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Comparative pharmacodynamic, pharmacokinetic and tissue distribution of Dahuang-Gancao decoction in normal and experimental constipation mice

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Chinese Journal of Natural Medicines 2019年第11期17卷 871-880页

作者： CHEN Yan-Yan Cao Yu-Jie TANG Yu-Ping YUE Shi-Jun duan jin-ao Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility and State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Researchand Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicineand Jiangsu Key Laboratory for High Technology Research of TCM FormulaeNanjing University of Chinese MedicineNanjing 210023China

Dahuang-Gancao decoction(DGD)is a classical formula,which is commonly used for reliving constipation in Chinese *** aim of this study was to investigate the pharmacodynamic,pharmacokinetic and tissue distribution alternations of DGD in normal and constipation *** exhibited stronger purgative effect in constipation mice by the increased fecal excretion and reduced first defection time compared with normal *** Cmax,AUC0-t and MRT0-t of rhein,aloe-emodin,rhein-8-O-β-D-glucoside,sennoside A,and glycyrrhizic acid as main bio-active components in DGD were markedly increased in constipation *** tissue distribution of the analytes in constipation mice were higher than those in normal mice with rhein>rhein-8-O-β-D-glucoside>aloe-emodin>glycyrrhizic acid>emodin in liver,and glycyrrhizic acid>rhein-8-O-β-D-glucoside>liquitin>sennoside A>rhein>aloe-emodin>emodin in *** kidney concentrations of the analytes showed a descending order of rhein>rhein-8-O-β-D-glucoside>sennoside A>glycyrrhizic acid>aloe-emodin>emodin,most of them were higher while rhein was lower in constipation mice than normal *** higher exposure of the anthraquinones in plasma,liver and colon may result in the stronger purgative effect in the constipation mice than normal *** is mainly excreted through the kidney,the decreased level of rhein in constipation mice may explain the alleviated side *** of glycyrrhizic acid in colon may related with the moderate property of *** results provided the experimental basis for understanding the therapeutic effects and metabolite profile of DGD.

关键词： Rhubarb Licorice Pharmacodynamic Pharmacokinetic Tissue distribution Constipation

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A target lipidomics approach to investigate the acute inflammatory irritation induced by indolealkylamines from Chansu water fraction in rats

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Chinese Journal of Natural Medicines 2021年第11期19卷 856-867页

作者： YANG Xin CHEN Wu-Yue GONG Yan DI Liu-Qing duan jin-ao ZHOU jing MA Hong-Yue Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM FormulaeCollege of PharmacyNanjing University of Chinese MedicineNanjing 210023China Jiangsu Engineering Research Center for Efficient Delivery System of TCM Nanjing University of Chinese MedicineNanjing 210023China

Chansu has demonstrated adverse reactions in clinical settings,which is associated with its toxicity and limits its clinical *** there are methodological limitations for drug safety *** the current study,ultra-high performance liquid chromatography,lipidomic profiling,and molecular docking were used to systemically assess Chansu-induced acute inflammatory irritation and further identify the underlying drug *** with the EtOAc extract,Chansu water fraction containing indolealkylamines caused acute inflammatory irritation in rats,including acute pain(spontaneous raising foot reaction),and inflammation(paw edema).At the molecular level,lipids analysis revealed significantly higher levels of pro-inflammatory mediators of the COX and LOX ***,anti-inflammatory mediators from the CYP 450,ALA,and DHA pathways markedly decreased after exposure to Chansu water ***,four indolealkylamines from Chansu showed a high theoretical affinity to a known irritation target,5-HT_(2A)*** results suggest that Chansu-induced inflammatory irritation is related to the distinct dysregulation of inflammatory lipids,and peripheral 5-HT_(2A)R is a potential target for irritation *** strategy used in this study can be a crucial approach in the safety evaluation of natural medicinal substances.

关键词： Chansu Acute inflammatory irritation Lipidomics Eicosanoids Molecular docking

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Characterization of molecular signature of the roots of Paeonia lactiflora during growth

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Chinese Journal of Natural Medicines 2017年第10期15卷 785-793页

作者： LIU Pei XU Yuan YAN Hui CHEN jing SHANG Er-Xin QIAN Da-Wei JIANG Shu duan jin-ao Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine Nanjing University of Chinese MedicineNanjing 210023China Institute of Bioengineering Zhejiang Chinese Medical UniversityHangzhou 310053China

The roots of Paeoniae lactiflora *** widely consumed as crude drugs in Asian countries due to their remarkable beneficial health *** present research was undertaken to illuminate the dynamic changes in metabolites and enzymes and facilitate selection of the harvesting time when the herb can provide optimum health *** roots were analyzed at 12 stages of growth for monoterpenoid glycosides,phenols,nucleosides,nucleobases,amino acids,and polysaccharides by high-performance liquid chromatography with photodiode array detector,ultra-high pressure liquid chromatography coupled with tandem mass spectrometry,and UV *** enzyme activities of plant β-glucosidases and esterases were determined by UV *** total content of monoterpenoid glycosides and phenols peaked in *** nucleosides and nucleobases,the highest content appeared in *** maximum phasic accumulation of the total amino acids took place in March,and the content of total polysaccharides reached a peak value in ***,April,and March were selected as the appropriate harvesting times for producing natural medicinal or health food *** β-glucosidases and esterases showed the highest activity in December and May,*** the activity of β-glucosidase increased,esterase activity decreased,while the contents of oxypaeoniflora and paeoniflorin *** esterase activity increased,the contents of benzoylpaeoniflorin,paeoniflorin,and gallic acid *** conclusion,the results from the present study would be useful in determination of the suitable time for harvesting *** roots for medicinal purposes.

关键词： Paeonia lactiflora Primary and secondary metabolites Plant enzymes Dynamic change Growth stage

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Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction,Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation

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Chinese Journal of Natural Medicines 2021年第6期19卷 422-431页

作者： SHI Xu-Qin ZHU Zhen-Hua YUE Shi-Jun TANG Yu-Ping CHEN Yan-Yan PU Zong-jin Tao Hui-Juan ZHOU Gui-Sheng duan jin-ao Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and Jiangsu Key Laboratory for High Technology Research of TCM Formulaeand National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative MedicineNanjing University of Chinese MedicineNanjing 210023China School of Artificial Intelligence and Information Technology Nanjing University of Chinese MedicineNanjing 210023China Institute of Mental Health Suzhou Psychiatric HospitalSoochow University Affiliated Guangji HospitalSuzhou 215100China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility and State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Researchand Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046China

Colon cancer-related anemia(CCRA)is mainly caused by systemic inflammation,intestinal bleeding,iron deficiency and chemotherapy-induced myelosuppression in colon ***,the best therapeutic schedule and related mechanism on CCRA were still *** on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction(DBD),Fe and rhEPO based on CCRA and gut microbiota modulation were conducted in this ***,CCRA model was successfully induced by subcutaneous inoculation of CT-26 and ***,rhEPO+DBD high dosage+Fe(EDF)and rhEPO+DBD high dosage(ED)groups had the best blood enrichment ***,EDF group also showed antitumor *** sequencing results of gut microbiota showed that compared to P group,the relative abundances of Lachnospiraceae and opportunistic pathogen(Odoribacter)in ED and EDF groups were ***,EDF also decreased the relative abundances of cancer-related bacteria(Helicobacter,Lactococcus,Alloprevotella)and imbalance-inducing bacteria(Escherichia-Shigella and Parabacteroides)and increased the relative abundances of butyrate-producing bacteria(Ruminococcaceae_UCG-014),however,ED showed the opposite effects to EDF,this might be the reason of the smaller tumor volume in EDF *** findings proposed the best treatment combination of DBD,rhEPO and Fe in CCRA and provided theoretical basis and literature reference for CCRA-induced intestinal flora disorder and the regulatory mechanism of EDF.

关键词： Danggui Buxue Decoction Cancer-related anemia Gut microbiota modulation Fe rhEPO

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Two new nonacosanetriols from the pollen of Typha angustifolia

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Chinese Chemical Letters 2010年第2期21卷 209-212页

作者： Tao, Wei Wei Yang, Nian Yun duan, jin ao Wu, De Kang Shang, Er Xin Qian, Da Wei Tang, Yu Ping Nanjing Univ Chinese Med Jiangsu Key Lab TCM Formuale Res Nanjing 210046 Peoples R China

Chemical investigation of the pollen of Typha angustifolia *** led to the isolation of two new nonacosanetriols,7,8,10- nonacosanetriol(1) and 7,9,10-nonacosanetriol(2).Their structures were elucidated by chemical rea... 详细信息

关键词： Typha angustifolia Nonacosanetriol Antiplatelet aggregation

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Effects of Ziziphus jujuba fruit extracts on cytochrome P450(CYP1A2) activity in rats

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Chinese Journal of Natural Medicines 2015年第8期13卷 588-594页

作者： jinG Xin-Yue PENG Yun-Ru WANG Xin-Min duan jin-ao Laboratory of Integrated Acupuncture and Medicine Nanjing University of Chinese Medicine Jiangsu Provincial Institute of Traditional Chinese Medicine Jiangsu Key Laboratory for High Technology Research of TCM Formulae Nanjing University of Chinese Medicine

Drug-drug interactions have become a serious problem in the clinic, since plant-based medicines are extensively used. The present study investigated the effects of Ziziphusjujuba fruit （Z J） extract on the pharmacokinetics of phenacetin, a typical substrate of a cytochrome P450 enzyme CYP 1A2, in rats. The rats were pretreated with the water extract （1.0 g·kg-l） or the ethanolic extract （3.6 g·kg-1） of ZJ for 10 days, and the pharmacokinetics of phenacetin was investigated after intravenous administration. In an in vitro assay, acetaminophen formation in the hepatic microsomes of ZJ-treated rats was investigated to assess CYP1A2 activity. Our results demonstrated that the treatment with the water and ethanolic extracts of ZJ decreased the plasma concentration of phenacetin and increased the plasma concentration of acetaminophen, resulting in a 43.2% and 15.5% reduction in the AUC0-120 of phenacetin, respectively, and a 53.2% and 64.9% increase in the AUC0-120 of acetaminophen, respectively after intravenous administration. The water or ethanolic extract of ZJ significantly increased the clearance of phenacetin and acetaminophen formation in hepatic microsomes. In conclusion, ZJ extracts displayed effects on the pharmacokinetics of phenacetin and increased the CYP1A2 activity in rats. Therefore, precaution on drug-drug interactions should be taken when ZJ is co-administered with drugs metabolized by CYP1A2, which may result in decreased concentrations of these drugs.

关键词： Ziziphusjujuba CYP1A2 Phenacetin Aeetaminophen Hepatic microsomes Plant drug-drug interactions

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中药资源化学研究技术体系的建立及其应用

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中国药科大学学报 2012年第4期43卷 289-292页

作者：段金廒南京中医药大学南京210046

中药资源是国家战略性资源,中药资源化学研究贯穿于中药资源生产与利用全过程。本课题组在国内外率先提出和创建了中药资源化学学科,形成了独具特色的中药资源化学研究技术体系,为药用生物资源的合理生产和科学利用提供有力支撑,为中药... 详细信息

中药资源是国家战略性资源,中药资源化学研究贯穿于中药资源生产与利用全过程。本课题组在国内外率先提出和创建了中药资源化学学科,形成了独具特色的中药资源化学研究技术体系,为药用生物资源的合理生产和科学利用提供有力支撑,为中药资源学科的丰富和完善做出重要贡献。通过持续的探索实践,逐步解决了中药资源生产与利用过程中的若干关键问题。研究成果的示范和推广为我国中药资源经济产业链的延伸,资源利用效率的提升,资源性产品的品质提高等中药及天然药物资源领域的健康可持续发展起到重要的引导和推动作用。

关键词：中药资源中药资源化学研究技术体系生产与利用

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Biodiversity and Antimicrobial Activity of Endophytic Fungi in Angelica sinensis

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Chinese Herbal Medicines 2013年第4期5卷 264-271页

作者： JIANG Shu QIAN Da-wei YANG Nian-yun Tao jin-hua duan jin-ao Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae Nanjing University of Chinese Medicine

Objective To systematically investigate the biodiversity,ecological distribution,and antimicrobial activities of the endophytic fungi in Angelica sinensis growing in several natural habitats in *** The isolation,culture,and identification of microorganism and mycelium growth inhibition test were adopted,and the relative data were analyzed by the statistical *** A total of 206 isolates of endophytic fungi representing 22 species were collected at different time periods from *** in three ***(45.1%)was the most prevalent followed by Dematiaceae(34.0%),mycelia sterilia(17.0%),Tuberculariaceae(2.9%),Moniliaceae(0.5%),and Leptostromataceae(0.5%).The main genera were Gongromella Ribaldi,Coniosporieae *** Fr.,Fusella Sacc.,Myxormia *** Br.,Ozonium *** Fr.,Pestalotia de Not.,Phacodium *** Wallr.,and Sphaceloma de *** from the samples of Min county showed more diversity,percentage colonization,and species richness compared to other two *** colonization frequency was also greater in Min county(56.5%)than those in Heqing county(29.5%)and Baoxing county(17.0%).As to endophytic community in different plant tissues,the maximum endophytes species richness and diversity appeared in root tissues rather than in stem and leaf tissues from each *** samples were colonized by greater numbers of endophytes relative to the stem and root samples of the same *** assay of the 206 endophytes showed that 20%was capable of inhibiting plant pathogenic fungi and eight strains displayed strong *** Endophytic fungi isolated from *** are specific in location,tissue,and season,and diverse in *** are potential sources of antimicrobial agents which might improve the stress resistance and growth of this medicinal plant and play the important biological functions in ***,endophytic fungi will explore a new way to control plant diseases and de

关键词： Angelica sinensis antimicrobial activity biodiversity ecological distribution endophytic fungi

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基于“蛋白质/肽组学-修饰组学”研究动物药功效物质基础的思路与方法

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药学学报 2020年第8期55卷 1735-1743页

作者：刘睿赵明段金廒南京中医药大学中药资源产业化与方剂创新药物国家地方联合工程研究中心/江苏省中药资源产业化过程协同创新中心江苏南京210023 南京中医药大学江苏省海洋药用生物资源研究与开发重点实验室江苏南京210023 南京中医药大学药学院江苏南京210023

动物药是传统中药的重要组成部分,由于缺乏适宜的研究思路与方法,中药动物药功效物质基础、质量评价研究等不够系统与完善,制约着动物药临床使用、制药工艺和质量控制等方面的应用与发展。为此,本文基于对角类、胶类动物药的研究及认识... 详细信息

动物药是传统中药的重要组成部分,由于缺乏适宜的研究思路与方法,中药动物药功效物质基础、质量评价研究等不够系统与完善,制约着动物药临床使用、制药工艺和质量控制等方面的应用与发展。为此,本文基于对角类、胶类动物药的研究及认识,结合国内外动物药研究进展与现状,探索性地提出基于"蛋白质/肽组学-修饰组学"研究动物药蛋白质、肽类物质与功效关联规律的思路及方法,即以蛋白质/肽组学的方法系统研究动物药物质组成,并以修饰组学研究蛋白质、肽类成分发生的化学修饰情况与规律,进一步探讨传统功效、成分和修饰组间的规律性与关联性,以期为中药动物药现代化研究和功效物质基础研究等提供借鉴与参考。

关键词：角类胶类动物药蛋白质组学多肽组学修饰组学

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Effects of ferulic acid on antioxidant activity in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and their combination

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Chinese Journal of Natural Medicines 2015年第6期13卷 401-408页

作者： WANG Lin-Yan TANG Yu-Ping LIU Xin ZHU Min Tao Wei-Wei LI Wei-Xia duan jin-ao jingjiang Hospital of Traditional Chinese Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization and National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine Nanjing University of Chinese Medicine

The present study aimed at exploring different roles of the same compound in different environment, using preparative HPLC, and the significance to investigating bio-active constituents in traditional Chinese medicine （TCM） on the basis of holism. In this study, the depletion of target component ferulic acid （FA） by using preparative HPLC followed by antioxidant activity testing was applied to investigate the roles of FA in Angelicae Sinansis Radix （DG）, Chuanxiong Rhizoma （CX） and their combination （GX）. The antioxidant activity was performed by 1, 1-diphenyl-2-picrylhydrazyl （DPPH） radical-scavenging activity testing. FA was successfully and exclusively depleted from DG, CX, and GX, respectively. By comparing the effects of the samples, it was found that FA was one of the main antioxidant constituents in DG, CX and GX, and the roles of FA were DG 〉 CX 〉 GX. Furthermore, the effects of FA varied at different doses in these herbs. This study provided a reliable and effective approach to clarifying the contribution of same compound in different TCMs to their bio-activities. The role of a constituent in different TCMs might be different, and a component with the same content might have different effects in different chemical environments. Furthermore, this study also suggested the potential utilization of preparative HPLC in the characterization of the roles of multi-ingredients in TCM.

关键词： HPLC Ferulic acid Angelica sinensis Ligusticum chuanxiong Herb pair Antioxidant activity

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