inner Mongolia Agricultural UniversityHohhot 010018China Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease Ministry of AgricultureHohhot 010018China College of Forestry Inner Mongolia Agricultural UniversityHohhot 010018China Immunology Progamme Life Sciences InstituteNational University of SingaporeSingapore 117597Singapore

Taurochenodeoxycholic acid(TCDCA)is one of the main effective components of bile acid,playing critical roles in apoptosis and immune responses through the TGR5 *** this study,we reveal the interaction between TCDCA and TGR5 receptor in TGR5-knockdown H1299 cells and the regulation of inflammation via the cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)-cAMP response element binding(CREB)signal pathway in NR8383 *** TGR5-knockdown H1299 cells,TCDCA significantly activated cAMP level via TGR5 receptor,indicating TCDCA can bind to TGR5;in NR8383 macrophages TCDCA increased cAMP content compared to treatment with the adenylate cyclase(AC)inhibitor ***,activated cAMP can significantly enhance gene expression and protein levels of its downstream proteins PKA and CREB compared with groups of ***,TCDCA decreased tumour necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6,IL-8 and IL-12 through nuclear factor kappa light chain enhancer of activated B cells(NF-κB)*** and CREB are primary regulators of anti-inflammatory and immune *** results thus demonstrate TCDCA plays an essential anti-inflammatory role via the signaling pathway of cAMP-PKA-CREB induced by TGR5 receptor.

关键词： Taurochenodeoxycholic acid TGR5 receptor Cyclic adenosine monophosphate Protein kinase A cAMP response element binding Anti-inflammation

Acupuncture effects on serum myelin basic protein and remyelination following 30 minutes and 2 hours of ischemia in a rat model of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2010年第4期5卷 261-266页

作者： Jiangang duan Ming liu Department of Neurology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Neurology Tianjin Huanhu Hospital Tianjin 300060 China

BACKGROUND： Acupuncture treatment on injured cerebral axons has shown to provide efficacy in clinical practice. It is unknown whether acupuncture produces therapeutic effects by protecting injured cerebral myelin in ischemic stroke. OBJECTIVE： To test whether acupuncture provides protection for injured cerebral myelin, based on quantitative data from cerebral ischemia-reperfusion rats, and to compare the effects of early and late acupuncture on serum myelin basic protein （MBP） content and remyelination of the ischemic internal ***, TIME AND SETTING： A randomized, controlled experiment was performed at the Neurobiological Laboratory, Sichuan University from March 2005 to March 2006. MATERIALS：＂Hua Tuo＂ Brand filiform needles were produced by the Medical Instrument Factory of Suzhou, ***： A total of 52 adult, healthy, male, Sprague Dawley rats were randomly assigned to four groups： control （n = 4）, model （n = 16）, early acupuncture （n = 16）, and late acupuncture （n = 16）. The focal cerebral ischemia-reperfusion model was established by middle cerebral artery occlusion in the right hemisphere using the modified thread embolism method in the latter three groups. Early and late acupuncture groups underwent acupuncture after ischemia for 30 minutes and 2 hours using the Xingnaokaiqiao needling method, respectively. Acupoints were ＂Neiguarf＇（PC 6） and ＂Sanyinjiao＂（SP 6） on the bilateral sides, as well as ＂Shuigou＇（DU 26） and ＂Baihui＂（DU 20） with stimulation for 1 minute at each acupoint. Acupuncture at all acupoints was performed two or three times while the needle was retained, once per day. No special handling was administered to the control *** OUTCOME MEASURES： For each group, remyelination of the internal capsule was observed by Pal-Weigert＇s myelin staining and serum MBP content was detected using enzyme-linked immunosorbent assay method on days 1,3, 5, and 7 following ischemia-reperfusion ***： Compared with the control gr

关键词： acupuncture focal cerebral ischemia-reperfusion serum myelin basic protein remyelination brain injury neural regeneration

Aβ-binding molecules: Possible application as imaging probes and as anti-aggregation agents

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Science China Chemistry 2008年第9期51卷 801-807页

作者： duan XinHong liu BoLi Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China College of Science Beijing Forestry UniversityBeijing 100875China

As amyloid β (Aβ) is at the centre of pathogenesis of Alzheimer's disease (AD), Aβ aggregate-specific probes for in vivo studies of Aβ are potentially important for the early diagnosis and the assessment of new treatment strategies in the AD brain by noninvasive imaging. Several series of compounds derived from Congo red (CR) and Thioflavin T (ThT) have been evaluated as potential probes for the Aβ imaging. They include a diversity of core structures contributing to their affinities to Aβ. Small-molecule inhibi- tors were known to inhibit the formation of Aβ oligomers and fibrils. This inhibition has to be performed in such a way that these inhibitors bind to Aβ in the binding channel where Aβ-binding probes should sit. Therefore, several of them were used as novel core structures to develop Aβ probes, with their de- rivatives exhibiting good Aβ affinities. This approach will facilitate the design of a variety of candidates for Aβ probe molecules and anti-aggregation-therapeutic drugs. Moreover, the finding of Aβ probes with diverse core structures recognized by binding sites on Aβs will likely provide a promising per- spective for the design of 99mTc-labeled probe-derived molecules.

关键词： Aβ binding core structure Aβ inhibitor hydrophobic and aromatic interaction bifunctional candidate

A field-deployable method for single and multiplex detection of DNA or RNA from pathogens using Cas12 and Cas13

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Science China(Life Sciences) 2022年第7期65卷 1456-1465页

作者： Lina Li Canxing duan Jianfeng Weng Xiantao qi Changlin liu Xinhai Li Jinjie Zhu Chuanxiao Xie National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural Sciences(CAAS)Beijing 100081 China Biotechnology Research Institute Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China

For some Cas nucleases,trans-cleavage activity triggered by CRISPR/Cas-mediated cis-cleavage upon target nucleic acid recognition has been explored for diagnostic *** single and multiplex nucleic acid-based detection is needed for crop pathogen management in ***,we harnessed and characterized RfxCas13d as an additional CRISPR/Cas nucleic acid detection *** systematically characterized AsCas12a,LbCas12a,LwaCas13a,and RfxCas13d combined with isothermal amplification to develop a CRISPR/Cas nucleic acid-based tool for single or multiplex pathogen *** data indicated that sufficient detection sensitivity was achieved with just a few copies of DNA/RNA targets as *** this tool,we successfully detected DNA from Fusarium graminearum and Fusarium verticillioides and RNA from rice black-streaked dwarf virus in crude extracts prepared in the *** method,from sample preparation to result readout,could be rapidly and easily deployed in the *** system could be extended to other crop pathogens,including those that currently lack a detection method and have metabolite profiles that make detection *** nucleic acid detection system could also be used for single-nucleotide polymorphism genotyping,transgene detection,and qualitative detection of gene expression in the field.

关键词： nucleic acid detection AsCas12a LbCas12a LwaCas13a RfxCas13d maize ear rot Fusarium head blight rice black-streaked dwarf virus(RBSDV)

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Fuzzy finite element model updating of bridges by considering the uncertainty of the measured modal parameters

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Science China(Technological Sciences) 2012年第11期55卷 3109-3117页

作者： liu Yang duan ZhongDong School of Transportatton Science and Engineering Harbin Institute of TechnologyHarbin 150090China Harbin Institute of Technology Shenzhen Graduate School Shenzhen 5180553China

It is significant to consider the effect of uncertainty of the measured modal parameters on the updated finite element(FE) model,especially for updating the FE model of practical bridges,since the uncertainty of the measured modal parameters cannot be ignored owing to the application of output-only identification method and the existence of the measured noise.A reasonable method is to define the objective of the FE model updating as the statistical property of the measured modal parameters obtained by conducting couples of identical modal tests,however,it is usually impossible to implement repeated modal test due to the limit of practical situation and economic *** this study,a method based on fuzzy finite element(FFM) was proposed in order to consider the effect of the uncertainty of the measured modal parameters on the updated FE model by using the results of a single modal *** updating parameters of bridges were deemed as fuzzy variables,and then the fuzzification of objective of the FE model updating was proposed to consider the uncertainty of the measured modal ***,the effectiveness of the proposed method was verified by updating the FE model of a practical bridge with the measured modal parameters.

关键词： bridge finite element model updating fuzzy finite element interval analysis fuzzy theory

掺杂单层MoS_(2)电子结构与光催化性质的第一性原理计算

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原子与分子物理学报 2025年第1期42卷 35-40页

作者：徐启远高朋刘正堂九江学院机械与智能制造学院九江332005 西北工业大学材料学院西安710072

为了提高MoS_(2)的光催化能力,本研究基于第一性原理平面波赝势方法,对Cr、W、Fe、Co、Ni替换单层MoS_(2)晶格中的Mo进行研究.结果表明:W的替换能为正值,Cr、Fe、Co、Ni的替换能为负值.Cr、W掺杂晶格产生畸变主要是杂质原子的共价半径... 详细信息

为了提高MoS_(2)的光催化能力,本研究基于第一性原理平面波赝势方法,对Cr、W、Fe、Co、Ni替换单层MoS_(2)晶格中的Mo进行研究.结果表明:W的替换能为正值,Cr、Fe、Co、Ni的替换能为负值.Cr、W掺杂晶格产生畸变主要是杂质原子的共价半径引起的;Fe、Co、Ni掺杂晶格产生畸变主要是掺杂原子的自旋导致的.Cr、W、Fe、Co、Ni掺杂单层MoS_(2)带隙类型没有发生改变,仍然为直接带隙,但禁带宽度变小,吸收带红移,尤其Fe、Co、Ni掺杂,导带下方有杂质能级使费米能级向高能方向移动,可以作为捕获电子陷阱,增加电子密度,减少光激发电子-空穴对的复合,有利于提升光催化能力.

关键词：掺杂单层二硫化钼光催化电子结构