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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： di Wu Yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Synergic catalysis of W and Ni originating from substitution of trivacant phosphotungstate for the selective oxidation of aniline to azoxybenzene

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Chinese Chemical Letters 2024年第2期35卷 558-563页

作者： Sheng Cai Xiao-Yuan Wu Weiming Wu sa-sa Wang Can-Zhong Lu CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Xiamen Institute of Rare Earth Materials Chinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Partial substitution of polyoxometalate(POM)is an efficient route to modulate the catalytic property of maternal *** this work,a new Keggin type POM involving{Ni 6}cluster,{[Ni(H_(2)O)_(2)(Dach)_(2)][Ni(Dach)_(2)]_(2)}{[Ni_(6)Cl(μ-OH)_(3)(H_(2)O)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))][Ni_(6)(μ-OH)_(3)(H_(2)O)_(2)(Dach)_(3)(WO_(4))(PW9 O_(3)_(4))]}Cl·27H_(2)O,(1,Dach=1,2-diaminocyclohexane)was *** 1 shows excellent catalytic performance in the selective oxidation of aniline to azoxybenzene(AOB)in *** apparently different results from that with the matrix{PW_(9)O_(34)}({PW9})suggest the successful regulation of the catalytic property of{PW9}by the introduction of the{Ni6}cluster into the *** experimental results indicate that the highlighted performance of 1 is contributed by the synergy of W and Ni sites,which are respectively responsible for the oxidation and condensation steps in the production of *** good selectivity to AOB is essentially attributed to the effective modulation of the reaction rates of oxidation and condensation steps by W and Ni sites,respectively.

关键词： Polyoxometalate {Ni_(6)}cluster Modulated catalytic property Aniline oxidation Azoxybenzene

Bioinspired nanotransducers for neuromodulation

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Nano Research 2024年第2期17卷 618-632页

作者： Fan Yang Xiang Wu sa Cai Guosong Hong Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Wu Tsai Neurosciences Institute Stanford UniversityStanfordCA 94305USA School of Science Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and *** convergence of these fields has resulted in the development of nanotransducers,devices that harness the synergies of these diverse *** nanotransducers,essential for neuromodulation,often draw inspiration from energy conversion processes found in nature for their unique *** this review,we will delve into the latest advancements in wireless neuromodulation facilitated by optical,magnetic,and mechanical *** will examine their working principles,properties,advantages,and limitations in comparison to current methods for deep brain neuromodulation,highlighting the impact of natural systems on their design and ***,we will underscore potential future directions,emphasizing how continued progress in materials science,neuroscience,and bioengineering might expand the horizons of what is achievable with nanotransducer-enabled neuromodulation.

关键词： bioinspired synthesis neuromodulation mechanoluminescence focused ultrasound nanotransducers sono-optogenetics

Tuning mechanical behaviors of highly entangled hydrogels with the random distribution of mobile entanglements

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 277-294页

作者： Jinlong LIU di LU Bin CHEN Department of Engineering Mechanics Zhejiang UniversityHangzhou 310027China Beijing System Design Institute of Electro-Mechanic Engineering Beijing 100854China Intelligent Robotic Research Center Zhejiang LaboratoryHangzhou 310027China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Hangzhou 311100China

Highly entangled hydrogels exhibit excellent mechanical properties,including high toughness,high stretchability,and low *** considering the evolution of randomly distributed entanglements within the polymer network upon mechanical stretches,we develop a constitutive theory to describe the large stretch behaviors of these *** the theory,we utilize a representative volume element(RVE)in the shape of a cube,within which there exists an averaged chain segment along each edge and a mobile entanglement at each *** employing an explicit method,we decouple the elasticity of the hydrogels from the sliding motion of their entanglements,and derive the stress-stretch relations for these *** present theoretical analysis is in agreement with experiment,and highlights the significant influence of the entanglement distribution within the hydrogels on their *** also implement the present developed constitutive theory into a commercial finite element software,and the subsequent simulations demonstrate that the exact distribution of entanglements strongly affects the mechanical behaviors of the structures of these ***,the present theory provides valuable insights into the deformation mechanism of highly entangled hydrogels,and can aid in the design of these hydrogels with enhanced performance.

关键词： highly entangled hydrogel constitutive theory entanglement gamma distribution

Quaternionic Monge–Ampère Measure on Pluripolar Set

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1431-1457页

作者： Hichame AMAL saïd ASSERDA Fadoua BOUKHARI Department of Mathematics Laboratory LaREAMIRegional Centre of Trades of Education and TrainingKenitraMorocco Ibn Tofail University Faculty of SciencesDepartment of MathematicsPO 242 KenitraMorroco

In this paper, we prove that in a hyperconvex domain Ω in H^(n), if a non-negative Borel measure is dominated by a quaternionic Monge–Ampère measure, then it is a quaternionic Monge–Ampère measure of a function i... 详细信息

关键词： Quaternion space Monge-Amp`ere operator plurisubharmonic function

Effect of Modulus Heterogeneity on the Equilibrium Shape and Stress Field ofαPrecipitate in Ti-6Al-4V

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1017-1028页

作者： di Qiu Rongpei Shi Materials Genome Institute Shanghai UniversityShanghai200444China School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen518055China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai200444China Zhejiang Laboratory Hangzhou311100China

For media with inclusions(e.g.,precipitates,voids,reinforcements,and others),the difference in lattice parameter and the elastic modulus between the matrix and inclusions cause stress concentration at the *** stress fields depend on the inclusions’size,shape,and distribution and will respond instantly to the evolving *** study develops a phase-field model concerningmodulus *** effect of modulus heterogeneity on the growth process and equilibrium state of theαplate in Ti-6Al-4V during precipitation is ***αprecipitate exhibits strong anisotropy in shape upon cooling due to the interplay of the elastic strain and interfacial *** calculated orientation of the habit plane using the homogeneous modulus ofαphase shows the smallest deviation fromthat of the habit plane observed in the experiment,compared to the case where the homogeneous modulus ofβphase is *** addition,the equilibrium volume ofαphase within the systemusing homogeneousβmodulus exhibits the largest dependency on the applied *** stress fields across theα/βinterface are further calculated under the assumption of modulus heterogeneity and compared to those using homogeneous modulus of eitherαorβ*** study provides an essential theoretical basis for developing mechanics models concerning systems with heterogeneous structures.

关键词： Elastic heterogeneity habit plane stress field titanium phase-field simulation

Consistency of Tropospheric Water Vapor between Reanalyses and Himawari-8/AHI Measurements over East Asia

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Advances in Atmospheric Sciences 2024年第1期41卷 19-38页

作者： di di Jun LI Yunheng XUE Min MIN Bo LI Zhenglong LI Collaborative Innovation Center on Forecast and Evaluation of Meteorological disasters Nanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory for Aerosol-Cloud-Precipitation China Meteorological AdministrationSchool of Atmospheric PhysicsNanjing University of Information Science and TechnologyNanjing 210044China FYSIC National Satellite Meteorological CenterChina Meteorological AdministrationBeijing 100081China Chengdu University of Information Science and Technology Chengdu 610225China School of Atmospheric Sciences and Guangdong Province Key laboratory for Climate Change and Natural disaster Studies Sun Yat-sen University and Southern Laboratory of Ocean Science and EngineeringZhuhai 519082China Cooperative Institute for Meteorological satellite Studies University of Wisconsin–MadisonMadison WI 53706WisconsinUSA Wuxi University Wuxi 214105China

High spatiotemporal resolution radiances from the advanced imagers onboard the new generation of geostationary weather satellites provide a unique opportunity to evaluate the abilities of various reanalysis datasets to depict multilayer tropospheric water vapor(WV),thereby enhancing our understanding of the deficiencies of WV in reanalysis *** on daily measurements from the Advanced Himawari Imager(AHI)onboard the Himawari-8 satellite in 2016,the bias features of multilayer WV from six reanalysis datasets over East Asia are thoroughly *** assessments show that wet biases exist in the upper troposphere in all six reanalysis datasets;in particular,these biases are much larger in ***,we find better depictions of WV in the middle troposphere than in the upper *** accuracy of WV in the ERA5 dataset is the highest,in terms of the bias magnitude,dispersion,and pattern *** characteristics of the WV bias over the Tibetan Plateau are significantly different from those over other parts of East *** addition,the reanalysis datasets all capture the shift of the subtropical high very well,with ERA5 performing better overall.

关键词： AHI reanalysis dataset multilayer water vapor assessment radiative transfer model

Mapping global research trends: Nutrition associations with nonalcoholic fatty liver disease - a Scopus bibliometric analysis

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World Journal of Gastroenterology 2024年第24期30卷 3106-3119页

作者： Muna Shakhshir sa'ed H Zyoud Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Public Health College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Center An-Najah National University HospitalNablus 44839Palestine

BACKGROUND Several bibliometric analyses have been carried out to identify research hotspots and trends in nonalcoholic fatty liver disease(NAFLD)***,there are still significant knowledge gaps that must be filled to advance our understanding of and ability to treat *** To evaluate,through bibliometric and visual analysis,the current status of related research,related research frontiers,and the developmental trends in the field of diet and *** We retrieved publications about diet and NAFLD published between 1987 and 2022 from ***,we used VOSviewer 1.6.20 to perform bibliometric analysis and *** We found a total of 1905 studies,including 1637(85.93%)original articles and 195(10.24%)reviews,focused on the examination of NAFLD and its correlation with diet that were published between 1987 and *** the remaining five types of documents,38 were letters,notes,editorials,meeting minutes,or brief surveys,representing 1.99%of the total *** countries with the most publications on this topic were China(n=539;28.29%),followed by the United States(n=379;19.90%),Japan(n=133;6.98%),and South Korea(n=127;6.6%).According to the citation analysis,the retrieved papers were cited an average of 32.3 times and had an h-index of 106,with 61014 total *** two main clusters on the map included those related to:(1)Inflammation and oxidative stress;and(2)dietary interventions for *** This was the first study to use data taken from Scopus to visualize network mapping in a novel bibliometric analysis of studies focused on diet and *** 2017,the two domains that received the most attention were“dietary interventions for NAFL”’and“‘inflammation and oxidative stress implicated in NAFLD and its correlation with diet.”We believe that this study provides important information for academics,dietitians,and doctors,and that additional research on dietary interventions and NAFLD is warranted.

关键词： dietary Nutrition Bibliometric Nonalcoholic fatty liver Scopus VOSviewer

Coordination Mechanism and Empirical Research on Marine Science Technology Innovation and Marine Eco-civilization:A Case Study of Coastal Areas of China

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Chinese Geographical Science 2024年第3期34卷 468-486页

作者： CHEN Xiaolong LIANG Chenlu di Qianbin School of Geographical Science Liaoning Normal UniversityDalian 116029China Institute of Marine Sustainable Development Liaoning Normal UniversityDalian 116029China

Marine science technology innovation provides power and guarantees for marine eco-civilization construction,which provides direction and material support for marine science technology ***,the coordinated development of the two is of great significance to the marine economy sustainable development in China’s coastal *** the basis of clarifying the connotations of marine science technology innovation and marine eco-civilization in China’s coastal areas from 2006 to 2019,the mechanism for their coordinated development was analysed.A comprehensive indicator system based on the connotation of the two was constructed,and the coordinated development relationship was empirically tested using the coupled coordination model and the panel vector autoregressive(PVAR)*** results show that:1)the level of China’s coastal marine science technology innovation continues to improve,gradually forming the core of the development of marine science technology innovation in the north,east and south of Shandong,Shanghai and Guangdong;the level of marine eco-civilization development fluctuating upward trend,showing obvious spatial differentiation characteristics.2)The degree of coordination of marine science technology innovation and marine eco-civilization is growing over *** is no causal relationship between marine science technology innovation and marine eco-civilization in the northern marine economic circle,but there is a two-way causal relationship between the two in the eastern and southern marine economic circles.3)Marine eco-civilization shows a significant positive and continuous impact on marine science technology innovation,and marine science technology innovation shows a long-term,continuous,fluctuating,and lagging impact on marine *** overall role of marine eco-civilization on marine science technology innovation is dominant,and there are significant differences in the impact effects of the two major marine economic circles.

关键词： marine science technology innovation marine eco-civilization coordinated development coastal areas of China