检索结果-南通市图书馆

Thiocytochalasins A−D,four sulfur-containing cytochalasans from an endophytic fungus Phoma multirostrata XJ-2-1

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第10期33卷 4572-4576页

作者： Xiaogang Peng Jinling Chang Ying Gao fangfang duan Hanli Ruan School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyHubei Key Laboratory of Natural Medicinal Chemistry and Resource EvaluationWuhan 430030China

Four unprecedented sulfur-containing cytochalasans,thiocytochalasins A−D(1−4),were isolated from an endophytic fungus Phoma multirostrata *** A(1)and B(2)feature a novel 5/6/14/5 tetracyclic scaffold,which are the first examples of cytochalasan containing a thiophene *** C(3)and D(4)are epimeric cytochalasan homodimers formed via a thioether *** structures with absolute configurations were established by detailed analysis of the HRESIMS,NMR,and X-ray *** plausible biogenetic pathway of 1−4 was *** 3 and 4 exhibited significant cytotoxicity against CT26 cells with IC_(50) values of 0.85 and 0.76µmol/L,respectively.

关键词： Phoma multirostrata XJ-2-1 Sulfur-containing cytochalasans Thiocytochalasins A-D Cytotoxicity Cell cycle

Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第6期15卷 5295-5304页

作者： Tianyuan Xue Zhirang Zhang Tianliang Fang Baoqi Li Yuan Li Liyan Li Yanghua Jiang fangfang duan Fanqiang Meng Xin Liang Xudong Zhang Department of Pharmacology Molecular Cancer Research CenterSchool of MedicineShenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Key Laboratory of Stem Cell and Regenerative Tissue EngineeringSchool of Basic Medical SciencesGuangdong Medical UniversityDongguan 523808China The First People’s Hospital of Chenzhou Chenzhou 423000China

Cancer cells aberrantly express immunosuppressive checkpoint ligands and produce certain metabolites that lead to T cell *** checkpoint blockade(ICB)therapy that reinvigorates exhausted T cells have achieved impressive response in clinical cancer ***,the limited clinical response rate and off-tumor toxicities restrict ICB ***,cellular vesicles displaying anti-programmed cell death-1(PD-1)single-chain variable fragment antibody(aPD-1-scFv)were prepared to reinvigorate T cell immunity to counteract *** nanovesicles displaying aPD-1-scFv(aPD-1-scFv NVs)could enhance the anti-tumor activation of T cells through PD-1 ***,NVs loading the A_(2a)adenosine receptor(A_(2a)R)antagonist CPI-444 assisted T cells to antagonize adenosine,an immunosuppressive metabolite produced by cancer ***,CPI-444 loaded aPD-1-scFv NVs could intensively increase the density and activity of tumor infiltrating T cells,directly restraining tumor progress and metastasis.

关键词： drug delivery A_(2a)receptor PD-1 receptor cancer immunotherapy

基于HIRFL-RIBLL1装置的放射性核弹性散射和破裂反应研究进展

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

科学通报 2022年第23期67卷 2727-2735页

作者：杨彦云杨过王康段芳芳中国科学院近代物理研究所兰州730000 中国科学院大学核科学与技术学院北京100080

放射性核束物理是当前核物理研究的重点领域之一,直接核反应是研究放射性核的反应机制和奇特结构的重要方法.本文回顾了近年来在HIRFL-RIBLL1上开展的放射性核的弹性散射和破裂反应研究,并介绍了国际上的研究现状.通过对典型中子晕核^(1... 详细信息

放射性核束物理是当前核物理研究的重点领域之一,直接核反应是研究放射性核的反应机制和奇特结构的重要方法.本文回顾了近年来在HIRFL-RIBLL1上开展的放射性核的弹性散射和破裂反应研究,并介绍了国际上的研究现状.通过对典型中子晕核^(11)Be和质子滴线核^(8)B在高于库仑势垒能区弹性散射的系统性比较研究,明确了即使在3倍库仑势垒附近的能区,破裂反应道仍然会对丰中子核的弹性散射道有强烈的耦合效应.研究表明,与入射能量相比,破裂反应对其他反应道耦合效应的强弱对奇特核的核结构更加敏感.此项研究加深了学界对放射性核反应动力学的认识.无论是丰中子核还是丰质子核,去弹破裂都在破裂反应中起到重要的作用,尤其在大角度范围内.总体而言,丰质子核的破裂截面明显小于丰中子核.同时理论研究表明,紧密束缚核的破裂反应主要来自去弹破裂的贡献,对破裂反应机制的理解还需要开展进一步的实验研究.

关键词： HIRFL-RIBLL1 放射性核弹性散射破裂反应耦合道效应

在线全文

学校读者我要写书评

暂无评论

酒精性肝病肝移植的研究进展

器官移植 2020年第3期11卷 413-418页

作者：段方方成军杨松首都医科大学附属北京地坛肝病二科 100015

肝移植是酒精性肝病(ALD)相关终末期肝硬化、肝衰竭、肝细胞癌(肝癌)与重症酒精性肝炎患者重要的治疗手段。本文从ALD肝移植的手术指征、受者生存情况、受者饮酒管理、受者全身疾病管理等方面综述最新研究进展,为临床更好管理ALD肝移植... 详细信息

肝移植是酒精性肝病(ALD)相关终末期肝硬化、肝衰竭、肝细胞癌(肝癌)与重症酒精性肝炎患者重要的治疗手段。本文从ALD肝移植的手术指征、受者生存情况、受者饮酒管理、受者全身疾病管理等方面综述最新研究进展,为临床更好管理ALD肝移植受者提供参考。

关键词：酒精性肝病酒精性肝炎肝移植酒精肝硬化肝细胞癌终末期肝病疾病管理

Research Progress of Heavy Ion Reaction Group in 2018

在线全文

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2018年第1期 39-40页

作者： Wang Jiansong Yang Yanyun Ma Peng Ma Junbing Liu Xingquan Bai Zhen Hu Qiang Jin Shilun Yu Gongming DPatel duan fangfang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Lanzhou University Chongqing 400715China

Heavy Ion Reaction Group is in charge of the operation and maintenance of the 1st Radioactive Ion Beam Line in Lanzhou(RIBLL1).Their research works are focused on the direct reactions induced by radioactive ion beams,nuclear reaction dynamics at Fermi energy and some international *** progress achieved in 2018 are as the following.

关键词： Fermi collaboration maintenance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

胸锁关节骨性关节炎的关节镜治疗研究

中华胸心血管外科杂志 2023年第12期39卷 754-757页

作者：谢昊李博闻段芳芳张强首都医科大学附属北京积水潭医院胸外科北京100035

目的探索关节镜下胸锁关节成形术治疗胸锁关节骨性关节炎的治疗效果。方法7例胸锁关节骨关节炎患者行关节镜下胸锁关节成形术。男3例,女4例;年龄34~62岁,平均43岁。术前和随访评估采用Constant评分和Rockwood胸锁关节评分系统。术后随访... 详细信息

目的探索关节镜下胸锁关节成形术治疗胸锁关节骨性关节炎的治疗效果。方法7例胸锁关节骨关节炎患者行关节镜下胸锁关节成形术。男3例,女4例;年龄34~62岁,平均43岁。术前和随访评估采用Constant评分和Rockwood胸锁关节评分系统。术后随访1~10个月,平均3.7个月。结果7例患者均于术后2周内恢复术前功能或完全活动。末次随访时,6例无疼痛,1例活动后轻度紧张感。Constant评分中位数从69.6分(62~80分)提高到94.3分(88~96分);Rockwood评分中位数从5.7分(3~8分)提高到14.3分(12~15分)(最多15分)。临床疗效7例全部为优(13~15分)。无并发症,关节稳定性未见异常。结论关节镜下胸锁关节成形术是治疗胸锁关节骨关节炎的一种新的安全有效的治疗方法。

关键词：胸锁关节骨性关节炎关节镜

A Newly Developed Silicon Detector Array for Radioactive Beam Experiments at HIRFL-RIBLL

在线全文

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2017年第1期 44-45页

作者： duan fangfang Yang Yanyun Gao Zhihao Liu Xingquan Ma Peng Wang Jiansong Bai Zhen Ma Junbing Hu Qiang Jin Shilun Jin Shuya Yu Gongming 不详

With the development of radioactive beam facilities,several exciting results were provided concerning the understanding of fundamental nuclear ***,typical-beam intensities are always low and the production is often in very small quantities,so,new generation detectors need to be developed with large solid angle and angular coverage,which can identify particle effectively as well as possesses high energy resolution,high spatial resolution and high geometric *** new detector based on Double Side Silicon Strip Detector(DSSD)is foreseen for the study of the reaction production in the experiment of direct nuclear reaction above the Coulomb barrier using RIBLL[1,2]at the HIRFL[3,4].However,the disadvantage of the RIBs is that it has a broad distribution in coordinate ***,new detector system with high resolution and a large solid angle was developed successfully for performing nuclear reaction experiments using *** geometric efficiency of the new detector array with 5 large area DSSD telescopes increases up to 70%.

关键词： resolution disadvantage beam

Experimental Measurement of Elastic and Breakup Channels for the ^(11)Be+^(208)Pb System at above the Coulomb Barrier

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2017年第1期 42-43页

作者： Yang Yanyun Wang Jiansong Liu Xingquan duan fangfang Gao Zhihao DPatel Ma Peng Ma Junbing Bai Zhen Hu Qiang Yu Yuechao Yu Gongming Ma Weihu 不详

Our previous experimental result for proton-rich nucleus ^(8)B at above the Coulomb barrier shows that in spite of its low proton separation energy(0.136 MeV)there is no strong breakup coupling effects[1].The fact is in contrast to the observation of neutron-rich nuclei ^(11)Be around the Coulomb barrier.A systematic study for elastic scattering cross sections of neutron-rich nucleus ^(11)Be and the proton-halo nucleus ^(8)B at low and higher energies shows that the Coulomb rainbow in the elastic scattering of ^(11)Be is still strongly suppressed at high energies[2].In order to examine the predictions,experimental measurements for 11Be elastic scattering and breakup for ^(11)Be+^(208)Pb system at 141 and 209 MeV were performed at the National Laboratory of Heavy Ion Research of the Institute of Modern Physics,Lanzhou,China.

关键词： Elastic separation system

2-27 Experimental Measurement of 7Be,8B and 9C on natPb Elastic Scattering Above the Coulomb Barriers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2016年第1期 64-65页

作者： Yang Yanyun Liu Xingquan Wang Jiansong duan fangfang Ma Peng Ma Junbing Jin Shilun Bai Zhen Gao Zhihao Hu Qiang Ma Weihu Yu Yuechao Yu Gongming 不详

The experiment was performed at the National Laboratory of Heavy Ion Research of the Institute of Modern Physics,Lanzhou,*** secondary beams of radioactive isotopes were produced by the fragmentation of the 12C6+primary on a 9Be target with a thickness of 2 652 m[1;2].The secondary beams,7Be,8B and 9C beams were delivered by the Radioactive Ion Beam Line in Lanzhou(RIBLL)[3,4]and impinged on a natPb target at RIBLL *** energies of the secondary beams,at the physical target,were about three times the Coulomb barriers,130 MeV for 7Be,178 MeV for 8B and 227 MeV for 9C,respectively.

关键词：