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Risk factors and outcomes of acute kidney injury after intracoronary stent implantation

World Journal of Emergency Medicine 2012年第3期3卷 197-201页

作者： Fei He Jun Zhang Zhong-qiu Lu Qing-ling Gao du-juan sha Li-gang Pei Guo-feng Fan Department of Emergency Medicine Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School Department of Emergency Medicine First Affiliated HospitalWenzhou Medical College Department of Cardiology Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School

Acute kidney injury following percutaneous coronary intervention （PCI） is associated with a worse outcome. However, the risk factors and outcomes of acute kidney injury （AKI） in patients after intracoronary stent implantation are still unknown. A retrospective case control study was done in 325 patients who underwent intracoronary stent implantation from January 2010 to March 2011 at the Drum Tower Hospital of Nanjing University School of Medicine. Those were excluded from the study if they had incomplete clinical data. The patients were divided into a normal group and a AKI group according to the standard of post-operation day 7 to identify AKI. The parameters of the patients included： 1） pre-operative ones： age, gender, hypertension, diabetes mellitus, cerebrovascular disease, left ventricular insufficiency, peripheral angiopathy, creatinine, urea nitrogen, estimated glomerular filtration rate （eGFR）, hyperuricemia, proteinuria, emergency operation, hydration, medications （ACEI/ARBs, statins）; 2） intraoperative ones： dose of contrast media, operative time, hypotension; and 3） postoperative one： hypotension. The parameters were analyzed with univariate analysis and multivariate logistical regression analysis. Of the 325 patients, 51（15.7%） developed AKI. Hospital day and in-hospital mortality were increased significantly in the AKI-group. Univariate analysis showed that age, pre-operative parameters （left ventricular insufficiency, peripheral angiopathy, creatinine, urea nitrogen, estimated glomerular filtration rate, hyperuricemia, proteinuria, hydration）, emergency operation, intraoperative parameters （operative time, hypotension） and postoperative hypotension were significantly different. However, multivariate logistic regression analysis revealed that increased age （OR=0.253, 95%CI=0.088-0.727）, pre-operative proteinuria （OR=5.351, 95%CI=2.128-13.459）, pre-operative left ventricular insufficiency （OR=8.704, 95%CI=3.170-23.898）, eGFR〈60 ml/min/1.73 m2 （OR=6.67

关键词： Intracoronary stent implantation Acute kidney injury Risk factor Outcome

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血浆高敏C-反应蛋白和血清D-二聚体浓度与脑梗死体积的关系

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国际脑血管病杂志 2008年第4期16卷 270-272页

作者：沙杜鹃张均南京大学附属南京市鼓楼医院急诊科 210008

目的：探讨脑梗死患者急性期血清高敏C-反应蛋白（ks-CRP）和血浆D-二聚体含量的变化及其与脑梗死体积的关系。方法：分别对94例脑梗死急性期患者和85例健康体检者血清ks—CRP、血浆D-二聚体含量进行测定，并分析两者与脑梗死体积的相... 详细信息

目的：探讨脑梗死患者急性期血清高敏C-反应蛋白（ks-CRP）和血浆D-二聚体含量的变化及其与脑梗死体积的关系。方法：分别对94例脑梗死急性期患者和85例健康体检者血清ks—CRP、血浆D-二聚体含量进行测定，并分析两者与脑梗死体积的相关性。结果：脑梗死组血清Hs—CRP和血浆D-二聚体浓度均显著高于对照组（P〈0．05）；与中等梗死（5-10cm^3）和小梗死者（≤5cm3）相比，大梗死者（≥10cm3）血清ks-CRP和血浆D-二聚体水平显著增高（P〈0．05）。结论：检测血清ks—CRP和血浆D-二聚体水平有助于脑梗死的早期诊断和梗死体积的判断。

关键词：脑梗死 C-反应蛋白 D-二聚体

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Logistic Weighted Profile-Based Bi-Random Walk for Exploring MiRNA-Disease Associations

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Journal of Computer Science & Technology 2021年第2期36卷 276-287页

作者： Ling-Yun Dai Jin-Xing Liu Rong Zhu juan Wang sha-sha Yuan School of Computer Science Qufu Normal UniversityRizhao 276826China

MicroRNAs(miRNAs)exert an enormous influence on cell differentiation,biological development and the onset of *** predicting potential miRNA-disease associations(MDAs)by biological experiments usually requires considerable time and money,a growing number of researchers are working on developing computational methods to predict *** accuracy is critical for *** date,many algorithms have been proposed to infer novel ***,they may still have some *** this paper,a logistic weighted profile-based bi-random walk method(LWBRW)is designed to infer potential MDAs based on known *** this method,three networks(i.e.,a miRNA functional similarity network,a disease semantic similarity network and a known MDA network)are constructed *** the process of building the miRNA network and the disease network,Gaussian interaction profile(GIP)kernel is computed to increase the kernel similarities,and the logistic function is used to extract valuable information and protect known ***,the known MDA matrix is preprocessed by the weighted K-nearest known neighbours(WKNKN)method to reduce the number of false ***,the LWBRW method is applied to infer novel MDAs by bi-randomly walking on the miRNA network and the disease ***,the predictive ability of the LWBRW method is confirmed by the average AUC of 0.9393(0.0061)in 5-fold cross-validation(CV)and the AUC value of 0.9763 in leave-one-out cross-validation(LOOCV).In addition,case studies also show the outstanding ability of the LWBRW method to explore potential MDAs.

关键词： miRNA-disease association logistic function Gaussian interaction profile weighted K-nearest known neighbour bi-random walk

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Quantification of beclomethasone 17-monopropionate in human plasma by LC-MS/MS and its application to beclomethasone dipropionate pharmacokinetic study

Quantification of beclomethasone 17-monopropionate in human ...

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中国药理学会第十一次全国学术会议

作者： CHEN Ke-guang~1,JIANG Zhi-mei~1,ZHANG du-juan~1,LIU sha~1,TENG Yan-ni~1, WEI Chun-min~2,WANG Ben-jie~2,LIU Xiao-yan~2,YUAN Gui-yan~2, ZHANG Rui~2,GUO Rui-chen~2 (1.College of Pharmacy,shandong University,Jinan 250012,China 2.Institute of Clinical Pharmacology, Qilu Hospital of shandong University,Jinan 250012,China)

A sensitive and selective liquid chromatography-electrospray ionization-tandem mass spectrometry method was devel- oped and validated for the quantification of beclomethasone 17-monopropionate(BMP),the main active metabolite of beclomethasone dipropionate(BDP),in human plasma,using diazepam as an internal standard(IS).Beclomethasone 17-monopropionate and diazepam in plasma were extracted by sample liquid-liquid extraction with ethyl *** analyte and IS were separated on a C reversed phase column,eluted with mobile phase of methanol-water(containing 33 mmol·L ammonium acetate and 0.5%formic acid)(85: 15,V/V),at flow-rate of 0.8 ml·min,and ionized by positive ion pneumatically assisted electrospray and detected in the multi-reaction monitoring mode using precursor→product ions of m/z 465.1→279.2 for BMP and 285.1→193.1 for the IS,*** calibration curve was linear(r≥0.99,n =5) over the concentration range of 0.02-2 ng·ml and with lower limit of quantitation of 0.02 ng·*** specificity,matrix effect,recovery,sensitivity,linearity,accuracy,precision,and several of stabilities have been validated for BMP in human *** conclusion,the validation results showed that this method is sensitive,economical and less toxic and it can successfully fulfill the requirement of clinical pharmacokinetic study of beclomethasone dipropionate in Chinese healthy volunteers.

关键词： beclomethasone 17-monopropionate beclomethasone dipropionate LC-MS/MS pharmacokinetics diazepam

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Method of reliability tolerance design based on EDA technology and its application on DC hybrid contactor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 426-433页

作者： WANG Shu-juan sha You-tao ZHANG Hui ZHAI Guo-fu School of Electrical Engineering and Automation Harbin Institute of Technology Harbin 150001 China

Tolerance design, including tolerance analysis and distribution, is an important part of the electronic system’s reli- ability design. The traditional design needs to construct mathematic model of material circuit, which involves large amount of workload and lacks of practicability. This paper discusses the basic theory of electronic system’s reliability tolerance design and presents a new design method based on EDA (Electronic Design Automatic) software. This method has been validated through the application research on reliability tolerance design of the DC hybrid contactor’s control circuit.

关键词： Reliability Tolerance analysis EDA (Electronic Design Automatic)

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Estimation method for random sonic fatigue life of thin-walled structure of a combustor liner based on stress probability distribution

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航空动力学报 2011年第4期26卷 727-734页

作者： sha Yun-dong GUO Xiao-peng LIAO Lian-fang XIE Li-juan Liaoning Key Laboratory of Digital Technology Simulation and Test Technique College of Power and Energy Engineering Shenyang Aerospace University Shenyang 110136 China Shenyang Aeroengine Research Institute Aviation Industry Corporation of China Shenyang 110015 China

As to the sonic fatigue problem of an aero-engine combustor liner structure under the random acoustic loadings,an effective method for predicting the fatigue life of a structure under random loadings was ***,the probability distribution of Von Mises stress of thin-walled structure under random loadings was studied,analysis suggested that probability density function of Von Mises stress process accord approximately with two-parameter Weibull *** formula for calculating Weibull parameters were *** on the Miner linear theory,the method for predicting the random sonic fatigue life based on the stress probability density was developed,and the model for fatigue life prediction was *** an example,an aero-engine combustor liner structure was *** power spectrum density(PSD) of the vibrational stress response was calculated by using the coupled FEM/BEM(finite element method/boundary element method) model,the fatigue life was estimated by using the constructed *** considering the influence of the wide frequency band,the calculated results were *** analysis shows that the estimated results of sonic fatigue of the combustor liner structure by using Weibull distribution of Von Mises stress are more conservative than using Dirlik distribution to some *** results show that the methods presented in this paper are practical for the random fatigue life analysis of the aeronautical thin-walled structures.

关键词： thin-walled structure sonic fatigue life estimation probability density function(PDF) power spectrum density(PSD)

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Gastric motility functional study based on electrical bioimpedance measurements and simultaneous electrogastrography

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 983-989页

作者： Zhang-yong LI Chao-shi REN Shu ZHAO Hong sha juan DENG College of Bioinformation Chongqing University of Posts and Telecommunications Chongqing 400065 China nstitute of Biomedical Engineering Chinese Academy of Medical Sciences ＆ Peking Union Medical College Tianjin 300192 China

For some time now,the research on gastric motility and function has fallen behind in the amount of research on gastric endocrine,exocrine secretion,and gastric *** this paper,a noninvasive method to study gastric motility was developed,taking bioimpedance measurements over the gastric area simultaneously with the electrogastrography(EGG).This is based on the concept of observing and analyzing simultaneously the intrinsic electrical gastric activity(basic electric rhythm) and the mechanical gastric ***,preliminary clinical studies of healthy subjects and subjects with functional dyspepsia(FD) and gastritis were carried *** impedance gastric motility(IGM) measurements of the healthy and FD subjects were compared,along with the studies of the FD subjects before treatment and after one week and three weeks of *** also compared IGM measurements of healthy subjects and subjects with erosive gastritis,along with the studies of the subjects with erosive gastritis before treatment and after one week of *** show that FD subjects have poor gastric motility(P0.05),These results suggest the possibility of clinic application of the proposed method.

关键词： Gastric motility Electrical bioimpedance Electrogastrography Functional dyspepsia Gastritis

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Advanced oxidation of bromide-containing drinking water: A balance between bromate and trihalomethane formation control

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Journal of Environmental Sciences 2013年第11期25卷 2169-2176页

作者： Yongjing Wang Jianwei Yu Po Han Jing sha Tao Li Wei An juan Liu Min Yang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Zhengzhou Water Supply Investment Holdings Co. Ltd.

Addition of H2O2 has been employed to repress bromate formation during ozonation of bromide-containing source water. However, the addition of H2O2 will change the oxidation pathways of organic compounds due to the generation of abundant hydroxyl radicals, which could affect the removal efficacy of trihalomethane precursors via the combination of ozone and biological activated carbon （O3-BAC）. In this study, we evaluated the effects of H2O2 addition on bromate formation and trihalomethane formation potential （THMFP） reduction during treatment of bromide-containing （97.6-129.1 μg/L） source water by the O3-BAC process. At an ozone dose of 4.2 mg/L, an H2O2/O3 （g/g） ratio of over 1.0 was required to maintain the bromate concentration below 10.0 μg/L, while a much lower H2O2/O3 ratio was sufficient for a lower ozone dose. An H2O2/O3 （g/g） ratio below 0.3 should be avoided since the bromate concentration will increase with increasing H2O2 dose below this ratio. However, the addition of H2O2 at an ozone dose of 3.2 mg/L and an H2O2/O3 ratio of 1.0 resulted in a 43% decrease in THMFP removal when compared with the O3-BAC process. The optimum H2O2/O3 （g/g） ratio for balancing bromate and trihalomethane control was about 0.7-1.0. Fractionation of organic materials showed that the addition of H2O2 decreased the removal efficacy of the hydrophilic matter fraction of DOC by ozonation and increased the reactivity of the hydrophobic fractions during formation of trihalomethane, which may be the two main reasons responsible for the decrease in THMFP reduction efficacy. Overall, this study clearly demonstrated that it is necessary to balance bromate reduction and THMFP control when adopting an H2O2 addition strategy.

关键词： bromate control hydrogen peroxide addition ozone-hydrogen peroxide trihalomethane formation potential ozone-biological activated carbon

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Relationship of lipid and lipoprotein ratios with coronary severity in patients with new on-set coronary artery disease complicated with type 2 diabetics

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Journal of Geriatric Cardiology 2016年第8期13卷 685-692页

作者： Ying du juan CHEN Man-Hua CHEN Sheng-Hua YANG sha LI Yuan-Lin GUO Cheng-Gang ZHU Rui-Xia XU Qian DONG Jian-Jun LI Division of Dyslipidemia State Key Laboratory of Cardiovascular Disease Fu Wai Hospital National Center for Cardiovascular Diseases Chinese Academyof Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology the Central Hospital of Wuhan Wuhan Hubei China

Background Diabetes mellitus （DM） is associated with coronary artery disease （CAD） progression. Although previous studies have demonstrated the association of lipid and lipoprotein ratios with CAD, no data are currently available concerning the relationship between lipid and lipoprotein ratios and the severity of new on-set CAD in diabetics. Therefore, the aim of the present study was to investigate the usefulness of lipid and lipoprotein ratios in predicting the severity of CAD in patients with type 2 DM （T2DM）. Methods A total of 380 consecutive T2DM patients with new on-set CAD were enrolled in the present study. Then, they were classified into the three groups ac-cording to Gensini score （GS） tertiles. The relationship between lipid and lipoprotein ratios currently used and the GS was investigated. Results Positive correlations of natural log-transformed GS （lnGS） with apolipoprotein B to apoA-I ratio （apoB/apoA-I）, non-high-density lipoprotein cholesterol to apoA-I ratio （non-HDL-C/apoA-I）, and low-density lipoprotein cholesterol to apoA-I ratio （LDL-C/apoA-I） were found （r = 0.18, 0.13, 0.12, respectively, all P 〈 0.05）. Multivariate logistic analysis indicated apoB/apoA-I as the strongest predictor for high GS （OR = 5.67, 95% CI： 1.45-23.92, P = 0.003）. Area under receivers operating characteristic curve of apoB/apoA-I was 0.63 （95% CI： 0.60-0.66, P = 0.001） for predicting high GS. The optimal cutoff value of apoB/apoA-I to predict high GS was 0.72 with the sensitivity of 61.2% and the specificity of 62.1%. Conclusions Lipid and lipoprotein ratios might be useful for predicting the severity of new on-set CAD in T2DM patients, and the apoB/apoA-I appeared as the most significant predictor in this population.

关键词： Coronary artery disease Lipid Lipoprotein Type 2 diabetes mellitus

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Bacterial community response to petroleum contamination in brackish tidal marsh sediments in the Yangtze River Estuary, China

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Journal of Environmental Sciences 2021年第1期33卷 160-167页

作者： Min Wang Chenyan sha Jian Wu Jinghua Su Jianqiang Wu Qing Wang juan Tan Shenfa Huang Research Institute of Natural Ecology Conseruation Shanghai Academy of Enuvironmental Sciences508 Qinzhou RoadShanghai 200233China

The brackish tidal marsh in the Baimaosha area of the Yangtze River Estuary was severely contaminated by 400 tons of heavy crude petroleum from a tanker that sank in December *** spill accident led to severe environmental damage owing to its high toxicity,persistence and wide *** communities play vital roles in petroleum degradation in marsh ***,taxonomic analysis,high-throughput sequencing and 16 S rRNA functional prediction were used to analyze the structure and function of microbial communities among uncontaminated(CK),lightly polluted(LP),heavily polluted(HP),and treated(TD)*** bacterial communities responded with increased richness and decreased diversity when exposed to petroleum *** dominant class changed from Deltaproteobacteria to Gammaproteobacteria after petroleum *** phylum Firmicutes increased dramatically in oil-enriched sediment by 75.78%,346.19%and 267.26%in LP,HP and TD,*** of the suspected oil-degrading genera,Dechloromonas,increased the most in oil-contaminated sediment,by 540.54%,711.27%and 656.78%in LP,HP and TD,*** protease,quinate dehydrogenase(quinone)and glutathione-independent formaldehyde dehydrogenase,three types of identified enzymes,increased enormously with the increasing petroleum *** conclusion,petroleum contamination altered the community composition and microorganism structure,and promoted some bacteria to produce the corresponding degrading ***,the suspected petroleum-degrading genera should be considered when restoring oil-contaminated sediment.

关键词： Brackish marsh sediment Petroleum contamination Bacterial community Gene enzyme

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