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Prediction of rat liver transplantation outcomes using energy metabolites measured by microdialysis

Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 392-401页

作者： Qi Pan Ying Cheng Zi-Gong Shao An-Yin wang Yong-Feng Liu Department of Transplantation and Hepatobiliary Surgery First Affiliated Hospital of China Medical University

Background: Warm ischemia jeopardizes graft quality and recipient survival in donation after cardiac death(DCD) transplantation. Currently, there is no system to objectively evaluate the liver quality from DCD. The present study tried to use energy metabolites to evaluate the donor liver quality. Methods: We divided 195 Sprague-Dawley rats into five groups: the control( n = 39), warm ischemic time(WIT) 15 min( n = 39), WIT 30 min( n = 39), WIT 45 min( n = 39), and WIT 60 min( n = 39) groups. Three rats from each group were randomly selected for pretransplant histologic evaluation of warm ischemiarelated damage. The remaining 36 rats were randomly divided into donors and recipients of 18 liver transplantations, and were subjected to postoperative liver function and survival analyses. Between cardiac arrest and cold storage, liver energy metabolites including glucose, lactate, pyruvate, and glycerol were measured by microdialysis. The lactate to pyruvate ratio(LPR) was calculated. Results: The changes in preoperative pathology with warm ischemia were inconspicuous, but the trends in postoperative pathology and aminotransferase levels were consistent with preoperative energy metabolite measurements. The 30-day survival rates of the control and WIT 15, 30, 45, and 60 min groups were 100%, 81.82%, 76.92%, 58.33%, and 25.00%, respectively. The areas under the receiver operating characteristic curves of glucose, lactate, glycerol, and LPR were 0.87, 0.88, 0.88, and 0.92, respectively. Conclusion: Glucose, lactate, glycerol, and LPR are predictors of graft quality and survival outcomes in DCD transplantation.

关键词： Energy metabolites Graft evaluation Warm ischemia Microdialysis Donation after cardiac death

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Highly efficient conversion of surplus electricity to hydrogen energy via polysulfides redox

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The Innovation 2021年第3期2卷 103-108页

作者： Mo Zhang j.ng Guan Yunchuan Tu Suheng wang Dehui Deng State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Catalysis iChEMDalian Institute of Chemical PhysicsChinese Academy of ScienceZhongshan Road 457Dalian 116023China School of Environmental&Municipal Engineering Qingdao University of TechnologyQingdao 266033China

Decoupled electrolysis of water is a promising strategy for peak load regulation of *** key to developing this technology is to construct decoupled devices containing stable redox mediators and corresponding efficient catalysts,which remains a considerable ***,we designed a high-performance device,using polysulfides as mediators and graphene-encapsulated Coni as *** produced H2 with a low potential of 0.82 V at 100 mA/cm^(2),saving 60.2%more energy than direct water *** capacity of H2 production reached 2.53105 mAh/cm^(2),which is the highest capacity reported so *** device exhibited excellent cyclability in 15-day recycle tests,without any decay of *** calculation results revealed that the electronic structure of the graphene shell was modulated by the electron transfer from n-dopant and metal core,which significantly facilitated recycle of polysulfides on graphene *** study provides a promising method for constructing a smart grid by developing efficient decoupled devices.

关键词： peak shaving and valley filling decoupled electrolysis H2 production chainmail catalyst polysulfides redox

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Effect of Boron Mud and CaF_2 on Surface Tension and Density of CaO-SiO_2-B_2O_3 Ternary Slag Systems

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journal of Iron and Steel Research International 2014年第8期21卷 745-748页

作者： Li-li YAnG Hong-ming wang Xiang ZHU Gui-rong LI School of Materials Science and Engineering Jiangsu University jiangsu Province Key Laboratory of High-End Structural Materials

The effect of boron mud and CaF2,which were used as fluxing agents,on surface tension and density of CaO-SiO2-B2O3 ternary slag systems was *** surface tension and density were measured by using the ring detachment method and Archimedean method,*** results indicated that surface tension and density of the slag systems decreased with increasing temperature in the range of 1380-1480℃.When 5%-10% CaF2 was employed as fluxing agent,the surface tension and density of slag were decreased with increasing CaF2 content,and the surface tension changed from 0.3to 0.6n/m,while the density changed from 3.4to 4.1g/***,when using 5%-10%boron mud as fluxing agent,the surface tension was enhanced,whereas the density decreased with the increase of boron mud content,and the variation range was 0.4-0.6n/m for surface tension and 3.2-3.9g/cm3 for the *** a conclusion,using boron mud as fluxing agent to substitute for CaF2 did not cause significant changes in slag surface tension and density.

关键词： boron mud calcium fluoride surface tension density

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Studies on the binding of vinpocetine to human serum albumin by molecular spectroscopy and modeling

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Chinese Chemical Letters 2012年第5期23卷 599-602页

作者： Hua jiang Rong Rong Chen Hong Cui wang Han Lin Pu Bio-engineering Institute College of Life Science and TechnologyJinan UniversityGuangzhou 510632China

The interaction between vinpocetine（VPC） and human serum albumin（HSA） in physiological buffer（pH 7.40） was investigated by fluorescence,FT-IR,UV-vis absorption and molecular *** effectively quenched the intrinsic fluorescence of HSA via static *** binding site number n and apparent binding constant K_a,corresponding thermodynamic parametersΔG,ΔH andΔS at different temperatures were *** synchronous fluorescence and FT-IR spectra were used to investigate the structural change of HSA molecules with addition of *** modeling indicated that VPC could bind to the site I of HSA and hydrophobic interaction was the major acting force,which was in agreement with the binding mode study.

关键词： Vinpocetine Human serum albumin Fluorescence quenching Molecular modeling

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Effects of Garcinia kola and Azadirachta indica Seeds in the Inhibition of Aspergillus flavus and Aspergillus parasiticus Isolated from Zea mays L. Awka, nigeria

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American journal of Plant Sciences 2016年第11期7卷 1555-1563页

作者： A. n. Achugbu j. E. Amadi C. V. Ilodibia M. n. Ikegbunam Department of Botany Nnamdi Azikiwe University Awka Nigeria Department of Pharmaceutical Microbiology and Biotechnology Nnamdi Azikiwe University Awka Nigeria

Crude extracts of neem and bitter kola seeds were evaluated for inhibition of the growth of aflatoxin-producing fungi (Aspergillus flavus and A. parasiticus) in Zea mays L. Different concentrations of the methanolic and ethanolic extracts of the test plants were tested individually and in combination against A. flavus and A. parasiticus. Inhibition of A. flavus using methanolic extracts of G. kola, neem and combination of (G. kola and neem) seeds revealed that inhibition was highest in G. kola (77.5) at 10% concentration, and lowest in neem (35.1) at 2.5% concentration. Statistical analysis showed a significant difference at 5%. Inhibition of A. flavus using ethanolic extracts of G. kola, neem and combination of G. kola and neem seeds revealed that inhibition was highest in the combination of (80.4) at 10% concentration and lowest in G. kola (31.4) at 2.5% concentration. Using methanolic extracts of G. kola, neem and combination against A. parasiticus showed that inhibition was highest in G. kola and combination of seeds (54.8) at 10% concentration and lowest in neem seeds (30.5) at 5.0% concentration. The percentage inhibition of A. parasiticus using ethanolic extracts of G. kola, neem and combination revealed that inhibition was highest in G. kola (79.5) at 10% concentration and lowest in the combination of G. kola and neem seeds (26.6) at 2.5% concentration. These results will be important in planning a management strategy against A. flavus and A. parasiticus and other fungi associated with spoilage of stored products.

关键词： Garcinia kola Azadirachta indica Inhibition Aspergillus Species Zea mays

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Convenient synthesis and application of novel bi-SO_3H-functionalized ionic liquids based on piperazinium

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Chinese Chemical Letters 2012年第9期23卷 1031-1034页

作者： Yuan Yuan wang Yue Tong Wu Kun Liu Li Yi Dai Department of Chemistry East China Normal UniversityChinaShanghai 200062

In this article, series of novel bi-SOaH-functionalized ILs were synthesized using simple, efficient and economic procedure. Hammer method had been used to determine the acidity order of these ionic liquids, and the acidifies of bi-SOaH-functionalized ILs were stronger than that of traditional single-SOaH-functionalized ILs. Their catalytic activities in the synthesis of n-（3-phenyl）-3- oxo-1-（phenylpropyl）acetamide were investigated and they were consistent with their acidities.

关键词： novel bi-SO3H-functionalized ionic liquids Synthesis Acidity characterization Hammett function Catalytic activity

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Molecular cloning and functional identification of a cDnA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii

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Acta Pharmaceutica Sinica B 2017年第2期7卷 208-214页

作者： Qiqing Cheng Yuru Tong Zihao wang Ping Su Wei Gao Luqi Huang School of Traditional Chinese Medicine Capital Medical University national Resource Center for Chinese Materia Medica Academy of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and Technology

The 4-hydroxy-3-methylbut-2-enyl diphosphate reductase(HDR) is the last step key enzyme of the methylerythritol phosphate(MEP) pathway,synthesizing isopentenyl diphosphate and its allyl isomer dimethylallyl diphosphate,which is important for regulation of isoprenoid *** the full-length cDnA of HDR,designated TwHDR(GenBank Accession ***933412.1),was isolated from Tripterygium wilfordii for the first *** has an open reading frame(ORF) of 1386 bp encoding461 amino *** exhibits high homology with HDRs of other plants,with an n-terminal conserved domain and three conserved cysteine *** cDnA was cloned into an expression vector and transformed into an Escherichia coli hdr *** loss-of-function *** hdr mutant is lethal,the result showed that transformation of TwHDR cDnA rescued the *** hdr *** complementation assay suggests that the TwHDR cDnA encodes a functional HDR *** expression of TwHDR was induced by methyl-jasmonate(Mj) in *** suspension *** expression of TwHDR reached the highest level after 1 h of Mj *** results indicate that we have identified a functional TwHDR enzyme,which may play a pivotal role in the biosynthesis of diterpenoid triptolide in ***.

关键词： Tripterygium wilfordii Triptolide 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase Complementation Gene expression

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c-j.n n-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning

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World journal of Gastroenterology 2016年第28期22卷 6509-6519页

作者： Akiko Suzuki Keisuke Kakisaka Yuji Suzuki Ting wang Yasuhiro Takikawa division of hepatology department of internal medicine iwate medical university Morioka 0208505 Japan

AIM: To clarify the relationship between autophagy and lipotoxicity-induced apoptosis, which is termed "lipoapoptosis," in non-alcoholic steatohepatitis. METHODS: Male C57BL/6j mice were fed a high-fat diet(HFD) for 12 wk, after which the liver histology and expression of proteins such as p62 or LC3 were evaluated. Alpha mouse liver 12(AML12) cells treated with palmitate(PA) were used as an in vitro model. RESULTS: LC3-Ⅱ, p62, and Run domain Beclin-1 interacting and cysteine-rich containing(Rubicon) proteins increased in both the HFD mice and in AML12 cells in response to PA treatment. Rubicon expression was decreased upon c-j.n n-terminal kinase(jnK) inhibition at both the m RnA and the protein level in AML12 cells. Rubicon knockdown in AML12 cells with PA decreased the protein levels of both LC3-Ⅱ and p62. Rubicon expression peaked at 4 h of PA treatment in AML12, and then decreased. Treatment with caspase-9 inhibitor ameliorated the decrease in Rubicon protein expression at 10 h of PA and resulted in enlarged AML12 cells under PA treatment. The enlargement of AML12 cells by PA with caspase-9 inhibition was canceled by Rubicon ***: The jnK-Rubicon axis enhanced lipoapoptosis, and caspase-9 inhibition and Rubicon had effects that were cytologically similar to hepatocyte ballooning. As ballooned hepatocytes secrete fibrogenic signals and thus might promote fibrosis in the liver, the inhibition of hepatocyte ballooning might provide antifibrosis in the nASH liver.

关键词： Ballooned hepatocyte Caspase 9 c-j.n n-terminal kinase Rubicon SP600125

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Distribution Characteristics of Sulfur and the Main Harmful Trace Elements in China's Coal

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Acta Geologica Sinica(English Edition) 2008年第3期82卷 722-730页

作者： TAnG Shuheng SUn Shenglin QIn Yong jIAnG Yaofa wang Wenfeng School of Energy Resources China University ofGeosciences Beijing 100083 China China national Administration of Coal Geology Beijing 100039 China School of Mineral Resource and Earth Science China University of Mining and Technology Xuzhou Jiangsu 221008 China Xuzhou Institute of Architectural Technology Xuzhou Jiangsu 221008 China

To promote the rational development and use of clean coal resources in China, data on the regional and age distribution of sulfur, arsenic and other harmful elements in Chinese coal was broadly collected, tested for content, and analyzed. Coal in northwestern China is characterized by low to extremely low levels of sulfur; the coal of the Taiyuan Formation in northern China mainly has high-sulfur content; that of the Shanxi Formation is mainly characterized by low sulfur coal; and the Late Permian coal in southern China has overall higher sulfur content; other regions have low sulfur coal. The average content of harmful trace elements in the bulk of China＇s coal is similar to the corresponding content in the coal of the north America and the rest of the world, whereas the content of various elements （Hg, Sb and Se） is different in magnitude to the corresponding percentage in the crust. The average content of the elements Cr, Se, Co, Be, U, Br in Late Permian coal in S China ranks first in the country whereas the average content of Hg and CI in the coals of Late Carboniferous to Early Permian age in n China are the highest. The average content of Mn in Early and Middle jurassic coal is higher in nW China. The high content of harmful elements in some coal should cause particular concern both in the development and utilization of coal.

关键词： coal sulfur harmful trace elements distribution patterns environment China

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Low temperature Si/Si wafer direct bonding using a plasma activated method

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journal of Zhejiang University-Science C(Computers and Electronics) 2013年第4期14卷 244-251页

作者： Dong-ling LI Zheng-guo SHAnG Sheng-qiang wang Zhi-yu WEn national Key Laboratory of Fundamental Science of novel Micro/nano Device and System Technology Chongqing University MOE Key Laboratory of Optoelectronic Technology & Systems Chongqing University Microsystem Research Center Chongqing University

Manufacturing and integration of micro-electro-mechanical systems （MEMS） devices and integrated circuits （ICs） by wafer bonding often generate problems caused by thermal properties of materials. This paper presents a low temperature wafer direct bonding process assisted by 02 plasma. Silicon wafers were treated with wet chemical cleaning and subsequently activated by 02 plasma in the etch element of a sputtering system. Then, two wafers were brought into contact in the bonder followed by annealing in n2 atmosphere for several hours. An infrared imaging system was used to detect bonding defects and a razor blade test was carried out to determine surface energy. The bonding yield reaches 90%--95% and the achieved surface energy is 1.76 j/m2 when the bonded wafers are annealed at 350 ~C in n2 atmosphere for 2 h. Void formation was systematically observed and eli-mination methods were proposed. The size and density of voids greatly depend on the annealing temperature. Short O2 plasma treatment for 60 s can alleviate void formation and enhance surface energy. A pulling test reveals that the bonding strength is more than 11.0 MPa. This low temperature wafer direct bonding process provides an efficient and reliable method for 3D integration, system on chip, and MEMS packaging.

关键词： Low temperature Wafer direct bonding O2 plasma activation Surface energy Void formation

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