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OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

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Research 2024年第1期2023卷 455-469页

作者： Yinghong Cui Wei Chen li du Zuping He The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human SSCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-MS(mass spectrometry),and GST pulldown ***2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human SSCs at S and G2/M phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

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Numerical Study on the Aerodynamic and Fluid−Structure Interaction of An NREL-5MW Wind Turbine

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China Ocean Engineering 2024年第3期38卷 363-378页

作者： ZHAO Mi YU Wan-li WANG Pi-guang QU Yang du Xiu-li Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China

A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic *** this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.

关键词： computational fluid dynamics methods(CFD) tower shadow effect aerodynamic performance fluidstructure interaction space flow field

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Analytical Solution and Simplified Formula for Added Mass of Horizontal and Vertical Motions of Truncated Cylinders Under Earthquake Action

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China Ocean Engineering 2024年第1期38卷 54-67页

作者： WANG Pi-guang LYU Si-yu QU Yang ZHAO Mi du Xiu-li State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of Tech-nologyBeijing 100124China

This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water *** governing equation of the hydrodynamic pressure acting on the cylinder is derived based on the radiation theory with the inviscid and incompressible *** governing equation is solved by using the method of separating variables and analytical solutions are obtained by assigning reasonable boundary *** analytical result is validated by a numerical model using the exact artificial boundary simulation of the infinite *** main variation and distribution characteristics of the hydrodynamic pressure acting on the side and bottom of the cylinder are analyzed for different combinations of wide-height and immersion *** added mass coefficient of the cylinder is calculated by integrating the hydrodynamic pressure and simplified formulas are proposed for engineering *** calculation results show that the simplified formulas are in good agreement with the analytical solutions.

关键词： earthquake hydrodynamic pressure truncated cylinder added mass simplified formula

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Vagus nerve stimulation in cerebral stroke:biological mechanisms,therapeutic modalities,clinical applications,and future directions

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Neural Regeneration Research 2024年第8期19卷 1707-1717页

作者： li du Xuan He Xiaoxing Xiong Xu Zhang Zhihong Jian Zhenxing Yang Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Stroke is a major disorder of the central nervous system that poses a serious threat to human life and quality of *** stro ke victims are left with long-term neurological dysfunction,which adversely affects the well-being of the individual and the broader socioeconomic ***,poststroke brain dysfunction is a major and difficult area of *** nerve stimulation is a Food and Drug Administration-approved exploratory treatment option for autis m,refractory depression,epilepsy,and Alzheimer’s *** is expected to be a novel therapeutic technique for the treatment of stroke owing to its association with multiple mechanisms such as alte ring neurotransmitters and the plasticity of central neuro *** animal models of acute ischemic stroke,vagus nerve stimulation has been shown to reduce infarct size,reduce post-stroke neurological damage,and improve learning and memory capacity in rats with stroke by reducing the inflammatory response,regulating bloodbrain barrier permeability,and promoting angiogenesis and *** present,vagus nerve stimulation includes both invasive and non-invasive vagus nerve *** studies have found that invasive vagus nerve stimulation combined with rehabilitation therapy is effective in im proving upper limb motor and cognitive abilities in stroke *** clinical studies have shown that non-invasive vagus nerve stimulation,including ear/ce rvical vagus nerve stimulation,can stimulate vagal projections to the central nervous system similarly to invasive vagus nerve stimulation and can have the same *** this paper,we first describe the multiple effects of vagus nerve stimulation in stroke,and then discuss in depth its neuroprotective mechanisms in ischemic *** go on to outline the res ults of the current major clinical applications of invasive and non-invasive vagus nerve ***,we provide a more comprehensive evaluation of the advantages and disadvantages of di

关键词： cerebral stroke neuroplasticity non-invasive vagus nerve stimulation rehabilitation vagus nerve stimulation

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A robust genomic-based prognostic model for the assessment ofcancer stemness and survival for patients with hepatocellularcarcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 97-102页

作者： Cheng-li du Shen-Yu Wei Yun-Hao Chen Kang-Jie Chen Division of Thoracic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang University School of Medicine Hangzhou 310003China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Hepatocellular carcinoma(HCC)is an aggressive malignancy with poor long-term prognosis[1].liver cancer stem cell(CSC)can drive the metastasis,drug resistance,and recurrence of HCC[2].The regulatory mechanisms about liver cancer stemness have been investigated,which encouraged the identification and characterization of novel prognostic and therapeutic strategies for HCC[3].

关键词： cancer prognosis liver

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Room-temperature synthesis of full-component APbX_(3)perovskite nanocrystal inks for optoelectronic applications

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Journal of Energy Chemistry 2024年第5期92卷 87-94页

作者： Xinyu Zhao du li Xuliang Zhang Hehe Huang Chenyu Zhao Wanli Ma Jianyu Yuan Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123JiangsuChina Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Soochow UniversitySuzhou 215123JiangsuChina Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123JiangsuChin

Lead halide perovskite nanocrystals(PNCs)have received great research interests due to their excellent optoelectronic ***,high temperature,inert gas protection and insulating long-chain ligands are used during the conventional hot-injection synthesis of PNCs,which limits their practical *** this work,we first develop a simple and scalable polar-solvent-free method for the preparation of full-component APbX_(3)(A=Cs,methylammonium(MA),formamidinium(FA),X=Cl,Br,I)PNCs under ambient *** an exothermic reaction between butylamine(BA)and propionic acid(PA)short ligands,the PbX_(2) precursors could be well dissolved without use of any polar ***,the relatively lower growth rate of PNCs in our room-temperature reaction enables us to modulate the synthetic procedure to enhance the scalability(40-fold)and achieve large-scale *** resultant short ligands passivated PNC inks are compatible with varying solution depositing technique like spray coating for large-area ***,we showcase that adopting the as-prepared MAPbI_(3) PNC inks,a self-powered photodetector is fabricated and shows a high *** results demonstrate that our ambient-condition synthetic approach can accelerate the preparation of tunable and ready-to-use PNCs towards commercial optoelectronic applications.

关键词： Room-temperaturesynthesis Perovskite nanocrystals Short-chainligands Large-scale Photodetector

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Traditional Chinese Medicine's Spleen Strengthening and Intestinal Microecology

Research and Inheritance of Traditional Chinese Medicine

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Research and Inheritance of Traditional Chinese Medicine 2024年第1期2卷 17-22页

作者： li du Fengqing Luo Sichuan Provincial Hospital of Traditional Chinese Medicine

The"spleen"in traditional Chinese medicine is the"acquired foundation"and the"source of qi and blood biochemistry".Strengthening the"spleen"is one of the important treat‐ment methods in traditional Chinese medicine;The gut microbiota has been a hot topic in modern scientific research in recent years,and its nutritional and immune functions correspond to some of the functions of the spleen in traditional Chinese *** terms of philosophy,traditional Chinese medicine emphasizes the balance between the spleen and the gut microbiota,emphasizing the importance of supporting the right and eliminating evil,preventing diseases before they occur,seeking the root cause of treat‐ment,and adapting measures to the three causes;Clinically,the treatment of obesity,con‐stipation,diarrhea and other diseases by invigorating the spleen and the treatment mechanism of acupuncture and moxibustion,chiropractic and invigorating the spleen are all related to *** article combines relevant literature on traditional Chinese medicine's"spleen"and"spleen health"to explore the treatment concept,clinical application,and correlation with intestinal microbiota of traditional Chinese medicine's"spleen health".It also elaborates on the latest literature,aiming to exchange ideas with peers and promote research on the microbiota of traditional Chinese medicine's"spleen".

关键词： traditional Chinese medicine spleen traditional Chinese medicine invigorates the spleen intestinal microbiota intestinal microbiota

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基于随机增强量子粒子群算法的弹性波数值模拟

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Applied Geophysics 2024年第1期21卷 80-92,204页

作者：朱孟权刘洪王之洋李幼铭 Yu du-li 北京化工大学信息科学与技术学院中国科学院地质与地球物理研究所油气资源研究院重点实验室中国科学院大学

在本文中,我们提出了一种随机增强量子粒子群优化算法,并基于该随机增强量子粒子群算法提出了一种新的有限差分格式。随机增强量子粒子群优化算法具有明显的收敛速度优势,可以在第200代内收敛。在相同条件下,未改进的量子粒子群算法的... 详细信息

在本文中,我们提出了一种随机增强量子粒子群优化算法,并基于该随机增强量子粒子群算法提出了一种新的有限差分格式。随机增强量子粒子群优化算法具有明显的收敛速度优势,可以在第200代内收敛。在相同条件下,未改进的量子粒子群算法的收敛速度远低于随机增强量子粒子群算法。数值频散分析表明,基于随机增强量子粒子群算法的优化有限差分格式具有更大的频谱覆盖范围并将精度误差控制在了有效范围之内,这意味着随机增强量子粒子群算法具有更好的搜索全局精确解的能力。最后,采用基于随机增强量子粒子群算法的优化有限差分格式对弹性波动方程进行数值模拟。数值模拟结果表明,基于随机增强量子粒子群算法的优化有限差分格式能有效压制数值频散。

关键词：有限差分量子粒子群算法多参数优化

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从“双轨政治”到“并轨政治”:中国国家治理的简约主义

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南京农业大学学报（社会科学版） 2024年第3期24卷 137-148页

作者：杜力上海交通大学国际与公共事务学院上海200030

超大国家治理的规模难题始终是中国国家治理面临的核心命题。在帝制中国的“双轨政治”结构下,国家以分而治之的方式实现简约治理。一方面,以地方精英为国家经纪人,运用半正式行政实现乡土之轨的简约治理;另一方面,以官吏分途和行政发... 详细信息

超大国家治理的规模难题始终是中国国家治理面临的核心命题。在帝制中国的“双轨政治”结构下,国家以分而治之的方式实现简约治理。一方面,以地方精英为国家经纪人,运用半正式行政实现乡土之轨的简约治理;另一方面,以官吏分途和行政发包实现科层之轨的简约治理。与之不同的是,现代中国的简约治理是“并轨政治”结构下的统合治理。“并轨政治”依靠独特的党政科层体系,以治理结构的复合化、治理策略的弹性化和治理关系的人格化,实现集权的简约治理。尽管这两种简约治理形态存在差异,但是强调治权集中、半正式治理和治理技术集约化的简约主义价值内核依然在现代中国国家治理的过程中得以存续,而这也构成了中国式国家治理现代化的底层逻辑。

关键词：简约治理双轨政治并轨政治统合治理

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领导型经纪:党建引领基层社会治理的新解释——基于A区治理创新的案例分析

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东北大学学报（社会科学版） 2024年第2期26卷 69-80页

作者：杜力上海交通大学国际与公共事务学院上海200030

随着基层治理情境的变化,传统经纪机制已难以适应国家构建共建共治共享的基层社会治理格局的现实需要。为此,国家开始尝试构建一种以基层党组织为基础,以党建引领为载体的领导型经纪,实现治理权威再造与治理效能提升。与传统经纪机制基... 详细信息

随着基层治理情境的变化,传统经纪机制已难以适应国家构建共建共治共享的基层社会治理格局的现实需要。为此,国家开始尝试构建一种以基层党组织为基础,以党建引领为载体的领导型经纪,实现治理权威再造与治理效能提升。与传统经纪机制基于权力支配逻辑的管控导向不同,领导型经纪具有鲜明的引领共治导向。它通过执政党的组织网络实现国家与社会的有效连接,以论坛建构、项目运作和社会联结,实现共识塑造、资源整合和联合行动,从而促进国家与社会的有效合作。从理解中国之治的角度来看,领导型经纪映射出迥异于西方国家政治情境的国家、政党与社会关系,对于国家—社会关系理论的本土化和构建中国特色政党基础理论具有重要意义。

关键词：领导型经纪经纪机制基层治理党建引领

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