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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 20-21页

作者： Lefaucheur J. P. drouot x. Von Raison F. 陈云春 Serv. Physiol. -Ex.lorationsF. H.opital Henri Mondor Ass it. Pub. Hop. Paris 51 Ave. L. Cr’eteil France

Objective: To assess the effects of focal motor cortex.stimulation on motor pe rformance and cortical ex.itability in patients with Parkinsons disease (PD). Methods: Repetitive transcranial magnetic stimulation (rTMS) was performed on th e left motor cortical area corresponding to the right hand in 12 offdrugpati ents with PD. The effects of subthreshold rTMS applied at 0.5 Hz (600 pulses) or at 10 Hz (2000 pulses) using a realor a shamcoil were compared to those obtained by a single dose of l dopa. The assessment included a clinical evalua tion by the Unified Parkinsons Disease Rating Scale and timed motor tasks, and a neurophysiological evaluation of cortical ex.itability by single and paired pulse TMS techniques. Results:RealrTMS at 10 or0.5 Hz, but notshamstim ulation, improved motor performance. High frequency rTMS decreased rigidity and bradykinesia in the upper limb contralateral to the stimulation, while low fre quency rTMS reduced upper limb rigidity bilaterally and improved walking. Concom itantly, 10 HzrTMS increased intracortical facilitation, while 0.5 HzrTMS restor ed intracortical inhibition. Conclusions: Low and highfrequency rTMS of the pri mary motor cortex.lead to significant but differential changes in patients with PD both on clinical and electrophysiological grounds. The effect s on cortical ex.itability were opposite to previous observations made in health y subjects, suggesting a reversed balance of cortical ex.itability in patients w ith PD compared to normals. However, the underlying mechanisms of these changes remain to determine, as well as the relationship with clinical presentation and response to l dopa therapy. Significance: The present study gives some clues to appraise the role of the primary motor cortex.in PD. Clinical improvement induc ed by rTMS was too short lasting to consider therapeutic application, but these results support the perspective of the primary motor cortex.as a possible targe t for neuromodulation in

关键词：帕金森病运动皮质经颅磁刺激左旋多巴评分量表侧运动临床评估药物治疗神经生理学电生理特征

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