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Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study

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Neural Regeneration Research 2019年第4期14卷 666-672页

作者： Mohammed Benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari Ismail Rammouz Mustapha Maaroufi Rabia Magoul driss boussaoud Laboratory of Clinical Neuroscience Faculty of Medicine Department of Neurosurgery University Hospital of Fez Laboratory of Neuroendocrinology and Nutritional and Climatic Environment Faculty of Sciences Dhar El Mahraz Department of Biophysics and Clinical MRI Methods Faculty of Medicine Department of Radiology and Clinical Imaging University Hospital of Fez Department of Psychiatry University Hospital of Fez Aix Marseille Université INSERM INS Institut de Neurosciences des Systèmes

Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease.

关键词： Parkinson’s disease emotion processing Blood oxygenation level-dependent functional magnetic resonance imaging brain activation dopamine neural regeneration

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