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早期炎症性肠病IBD5基因的OCTN1/2变异与疾病易感性和生长指数的关系

世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 40-41页

作者： Russell R.K. drummond h.e. Nimmo e.R. 廖新华 Gastrointestinal Unit University of EdinburghWestern General HospitalCrewe RoadEdinburgh EH4 2XUUnited Kingdom Dr.

Background and aims:The OCTN1(SLC22A4 1672C→ T) and OCTN2(SLC22A5-207G→ C) variants within the IBD5 locus have been associated with susceptibility to adult onset Crohn’s disease(CD) ,but their contribution in children has not been ***:These OCTN1/2 variants and IBD5 marker single nucleotide polymorphisms(SNPs) (IGR2096a-1,IGR2198a-1,and IGR2230a-1) were examined in 299 Scottish children(200 with CD,74 with ulcerative colitis(UC) ,and 25 with indeterminate colitis(IC) ) ,together with 502 parents(for transmission disequilibrium testing) and 250 ***:All SNPs were in strong linkage disequilibrium(D’ >0.94) .TDT analysis showed association of the OCTN1 variant with inflammatory bowel disease(IBD) (p = 0.01) and CD(p = 0.04) .Allele frequencies of the OCTN1/2 variants were significantly higher in IBD/CD cases(p he homozygous mutant OCTN1/2 haplotype was increased in IBD(24.3% v 16.1%,p = 0.02) and UC(28.2% v 16.1%,p = 0.02) compared with *** OCTN1/2 variants were not independent of the background IBD5 risk haplotype in conferring disease *** analysis in CD patients showed that carriage of the TC haplotype was associated with lower weight,height,and BMI centile(h centile) at diagnosis(weight:87.9% v 67.3%(p = 0.002) ,odds ratio(OR) = 3.52(95% confidence interval,1.51 to 8.22) ;height:84.1% v 68.4%(per weight centile at follow up(87.5% v 64.6%(p = 0.03) ,OR = 3.83(1.03 to 14.24) ) .Multifactorial binary logistic regression analysis confirmed association of the TC haplotype with lower weight centile at diagnosis(p = 0.02,OR = 3.41(1.20 to 9.66) ) .Conclusions:These data implicate variants within the IBD5 haplotype,as determinants of disease susceptibility and growth indices in early onset *** OCTN1/2 variants remain potential positional candidate genes,but require further analysis.

关键词：炎症性肠病 IBD5 OCTN1/2 疾病易感性生长指数克罗恩病溃疡性结肠炎遗传不稳定性携

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Insights into kidney stem cell development and regeneration using zebrafish

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World Journal of Stem Cells 2016年第2期8卷 22-31页

作者： Bridgette e drummond Rebecca A Wingert Department of Biological Sciences Center for Zebrafish ResearchCenter for Stem Cells and Regenerative MedicineUniversity of Notre Dame

Kidney disease is an escalating global health problem,for which the formulation of therapeutic approaches using stem cells has received increasing research *** complexity of kidney anatomy and function,which includes the diversity of renal cell types,poses formidable challenges in the identification of methods to generate replacement *** work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney,known as nephrons,following acute ***,we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology,which may uncover important clues for regenerative medicine.

关键词： Kidney Renal stem cell Renal progenitor Regeneration Nephron Blood filter Renal corpuscle Tubule

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estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo

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Protein & Cell 2011年第4期2卷 333-346页

作者： Sharyn Bayne he Li Margaret e.e.Jones Alex R.Pinto Michelle van Sinderen Ann drummond evan R.Simpson Jun-Ping Liu Department of Immunology Central Eastern Clinical SchoolMonash UniversityVictoria 3800Australia Prince henry’s Institute of Medical Research Clayton VIC 3168Australia Current address:Research Services M459The University of Western Australia35 Stirling HighwayCRAWLEY WA 6009Australia Current address:Murdoch Children’s Research Institute Royal Children’s HospitalParkvilleVic 3052Australia

estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully *** we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific *** inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of *** expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TeRT),in response to estrogen *** replacement therapy led to increases in TeRT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four *** data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TeRT in *** deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through.e.trogen regulation of telomere remodeling.

关键词： estrogen telomerase reverse transcriptase(TeRT) telomeres ovary mice

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Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity:a review

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Journal of Integrative Medicine 2018年第4期16卷 211-222页

作者： Bruno Jose Martins Da Silva Amanda Anastacia Pinto hage edilene Oliveira Silva Ana Paula drummond Rodrigues Laboratory of Parasitology and Laboratory of Structural Biology Institute of Biological SdencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging Rio de JaneiroRio de Janeiro 21941-901Brazil Laboratory of electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil

Leishmaniasis, a neglected disease caused by Leishmania protozoans, primarily affects people in tropical and subtropical areas. Chemotherapy based on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosine and liposomal amphotericin B is currently the only effective treatment. however, adverse effects, long-term treatment and the emergence of parasite resistance have led to the search for alternative treatments. Natural products used in traditional medicine provide an unlimited source of molecules for the identification of new drugs, and the Amazon region has abundant biodiversity that includes several species of plants and animals, providing a rich source of new products and com- pounds. Although the literature describes numerous promising compounds and extracts for combating Leishmania protozoans, the results of such research have not been embraced by the pharmaceutical industry for the development of new drugs. Therefore, this review focused on the antileishmanial activity of extracts, isolated compounds and essential oils commonly used by the local population in the Brazilian Amazonian region to treat several illnesses and described in the literature as promising compounds for combating leishmaniasis.

关键词： Amazonian plants Leishmaniasis treatment Plant compounds Plant extracts Plant oils

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On First Order Optimality Conditions for Vector Optimization

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Acta Mathematicae Applicatae Sinica 2003年第3期19卷 371-386页

作者： L.M.Gra■a drummond A.N.Iusem B.F.Svaiter Programa de engenharia de Sistemas de Computacao COPPE-UFRJCP 68511Rio de Janeiro-RJ21945970BrazilInstituto de Matematica Pura e Aplicada (IMPA) Estrada Dona Castorina 110Rio de JaneiroRJCEP 22460-320BrazilInstituto de Matematica Pura e Aplicada (IMPA)Estrada Dona Castorina 110Rio de JaneiroRJCEP 22460-320Brazil

We develop first order optimality conditions for constrained vector optimization. The partial orders for the objective and the constraints are induced by closed and convex cones with nonempty interior. After presenting some well known existence results for these problems, based on a scalarization approach, we establish necessity of the optimality conditions under a Slater-like constraint qualification, and then sufficiency for the K-convex case. We present two alternative sets of optimality conditions, with the same properties in connection with necessity and sufficiency, but which are different with respect to the dimension of the spaces to which the dual multipliers belong. We introduce a duality scheme, with a point-to-set dual objective, for which strong duality holds. Some examples and open problems for future research are also presented.

关键词： Cone constraints vector optimization Pareto minimization first order optimality conditions convex programming duality

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Quantum dynamics in ultracold atomic physics

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Frontiers of physics 2012年第1期7卷 16-30页

作者： Qiong-Yi he (1) Margaret D. Reid (1) Bogdan Opanchuk (1) Rodney Polkinghorne (1) Laura e. C. Rosales-Zárate (1) Peter D. drummond (1) 1. Centre for Atom Optics and Ultrafast Spectroscopy Swinburne University of Technology Melbourne 3122 Australia

We review recent developments in the theory of quantum dynamics in ultracold atomic physics, including exact techniques and methods based on phase-space mappings that are applicable when the complexity becomes exponentially large. Phase-space representations include the truncated Wigner, positive-P and general Gaussian operator representations which can treat both bosons and fermions. These phase-space methods include both traditional approaches using a phase-space of classical dimension, and more recent methods that use a non-classical phase-space of increased dimensionality. examples used include quantum einstein Podolsky-Rosen （ePR） entanglement of a four-mode BeC, time-reversal tests of dephasing in single-mode traps, BeC quantum collisions with up to 106 modes and 105 interacting particles, quantum interferometry in a multi-mode trap with nonlinear absorption, and the theory of quantum entropy in phase-space. We also treat the approach of variational optimization of the sampling error, giving an elementary example of a nonlinear oscillator.

关键词： quantum dynamics atomic ultracold collisions entanglement phase-space

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In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum

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Journal of Integrative Medicine 2018年第6期16卷 404-410页

作者： Bruno Jose Martins Da Silva Sandro Wilson Gomes Pereira Ana Paula drummond Rodrigues Jose Luiz Martins Do Nascimento edilene Oliveira Silva Laboratory of Structural Biology Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Structural Biology and Bioimaging(INCT-INBeB) Rio de Janeiro 21941-901Brazil Laboratory of electron Microscopy Department of Health SurveillanceMinistry of HealthEvandro Chagas InstituteBelemPard 66087-082Brazil Laboratory of Molecular and Cellular Neurochemistry Institute of Biological SciencesFederal University of PardBelemPard 66075-110Brazil National Institute of Science and Technology in Neuroimmunomodulation(INCT-NIM) Rio de Janeiro 21040-360Brazil

Objective： In the present study, we evaluated the effects of the aqueous extract of Physalis angulata root （AePa） on Leishmania infanturn proliferation, morphology, and the driving mechanism in leishmanicidal activity and modulatory action on macrophages. Methods： I., infantum promastigotes were treated with 50 and 100 μg/mL AePa for 72 h and then antipro- mastigote assay was performed by counts in a Newbauer chamber, morphological changes were analyzed by transmission electron microscopy and the mechanism of the leishmanicidal activity was detected. In addition, macrophages were infected with L. infantum and were used to evaluate anti-amastigote activity of AePa and effects of AePa on cytokine secretion after 72-hour treatment. Results： Treatment with AePa reduced the numbers ofL infantum promastigotes （50% inhibitory concen- tration （ICso） = 65.9μg/mL; selectivity index （SI）= 22.1） and amastigotes （ICso = 37.9 μg/mL; SI = 38.5） compared with the untreated control. Amphotericin B reduced 100% of the promastigote numbers after 72 h of treatment （IC50 = 0.2μg/mL）. AePa induced several morphological changes and increased the production of reactive oxygen species and apoptotic death in promastigotes after treating for 72 h. AePa （100 μg/mL） promoted tumor necrosis factor-α secretion in macrophages infected with L. infantum after 72 h of treatment, but did not induce an increase in this cytokine in noninfected macrophages. In addition, AePa showed no cytotoxic effect on J774-A1 cells （50% cytotoxic concentration 〉1000μg/mL）. Conclusion： AePa presented antileishmanial activity against the promastigotes and amastigotes of I.. infantum without macrophage cytotoxicity; these results show that natural products such as P. angulata have leishmanicidal potential and in the future may be an alternative treatment for leishmaniasis.

关键词： Leishmanicidal activity Leishmania infantum Reactive oxygen species Apoptosis Physalis angulata

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沸腾热液体系的化学演化与矿物沉淀作用

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地球与环境 1987年第5期 10-19页

作者： S.e.drummond ,h.Ohmo■ ,徐九华北京钢铁学院地质系

过去二十年中,大量地质文献证明,许多古热液成矿体系都有液-气二相流体。这种液-气状态,无疑是在液/气比值变化很大的流体包体附近产出的。

关键词：矿物方解石硬石膏无水石膏非金属矿物沉淀机制沸腾热液封闭体系饱和溶液化学演化出溶

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豌豆幼苗生长中氯化物对硝酸根离子吸收的抑制和硝酸盐对氯离子吸收的抑制

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核农学通报 1988年第3期 133-136页

作者： C.e.Deane-drummond 陈一珠

本试验对生长在不同氯化物和硝酸盐含量的培养液中的豌豆苗（品种:FelthamFirst）对 NO3-、36ClO3-/NO3-和36Cl-的吸收状况进行了研究。当幼苗（6天）生长在缺 N 条件下时,硝酸盐的增加刺激了硝酸根离子的吸收和36ClO3-/NO3-均积累（r2=... 详细信息

本试验对生长在不同氯化物和硝酸盐含量的培养液中的豌豆苗（品种:FelthamFirst）对 NO3-、36ClO3-/NO3-和36Cl-的吸收状况进行了研究。当幼苗（6天）生长在缺 N 条件下时,硝酸盐的增加刺激了硝酸根离子的吸收和36ClO3-/NO3-均积累（r2=0.99）,而氯化物的增加则抑制了硝酸根离子的吸收和

关键词：硝酸根离子 Cl 氯化物卤化物氯离子阴离子豌豆幼苗硝酸盐营养盐

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^(18)F-FDG PeT/CT发现肿瘤患者意外病灶的临床价值

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中华核医学杂志 2007年第1期27卷 1-4页

作者：王国慧 eddie W.F. Lau Ramdave Shakher Robert e.Ware David S.Binns Annette hogg elizabeth drummond Rodney J.hicks 中山大学肿瘤防治中心核医学科广州510060 The Center for Molecular Imaging Peter MacCallum Cancer Center Melbourne Victoria Australia

目的评价^(18)F-脱氧葡萄糖(FDG)PeT/CT 全身显像探测肿瘤患者意外病灶的临床价值。方法回顾性分析澳大利亚 Peter MacCallum 肿瘤医院 PeT/CT 中心2002年8月～2003年7月1727例肿瘤患者^(18)F-FDG PeT/CT 全身显像报告,男980例,女747例... 详细信息

目的评价^(18)F-脱氧葡萄糖(FDG)PeT/CT 全身显像探测肿瘤患者意外病灶的临床价值。方法回顾性分析澳大利亚 Peter MacCallum 肿瘤医院 PeT/CT 中心2002年8月～2003年7月1727例肿瘤患者^(18)F-FDG PeT/CT 全身显像报告,男980例,女747例,中位年龄63岁,随访37个月(中位时间为27.5个月)。意外病灶指新发现的与原发肿瘤无关的良性病灶或第2原发肿瘤。通过分析病历记录、病理结果、其他影像学检查结果及临床随访,确定病灶最终结果。结果 1727例患者共发现238例(13.8%)有意外病灶,其中213例220个意外病灶具有完整的随访资料。60个病灶怀疑为意外第2原发肿瘤,其中21.7%(13/60)证实为真阳性,70.0%(42/60)为假阳性,8.3%(5/60)至研究结束时未得到证实。38个甲状腺意外良性病灶,其中9个被证实为临床前恶性或恶性病灶,26个良性,3个未能证实。38个纵隔意外良性病灶,其中86.8%(33/38)证实为良性,7.9%(3/38)为原发肿瘤淋巴结侵犯,5.3%(2/38)未能证实其性质。其他部位84个意外良性病灶,94.0%(79/84)证实为真阴性,6.0%(5/84)未能证实。共22例患者被证实存在第2原发肿瘤病灶,占本研究总人群的1.3%。结论 ^(18)F-FDG PeT/CT 全身显像是目前探测肿瘤患者意外病灶较好的无创方法,为制定临床治疗方案提供及时准确的依据。

关键词：肿瘤体层摄影术发射型计算机体层摄影术 X线计算机脱氧葡萄糖诊断,鉴别随访研究

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