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Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles

Military Medical Research 2023年第2期10卷 191-206页

作者： Yang-lin Wu Chen-Hui Zhang Yun Teng Ying Pan nai-Cheng Liu Pei-Xin Liu Xu Zhu Xin-lin Su Jun lin Department of Orthopaedics Suzhou Dushu Lake HospitalDushu Lake Hospital Affiliated to Soochow UniversityMedical Centre of Soochow UniversitySuzhou 215001JiangsuChina Department of Orthopaedics the First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006JiangsuChina Department of Infectious Diseases the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China

Background:Wear particles-induced osteolysis is a major long-term complication after total joint *** to now,there is no effective treatment for wear particles-induced osteolysis except for the revision surgery,which is a heavy psychological and economic burden to patients.A metabolite of gut microbiota,short chain fatty acids(SCFAs),has been reported to be beneficial for many chronic inflammatory *** study aimed to investigate the therapeutic effect of SCFAs on ***:A model of inflammatory osteolysis was established by applying CoCrMo alloy particles to mouse *** two weeks of intervention,the anti-inflammatory effects of SCFAs on wear particle-induced osteolysis were evaluated by micro-CT analysis and immunohistochemistry *** vitro study,lipopolysaccharide(LPS)primed bone marrow-derived macrophages(BMDMs)and Tohoku hospital pediatrics-1(THP-1)macrophages were stimulated with CoCrMo particles to activate inflammasome in the presence of acetate(C2),propionate(C3),and butyrate(C4).Western blotting,enzyme-linked immunosorbent assay,and immunofluorescence were used to detect the activation of NLRP3 *** effects of SCFAs on osteoclasts were evaluate by qRT-PCR,Western blotting,immunofluorescence,and tartrate-resistant acid phosphatase(TRAP)***,histone deacetylase(HDAC)inhibitors,agonists of GPR41,GPR43,and GPR109A were applied to confirm the underlying mechanism of SCFAs on the inflammasome activation of macrophages and ***:C3 and C4 but not C2 could alleviate wear particles-induced osteolysis with fewer bone erosion pits(P1),higher level of bone volume to tissue volume(BV/TV,P1),bone mineral density(BMD,P1),and a lower total porosity(P1).C3 and C4 prevented CoCrMo alloy particles-induced ASC speck formation and nucleationinduced oligomerization,suppressing the cleavage of caspase-1(P1β(P<0.05)stimulated by CoCrMo alloy particles.C3

关键词： NLRP3 inflammasome Pyroptosis Short chain fatty acids Osteolysis Osteoclast

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Acute ischemic Stroke combined with Stanford type A aortic dissection:A case report and literature review

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World Journal of Clinical Cases 2022年第22期10卷 8009-8017页

作者： Zhi-Yang He lin-Peng Yao Xiao-Ke wang nai-Yun Chen Jun-Jie Zhao Qian Zhou Xiao-Feng Yang Department of Emergency and Trauma Center The International Medical CenterThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Radiology The First Affiliated HospitalZhejiang University school of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Acute aortic dissection(AAD)is a high mortality disease that can lead to acute ischemic strokes(AIS).Some of the patients with AAD combined with AIS initially present with neurological symptoms,which can easily lead to missed or delayed AAD *** is attributed to the lack of physician awareness or the urgency of patient *** administration of thrombolytic therapy(IVT)for AAD is associated with poor prognostic *** report a patient with AIS combined with AAD who developed a massive cerebral infarction after receiving IVT for a missed AAD *** SUMMARY A 49-year-old man was admitted to a local hospital with an acute onset of leftsided limb weakness accompanied by slurred *** patient had a history of hypertension that was not regularly treated with *** examination revealed incomplete mixed aphasia and left limb *** computed tomography(CT)scan showed bilateral basal ganglia and lateral ventricular paraventricular infarct *** patient was diagnosed with AIS and was administered with *** IVT,patient’s muscle strength and consciousness *** the local hospital,he was referred to our hospital for further *** head and neck CT angiography(CTA)scans were *** showed multiple cerebral infarctions,and aortic dissection in the ascending aorta,innominate artery,as well as in the right common carotid ***,the CTA of thoracoabdominal aorta was performed,which revealed a Stanford type A aortic dissection and aortic dissection extending from the aortic root to the left external iliac *** was located in the lesser curvature of the aortic *** complicated with AIS was considered,and the patient was immediately subjected to cardiovascular surgery for *** next day,the patient underwent aortic arch and ascending aortic replacement and aortic *** Clinical manifestations for AAD combined wi

关键词： Acute aortic dissection Acute ischemic stroke Intravenous thrombolysis Ultrasound evaluation Case report

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Matrix Effect on Polydiarylfluorenes Electrospun Hybrid Microfibers: From Morphology Tuning to High Explosive Detection Efficiency

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Chinese Journal of Polymer Science 2023年第7期41卷 1011-1017页

作者： Wei Xue Man Xu Chuan-Xin Wei Hua-Min Sun Li-Li Sun Sheng-Jie wang Jin-Yi lin nai-En Shi ling-Hai Xie Wei Huang State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing210023China Center for Supramolecular Optoelectronics(CSO) Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM)Nanjing Tech University(NanjingTech)Nanjing211816China Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Institute of Biomedical Materials and Engineering(SIBME)Northwestern Polytechnical University(NPU)Xi’an710072China

Precisely optimizing the morphology of functional hybrid polymeric systems is crucial to improve its photophysical property and further extend their optoelectronic applications. The physic-chemical property of polymeric matrix in electrospinning (ES) processing is a key factor to dominate the condensed structure of these hybrid microstructures and further improve its functionality. Herein, we set a flexible poly(ethylene oxide) (PEO) as the matrix to obtain a series of polydiarylfluorenes (including PHDPF, PODPF and PNDPF) electrospun hybrid microfibers with a robust deep-blue emission. Significantly different from the rough morphology of their poly(N-vinylcarbazole) (PVK) ES hybrid fibers, polydiarylfluorenes/PEO ES fibers showed a smooth morphology and small size with a diameter of 1∼2 µm. Besides, there is a relatively weak phase separation under rapid solvent evaporation during the ES processing, associated with the hydrogen-bonded-assisted network of PEO in ES fibers. These relative “homogeneous” ES fibers present efficient deep-blue emission (PLQY>50%), due to weak interchain aggregation. More interestingly, low fraction of planar (β) conformation appears in the uniform PODPF/PEO ES fibers, induced by the external traction force in ES processing. Meanwhile, PNDPF/PEO ES fibers present a highest sensitivity than those of other ES fibers, associated with the smallest diameter and large surface area. Finally, compared to PODPF/PVK fibers and PODPF/PEO amorphous ES fibers, PODPF/PEO ES fibers obtained from DCE solution exhibit an excellent quenching behavior toward a saturated DNT vapor, mainly due to the synergistic effect of small size, weak separation, β-conformation formation and high deep-blue emission efficiency.

关键词： Matrix effect Electrospun fibers Polydiarylfluorenes Planar conformation Explosive detection

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A New Type of Bistable Switching in Two-Dimensional Nonlinear Optical Superlattices

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Chinese Physics Letters 1996年第2期13卷 109-112页

作者： wang Zhen-lin YANG Zhen-ju MIN nai-ben National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093

we investigate theoretically optical responsc in a two-dimensional optical superlattice with Kerr-type *** ind that in addition to the bistability reported in ***.71(1993)1003 by Xu et,al.,a new type of bista ble switching behavior *** bistability is based on the occurrence of the stop gap in the lincar spectraand the nonlinear mechanism on it,which makes switching between transmitting and non-transmitting states achievable.

关键词： Nonlinear addition nonlinear

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Modified Closed Reduction and Percutaneous Kirschner Wires Internal Fixation for Treatment of Supracondylar Humerus Fractures in Children

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当代医学科学(英文) 2021年第4期41卷 777-781页

作者： Shu-bin wang Bin-hui lin Wei LIU Guo-jun WEI Zong-guang LI nai-chun YU Guang-rong JI Department of Orthopedic Surgery Xiang'an Hospital of Xiamen universityXiamen 361000China

Objective Supracondylar humerus fractures are the most frequent fractures of the paediatric *** present study introduced a modified surgical procedure for treatment of supracondylar humerus fractures in *** From February 2.15 to August 2.19,73 patients with Gartland’s type II and III supracondylar fractures were treated with this modified ***,68 of all patients were followed up for 3–12 months(mean 8.25 months).The evaluation results included fracture nonunion,ulnar nerve injury,pin track infection,carrying angle and elbow joint Flynn *** The results showed that bone union was observed in all children,one case had an iatrogenic ulnar nerve injury,and the symptoms were completely relieved in 4 months after removing of the medial-side *** children had no cubitus varus deformity and no pin track infection,and the rate of satisfactory results according to Flynn’s criteria score was 100%.Conclusion The modified closed reduction and Kirschner wires internal fixation could effectively reduce the rate of open reduction,the risk of iatrogenic ulnar nerve injury,and the incidence of cubitus varus deformity in treatment of supracondylar humerus fractures in children.

关键词： supracondylar humerus fractures closed reduction Kirschner wires internal fixation surgical method

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Path planning for moving target tracking by fixed-wing UAV

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Defence Technology（防务技术） 2020年第4期16卷 811-824页

作者： Song-lin Liao Rong-ming Zhu nai-qi Wu Tauqeer Ahmed Shaikh Mohamed Sharaf Almetwally M.Mostafa school of Electro-Mechanical Engineering Xidian UniversityXi'an 710071China Institute of Systems Engineering Macao University of Science and TechnologyTaipa999078Macao Electrical Engineering Department College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia Industrial Engineering Department College of EngineeringKing Saud UniversityP.O.Box 800Riyadh 11421Saudi Arabia College of Computer and Information Sciences King Saud UniversityP.O.Box 800Riyadh 11421Saudi Arabia Faculty of Engineering Alazhar University CairoEgypt

For the automatic tracking of unknown moving targets on the ground,most of the commonly used methods involve circling above the *** such a tracking mode,there is a moving laser spot on the target,which will bring trouble for cooperative manned *** this paper,we propose a new way of tracking,where an unmanned aerial vehicle(UAV) circles on one side of the tracked target.A circular path algorithm is developed for monitoring the relative position between the UAV and the target considering the real-time range and the bearing *** can determine the center of the new circular path if the predicted range between the UAV and the target does not meet the monitoring requirements.A transition path algorithm is presented for planning the transition path between circular paths that constrain the turning radius of the *** transition path algorithm can generate waypoints that meet the flight *** this paper,we analyze the entire method and detail the scope of *** formulate an observation angle as an evaluation index.A series of simulations and evaluation index comparisons verify the effectiveness of the proposed algorithms.

关键词： Bearing angle Fixed-wing UAV Laser designation Moving target tracking Path planning

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Wafer bin map inspection based on DenseNet

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Journal of Central South university 2021年第8期28卷 2436-2450页

作者： YU nai-gong XU Qiao wang Hong-lu lin Jia Faculty of Information Technology Beijing University of TechnologyBeijing 100124China Beijing Key Laboratory of Computing Intelligence and Intelligent System Beijing 100124China Engineering Research Center of Digital Community Ministry of EducationBeijing 100124China

Wafer bin map(WBM)inspection is a critical approach for evaluating the semiconductor manufacturing *** excellent inspection algorithm can improve the production efficiency and *** paper proposes a WBM defect pattern inspection strategy based on the DenseNet deep learning model,the structure and training loss function are improved according to the characteristics of the *** addition,a constrained mean filtering algorithm is proposed to filter the noise *** model prediction,an entropy-based Monte Carlo dropout algorithm is employed to quantify the uncertainty of the model *** experimental results show that the recognition ability of the improved DenseNet is better than that of traditional algorithms in terms of typical WBM defect *** the model uncertainty can not only effectively reduce the miss or false detection rate but also help to identify new patterns.

关键词： wafer defect inspection convolutional neural network DenseNet model uncertainty

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竞技武术套路中腾空摆莲B和C级跳跃落地稳定性的研究

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天津体育学院学报 2008年第3期23卷 259-262页

作者：杨乃静林小美尹燕强张再昂浙江理工大学体育教研部杭州310008 浙江大学教育学院体育系杭州310028

竞技武术套路中腾空摆莲B和C级跳跃落地接马步是长拳、南拳武术项目的两个难度动作。通过对该组动作落地技术的动力学及相关稳定性因素的分析,提出合理的落地技术和训练中需解决的问题。采用录像观察与试验分析相结合的方法,针对男女运... 详细信息

竞技武术套路中腾空摆莲B和C级跳跃落地接马步是长拳、南拳武术项目的两个难度动作。通过对该组动作落地技术的动力学及相关稳定性因素的分析,提出合理的落地技术和训练中需解决的问题。采用录像观察与试验分析相结合的方法,针对男女运动员的腾空与落地的特点,提出相应的解决办法和训练理论。

关键词：竞技武术腾空摆莲B和C级跳跃连接难度

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细胞焦亡与肺动脉高压的关系及治疗肺动脉高压药物研究进展

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中国药理学通报 2024年第1期40卷 25-30页

作者：颜倩孙洋龙俊鹏刘莎莎姚娇林玉婷阳松威杨岩涛裴刚艾启迪陈乃宏湖南中医药大学药学院湖南长沙410208 湖南省中药饮片标准化及功能工程技术研究中心湖南长沙410208 湘潭市中心医院湖南湘潭411199 中国医学科学院药物研究所北京协和医学院药物研究所北京100050

细胞焦亡(pyroptosis)是指伴有炎性反应的一种细胞程序性死亡方式,其广泛参与了多种疾病的发生发展,例如感染性疾病、心血管疾病和神经性退行等。研究表明,细胞焦亡参与了心血管疾病中动脉性肺动脉高压(pulmonary arterial hypertension... 详细信息

细胞焦亡(pyroptosis)是指伴有炎性反应的一种细胞程序性死亡方式,其广泛参与了多种疾病的发生发展,例如感染性疾病、心血管疾病和神经性退行等。研究表明,细胞焦亡参与了心血管疾病中动脉性肺动脉高压(pulmonary arterial hypertension, PAH)的发病机制。PAH患者的肺部存在血管周围炎症浸润,肺血管病变存在于极度发炎的微环境里,细胞焦亡中的促炎因子驱动了PAH患者的肺部血管重塑。本文针对细胞焦亡在PAH发病机制中的作用及治疗PAH药物的相关研究进行综述,旨在为临床上治疗PAH提供新思路。

关键词：细胞焦亡动脉性肺动脉高压肺动脉高压治疗药物炎症小体发病机制

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Corrosion and discharge performance of Mg-9%Al-2.5%Pb alloy as anode for seawater activated battery

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Transactions of Nonferrous Metals Society of china 2016年第8期26卷 2144-2151页

作者： Min DENG Ri-chu wang Yan FENG nai-guang wang lin-qian wang school of Materials Science and Engineering Central South University Changsha 410083 China

To obtain a new kind of Mg?Al?Pb alloy anode material with low content of Pb, the corrosion and discharge behavior of Mg?9%Al?2.5%Pb (hereafter in mass fraction) alloy were investigated by immersion tests and electrochemical techniques, and compared with those of Mg?6%Al?5%Pb alloy. The results indicate that Mg?9%Al?2.5%Pb alloy exhibits a lower self-corrosion rate and higher utilization efficiency in contrast with Mg?6%Al?5%Pb alloy because of the higher content of Al. As the result of the decrease of Pb content, the discharge activity of Mg?9%Al?2.5%Pb alloy is relatively weaker but still meets the requirement of anode. These results reveal that Mg?9%Al?2.5%Pb alloy with a low content of Pb can serve as a good candidate for the anode material used in seawater activated battery.

关键词： Mg.Al.Pb alloy anode material self-corrosion rate utilization efficiency discharge activity

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