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BIOCELL 2023年第11期47卷 2445-2452页

作者： HAIYING YUE CHUNHUI WANG HUIJUN ZHU QINGHUA du JIAN LI XUE OU XIANGDE LI QIULU ZHONG YITING XIE DANJING LUO YIHE LI CHUNXIAO LIANG XUEMEI XU songnan du WENQI LIU Department of Radiotherapy The Second Affiliated Hospital of Guangxi Medical UniversityNanningChina

Background:Nasopharyngeal carcinoma(NPC)is one of the most prevalent cancers in Southeast Asia.Sirtuin 2(SIRT2)is a member of the NAD+-dependent deacetylase family and has been shown to play important roles in numerous biological processes.However,Its function in NPC remains uncertain.The primary aim of this study is to clarify the role of SIRT2 in NPC.Methods:In this research,we examined the effect of SIRT2 silencing on NPC cell proliferation and colony formation using vitro NPC cell lines.Co-immunoprecipitation and mass spectrometry was applied to identify SIRT2-interacting proteins in NPC cells.Results:In comparison to nasopharyngeal epithelial NP69 cells,SIRT2 was up-regulated in multiple NPC cell lines,particularly in CNE2 cells.SIRT2 knockdown abrogated CNE2 cell proliferation and colony formation,whereas SIRT2 overexpression promoted HNE1 cell proliferation and colony formation.The SIRT2-interacting proteins were gathered in gene expression and regulation processes including RNA processing and translation.Among the SIRT2-interacting proteins,there were multiple DEAD-box(DDX)family members.Of note,silencing of DDX24 phenocopied the effect of SIRT2 knockdown on NPC growth.Overexpression of DDX24 restored SIRT2-depleted CNE2 cells to proliferative and colony formation.Conclusions:Our study indicates that SIRT2 can interact with DDX24 to enhance NPC growth.The clinical relevance of SIRT2 and DDX24 in NPC warrants further investigation.

关键词： Nasopharyngeal carcinoma Sirtuin 2 DDX24 Proliferation

Emerging applications of nanofibers electrospun from carbohydrate polymers

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Journal of Future Foods 2024年第4期4卷 289-299页

作者： Nicole Angel songnan Li Lingyan Kong Deparment of Mechanical Engineering.The University of Alabama TuscaloosaAL 35487USA Joint Intemnarional Research Laboratory of Agriculture and Agni-Product Saferty of the Ministry of Education of China Institutes of Agricultural Science and Techmology DevelopmentYangzhou UniversityYangzhou 225009China Deparment of Human Nutrition and Hospitality Management The University of AlabamaTuscaloosaAI 35487USA

Electrospinning is a simple and versatile technique that uses electrostatic forces to create fbers in the nano o micro range from a variety of materials,both synthetic and natural due to the high surface area to volume ratio,high porosity,and desirable mechanic characteristics of electrospun fbers,they are of current interest for a wide variety of applications.Some of the most signifcant applications of these fbers being researched include tissue engineering.drug delivery,wound dressings,environmental and energy applications,and protective materials.Notably,electrospun fbers may be specially tailored to better ft their fnal application through the direct 1oading of materials during the spining process as well as by choosing the correct base material for the fber.For example,it is desirable to use a biocompatible and biodegradable material in fibers desired for applications in the biomedical field;this way the fbers are able to safely interact with the human body.This review will explore the applications,as previously listed,with a focus on how fbers are made using carbohydrate polymers(such as alginate,cellulose and its derivatives,chitosan and chitin,starch,pul1ulan,hyaluronic acid,dextran,and 1evan)as their base material,and their applicability and functionality in various applications.

关键词： Electrospinning Tissue engineering Drug delivery Wound dresing Envionment Energy Protective fabric

Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

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Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo Tang songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongchen Hao Jun Liu Jing Liu Xin du Louise Morgan Gregg C.Fonarow Sidney C.Smith Jr Gregory Y.H.Lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in China.Methods:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was assessed.Results:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low risk.On admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking OAC.The use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;P70%of AF patients were at a high risk of stroke.Although poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF population.Registration:ClinicalTrials.gov,NCT02309398.

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

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深红至近红外碳点光热特性研究进展

发光学报 2024年第1期45卷 11-24页

作者：吴君曲松楠澳门大学应用物理及材料工程学院教育部联合重点实验室中国澳门999078 澳门大学科技学院物理化学系中国澳门999078 澳门大学教育部精准肿瘤学前沿科学中心中国澳门999078

碳点(CDs)作为一种新型光热纳米材料引起了肿瘤治疗领域的关注。然而,作为光热剂,碳点在深红(DR)至近红外(NIR)区域的光热转换效率有限。此外,碳点对肿瘤组织的靶向性也是急需解决的一个重要问题。本综述介绍了一些增强碳点深红或近红... 详细信息

碳点(CDs)作为一种新型光热纳米材料引起了肿瘤治疗领域的关注。然而,作为光热剂,碳点在深红(DR)至近红外(NIR)区域的光热转换效率有限。此外,碳点对肿瘤组织的靶向性也是急需解决的一个重要问题。本综述介绍了一些增强碳点深红或近红外吸收和光热转换效率的实用策略,包括尺寸调整、元素掺杂、表面修饰、半导体耦合和生物大分子包覆等。基于这些策略可以构建合适的碳点及其复合物,实现对肿瘤的靶向光热治疗。最后,我们希望建立高效的肿瘤识别和光热治疗一体化系统,实现碳点在肿瘤治疗中的临床应用,并为解决肿瘤相关问题和促进健康发展提供重要的科学意义和应用价值。

关键词：碳点近红外吸收光热特性光热疗法

基于灰色系统理论的电网工程绿色建造模糊综合评价模型

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沈阳工业大学学报 2024年第1期46卷 42-48页

作者：张琦姜雪张鸥张爽莹刘松楠辽宁省电力有限公司经济技术研究院辽宁沈阳110065

为贯彻落实绿色发展理念,提升现有电网工程绿色建造评价方法的全面性、系统性以及客观性,提出了一种基于灰色系统理论的模糊综合评价模型。通过研究影响电网工程设计、施工与交付等环节的重要绿色评价因子,构建了多层次的绿色建造评价... 详细信息

为贯彻落实绿色发展理念,提升现有电网工程绿色建造评价方法的全面性、系统性以及客观性,提出了一种基于灰色系统理论的模糊综合评价模型。通过研究影响电网工程设计、施工与交付等环节的重要绿色评价因子,构建了多层次的绿色建造评价指标体系。并基于灰色系统理论确定指标权重,建立了多层级模糊综合评价模型。同时选取电网工程案例来进行验证,证明了该模型能够科学、合理地确定各指标的权重,从而为电网工程绿色建造评价及不断优化提供了支撑。

关键词：电网工程绿色建造灰色系统理论模糊综合评价评价指标体系指标权重多层次绿色评分

沁水盆地古交区块煤层气水平井产能影响因素分析

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中国海上油气 2024年第2期36卷 110-118页

作者：郭广山王海侨刘松楠陈朝晖中海油研究总院有限责任公司北京100028

近年来,水平井逐渐成为中国煤层气开发的主要井型,在多个区块取得显著产气效果,但井间产量差异大,整体达产率偏低。为摸清煤层气水平井产能影响因素,从地质因素、工程工艺和排采管理等方面展开研究。选取沁水盆地北部古交区块20口煤层气... 详细信息

近年来,水平井逐渐成为中国煤层气开发的主要井型,在多个区块取得显著产气效果,但井间产量差异大,整体达产率偏低。为摸清煤层气水平井产能影响因素,从地质因素、工程工艺和排采管理等方面展开研究。选取沁水盆地北部古交区块20口煤层气L型水平井,在地质条件和生产动态剖析基础上,筛选出含气性、井控地质储量、钻井质量、储层改造、生产动态参数等10个关键参数,探讨了对煤层气水平井产能的影响,并提出适用于研究区地质条件的针对性技术对策。研究表明:位于构造高部位的煤层气水平井,含气量、含气饱和度和井控地质储量是实现水平井高产的资源基础;在构造简单和断层不发育的情况下,水平段长应在600 m以上,且保证煤层钻遇率80%以上;水平段长600~800 m时,压裂段数应控制在10段以下,压裂段长最佳为60~80 m;尽量降低排采中断次数,提高排采连续性,在排水期和提产期要分别制定不同合理压降速率,增大泄压面积,实现煤层气水平井产能最大释放。

关键词：煤层气水平井产能地质因素工程质量降压速率沁水盆地古交区块

基于TNF-α/NF-κB通路探讨四君子汤对快速衰老型小鼠海马神经元炎症因子调节自噬蛋白的作用机制研究

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免疫学杂志 2024年第1期40卷 53-58页

作者：刘旭东王松楠马丹单德红任路辽宁中医药大学中西医结合学院生理心理教研室沈阳110847

目的探讨四君子汤(Sijunzi decoction,SJZD)对快速衰老型(senescence-accelerated mouse prone 8,SAMP8)小鼠海马组织炎症因子、自噬蛋白表达的影响及作用机制。方法将SAMR1小鼠作为对照组、32只SAMP8小鼠分为模型组、多奈哌齐组(Done... 详细信息

目的探讨四君子汤(Sijunzi decoction,SJZD)对快速衰老型(senescence-accelerated mouse prone 8,SAMP8)小鼠海马组织炎症因子、自噬蛋白表达的影响及作用机制。方法将SAMR1小鼠作为对照组、32只SAMP8小鼠分为模型组、多奈哌齐组(Donepezil)、SJZD低、高剂量治疗组。采用Y字迷宫实验检测小鼠记忆功能的变化;免疫组化法检测NF-κB蛋白表达变化;ELISA法检测肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)含量;Western blot法检测海马组织Aβ蛋白、caspse-1、beclin-1、LC3-II蛋白表达。结果与对照组比较,模型组小鼠总进臂次数减少、交替次数减少,TNF-α、IL-1β、IL-6含量升高,Aβ蛋白、caspse-1蛋白表达上调,beclin-1蛋白及LC3-II蛋白表达下调;Donepezil与模型组比较,总进臂次数增加,交替次数增加,IL-6含量减少,Aβ蛋白表达下调。SJZD低剂量组和高剂量组,与模型组比较,总进臂次数增加,交替次数增加;TNF-α、IL-1β、IL-6、Aβ蛋白、caspase-1含量降低;beclin-1、LC3-II蛋白表达上调。结论四君子汤治疗阿尔茨海默病可能与纠正中枢海马相关炎症因子及自噬功能失调有关。

关键词：四君子汤阿尔茨海默炎症因子自噬

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基于模糊PID的大型双旋翼无人机

电子科技 2024年第8期37卷 54-59,67页

作者：金睿金海莫松楠浙江理工大学信息科学与工程学院浙江杭州310018

相较于四旋翼无人机(Unmanned Aerial Vehicle,UAV),大型双旋翼无人机具有价格低廉、续航长以及效率高等优点,但存在耦合严重、抗干扰能力差等问题。为解决上述问题,文中提出了一种采用变论域模糊PID(Proportional Integration Differen... 详细信息

相较于四旋翼无人机(Unmanned Aerial Vehicle,UAV),大型双旋翼无人机具有价格低廉、续航长以及效率高等优点,但存在耦合严重、抗干扰能力差等问题。为解决上述问题,文中提出了一种采用变论域模糊PID(Proportional Integration Differentiation)双旋翼控制算法。将无人机系统分解为位置控制和姿态控制两部分,在姿态控制上采用模糊PID实时调节PID参数,从而提高无人机的稳定性。根据无人机的运动方式提出一种新型无人机结构,搭建了双旋翼的动力学模型,并在Simulink上搭建了仿真模型进行验证。结果表明,相较于普通PID控制算法,所提算法将控制的超调量减少了50%,说明该算法在大型双旋翼无人机上具有更好的稳定性,在受到干扰的情况下可更快恢复。

关键词：大型双旋翼无人机变论域模糊控制 PID 抗干扰运动控制 MATLAB 自动控制原理

Assessing 10 Satellite Precipitation Products in Capturing the July 2021 Extreme Heavy Rain in Henan, China

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Journal of Meteorological Research 2022年第5期36卷 798-808页

作者： songnan LIU Jun WANG Huijun WANG Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044 Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029

On 20 July 2021,a sudden rainstorm happened in central and northern Henan Province,China,killing at least 302people.This extreme precipitation event incurred substantial socioeconomic impacts and resulted in serious losses.Accurate monitoring of such rainstorm events is crucial.In this study,qualitative and quantitative methods are used to comprehensively evaluate the abilities of 10 high-resolution satellite precipitation products[CMORPH-Raw(Climate Prediction Center morphing technique),CMORPH-RT,PERSIANN-CCS(Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks),GPM IMERG-Early(Integrated Multisatellite Retrievals for Global Precipitation Measurement),GPM IMERG-Late,GSMaP-Now(Global Satellite Mapping of Precipitation),GSMaP-NRT,FY-2F,FY-2G,and FY-2H]in capturing this extreme rainstorm event,as well as their performances in monitoring different precipitation intensities.The results show that these satellite precipitation products are able to capture the spatial distributions of the rainstorm(e.g.,its location in central and northern Henan),but all products have underestimated the amount of precipitation in the rainstorm center.With the increase in precipitation intensity,the hit rate decreases,the threat score decreases,and the false alarm rate increases.CMORPH-RT is better at capturing the rainstorm than CMORPH-Raw,and it depictes the rainstorm process well;GPM IMERG-Late is more accurate than GPM IMERG-Early;GSMaP-NRT has performed better than GSMaP-Now;and PERSIANNCCS and FY-2F perform poorly.Among the products,CMORPH-RT performs the best,which has accurately captured the center of the rainstorm,and is also the closest to the station-based observations.In general,the satellite precipitation products that integrate infrared and passive microwave data are found to be better than those that only make use of infrared data.The satellite precipitation retrieval algorithm and the amount of passive microwave data have a relatively greater impact on the accuracy of satellite precip

关键词： heavy rain CMORPH(Climate Prediction Center morphing technique) FY(Fengyun) GPM(Global Precipitation Measurement)