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Acceptor-engineering tailored type-Ⅰ photosensitizer with aggregation-induced NIR-II emission for cancer multimodal phototheranostics

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Science China Chemistry 2024年第8期67卷 2647-2660页

作者： Jiangao Li Niu Niu Deliang wang Xue Liu Yi qin Lei wang Ben Zhong Tang Dong wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target Clinical Pharmacologythe State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline(ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared(NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole(BBTD) and 6,7-diphenylthiadiazoloquinoxaline(DPTQ), ITQ-based photosensitizer(TITQ) showed superior aggregation-induced emission(AIE) characteristics, much stronger type-I reactive oxygen species(ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.

关键词： phototheranostics aggregation-induced emission NIR-Ⅱfluorescence acceptor engineering photodynamic-photothermal therapy

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In-Vehicle Network Injection Attacks Detection Based on Feature Selection and Classification

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Automotive Innovation 2024年第1期7卷 138-149页

作者： Haojie Ji Liyong wang Hongmao qin Yinghui wang Junjie Zhang Biao Chen Key Laboratory of Modern Measurement and Control Technology Ministry of EducationBeijing Information Science and Technology UniversityBeijing 100192China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Hefei Innovation Research Institute Beihang UniversityHefei 230012China

Detecting abnormal data generated from cyberattacks has emerged as a crucial approach for identifying security threats within in-vehicle *** transmission of information through in-vehicle networks needs to follow specific data for-mats and communication protocols ***,statistical algorithms are employed to learn these variation rules and facilitate the identification of abnormal ***,the effectiveness of anomaly detection outcomes often falls short when confronted with highly deceptive in-vehicle network *** this study,seven representative classification algorithms are selected to detect common in-vehicle network attacks,and a comparative analysis is employed to identify the most suitable and favorable detection *** consideration of the communication protocol characteristics of in-vehicle networks,an optimal convolutional neural network(CNN)detection algorithm is proposed that uses data field characteristics and classifier selection,and its comprehensive performance is *** addition,the concept of Hamming distance between two adjacent packets within the in-vehicle network is introduced,enabling the proposal of an enhanced CNN algorithm that achieves robust detection of challenging-to-identify abnormal *** paper also presents the proposed CNN classifica-tion algorithm that effectively addresses the issue of high false negative rate(FNR)in abnormal data detection based on the timestamp feature of data *** experimental results validate the efficacy of the proposed abnormal data detection algorithm,highlighting its strong detection performance and its potential to provide an effective solution for safeguarding the security of in-vehicle network information.

关键词： Classification algorithm Anomaly detection In-vehicle network Feature extraction Injecting attack

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Cytokine Storm:The Novel Mechanism for Sleep Deprivation-induced Multiple Organ Dysfunction Syndrome

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Neuroscience Bulletin 2024年第7期40卷 1031-1033页

作者： Liwen wang Huimei Liu Li qin Lanfang Li Institute of Pharmacy and Pharmacology University of South ChinaHengyang 421001China Hengyang Medical School University of South ChinaHengyang 421001China

It is well known that sleep is one of the inevitable activities of daily living and it is one of the most important factors contributing to human *** in mammals is a cyclic occurrence of two distinct states,rapid eye ... 详细信息

关键词： NREM Sleep movement

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Bioprinting of inorganic-biomaterial/neural-stem-cell constructs for multiple tissue regeneration and functional recovery

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National Science Review 2024年第4期11卷 228-244页

作者： Hongjian Zhang Chen qin Zhe Shi Jianmin Xue Jianxin Hao Jinzhou Huang Lin du Hongxu Lu Chengtie Wu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Tissue regeneration is a complicated process that relies on the coordinated effort of the nervous, vascular and immune systems. While the nervous system plays a crucial role in tissue regeneration, current tissue engineering approaches mainly focus on restoring the function of injury-related cells, neglecting the guidance provided by nerves. This has led to unsatisfactory therapeutic outcomes. Herein, we propose a new generation of engineered neural constructs from the perspective of neural induction, which offers a versatile platform for promoting multiple tissue regeneration. Specifically, neural constructs consist of inorganic biomaterials and neural stem cells(NSCs), where the inorganic biomaterials endows NSCs with enhanced biological activities including proliferation and neural differentiation. Through animal experiments, we show the effectiveness of neural constructs in repairing central nervous system injuries with function recovery. More importantly, neural constructs also stimulate osteogenesis, angiogenesis and neuromuscular junction formation, thus promoting the regeneration of bone and skeletal muscle, exhibiting its versatile therapeutic performance. These findings suggest that the inorganic-biomaterial/NSC-based neural platform represents a promising avenue for inducing the regeneration and function recovery of varying tissues and organs.

关键词： 3D bioprinting neural stem cells inorganic biomaterials neural constructs multiple tissue regeneration

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SAR regional all-azimuth observation orbit design for target 3D reconstruction

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Journal of Systems Engineering and Electronics 2024年第3期35卷 609-618页

作者： wang Yanan ZHOU Chaowei LIU Aifang MAO qin Beijing Institute of Tracking and Communication Technology Beijing 100094China Nanjing Research Institute of Electronics Technology Nanjing 210012China Shanghai Aerospace Electronic Technology Institute Shanghai 201109China

Three-dimensional(3D) synthetic aperture radar(SAR)extends the conventional 2D images into 3D features by several acquisitions in different aspects. Compared with 3D techniques via multiple observations in elevation, e.g. SAR interferometry(InSAR) and SAR tomography(TomoSAR), holographic SAR can retrieve 3D structure by observations in azimuth. This paper focuses on designing a novel type of orbit to achieve SAR regional all-azimuth observation(AAO) for embedded targets detection and holographic 3D reconstruction. The ground tracks of the AAO orbit separate the earth surface into grids. Target in these grids can be accessed with an azimuth angle span of360°, which is similar to the flight path of airborne circular SAR(CSAR). Inspired from the successive coverage orbits of optical sensors, several optimizations are made in the proposed method to ensure favorable grazing angles, the performance of 3D reconstruction, and long-term supervision for SAR sensors. Simulation experiments show the regional AAO can be completed within five hours. In addition, a second AAO of the same area can be duplicated in two days. Finally, an airborne SAR data process result is presented to illustrate the significance of AAO in 3D reconstruction.

关键词： synthetic aperture radar(SAR) orbit design all-azimuth observation(AAO) three-dimensional(3D)reconstruction successive coverage

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Physics-data coupling-driven method to predict the penetration depth into concrete targets

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 184-192页

作者： Shuai qin Hao Liu Jianhui wang Qiang Zhao Lei Zhang Institute of Defense Engineering AMSLuoyang 471000China Harbin Engineering University Harbin 150001China

The projectile penetration process into concrete target is a nonlinear complex *** the increase ofexperiment data,the data-driven paradigm has exhibited a new feasible method to solve such complex ***,due to poor quality of experimental data,the traditional machine learning(ML)methods,whichare driven only by experimental data,have poor generalization capabilities and limited prediction ***,this study intends to exhibit a ML method fusing the prior knowledge with experiment *** newML method can constrain the fitting to experimental data,improve the generalization ability and the predic-tion *** results show that integrating domain prior knowledge can effectively improve theperformance of the prediction model for penetration depth into concrete targets.

关键词： Penetration into concrete Artificial neural networks Prior knowledge fusion Prediction model

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Magnetic resonance imaging-based lymph node radiomics for predicting the metastasis of evaluable lymph nodes in rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1849-1860页

作者： Yong-Xia Ye Liu Yang Zheng Kang Mei-qin wang Xiao-Dong Xie Ke-Xin Lou Jun Bao Mei du Zhe-Xuan Li Department of Radiology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina1 Department of Pathology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Colorectal Center The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina

BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient *** radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI)poses a *** To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable *** In this retrospective study,270 LNs(158 nonmetastatic,112 metastatic)were randomly split into training(n=189)and validation sets(n=81).LNs were classified based on pathology-MRI *** MRI features[size,shape,margin,T2-weighted imaging(T2WI)appearance,and CE-T1-weighted imaging(T1WI)enhancement]were *** radiomics models used 3D features from T1WI and T2WI ***,a nomogram model combining conventional MRI and radiomics features was *** model used univariate analysis and multivariable logistic *** employed the receiver operating characteristic curve,with DeLong test for comparing diagnostic *** performance was assessed using calibration and decision curve *** The nomogram model outperformed conventional MRI and single radiomics models in evaluating *** the training set,the nomogram model achieved an area under the curve(AUC)of 0.92,which was significantly higher than the AUCs of 0.82(P<0.001)and 0.89(P<0.001)of the conventional MRI and radiomics models,*** the validation set,the nomogram model achieved an AUC of 0.91,significantly surpassing 0.80(P<0.001)and 0.86(P<0.001),*** The nomogram model showed the best performance in predicting metastasis of evaluable LNs.

关键词： Radiomics Lymph node metastasis Rectal cancer Magnetic resonance imaging

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Transient state analysis of a rub-impact rotor system during maneuvering flight

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Chinese Journal of Aeronautics 2024年第7期37卷 236-251页

作者： Jun wang Yunfei LIU Zhaoye qin Liang MA Fulei CHU Beijing Key Laboratory of Health Monitoring and Self-Recovery for High-End Machinery Equipment Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China College of Aeronautical Engineering Civil Aviation University of ChinaTianjin 300300China

Maneuvering flight substantially affects the dynamic behavior of rotors;particularly,such flight may cause rubbing between a rotor and stator,which is one of the most serious damages in aircraft *** this paper,a nonlinear dynamic model for describing the dynamic characteristics of a rub-impact rotor system during maneuvering flight is established based on the Lagrange ***,numerical simulations employing the Newmark method are performed,delving into the detailed discussion of the influence of parameters such as rotational speed and maneuvering flight on the transient and steady-state responses of the rotor *** effect mechanism of maneuver load and its coupling with rub impact is *** results show that the impact response induced by maneuvering flight is more obvious in the subcritical state than in the supercritical *** additional stiffness and damping are also induced;in particular,the additional damping has a coupling ***,the rub impact imposes an additional constraint on the rotor system,thereby weakening the influence of the maneuver load and becoming the major factor that determines the dynamic behavior of the rotor system at high speeds.

关键词： Maneuvering flight Rub impact Rotor system Dynamic response Impact response

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Hot Deformation Behavior and Microstructures Evolution of GNP-Reinforced Fine-Grained Mg Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 407-424页

作者： Hengrui Hu Jiayu qin Yunpeng Zhu Jinhui wang Xiaoqiang Li Peipeng Jin qinghai Provincial Key Laboratory of New Light Alloys Qinghai UniversityXining 810016China qinghai Provincial Engineering Research Center of High Performance Light Metal Alloys and Forming Qinghai UniversityXining 810016China Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China School of Material Science and Engineering Lanzhou University of TechnologyLanzhou 730050China

Graphene nanoplates(GNPs)-reinforced magnesium matrix composites have been attracted great ***,knowledge is lack for the hot deformation behavior of GNP-reinforced magnesium(GNPs/Mg)*** this study,the fine-grained GNPs/Mg composite was fabricated by powder metallurgy process followed by *** hot deformation behavior,microstructure evolution and dynamic recrystallization(DRX)mechanism of fine-grained GNPs/Mg composite were investigated by hot compression test and electron back-scatter diffraction(EBSD).The hot compression tests of the composite were conducted at temperatures between 423 and 573 K with the strain rates from 0.001 to 1 s^(-1).The strain compensated power law equation was established to describe the hot deformation behavior of the *** stress exponent and activation energy of the composite are 7.76 and 83.23 kJ/mol,respectively,suggesting that the deformation mechanism is grain boundary slip controlled dislocation climb *** abnormally high stress exponent and activation energy are unattainable in the composite due to the fine grain size of the composites and the absence of Zener pinning and Orowan effects of GNPs *** grain size increases with the decrease in Zener-Hollomn(Z)parameter,which can be well fitted by power-law *** the increase in grain size and decrease in Z parameter,the geometrically necessary dislocation density decreases,which shows the approximately power-law relationship.A random and weak texture was formed after hot *** discontinuous dynamic recrystallization and continuous dynamic recrystallization mechanism dominated the DRX behavior at 473 K/0.001 s^(-1) and 573 K/0.001 s^(-1),respectively.

关键词： GNPs Mg composite Hot deformation behavior Constitutive equations Microstructure evolution Dynamic recrystallization

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Electrochemical Hydrogen Charging on Corrosion Behavior of Ti-6Al-4V Alloy in Artificial Seawater

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 296-308页

作者： Yanxin Qiao Yue qin Huiling Zhou Lanlan Yang Xiaojing wang Zhengbin wang Zhenguang Liu Jiasheng Zou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Yangzhou Changelight Co. LtdYangzhou 225012China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

This study employs advanced electrochemical and surface characterization techniques to investigate the impact of electrochemical hydrogen charging on the corrosion behavior and surface film of the Ti-6Al-4V *** findings revealed the formation ofγ-TiH andδ-TiH_(2) hydrides in the alloy after hydrogen *** hydrogen charging resulted in more significant degradation of the alloy microstructure,leading to deteriorated protectiveness of the surface *** trend was further confirmed by the electrochemical measurements,which showed that the corrosion resistance of the alloy progressively worsened as the hydrogen charging time was ***,this work provides valuable insights into the mechanisms underlying the corrosion of Ti-6Al-4V alloy under hydrogen charging conditions.

关键词： Ti-6Al-4V alloy Hydrogen charging Electrochemical corrosion Passive film

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