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Successful treatment of acute relapse of chronic eosinophilic pneumonia with benralizumab and without corticosteroids:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6105-6109页

作者： Shimon Izhakian Barak Pertzov dror rosengarten Mordechai R Kramer Pulmonary Institute Rabin Medical CenterPetach Tikva 49100Israel Affiliated to Sackler Faculty of Medicine Tel Aviv UniversityRamat AvivIsrael

BACKGROUND Currently,the mainstay of chronic eosinophilic pneumonia(CEP)treatment is corticosteroids,usually with a favorable response and good ***,relapse is common,requiring long-term use of corticosteroids,with risk of significant treatment-related *** dire need to develop new treatments for patients with CEP,who are dependent on,or resistant to corticosteroids has led to exploring novel *** herein describe a patient with acute relapse of CEP,who was successfully treated with benralizumab,an IL-5 Rαantagonist that has demonstrated rapid anti-eosinophil action in patients with ***,only three recent patient reports on CEP relapse,also demonstrated successful treatment with benralizumab alone,without *** SUMMARY A 31-year-old non-smoking woman presented in our hospital with a 3 wk history of shortness of breath,dry cough and fever up to 38.3℃.Laboratory examination revealed leukocytosis 10240 K/μL,eosinophilia 900 K/μL and normal values of hemoglobin,platelets,creatinine and liver *** tomography of the chest showed a mediastinal lymphadenopathy and consolidations in the right upper and left lower *** was diagnosed,and the patient was treated with hydrocortisone intravenously,followed by oral prednisone,with prompt *** months later,she presented with relapse of CEP:aggravation of dyspnea,rising of eosinophilia and extension of pulmonary infiltrates on chest *** was treated with benralizumab only,with clinical improvement within 2 wk,and complete resolution of lung infiltrates following 5 *** Due to Benralizumab’s dual mechanism of action,it both neutralizes IL-5 Rαpro-eosinophil functions and triggers apoptosis of *** therefore maintain benralizumab can serve as a reasonable therapy choice for every patient with chronic eosinophilic pneumonia and a good alternative for corticosteroids.

关键词： Benralizumab Eosinophilic pneumonia Interstitial lung disease Corticosteroid withdrawal Case report

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