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nECAB family of neuronal calcium-binding proteins in health and disease

neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.E.Schafer Sudena wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The n-terminal EF-hand calcium-binding proteins 1–3(nECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. nECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. nECAB2 interacts with predominantly striatal G-protein-coupled receptors, while nECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. nECAB proteins exhibit distinct subcellular localizations: nECAB1 is found in the nucleus and cytosol, nECAB2 resides in endosomes and the plasma membrane, and nECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in nECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of nECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

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Synergistically enhanced ORR and HER performance on Co-n-C coupled in-situ generated PtCo intermetallic

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journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen Shuang wang Deli wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@ConC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@ConC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@ConC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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陕西医学杂志 2025年第1期54卷 97-100页

作者：王萌杜俊秋徐州医科大学附属淮安医院江苏淮安223000

目的:探讨急性缺血性脑卒中(AIS)相关性肺炎(SAP)危险因素分析及急性缺血性脑卒中相关肺炎(AIS-APS)评分的预测价值研究。方法:选择160例AIS患者为研究对象,根据是否发生SAP感染分为SAP组(n=70)和非SAP组(n=90),分析AIS患者感染SAP的危... 详细信息

目的:探讨急性缺血性脑卒中(AIS)相关性肺炎(SAP)危险因素分析及急性缺血性脑卒中相关肺炎(AIS-APS)评分的预测价值研究。方法:选择160例AIS患者为研究对象,根据是否发生SAP感染分为SAP组(n=70)和非SAP组(n=90),分析AIS患者感染SAP的危险因素及多因素Logistic回归分析,收集AIS患者痰液标本,记录标本来源并进行菌种鉴定,用ROC曲线分析AIS-APS评分对AIS患者感染SAP的预测价值。结果:年龄、糖尿病、慢性阻塞性肺疾病、入院时美国国立卫生研究院卒中表(nIHSS)评分>8、AIS-APS评分是影响AIS患者发生SAP的危险因素(均PnIHSS评分>8、AIS-APS评分是影响AIS患者发生SAP的危险因素,AIS-APS评分是预测AIS患者感染SAP的有效工具。

关键词：急性缺血性脑卒中脑卒中相关性肺炎危险因素 AIS-APS评分预测价值病原菌

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul navik Eryu wang Xiao Ding Huang Yunyi Yiyu Liu jia Li Guangdong-Hong Kong joint Laboratory for Carbon neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable n2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** n2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

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Prediction of subsurface settlement induced by shield tunnelling in sandy cobble stratum

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journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 192-212页

作者： Fan wang Xiuli du Pengfei Li Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing100124China

This study focuses on the analytical prediction of subsurface settlement induced by shield tunnelling in sandy cobble stratum considering the volumetric deformation modes of the soil above the tunnel crown.A series of numerical analyses is performed to examine the effects of cover depth ratio(C/D),tunnel volume loss rate(h t)and volumetric block proportion(VBP)on the characteristics of subsurface settle-ment trough and soil volume *** the ground loss variation with depth,three modes are deduced from the volumetric deformation responses of the soil above the tunnel ***,analytical solutions to predict subsurface settlement for each mode are presented using stochastic medium *** influences of C/D,h t and VBP on the key parameters(i.e.B and n)in the analytical expressions are discussed to determine the fitting formulae of B and ***,the proposed analytical solutions are validated by the comparisons with the results of model test and numerical *** show that the fitting formulae provide a convenient and reliable way to evaluate the key ***,the analytical solutions are reasonable and available in predicting the subsurface settlement induced by shield tunnelling in sandy cobble stratum.

关键词： Shield tunnelling Sandy cobble stratum Subsurface settlement Volumetric deformation mode Stochastic medium theory

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Experimental and Data Fitting Guidelines for the Determination of Polymer Crystallization Kinetics

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Chinese journal of Polymer Science 2022年第6期40卷 658-691页

作者： Ricardo Arpad Perez-Camargo Guo-Ming Liu du-j.n wang Alej.ndro j.Muller Beij.ng national Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China POLYMAT and Department of Polymers and Advanced Materials:Physics Chemistry and TechnologyFaculty of ChemistryUniversity of the Basque Country UPV/EHUDonostia-San Sebastián 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain

The crystallization kinetics of semicrystalline polymers is often studied with isothermal experiments and analyzed by fitting the data with analytical expressions of the Avrami and Lauritzen and Hoffman(LH)*** correctly carry out the analysis,precautions in both experiments and data fitting should be ***,we systematically discussed the factors that influence the validity of the crystallization kinetics *** basic concepts and fundamentals of the Avrami and LH theories were introduced at ***,experimental protocols were discussed in *** clarify the impact of various experimental parameters,selected common polymers,i.e.,polypropylene and polylactide,were studied using various experimental techniques(i.e.,differential scanning calorimetry and polarized light optical microscopy).Common mistakes were simulated under conditions when non-ideal experimental parameters were ***,from a practical point of view,we show how to fit the experimental data to the Avrami and the LH theories,using an Origin■App developed by us.

关键词： Isothermal crystallization Avrami equation Lauritzen and Hoffman theory Thermal analysis Step-crystallization

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Orbifold Gromov-Witten theory of weighted blowups

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Science China Mathematics 2020年第12期63卷 2475-2522页

作者： Bohui Chen Cheng-Yong du Rui wang Department of Mathematics and Yangtze Center of Mathematics Sichuan UniversityChengdu 610064China School of Mathematical Sciences and V.C.&V.R.Key Lab Sichuan Normal UniversityChengdu 610068China Department of Mathematics University of CaliforniaBerkeleyBerkeleyCA 94720USA

Consider a compact symplectic sub-orbifold groupoid S of a compact symplectic orbifold groupoid(X,ω).LetXabe the weight-a blowup of X along S,and Da=Pna be the exceptional divisor,where n is the normal bundle of S in *** this paper we show that the absolute orbifold Gromov-Witten theory ofXacan be effectively and uniquely reconstructed from the absolute orbifold Gromov-Witten theories of X,S and Da,the natural restriction homomorphism HCR^*(X)→HCR*(S)and the first Chern class of the tautological line bundle over *** achieve this we first prove similar results for the relative orbifold Gromov-Witten theories of(Xa|Da)and(na|Da).As applications of these results,we prove an orbifold version of a conjecture of Maulik and Pandharipande(Topology,2006)on the Gromov-Witten theory of blowups along complete intersections,a conjecture on the Gromov-Witten theory of root constructions and a conjecture on the Leray-Hirsch result for the orbifold Gromov-Witten theory of Tseng and You(j Pure Appl Algebra,2016).

关键词： orbifold Gromov-Witten theory Leray-Hirsch result weighted projective bundle weighted blowup root stack blowup along complete intersection

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Microstructural characteristics and mechanical properties of the hot extruded Mg-Zn-Y-nd alloys

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journal of Materials Science & Technology 2021年第1期60卷 44-55页

作者： B.n.du Z.Y.Hu L.Y.Sheng D.K.Xu Y.X.Qiao B.j.wang j.wang Y.F.Zheng T.F.Xi Shenzhen Institute Peking UniversityShenzhen 518057China Key Laboratory of nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China jiangsu University of Science and Technology Zhenjiang 212003China Shenzhen Yezhan Electronics Co. LtdShenzhen 518110China

A new type of Mg-Zn-Y-nd alloy for degradable orthopedic implants was *** the present study,the Zn and Y content was adjusted and their influences on the microstructures and mechanical behaviors were discussed in *** results showed that the as-extruded Mg-Zn-Y-nd alloys are mainly composed of fine dynamic recrystallized grains(DRXed grains),la rge unDRXed grains and linearly distributed secondary *** cha nge of Zn content exerts little influence on the grain structure of the extruded Mg-Zn-Y-nd alloy,while the increase of Y content would hinder the dynamic recrystallization process and the growth of the DRXed grains,thus the size and volume fraction of the equiaxed DRXed grains *** tensile and compressive properties are very little affected by Zn content because of the similar grain *** Y content increases,the tensile yield strength(TYS) and ultimate strength(TUS) increase while the elongation decreases,this is caused by a combined strengthening effect of grain refinement,texture,precipitation and *** compressive yield strength(CYS) and ultimate strength(CUS) of Mg-Zn-Y-nd alloy with diffe rent Y content exhibit a similar tendency as the tensile test.

关键词： Mg-Zn-Y-nd alloy Microstructure Tensile properties Compressive properties Basal texture Twin

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Characterization of meso-scale mechanical properties of Longmaxi shale using grid microindentation experiments

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journal of Rock Mechanics and Geotechnical Engineering 2021年第3期13卷 555-567页

作者： jianting du Andrew j.Whittle Liming Hu Thibaut Divoux jay n.Meegoda State Key Laboratory of Hydro-Science and Engineering Tsinghua UniversityBeijing100084China Department of Civil and Environmental Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA MultiScale Material Science for Energy and Environment UMI 3466CNRS-MITCambridgeMA02139USA Univ Lyon Ens de LyonUniv Claude BernardCNRSLaboratoire de PhysiqueLyonF-69342France Department of Civil and Environmental Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

Mechanical properties,such as the hardness H,Young’s modulus E,creep modulus C,and fracture toughness Kc,are essential parameters in the design of hydraulic fracturing systems for prospective shale gas *** this study,a practical methodology is presented for obtaining these properties through microindentation experiments combined with quantitative observations of the mineralogical phases using X-ray diffraction(XRD),scanning electron microscopy(SEM)with backscattered electron(BSE)imaging,and energy-dispersive X-ray spectroscopy(EDS)*** apply this method in the case of three types of Longmaxi shales with different mineralogies(***-,clay-,and quartz-rich,respectively),which allows us to determine the characteristic indentation depth,hc?8e10 mm,beyond which the mechanical response of the carbonate-rich shale is homogeneous and independent of its complex heterogeneous ***,exploiting the results of a large number of indentation tests,we demonstrate that the indentation modulus M of the shale increases as a power-law of hardness H,and its creep modulus C increases linearly with *** also compute the fracture toughness Kc from the indentation data by assuming a perfectly plastic behavior of the *** results are in good agreement with independent measurements of Kc determined by microscratch ***,further tests on quartz-and clay-rich samples of the Longmaxi shale suggest further variations in the samples’mechanical properties depending on their burial conditions and the mechanical properties of their dominant mineral phases.

关键词： Grid microindentation Mineral identification Hardness Modulus Creep Fracture toughness

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Magnetic Field Fluctuations in the Solar Wind, Foreshock and Magnetosheath:Cluster Data Analysis

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空间科学学报 2005年第5期25卷 368-373页

作者： j. du C. wang X. X. Zhang n. n. Shevyre G. n. Zastenker Key Laboratory of Space Weather Center for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China Graduate School Chinese Academy of Sciences Space Research Institute Russian Academy of Sciences Moscow Russia

46 magnetosheath crossing events from the two years (2001.2-2003.1) of Cluster magnetic field measurements are identified and used to investigate the characters of the magnetic field fluctuations in the regions of undisturbed solar wind, foreshock, magnetosheath. The preliminary results indicate the properties of the plasma turbulence in the magnetosheath are strongly controlled by IMF orientation with respect to the bow shock normal. The amplitude of the magnetic field magnitude and direction variations behind quasiparallel bow shock are larger than those behind quasi-perpendicular bow shock. Almost purely compressional waves are found in quasi-perpendicular magnetosheath.

关键词：太阳风磁场磁鞘行星

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