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Clinical efficacy of Gamma Knife® combined with transarterial chemoembolization and immunotherapy in the treatment of primary liver cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1601-1608页

作者： Guo-Feng Wang Chang-xin Shu Xiao-Dong Cai Hong-Bo Wang Jian-Hong Xu Yu-qing Jia Department of General Surgery Yangzhou Friendship Hospital Affiliated to Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND This study was designed to investigate the clinical efficacy and safety of Gamma Knife®combined with transarterial chemoembolization(TACE)and immunotherapy in the treatment of primary liver *** To investigate the clinical efficacy and safety of Gamma Knife®combined with TACE and immune-targeted therapy in the treatment of primary liver *** Clinical data from 51 patients with primary liver cancer admitted to our hospital between May 2018 and October 2022 were retrospectively *** patients underwent Gamma Knife®treatment combined with TACE and *** clinical efficacy,changes in liver function,overall survival(OS),and progression-free survival(PFS)of patients with different treatment responses were evaluated,and adverse reactions were *** The last follow-up for this study was conducted on October 31,*** evaluation of the 51 patients with primary liver cancer revealed a partial response(PR)in 27 patients,accounting for 52.94%(27/51);stable disease(SD)in 16 patients,accounting for 31.37%(16/51);and progressive disease(PD)in 8 patients,accounting for 15.69%(8/51).The objective response rate was 52.94%,and the disease control rate was 84.31%.Alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,and alpha-fetoprotein isoform levels decreased after treatment compared with pretreatment(all P=0.000).The median OS was 26 months[95%confidence interval(95%CI):19.946-32.054]in the PR group and 19 months(95%CI:14.156-23.125)in the SD+PD group,with a statistically significant difference(P=0.015).The median PFS was 20 months(95%CI:18.441-34.559)in the PR group and 12 months(95%CI:8.745-13.425)in the SD+PD group,with a statistically significant difference(P=0.002).Common adverse reactions during treatment included nausea and vomiting(39.22%),thrombocytopenia(27.45%),and leukopenia(25.49%),with no treatment-related deaths *** Gamma Knife®combined with TACE and immune-targeted th

关键词： Gamma Knife® Transarterial chemoembolization Immunotherapy Primary liver cancer Liver function

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Activation of glutamatergic neurons in the somatosensory cortex promotes remyelination in ischemic vascular dementia

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Fundamental Research 2024年第1期4卷 188-198页

作者： Yi-Ting Zhou Da-Dao An Yi-xin Xu Ying Zhou qing-qing Li Hai-Bin Dai Xiang-Nan Zhang Yi Wang Min Lou Zhong Chen Wei-Wei Hu Department of Pharmacology and Department of Pharmacy of the Second Affiliated Hospital NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Basic Medical SciencesCollege of Pharmaceutical SciencesZhejiang University School of MedicineHangzhou 310058China Department of Pharmacy Sir Run Run Shaw HospitalHangzhou 310012China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology the Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310003China

Chronic cerebral hypoperfusion can cause progressive demyelination as well as ischemic vascular dementia,however no effective treatments are ***,based on magnetic resonance imaging studies of patients with white matter damage,we found that this damage is associated with disorganized cortical *** a mouse model,optogenetic activation of glutamatergic neurons in the somatosensory cortex significantly promoted oligodendrocyte progenitor cell(OPC)proliferation,remyelination in the corpus callosum,and recovery of cognitive ability after cerebral *** therapeutic effect of such stimulation was restricted to the upper layers of the cortex,but also spanned a wide time window after ***,enhancement of glutamatergic neuron-OPC functional synaptic connections is required to achieve the protection effect of activating cortical glutamatergic ***,skin stroking,an easier method to translate into clinical practice,activated the somatosensory cortex,thereby promoting OPC proliferation,remyelination and cognitive recovery following cerebral *** summary,we demonstrated that activating glutamatergic neurons in the somatosensory cortex promotes the proliferation of OPCs and remyelination to recover cognitive function after chronic cerebral *** should be noted that this activation may provide new approaches for treating ischemic vascular dementia via the precise regulation of glutamatergic neuron-OPC circuits.

关键词： Chronic cerebral hypoperfusion Optogenetic stimulation Oligodendrocyte progenitor cellIschemic vascular dementia Glutamatergic neuron Remyelination

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Immune Regulatory Networks and Therapy of yδT Cells in Liver Cancer:Recent Trends and Advancements

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Journal of Clinical and Translational Hepatology 2024年第3期12卷 287-297页

作者： Kun-Li Yin Kai-Jian Chu Ming Li Yu-xin duan Yan-Xi Yu Mei-qing Kang Da Fu Rui Liao Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Biliary Surgical Department I the Eastern Hepatobiliary Surgical HospitalNaval Medical UniversityShanghaiChina General Surgery Institute of Pancreatic DiseasesRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

The roles of γδ T cells in liver cancer,especially in the poten-tial function of immunotherapy due to their direct cytotoxic effects on tumor cells and secretion of important cytokines and chemokines,have aroused research *** re-view briefly describes the basic characteristics of γδ T cells,focusing on their diverse effects on liver *** particular,different subtypes of γδ T cells have diverse or even opposite effects on liver *** provide a detailed description of the immune regulatory network of γδ T cells in liver can-cer from two aspects:immune components and nonimmune *** interactions between various components in this immune regulatory network are dynamic and pluralis-tic,ultimately determining the biological effects of γδ T cells in liver *** also integrate the current knowledge of γδ T-cell immunotherapy for liver cancer treatment,emphasiz-ing the potential of these cells in liver cancer immunotherapy.

关键词： Liver cancer γδT cells Immunotherapy Tumor microenvironment

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Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol

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Acta Pharmacologica Sinica 2007年第7期28卷 1037-1044页

作者： Miao-rong SHE~(1,3,4),Jing-gao LI~(2,4),Kun-yuan GUO~(3,5),Wei LIN~1,xin du~1,xin-qing NIU~3~1 Department of Hematology,Guangdong Provincial People's Hospital,Guangzhou 510080,China ~2 Department of Nephrology,the SecondAffiliated Hospital,Sun Yat-Sen University,Guangzhou 510120,China,~3 Department of Hematology,Zhujiang Hospital of Southern MedicalUniversity,Guangzhou 510282,China Department of Hematology Guangdong Provincial Peopleos Hospital Guangzhou510080 China. gzyuan@***.

Aim:To investigate the effects of 2-methoxyestradiol (2-ME) on 2 myeloid leuke-mia cell lines HL-60 and U937,and to explore its ***:Humanmyeloid leukemia cells HL-60 and U937 were *** of mitochondrialmembrane potential (Dym) was performed using 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide (JC-1).Apoptosis and cellular nitricoxide (NO) were detected by flow cytometry using Annexin V and NO sensor *** anion was measured with a fluorescent plate reader by dihydroethidium(DHE).Cytotoxicity was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium ***:2-ME resulted in viability decrease in a dose-depen-dent manner.2-ME treatment also generated reactive oxygen species (ROS),including NO and superoxide anions,which resulted in mitochondria damage.2-ME-induced apoptosis was correlated with an increase in *** quenchingof ROS with N-acetyl-L-cysteine protected leukemia cells from 2-ME cytotoxicityand prevented apoptosis induction by ***,the addition ofmanumycin,a farnesyltransferase inhibitor,significantly enhanced apoptosis in-duced by ***:Cellular ROS generation plays an important role inthe cytotoxic effect of *** is possible to use ROS generation agents,such asmanumycin,to enhance the antileukemic *** combination strategy needsfurther in vivo justification and may have potential clinical application.

关键词： 2-methoxyestradiol apoptosis reactive oxygen species nitric oxide superoxides leukemia

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The AaBBX21–AaHY5 module mediates light-regulated artemisinin biosynthesis in Artemisia annua L.

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Journal of Integrative Plant Biology 2024年第8期66卷 1735-1751页

作者： Weizhi He Hang Liu Zhangkuanyu Wu qing Miao xinyi Hu xin Yan Hangyu Wen Yaojie Zhang Xueqing Fu Li Ren Kexuan Tang Ling Li Frontiers Science Center for Transformative Molecules Joint International ResearchLaboratory of Metabolic and Developmental SciencesKey Laboratory of Urban Agriculture(South)Ministry of AgriculturePlant Biotechnology Research CenterFudan-SJTU-Nottingham Plant Biotechnology R&D CenterSchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Institute for Agri-Food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

The sesquiterpene lactone artemisinin is an important anti-malarial component produced by the glandular secretory trichomes of sweet wormwood(Artemisia annua L.).Light was previously shown to promote artemisinin production,but the underlying regulatory mechanism remains *** this study,we demonstrate that ELONGATED HYPOCOTYL5(HY5),a central transcription factor in the light signaling pathway,cannot promote artemisinin biosynthesis on its own,as the binding of AaHY5 to the promoters of artemisinin biosynthetic genes failed to activate their *** analysis and yeast two-hybrid screening revealed the B-box transcription factor AaBBX21 as a potential interactor with ***21 showed a trichome-specific expression ***,the AaBBX21–AaHY5 complex cooperatively activated transcription from the promoters of the downstream genes AaGSW1,AaMYB108,and AaORA,encoding positive regulators of artemisinin ***,AaHY5 and AaBBX21 physically interacted with the *** E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1(COP1).In the dark,AaCOP1 decreased the accumulation of AaHY5 and AaBBX21 and repressed the activation of genes downstream of the AaHY5–AaBBX21 complex,explaining the enhanced production of artemisinin upon light *** study provides insights into the central regulatory mechanism by which light governs terpenoid biosynthesis in the plant kingdom.

关键词： AaBBX21 AaHY5 AaCOP1 Artemisia annua L. artemisinin biosynthesis light

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An adaptive finite-difference method for seismic traveltime modeling based on 3D eikonal equation

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Petroleum Science 2024年第1期21卷 195-205页

作者： Bao-Ping Qiao qing-qing Li Wei-Guang He Dan Zhao Qu-Bo Wu CNNC Beijing Research Institute of Uranium Geology Beijing 100029China National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShangdongChina SINOPEC Geophysical Research Institute Nanjing211103JiangsuChina

3D eikonal equation is a partial differential equation for the calculation of first-arrival traveltimes and has been widely applied in many scopes such as ray tracing,source localization,reflection migration,seismic monitoring and tomographic *** recent years,many advanced methods have been developed to solve the 3D eikonal equation in heterogeneous ***,there are still challenges for the stable and accurate calculation of first-arrival traveltimes in 3D strongly inhomogeneous *** this paper,we propose an adaptive finite-difference(AFD)method to numerically solve the 3D eikonal *** novel method makes full use of the advantages of different local operators characterizing different seismic wave types to calculate factors and traveltimes,and then the most accurate factor and traveltime are adaptively selected for the convergent updating based on the Fermat *** with global fast sweeping describing seismic waves propagating along eight directions in 3D media,our novel method can achieve the robust calculation of first-arrival traveltimes with high precision at grid points either near source point or far away from source point even in a velocity model with large and sharp *** numerical examples show the good performance of the AFD method,which will be beneficial to many scientific applications.

关键词： 3D eikonal equation Accurate traveltimes Global fast sweeping 3D inhomogeneous media Adaptive finite-difference method

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FPGA and computer-vision-based atom tracking technology for scanning probe microscopy

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Chinese Physics B 2024年第5期33卷 76-85页

作者：俞风度刘利王肃珂张新彪雷乐黄远志马瑞松郇庆 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China ACME (Beijing) Technology Co. Ltd.Beijing 101407China Key Laboratory for Vacuum Physics University of Chinese Academy of SciencesBeijing 100190China

Atom tracking technology enhanced with innovative algorithms has been implemented in this study,utilizing a comprehensive suite of controllers and software independently developed *** an on-board field-programmable gate array(FPGA)with a core frequency of 100 MHz,our system facilitates reading and writing operations across 16 channels,performing discrete incremental proportional-integral-derivative(PID)calculations within 3.4 *** upon this foundation,gradient and extremum algorithms are further integrated,incorporating circular and spiral scanning modes with a horizontal movement accuracy of 0.38 *** integration enhances the real-time performance and significantly increases the accuracy of atom *** tracking achieves an equivalent precision of at least 142 pm on a highly oriented pyrolytic graphite(HOPG)surface under room temperature atmospheric *** applying computer vision and image processing algorithms,atom tracking can be used when scanning a large *** techniques primarily consist of two algorithms:the region of interest(ROI)-based feature matching algorithm,which achieves 97.92%accuracy,and the feature description-based matching algorithm,with an impressive 99.99%*** implementation approaches have been tested for scanner drift measurements,and these technologies are scalable and applicable in various domains of scanning probe microscopy with broad application prospects in the field of nanoengineering.

关键词： atom tracking FPGA computer vision drift measurement

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Molecular docking-aided AIEgen design: concept, synthesis and applications

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Science China Chemistry 2024年第8期67卷 2614-2628页

作者： Jian-qing Zhang Xiao-Yu Xu Fu-Sheng Liu Shu-Qiang Cao Yu-xin Gui Yi-Wen Su Xiao-Yu He Ji-Yuan Liang You-Quan Zou Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationWuhan UniversityWuhan 430071China Tai Kang Center for Life and Medical Sciences Wuhan UniversityWuhan 430071China Department of Hepatobiliary Pancreatic SurgeryZhongnan Hospital of Wuhan UniversityWuhan 430071China

Aggregate-induced emission luminogens(AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable research interests during the last few years. Herein, molecular docking-aided AIEgen design has been reasonably proposed and AIEgen TBQZY with excellent ~1O_(2) generation ability has been synthesized. The newly developed TBQZY could efficiently kill S. epidermidis and methicillinresistant S. epidermidis(MRSE) by tightly binding to bacteria and triggering the accumulation of ~1O_(2) in bacteria. TBQZY specifically regulated the immune system and polarized macrophages from M1 to M2 to accelerate the elimination of biofilm in vivo. In addition, healing acceleration was observed in chronic wounds treated with TBQZY, and side effects were ***, TBQZY had extraordinary potential for combating drug-resistant bacteria in the clinical setting. This research not only provided new concepts for the design of AIEgens, but also shed some lights on the discovery of drugs against drug-resistant bacteria.

关键词： AIEgen molecular docking drug-resistant bacteria biofilm chronic wounds healing

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Gamma/Hadron Separation Method for the HADAR Experiment

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Research in Astronomy and Astrophysics 2024年第3期24卷 70-74页

作者： Yang-Zhao Ren Tian-Lu Chen You-Liang Feng Dan-Zeng Luo-Bu Yi-qing Guo Cheng Liu Qi Gao Mao-Yuan Liu Xiang-Li Qian Ya-Ping Wang Zi-Hao Zhang xin-Long Li qing-Yuan Hou Heng-Jiao Liu qing-Qian Zhou Shan-Jie Shu The Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences University of Chinese Academy of Sciences School of Intelligent Engineering Shandong Management University

Ground-based arrays of imaging atmospheric Cherenkov telescopes(IACTs)are the most sensitiveγ-ray detectors for energies of approximately 100 Ge V and *** such IACT is the High Altitude Detection of Astronomical Radiation(HADAR)experiment,which uses a large aperture refractive water lens system to capture atmospheric Cherenkov photons(i.e.,the imaging atmospheric Cherenkov technique).The telescope array has a low threshold energy and large field of view,and can continuously scan the area of the sky being observed,which is conducive to monitoring and promptly responding to transient *** process ofγ-hadron separation is essential in very-high-energy(>30 Ge V)γ-ray astronomy and is a key factor for the successful utilization of *** this study,Monte Carlo simulations were carried out to model the response of cosmic rays within the HADAR *** analyzing the Hillas parameters and the distance between the event core and the telescope,the distinction between air showers initiated byγ-rays and those initiated by cosmic rays was ***,a Quality Factor was introduced to assess the telescope’s ability to suppress the background and to provide a more effective characterization of its performance.

关键词： astroparticle physics-telescopes-methods data analysis

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垂直振动下干湿颗粒样品的体积模量与耗散

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物理学报 2022年第18期71卷 245-252页

作者：杜清馨孙其诚丁红胜张国华范彦丽安飞飞北京科技大学物理系北京100083 清华大学水沙科学与水利水电工程国家重点实验室北京100084

研究了垂直振动条件下,干、湿玻璃珠样品的体积模量和相对耗散.实验发现:1)在低饱和度下,干、湿玻璃珠样品的体积模量随压强幂律变化,与基于赫兹接触势的有效介质理论预言的1/3幂律关系接近;加入少量液体会增加体积模量.同一压强和液体... 详细信息

研究了垂直振动条件下,干、湿玻璃珠样品的体积模量和相对耗散.实验发现:1)在低饱和度下,干、湿玻璃珠样品的体积模量随压强幂律变化,与基于赫兹接触势的有效介质理论预言的1/3幂律关系接近;加入少量液体会增加体积模量.同一压强和液体含量下,随着液体黏度的增大,体积模量随之增加.基于赫兹接触力学,提出了有效弹性网络模型来阐述湿玻璃珠样品体积模量的增加机制.2)干、湿玻璃珠样品的相对耗散随压强幂律降低,湿玻璃珠样品的相对耗散与液体黏度呈正比.3)随着应变幅值的增大,湿玻璃珠样品表现出类似干玻璃珠样品的软化行为,且液体黏度会抑制玻璃珠样品的软化行为.

关键词：颗粒物质体积模量能量耗散液桥力

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