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Synthesis and Antibacterial Activities of New 2-(Benzylthio)pyrimidines and 2-(Benzimidazolylmethylthio)pyrimidines Derivatives

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Open Journal of Medicinal Chemistry 2021年第3期11卷 27-39页

作者： Achi Patrick-Armand Coulibali Siomenan Zon Doumade Timotou Adéyolé Bolou Eric touré Daouda Sissouma Drissa Adjou Ané Laboratoire de Constitution et Réaction de la Matière UFR Sciences des Structures de la Matière et Technologie Université Félix Houphou&#235t Boigny de Cocody Abidjan C&#244te d’Ivoire Département de Mathématiques-Physique-Chimie UFR des Sciences Biologiques Université Peleforo Gon Coulibaly Korhogo C&#244te d’Ivoire Centre National de Floristique Université Félix Houphou&#235t-Boigny de Cocody Abidjan C&#244te d’Ivoire Département de Biochimie-Génétique UFR des Sciences Biologiques Université Peleforo Gon Coulibaly Korhogo C&#244te d’Ivoire

A series of 2-(benzylthio)pyrimidines (6a-l) and 2-(benzimidazolylmethylthio)-pyrimidines derivatives (6m and 6n) analogues of ethyl 2-(benzylthio)-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylates and ethyl 2-(((1H-benzimidazol-2-yl)methyl)thio)-6-methyl-4-phenyl-1,4-dihydropyri-midine-5-carboxylates were prepared and evaluated for antibacterial activity. These compounds were obtained by condensation of 2-thiopyrimidines (4) with benzyl halides or 2-(chloromethyl)-1H

Intraventricular Hemorrhage, a Rare Complication of a Cerebral Tuberculoma: Study of a Case in the Neurology Department of the University Hospital of Conakry

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Case Reports in Clinical Medicine 2023年第1期12卷 1-8页

作者： Doumbouya Idrissa touré Mohamed Lamine Barry Djénabou Négué Diawara Karinka Traoré Mohamed Cissé Fodé Abass Department of Neurology University Hospital of Conakry Conakry Guinea

Intraventricular haemorrhage (IVH) is an extremely rare and poorly described complication of central nervous system Tuberculosis (CNS-TB). In this study, we report the case of a 42-year-old man who presented with a weakness of the left hemibody with diffuse headache, altered consciousness associated with fever. No notion of contagion was noted. Brain computed tomography (CT) showed a hematoma in the occipital horns of the lateral ventricles with peri-lesional oedema of the right hemisphere;after injection of contrast product (CP), there were ring-shaped contrasts in the occipital horn of the lateral ventricle and the right thalamus. Angioscan showed no aneurysms or vascular anomalies. Chest X-ray showed micronodular opacities less than 1.5 cm in size in relation to miliary. Xpert MTB/RIF of sputum and cerebrospinal fluid (CSF) showed Mycobacterium tuberculosis (MT). The patient’s course was favourable under antihypertensive and antitubercular treatment. Conclusion: This case illustrates the diagnostic difficulties of CNS-TB due to the polymorphism of the clinical and radiological presentation of CNS-TB.

关键词： Intraventricular Haemorrhage Tuberculosis Tuberculoma

Sensitivity of Solar Photovoltaic Panel Efficiency to Weather and Dust over West Africa: Comparative Experimental Study between Niamey (Niger) and Abidjan (Côte d’Ivoire)

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Computational Water, Energy, and Environmental Engineering 2016年第4期5卷 123-147页

作者： Alima Dajuma Saleye Yahaya Siaka touré Arona Diedhiou Rabani Adamou Abdourahamane Konaré Mariama Sido Michel Golba WASCAL MRP Climate Change and Energy Université Abdou Moumouni Niamey Niger Centre National d’Energie Solaire CNES Niamey Niger Laboratoire d’Energie Solaire Université Félix Houphouet Boigny Abidjan Cote d’Ivoire LTHE-IRD Université Grenoble-Alpes Grenoble France Faculté des Sciences et Techniques Université Abdou Moumouni Niamey Niger Centre d’Excellence Africain en Changement Climatique Biodiversité et Agriculture Durable (CCBAD) Université Félix Houphouet Boigny Abidjan Cote d’Ivoire Energy and Semiconductor Research Laboratory Carl von Ossietzky University Oldenburg Oldenburg Germany

Energy demand is increasing while we are facing a depletion of fossils fuels, the main source of energy production in the world. These last years, photovoltaic (PV) system technologies are growing rapidly among alternative sources of energy to contribute to mitigation of climate change. However, PV system efficiency researches operating under West African weather conditions are nascent. The first objective of this study is to investigate the sensitivity of common monocrystalline PV efficiency to local meteorological parameters (temperature, humidity, solar radiation) in two contrasted cities over West Africa: Niamey (Niger) in a Sahelian arid area and Abidjan (Cote d’Ivoire) in atropical humid area. The second objective is to quantify the effect of dust accumulation on PV efficiency in Niamey (Niger). The preliminary results show that PV efficiency is more sensitive to high temperature change especially under Niamey climate conditions (warmer than Abidjan) where high ambient temperatures above 33°C lead to an important decrease of PV efficiency. Increase of relative humidity induces a decrease of PV efficiency in both areas (Niamey and Abidjan). A power loss up to 12.46% is observed in Niamey after 21 days of dust accumulation.

关键词： Solar Energy PV Efficiency Temperature Dust Humidity Niamey Abidjan

Epidemiological Aspects of Metastatic Relapse of Breast Cancer in an African Context

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Open Journal of Obstetrics and Gynecology 2017年第5期7卷 552-561页

作者： Jean Marc Dia Corneille Saki Oyeladé Mouhideen Eric Bohoussou Moctar touré Gerard Okon Privat Guié Simplice Anongba Gynecology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire Cancerology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire

Objectives: This study aimed to describe the epidemiological characteristics of metastatic relapse in breast cancer at the University and Hospital Center of Treichville. Methodology: This is a cohort and retrospective study conducted from January 2000 to December 2015 on 178 patients with metastaticrelapse in breast cancer. Results: The prevalence of metastatic relapses was 49% and the patients had an average age of 53.4 years and among them, 91.6% received school education and 88.2% did not have a high socioeconomic level. The majority of initial tumors were in Stage III (47.8%), SBR III (47.2%), High Ki 67 (46.5%), Negative RH (79.3%), and HER2 negative (58%). Metastases were generally unique (62.9%), dominated by bone sites (36.6%), with an average occurrencedelay of 2.4 years. After the occurrence of metastases, the cumulative survival rate was 5% at 3 years, and nil at 5 years. Conclusion: Metastatic relapses were common with poor prognosis.

关键词： Breast Cancer Risk Factors Metastatic Relapses

Fracture of the Humeral Palette in Adult Patient: Therapeutic and Evolutive Aspect at Gabriel touré Hospital: About 35 Cases

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Surgical Science 2023年第4期14卷 271-276页

作者： Mahamadou Diallo Abdoul Kadri Moussa Kalifa Coulibaly Layes touré Mahamadou Dama Mamadou Bassirou Traoré Cheick Oumar Sanogo Terna Traoré Famakan Doumbia Mamadou Diallo Amadou Maiga Adégné Pierre Togo Tiéman Coulibaly Service d’Orthopédie-Traumatologie CHU Gabriel Touré Bamako Mali

Introduction: Fractures of the humeral pallet occur between the distal insertion of the anterior brachial muscle and the joint space of the elbow. It represents 2% of all elbow fractures. These lower humeral fractures present a therapeutic challenge to trauma. These fractures are in the majority of joint cases and can be accompanied by loss of substance, which makes their functional prognosis random despite the application of the main therapeutic principles: exact reduction with possible bone graft;stable osteosynthesis, usually allowing early rehabilitation. This work focused on identifying therapeutic aspects and assessing treatment outcomes. Material and Methods: This was a descriptive cross-sectional study of patients with a fracture of the humeral palette from January 2015 to December 2019 at the Orthopaedic Trauma Department CHU Gabriel touré Bamako. Results: We collected 35 cases of fractures of the humeral palette. The average age was 39.25 years with extremes of 22 and 74 years. The male gender predominated (71.4%) with a sex ratio of 2.5. Etiologies were dominated by falls with 19 cases (54.3%) and stroke with 13 cases (37.1%). The standard X-ray of the face and profile of the elbow was performed in all our patients. The most frequent types of anatomoradiology were supra condylar fractures type A in 16 cases (45.7%), supra and inter condylar fractures type C in 15 cases (42.9%);4 cases of uni condylar fractures type B (11.4%). Associated lesions were observed in 42.85%. Surgical treatment was performed in 80% of cases. Complications were dominated by elbow stiffness in 18 cases (51.42%), secondary displacement in 5 cases (14.28%), ossifications in 4 cases (11.42%). At an average decrease of 3.2 years our results were considered good in 45.7%. Conclusion: Fractures of the humeral palette are relatively common with associated lesions. The complexity of the fracture with associated lesions makes treatment difficult with unpredictable evolution.

关键词： Fracture Humeral Palette Anatomopathology Treatment Evolution Bamako Mali

Theoretical and Experimental Studies of a Box-Type Solar Cooker in Unfavorable Climatic Conditions

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Smart Grid and Renewable Energy 2020年第4期11卷 51-60页

作者： D. Soro Daouda Soro M. Sidibé Y. Doumbia S. touré B. Marí Département des Sciences et Technologie Ecole Normale Supérieure (ENS) d’Abidjan C&#244te d’Ivoire Universite Jean Lorougnon Guede (UJLOG) de Daloa C&#244te d’Ivoire Laboratoire d’Energie Solaire Université FHB D’Abidjan-Cocody D’Abidjan-Cocody C&#244te d’Ivoire Departament de Física Aplicada-IDF Universitat Politècnica de València Valencia Spain

A box-type solar cooker with an inclined surface, equipped with a concentration reflector to allow maximum energy to be collected, enabled cooking tests to be carried out in the rainy season. Different thermocouples were implanted on various places of the cooker. The temperature measurements from these sensors were taken every 10 minutes. The tests presented in this article relate to the preparation of eggs and rice. The absorber temperatures during the tests exceeded 100°C. The cooking times were between 1 h 50 min and 2 h 20 min despite the numerous cloudy periods. The cooker made it possible to reach sufficient temperatures for healthy cooking of food. The results obtained for these first tests are satisfactory and very encouraging.

关键词： Solar Radiation Box-Type Solar Cooker Energy Inclined Aperture Area

Isolated Right Pulmonary Agenesis in a 2-Month-Old Infant in the Pediatric Ward of Hospital of Mali

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Open Journal of Pediatrics 2020年第2期10卷 274-279页

作者： Bourama Kané Mody Abdoulaye Camara Seydou Togo Mohame Maba Traoré Boubacar Mami touré Moussa Abdoulaye Ouattara Department of Pediatrics of the Hospital of Mali Bamako Mali Medical Imaging Service of the Mali Hospital Bamako Mali Department of Thoracicsurgery of the Hospital of Mali Bamako Mali

Introduction: Pulmonary agenesis is a rare congenital abnormality defined by the absence of parenchyma, bronchi and pulmonary vessels, frequently associated with other malformations. We describe a case of isolated right pulmonary agenesis diagnosed in the pediatric ward of the Mali Hospital. Clinical case: He was a month-old baby boy, born at term by cesarean section of a well-followed pregnancy. He was not resuscitated. He developed dyspnea after a cold. An emergency chest X-ray revealed a right opaque lung. He was referred to the hospital for the exploration of this opacity. At the entrance, it weighed 3910 g, size: 54 cm and the temperature was 36.9°C. He had a polypnea, an intercostal print. The sounds of the heart were diverted to the right. The rest of the clinical examination was without much particularity. The chest CT scan confirmed the right pulmonary agenesis. Abdominal and cardiac ultrasound was normal. A healing includes oxygenotherapy, serum glucose 10% minding 100 ml/ Kg/day and amoxicillin minding 100 mg/ Kg/day at 3 times by oral way. After 24 hours of treatment, we observed an improvement in dyspnea. On D2,

关键词： Pulmonary Isolated Agenesis Pediatric Hospital of Mali

A REMARK ON FORMAL MODELS FOR NONLINEARLY ELASTIC MEMBRANE SHELLS

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Chinese Annals of Mathematics,Series B 2001年第3期22卷 307-324页

作者： C. COLLARD Laboratoire d’Analyse Numerique, tour n°55, Universite Pierre et Marie Curie, 4, place Jussieu, 75005 Paris, France. Laboratoire de Mathematiques Appliquees au Calcul Scientifique, Universite de Valenciennes et du Hainaut-Cambresis, Le Mont H Labiratoire d'Analyse Numérique Tour n°55 Université Pierre et Marie Curie 4 place Jussieu 75005 Paris France Laboratoire de Mathématiques Appliquées au Calcul Scientifique Université de Valenciennes et du Hainaut-Cambresis Le Mont Houy - B.P. 311 - F 59304 Valenciennes cedex France

This paper gives all the two-dimensional membrane models obtained from formal asymptotic analysis of the three-dimensional geometrically exact nonlinear model of a thin elastic shell made with a Saint Venant-Kirchhoff material. Therefore, the other models can be quoted as flexural nonlinear ones. The author also gives the formal equations solved by the associated stress tensor and points out that only one of those models leads, by linearization, to the "classical" linear limiting membrane model, whose justification has already been established by a convergence theorem.

关键词： Nonlinear elastic shell Convergence theorem Asymptotic analysis

Profile of the Blood Count among People Living with HIV Monitored at the Institute of Social Hygiene and the Aristide Le Dantec Hospital in Dakar

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Open Journal of Blood Diseases 2022年第4期12卷 133-141页

作者： Faye Cheikh Ibrahima Coly Mame Ngoné Makalou Demba Sène Abdoulaye Sall Abibatou touré Awa Oumar Ly Fatouamata Hematology Laboratory of the Aristide le Dantec Hospital Dakar Senegal Health Sciences Training and Research Unit Hematology Laboratory of the Ziguinchor Peace Hospital Assane Seck University of Ziguinchor Ziguinchor Senegal Training and Research Unit in Health Sciences Hematology Laboratory of the Sickle Cell Disease Control Center of Saint Louis Gaston Berger University of Saint Louis Dakar Senegal Pharmacy and Odontostomatology Faculty of Medicine Cheikh Anta Diop University of Dakar Dakar Senegal Dermatology Department of the Social Hygiene Institute of Dakar Dakar Senegal

Introduction: The human immunodeficiency virus (HIV) is a pandemic of concern to the World Health Organization. It is all the more worrisome because if not properly managed, it can be responsible for several complications, including abnormal blood counts. These abnormalities may also be related to treatment. Objectives: The main objective of this study is to show that adequate antiretroviral therapy can correct various abnormalities exerted by HIV on patients’ blood counts. The specific objective is to determine all the abnormalities we can see in blood count before and during HIV treatment. Materials and Methods: Our study was conducted in the hematology laboratory and the dermatology departments of the Aristide Le Dantec Hospital and the Institute of Social Hygiene. It took place from December 2009 to October 2011. It is a retrospective descriptive and analytical study involving HIV-positive patients (HIV 1 and 2) and under antiretroviral treatment (at least six months of treatment). We included 110 patients in the study. Blood counts were performed at the hematology laboratory of the Aristide le Dantec hospital using a KX21 automaton. Each patient received three blood counts during the first six months of treatment (M0, M3 and M6). A univariate analysis was performed to determine the profile of the abnormalities of the blood count and the chi 2 test was used and a threshold of p 0.05 was considered significant. Results: The mean age of the patients was 38.6 ± 8.6 years (extremes of 18 and 64 years) with a sex ratio of 0.42 (77 females and 33 males). The prevalence of anemia was 80% (n = 88) at M0, 53, 63% at M3 (n = 59), and 38.20% at M6 (n = 42) (p = 0.02). We noted a favorable evolution with treatment. For the other abnormalities, the evolution was favorable for leukopenia (p = 0.011) and thrombocytopenia (p = 0.007). Conclusion: Our study showed a correction of blood count abnormalities in PLHIV with antiretroviral treatment.

关键词： Blood Count Abnormalities Antiretroviral Treatment PLHIV