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Pancreatic neuroendocrine tumors:Are tumors smaller than 2 cm truly indolent?

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1756-1762页

作者： sergio Hoyos Pablo Posada-Moreno Natalia Guzman-Arango Romario Chanci-drago Jaime Chavez Alvaro Andrés-Duarte santiago salazar-Ochoa Hepatobilary and Liver Transplant Unit Hospital Pablo Tobon Uribe and Gastrohepathology Group Universidad de AntioquiaMedellin 050034AntioquiaColombia Department of General surgery Universidad Pontificia BolivarianaMedellín 050034AntioquiaColombia

BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are relatively rare but rank as the second most common pancreatic *** can be functional,causing early metabolic disturbances due to hormone secretion,or non-functional and diagnosed later based on tumor size-related *** diagnoses of PNETs under 2 cm in size have sparked debates about their management;some practitioners advocate for surgical removal and others suggest observation due to the tumors’lower potential for ***,it is unclear whether managing these small tumors expectantly is truly *** To evaluate poor prognostic factors in PNETs based on tumor size(>2 cm orsurgically treated *** This cohort study included 64 patients with PNETs who underwent surgical resection between 2006 and 2019 at a high-complexity reference hospital in Medellín,*** assess patient survival,quarterly follow-ups were conducted during the first year after surgery,followed by semi-annual con-sultations at the hospital's hepatobiliary surgery *** variables were described using absolute and relative frequencies,and quantitative variables were expressed using measures of central tendency and their corresponding measures of *** The presence of lymph node involvement,neural involvement,and lymphovascular invasion were all associated with an increased risk of mortality,with hazard ratios of 5.68(95%CI:1.26–25.61,P=0.024),6.44(95%CI:1.43–28.93,P=0.015),and 24.87(95%CI:2.98–207.19,P=0.003),*** involvement and lymphovascular invasion were present in tumors smaller than 2 cm in diameter and those larger than 2 cm in *** recurrence rates between the two tumor groups were furthermore similar:18.2%for tumors smaller than 2 cm and 21.4%for tumors larger than 2 *** survival was additionally comparable between the two tumor *** Tumor size does not dictate prognosis;lymph node and lymphovascular involvement a

关键词： Neuroendocrine tumor Pancreatic neoplasm Pancreas Pancreatic neuroendocrine neoplasm Pancreatic neuroendocrine tumors

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碘和某些吡啶系列配合物的光谱和热力学研究

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化学学报 1984年第7期42卷 660-663页

作者：游效曾 drago.R.s. MillerJ.G. 南京大学配位化学研究所美国Illinois大学化学系

测定了碘与3-氯吡啶,4-氰基吡啶和s-氰基吡啶形成的授体配合物的可见光谱,并求得了一些相应的热力学参数△G,△H和△s.发现△G与π~*-σ~*跃迁吸收波数之间存在线性关系.证实了这一系列配合物的平衡常数符合Hammett方程,并且初步将它们... 详细信息

测定了碘与3-氯吡啶,4-氰基吡啶和s-氰基吡啶形成的授体配合物的可见光谱,并求得了一些相应的热力学参数△G,△H和△s.发现△G与π~*-σ~*跃迁吸收波数之间存在线性关系.证实了这一系列配合物的平衡常数符合Hammett方程,并且初步将它们引用于E-C方程.

关键词：配合物可见光谱热力学参数平衡常数吡啶氮杂苯氮杂环化合物

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RhCl[P（ρ-tolyl）3]2-3-Cl-Py配合物及其二氢化物的光谱和NMR研究

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化学学报 1984年第1期42卷 14-19页

作者：游效曾 R.s.drago J.G.Miller 南京大学化学系 Illinois大学化学系 Illinois大学化学系美国

利用光谱及P和H NMR等物理方法,确定了双核簇合物{RhCl[P（p-tolyl）]}与3-氯吡啶在甲苯溶液中进行的裂解反应及其产物的氢化反应的平衡常数,以及这些反应中的物种结构。

关键词： NMR RhCl[P tolyl 配合物二氢化物

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Blueberry Extract Reduces Oxidative stress in Patients with Metabolic syndrome

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Journal of Life sciences 2016年第3期10卷 145-152页

作者： Raul Francisco Pastor Gonzalez E Cassini M. s. Pastor I saure M saavedra E. siman Menem M. I. drago s Iermoli R. H InternalMedicineIVChair HospitaldeClinicas"JosddeSanMartin"UniversityofBuenosAiresBuenosAiresArgentina CentrodeDiagn6sticoMoleculars.A.(MolecularDiagnosisCenter) BuenosAiresArgentina CEsAN(CentrodeEndocrinologia SaludAlimentaci6nyNutricidn)CenterforEndocrinologyHealthEatingandNutritionBuenosAiresArgentina

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Viral infections in orthopedics: A systematic review and classification proposal

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World Journal of Orthopedics 2022年第11期13卷 1015-1028页

作者： Konstantinos sidiropoulos savvas Ilias Christofilos Konstantinos Tsikopoulos Dimitrios Kitridis Lorenzo drago Gabriele Meroni Carlo Luca Romanò Venu Kavarthapu General Hospital of serres Serres 62100Greece Department of Genetics Evolution and EnvironmentUniversity College LondonLondon WC1E 6BTUnited Kingdom Department of Orthopaedics 404 Army General HospitalLarissa 41222Greece the First Department of Orthopaedics Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Biomedical sciences for Health and Microbiome University of MilanMilan 20133Italy Department of Biomedical Surgicaland Dental SciencesOne Health UnitUniversity of MilanMilan 20133Italy Gruppo di studio sIOT Infezioni-Clinica san Gaudenzio-Novara-Gruppo Policlinico di Monza University of MilanMilan 20100Italy Trauma and OrthopaedicsKings College Hospital LondonDenmark HillLondon SE59RSUnited Kingdom

BACKGROUND Although the impact of microbial infections on orthopedic clinical outcomes is well recognized,the influence of viral infections on the musculoskeletal system might have been *** To systematically review the available evidence on risk factors and musculoskeletal manifestations following viral infections and to propose a pertinent classification *** We searched MEDLINE,Cochrane Central Register of Controlled Trials(CENTRAL),the Reference Citation Analysis(RCA),and scopus for completed studies published before January 30,2021,to evaluate risk factors and bone and joint manifestations of viral infection in animal models and patient *** assessment was performed using sYRCLE's risk of bias tool for animal studies,Moga score for case series,Wylde score for registry studies,and Newcastle-Ottawa scale for case-control *** six human and four animal studies were eligible for inclusion in the qualitative *** C virus was implicated in several peri-and post-operative complications in patients without cirrhosis after major orthopedic *** virus may affect the integrity of lumbar discs,whereas Ross River and Chikungunya viruses provoke viral arthritis and bone *** Evidence of moderate strength suggested that viruses can cause moderate to severe arthritis and *** factors such as pre-existing rheumatologic disease contributed to higher disease severity and duration of ***,based on our literature search,the proposed clinical and pathogenetic classification scheme is as follows:(1)Viral infections of bone or joint;(2)Active bone and joint inflammatory diseases secondary to viral infections in other organs or tissues;and(3)Viral infection as a risk factor for post-surgical bacterial infection.

关键词： Viral infection Musculoskeletal system Bone and joint manifestations Chikungunya Zika Hepatitis C virus Herpesviridae Ross River virus Cross-reactivity Classification

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Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification

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世界骨科杂志：英文版 2017年第5期8卷 400-411页

作者： David A George Lorenzo drago sara scarponi Enrico Gallazzi Fares s Haddad Carlo L Romano Department of Trauma and Orthopaedics University College London Hospitals Microbiological Laboratory Orthopaedic Re-search Institute Galeazzi Centre for Reconstructive surgery and Osteoarticular Infections Orthopaedic Research Institute Galeazzi

AIM To undertook a systematic review to determine factors that increase a patient's risk of developing lower limb periprosthetic joint infections(PJI).METHODs This systematic review included full-text studies that reviewed risk factors of developing either a hip or knee PJI following a primary arthroplasty published from January 1998 to November 2016. A variety of keywords were used to identify studies through international databases referencing hip arthroplasty, knee arthroplasty, infection, and risk factors. studies were only included if they included greater than 20 patients in their study cohort, and there was clear documentation of the statistical parameter used; specifically P-value, hazard ratio, relative risk, or/and odds ratio(OR). Furthermore a quality assessment criteria for the individual studies was undertaken to evaluate the presence of record and reporting bias. REsULTs Twenty-seven original studies reviewing risk factors relating to primary total hip and knee arthroplasty infections were included. Four studies(14.8%) reviewed PJI of the hip, 3(11.21%) of the knee, and 20(74.1%) reviewed both joints. Nineteen studies(70.4%) were retrospective and 8(29.6%) prospective. Record bias was identified in the majority of studies(66.7%). The definition of PJI varied amongst the studies but there was a general consensus to define infection by previously validated methods. The most significant risks were the use of preoperative high dose steroids(OR = 21.0, 95%CI: 3.5-127.2, P se(OR = 12.76, 95%CI: 2.47-66.16, P= 0.017), body mass index below 20(OR = 6.00, 95%CI: 1.2-30.9, P = 0.033), diabetes(OR = 5.47, 95%CI: 1.77-16.97, P = 0.003), and coronary artery disease(OR = 5.10, 95%CI: 1.3-19.8, P = 0.017).CONCLUsION We have highlighted the need for the provider to optimise modifiable risk factors, and develop strategies to limit the impact of non-modifiable factors.

关键词： Periprosthetic joint infection Risk factor Predictive Hip arthroplasty Knee arthroplasty

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Role of dynamic perfusion magnetic resonance imaging in patients with local advanced rectal cancer

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World Journal of Gastroenterology 2020年第20期26卷 2657-2668页

作者： Davide Ippolito silvia Girolama drago Anna Pecorelli Cesare Maino Giulia Querques Ilaria Mariani Cammillo Talei Franzesi sandro sironi Department of Diagnostic Radiology H.S.Gerardo MonzaSan Gerardo HospitalUniversity of Milano-BicoccaMonza 20900Italy Department of Diagnostic Radiology Papa Giovanni XXIII HospitalUniversity of Milano-BicoccaBergamo 20110Italy

BACKGROUND The management of rectal cancer patients is mainly based on the use of the magnetic resonance imaging(MRI)technique as a diagnostic tool for both staging and *** treatment,to date,the evaluation of complete response is based on the histopathology assessment by using different tumor regression grade(TRG)features(e.g.,Dworak or Mandard classifications).While from the radiological point of view,the main attention for the prediction of a complete response after chemotherapy treatment focuses on MRI and the potential role of diffusion-weighted images and perfusion imaging represented by dynamiccontrast enhanced *** main aim is to find a reliable tool to predict tumor response in comparison to histopathologic *** To investigate the value of dynamic contrast-enhanced perfusion-MRI parameters in the evaluation of the healthy rectal wall and tumor response to chemo-radiation therapy in patients with local advanced rectal cancer with histopathologic *** Twenty-eight patients with biopsy-proven rectal adenocarcinoma who underwent a dynamic contrast-enhanced MR study performed on a 1.5 T MRI system(Achieva,Philips),before(MR1)and after chemoradiation therapy(MR2),were enrolled in this *** protocol included T1 gadolinium enhanced THRIVE sequences acquired on axial planes.A dedicated workstation was used to generate color permeability *** of interest was manually drawn on tumor tissue and normal rectal wall,hence the following parameters were calculated and statistically analyzed:Relative arterial enhancement(RAE),relative venous enhancement(RVE),relative late enhancement(RLE),maximum enhancement(ME),time to peak and area under the curve(AUC).Perfusion parameters were related to pathologic TRG(Mandard’s criteria;TRG1=complete regression,TRG5=no regression).REsULTs Ten tumors(36%)showed complete or subtotal regression(TRG1-2)at histology and classified as responders;18 tumors(64%)were classified as non-responders(TR

关键词： Rectal neoplasm Chemotherapy Radiotherapy Tumor staging Treatment response Magnetic resonance imaging

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3D Non-Fluoroscopic Cryoablation of Right-sided Accessory Pathways in Children:Monocentric study and Literature Review

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Congenital Heart Disease 2021年第6期16卷 561-572页

作者： Fabrizio drago Irma Battipaglia Pietro Paolo Tamborrino Luigina Porco Camilla Calvieri Mario salvatore Russo Vincenzo Pazzano Romolo Remoli Massimo stefano silvetti Pediatric Cardiology and Cardiac Arrhythmias Unit Department of Pediatric Cardiology and Cardiac SurgeryBambino GesùChildren’s HospitalIRCCSRomeItaly

Background:Cryoablation of accessory pathways(APs)is effective and very safe in children,as previously reported by our *** aim of this retrospective study was to evaluate the current efficacy of 3D non-fluoroscopic cryoablation of right sided APs in children,comparing results obtained with the Ensite VelocityTM and the more recent Ensite PrecisionTM 3D mapping *** and Results:From January 2016 to December 2019,102 pediatric patients[mean age 12.5±2.8,62 males(61%of total cohort)]with right APs underwent 3D non-fluoroscopic transcatheter cryoablation at our ***(14.7%)patients had previously undergone catheter *** procedural success rate was 95.1%(n=97).No significant differences were detected in acute success rates achieved with Ensite Velocity^(TM)or Ensite PrecisionTM systems nor between manifest(94%)and concealed APs(100%).No permanent complications *** follow-up(428±286 days,median 396 days[interquartile range 179-713]),19 patients(19.6%)had *** were more frequent for parahissian/anterior APs compared to midseptal/posterior and lateral APs(p=0.043).Recurrences were not related to the Ensite system used.A redo ablation procedure was attempted in 13 cases,11 cryoablation and 2 radiofrequency ablations:the former was successful in 10 cases out of 11(90.9%).Conclusion:3D cryoablation of right-sided APs is associated with a very high acute success rate with limited use of fluoroscopy,resulting in great benefit to the *** rates are not high and patients can be retreated with cryo-energy with higher success rates.

关键词： 3D Mapping accessory pathway children cryoablation pediatric tachyarrhythmias

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Liver-side of inflammatory bowel diseases:Hepatobiliary and druginduced disorders

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World Journal of Hepatology 2021年第12期13卷 1828-1849页

作者： stefano Mazza sara soro Maria Chiara Verga Biagio Elvo Francesca Ferretti Fabrizio Cereatti Andrea drago Roberto Grassia Gastroenterology and Digestive Endoscopy Unit ASST CremonaCremona 26100Italy Gastroenterology Unit ASST Fatebenefratelli-SaccoDepartment of Biomedical and Clinical Sciences(DIBIC)Universitàdegli Studi di MilanoMilan 20157Italy

Hepatobiliary disorders are among the most common extraintestinal manifestations in inflammatory bowel diseases(IBD),both in Crohn’s disease and ulcerative colitis(UC),and therefore represent a diagnostic *** conditions include primary sclerosing cholangitis(PsC)as the main form,variant forms of PsC(namely small-duct PsC,PsC-autoimmune hepatitis overlap syndrome and IgG4-related sclerosing cholangitis)and granulomatous *** is by far the most common,presenting in up to 8%of IBD patients,more frequently in *** genetic foci have been identified,but environmental factors are preponderant on disease *** course of the two diseases is typically *** diagnosis is based mostly on typical radiological findings and exclusion of secondary *** of cholangiocarcinoma is significantly increased in PsC,as well as the risk of colorectal cancer in patients with PsC and IBD-related *** disease-modifying drugs are approved to ***,PsC management is directed against symptoms and complications and includes medical therapies for pruritus,endoscopic treatment of biliary stenosis and liver transplant for end-stage liver *** nonimmune-mediated hepatobiliary disorders are gallstone disease,whose incidence is higher in IBD and reported in up to one third of IBD patients,non-alcoholic fatty liver disease,pyogenic liver abscess and portal vein *** liver injury(DILI)is an important issue in IBD,since most IBD therapies may cause liver toxicity;however,the incidence of serious adverse events is *** and methotrexate are the most associated with DILI,while the risk related to anti-tumor necrosis factor-αand anti-integrins is *** on hepatotoxicity of newer drugs approved for IBD,like anti-interleukin 12/23 and tofacitinib,are still scarce,but the evidence from other rheumatic diseases is *** B reactivation during immunosuppressive therapy is a major

关键词： Inflammatory bowel diseases Hepatobiliary disorders Primary sclerosing cholangitis Drug-induced liver injury Biological drugs Viral hepatitis

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Arrhythmic Risk in Paediatric Patients Undergoing surgical Repair for Pulmonary Atresia with Intact Ventricular septum

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Congenital Heart Disease 2021年第1期16卷 85-94页

作者： Pietro Paolo Tamborrino Corrado Di Mambro Cecilia Marcolin Walter Vignaroli Giulia Cafiero Gianluca Brancaccio sonia Albanese Massimo stefano silvetti Adriano Carotti Fabrizio drago Paediatric Cardiology and Cardiac Arrhythmia Unit Department of Paediatric Cardiology and Cardiac SurgeryBambino GesùChildren’s HospitalIRCCSRomeItaly European Reference Network for Rare and Low Prevalence Complex Disease of the Heart Paediatric Cardiac surgery Unit Department of Paediatric Cardiology and Cardiac SurgeryBambino GesùChildren’s HospitalIRCCSRomeItaly sport Medicine Unit Department of Paediatric Cardiology and Cardiac SurgeryBambino GesùChildren’s HospitalIRCCSRomeItaly

Introduction:While previous studies only focused on the arrhythmic risk associated with specific correction strategies,this study evaluates this risk in a large cohort of paediatric patients with all phenotypes of PA-IVs after surgical ***:In this single centre observational cohort study,we retrospectively evaluated 165 patients with a diagnosis of PA-IVs and we excluded those with an exclusively percutaneous treatment,patients lost or with insufficient follow-up and those affected by other arrhythmic *** history and clinical outcomes were ***:86 patients were included in the study(54 male[62.8%],mean age 16.4±6.1 years),with median follow-up from definitive repair of 12.8 years(6.4–18.9 years).They underwent three different final repairs:23 patients(26.7%)univentricular palliation,43(50%)biventricular correction,and 20(23.3%)one and a half ventricle *** patients(15%)developed arrhythmia:6 patients(all the subgroups)sinus node disfunction(sND);2(biventricular repair)premature ventricular complexes;2(one and a half ventricle repair)non-sustained ventricular tachycardia;1(biventricular repair)intra-atrial re-entrant tachycardia;1(one and a half ventricle repair)supraventricular tachyarrhythmia;1(biventricular repair)atrial *** patients with sND needed a pacemaker *** Fontan circulation showed an association with sND,while the other two groups heterogeneous types of ***:The low arrhythmic risk is related to surgical repair,it does not appear to be associated with native cardiomyopathy,and it appears to increase with length of follow *** follow-up in specialized centres is necessary to make an early diagnosis and to manage the potential haemodynamic impact at medium-long term.

关键词： Pulmonary atresia with intact ventricular septum arrhythmic risk univentricular palliation Fontan circulation biventricular repair one and a half repair

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