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Immunotherapy in the treatment of lymphoma

World Journal of Stem Cells 2021年第6期13卷 503-520页

作者： Lazar S Popovic Gorana Matovina-Brko Maja Popovic Milica Popovic Ana Cvetanovic Ivan Nikolic Biljana Kukic dragana petrovic Department for Medical Oncology Oncology Institute of VojvodinaUniversity of Novi SadNovi Sad 21000Serbia Department for Medical Oncology Oncology Institute of VojvodinaNovi Sad 21000Serbia Department for Nephrology and Clinical Immunology Clinical Center of VojvodinaUniversity of Novi SadNovi Sad 21000Serbia Department for Medical Oncology Clinical Center of NisUniversity of NisNis 18000Serbia

Relapsed or refractory non-Hodgkin’s lymphomas,especially diffuse large B-cell lymphoma as well as relapsed or refractory Hodgkin lymphomas are hard-to-treat *** who do not respond to initial therapy or experience relapse are treated with salvage regimens,and if eligible for aggressive therapy,treatment is continued with high-dose chemotherapy and autologous stem cell *** therapy options can cure substantial numbers of patients,however for some it is still an uncurable *** new drugs and cell therapies are being investigated for the treatment of relapsed or refractory *** types of immunotherapy options have shown promising results,and some have already become the standard of ***,we review immunotherapy options for the treatment of lymphoma and discuss the results,positions,practical aspects,and future directions of different drugs and cellular therapies for the treatment of this disease.

关键词： Immunotherapy Receptors Chimeric antigen Antibodies Monoclonal Immunoconjugates Hodgkin disease Lymphoma Large B-cell Diffuse

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High dose chemotherapy with stem cell support in the treatment of testicular cancer

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World Journal of Stem Cells 2015年第11期7卷 1222-1232页

作者： Lazar Popovic Gorana Matovina-Brko Milica Popovic dragana petrovic Ana Cvetanovic Jelena Vukojevic Darjana Jovanovic Medical School University of Novi Sad Department for Medical Oncology Oncology Institute of Vojvodina Department for Internal Medicine Clinical Center of Vojvodina Department for Oncology Clinical Center Nis

Testicular germ cell cancer(TGCC) is rare form of malignant disease that occurs mostly in young man between age 15 and 40. The worldwide incidence of TGCC is 1.5 per 100000 man with the highest rates in North Europe. After discovery of cisplatin cure rates of TGCC are very favorable between 90%-95% and unlike most solid tumors, cure rate for metastatic TGCC is around 80%. Metastatic TGCC is usually treated with 3-4 cycles of bleomycin, etoposide, cisplatinum chemotherapy with or without retroperitoneal surgery and cure rates with this approach are between 41% in poor risk group and 92% in good risk group of patients. Cure rates are lower in relapsed and refractory patients and many of them will die from the disease if not cured with first line chemotherapy. High dose chemotherapy(HDCT) approach was used for the first time during the 1980 s. Progress in hematology allowed the possibility to keep autologous haematopoietic stem cells alive ex-vivo at very low temperatures and use them to repopulate the bone marrow after sub-lethal dose of intesive myeloablative chemotherapy. Despite the fact that there is no positive randomized study to prove HDCT concept, cure rates in relapsed TGCC are higher after high dose therapy then in historical controls in studies with conventional treatment. Here we review clinical studies in HDCT for TGCC, possibilities of mobilising sufficient number of stem cells and future directions in the treatment of this disease.

关键词： High dose chemotherapy Germ-cell cancer Stem cell transplantation Plerixafor

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The Influence of Solonetz Soil Limited Growth Conditions on Bread Wheat Yield

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Journal of Agricultural Science and Technology 2011年第2期5卷 194-201页

作者： M. Dimitrijevic S. petrovic M. Belic B. Banjac M. Vukosavljev N. Mladenov N. Hristov Faculty of Agriculture University of Novi Sad Sq. Dositeja Obradovica 8 21000 Serbia Institute of Field and Vegetable Crops St. Maksima Gorkog 30 21000 Novi Sad Serbia

The wheat yield variation on solonetz and chernozem soil in six environments was in study in order to obtain information for use of genetic variability and for building strategy in plant breeding for less productive and marginal environments. The sample of eight bread wheat varieties: Renesansa, Pobeda, Rapsodija, dragana, Cipovka, Evropa 90, NSR-5 and Nevesinjka, which are characterized by tolerance to stressful growing conditions and broader adaptability, was selected for the study. The trial was established by Randomized Complete Block Design in three replications at two locations in the Pannonian Plain, Northern Serbia in two vegetation periods 2004/2005 and 2008/2009. Locations differed in a soil type, primarily. The tested locality was on solonetz, while control locality was on chernozem soil type. Additive Main and Multiplicative Interaction model (AMMI) grouped varieties that exhibited strong reaction to environmental improvement (Nevesinjka and Evropa 90), varieties showing fairly small GE interaction (Renesansa, Cipovka and Pobeda) and varieties having the ability for maximum use of less productive soil in better meteorological conditions (dragana, Rapsodija and NSR-5). Meteorological conditions significantly influenced the effect of soil quality variation on grain yield in trial. Varieties have interacted differently with the environment, depending on their genetic background.

关键词： Wheat yield AMMI (Additive Main and Multiplicative Interaction model) interaction solonetz stress

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