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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep tomàs Víctor cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta tomàs carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and c(PKA and PKc)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKc activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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A class of second-order sliding mode controller for servo systems

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控制理论与应用（英文版） 2012年第2期10卷 268-272页

作者： tom.c. KONG Institute of Precision Engineering The Chinese University of Hong Kong

Sliding mode control （SMc） has been widely investigated in recent years. In this paper, a class of second- order SMc is proposed and used to achieve good tracking performance in servo systems. SMc has good robustness to the disturbances, but conventional SMc uses a sign function to drive the error on the sliding surface, which could generate chattering effect. In order to avoid this problem, our improved SMc uses the integral of the sign function. coupled with an exponential reaching law, the new SMc can better suppress torque disturbances and chatter, This paper first gives the derivation of the new SMc. Simulation and experimental results are then carried out to demonstrate its tracking performance and robustness against torque disturbance and chatter.

关键词： Sliding mode control (SMc) Servo system Position tracking Disturbance suppression

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Laboratory and field testing of bolting systems subjected to highly corrosive environments

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International Journal of Mining Science and Technology 2017年第1期27卷 101-106页

作者： Meikle tom Tadolini Stephen c. Sainsbury Bre-Anne Bolton John Minova Richmond Vale NSW 2327Australia Minova Georgetown KY 43204USA Mining and Resource Engineering Monash University VIC 3800 CaulfieldAustralia

The capacity of ground support components which have been affected by corrosion is reduced and may ultimately lead to dynamic failure of the component and the strata. In order to maintain an effective,long-term ground support system, significant campaigns of rehabilitation are often required in corrosion affected areas which also expose the workers to hazardous conditions. The most common corrosion protection for steel ground support utilises sacrificial systems such as galvanising. Galvanising has previously been proven to be susceptible to some corrosion processes. Stainless steel is the most effective in resistance to corrosion, but can be cost prohibitive, and its mechanical properties often make it unsuited to use in ground support components. Providing an outer protective plastic coating to bolts has proven to be an effective means of protecting the inner steel bar from corrosion. However, these support systems tend to be susceptible to coating damage, and require post cement grouting to provide full encapsulation. In comparison to a standard bolt/resin system, they can be slow to install and *** systems have also been shown to reduce overall load transfer performance of the bolting system. In order to provide a higher level of corrosion protection whilst maintaining current installation practices and bolting cycle times, Minova has developed the Enduro^(TM)steel ground support range. The Enduro^(TM) range consists of standard Minova steel ground support components which have been treated with a unique coating process. The Enduro^(TM)coating has been tested in the harshest of conditions, in laboratory controlled conditions and in underground trials. It has been proven to effectively resist or completely eliminate the formation of corrosion, even in the most aggressive environments. This paper explains the process and provides the details of the laboratory and underground corrosion performance testing carried out on Enduro^(TM)ground support product

关键词： corrosion coatings Galvanised Salt spray Accelerated corrosion testing

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Aggregator Based RPL for an IoT-Fog Based Power Distribution System with 6LoWPAN

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china communications 2020年第1期17卷 104-117页

作者： Rijo Jackson tom Suresh Sankaranarayanan Victor Hugo c.de Albuquerque Joel J.P.c.Rodrigues cMR Institute of Technology Bengaluru 560037India SRM Institute of Science and Technology Chennai 603203India University of Fortaleza(Unifor) FortalezaCE 60811-905Brazil Federal University of Piaui Teresina-PI64049-550Brazil Instituto de Telecomunicacoes 1049-001 LisboaPortugal

Advanced Metering Infrastructure(AMI)forms an important part in Smart *** the data effectively from smart meters to the Edge/Fog node requires an efficient routing *** Protocol for Low Power Lossy Area Network(RPL)is a standard routing protocol for IPv6 over Low Power Personal Area Network(6LoWPAN).In a Power Distribution system all the smart meters together form 6LoWPAN *** communicate with the fog router,which acts as the 6LoWPAN *** was evaluated using cooja Network simulator for a power distribution network *** nodes which were far away from the fog node gave low Packet Delivery Ratio(PDR)and large End to End *** paper proposes an aggregation RPL scheme by modifying the existing contiki *** smart meter nodes communicate to the aggregator,which communicates to the fog *** results show that the aggregation scheme has 35.6%increase in PDR,lesser hop count and 13.24%decrease in End to End delay on an average compared to existing RPL.

关键词： IoT 6LoWPAN RPL routing distribution automation smart grid fog computing

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Histological evaluation in ulcerative colitis

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Gastroenterology Report 2014年第3期2卷 178-192页

作者： tom.c.DeRoche Shu-Yuan Xiao Xiuli Liu Department of Pathology Wake Forest Baptist Medical CenterWinston-SalemNorth CarolinaUSA Department of Pathology University of ChicagoChicagoIllinoisUSA Department of Anatom.c Pathology Cleveland ClinicClevelandOhioUSA

This review summarizes diagnostic problems,challenges and advances in ulcerative colitis(Uc).It emphasizes that,although histopathological examination plays a major role in the diagnosis and management of Uc,it should always be interpreted in the context of clinical,endoscopic,and radiological *** diagnosis requires knowledge of the classic morphological features of Uc,as well as a number of atypical pathological presentations that may cause mis-classification of the disease process,either in resection or biopsy *** atypical pathological presentations include rectal sparing and patchiness of disease at initial presentation of Uc in pediatric patients or in the setting of medically treated Uc,cecal or ascending colon inflammation in left-sided Uc,and backwash ileitis in patients with severe ulcerative *** formed microgranulomas,with pale foamy histiocytes adjacent to a damaged crypt or eroded surface,should not be interpreted as evidence of crohn’s *** colitis should only be used in colectomy specimens as a provisional pathological *** with Uc are at risk for the development of dysplasia and carcinoma;optimal outcomes in Uc surveillance programs require familiarity with the diagnostic criteria and challenges relating to Uc-associated dysplasia and *** biopsy from Uc patients should always be evaluated for dysplasia based on cytological and architectural *** interpretation and classification of dysplasia in colon biopsy from Uc patients as sporadic adenoma or Uc-related dysplasia[flat,adenoma-like,or dysplasia-associated lesion or mass(DALM)]requires clinical and endoscopic *** polypoid dysplastic lesions are considered to be sporadic adenoma if occurring outside areas of histologically proven colitis,or adenoma-like dysplasia if occurring in the diseased *** data suggest that such lesions may be treated adequately by polypectomy in the

关键词： ulcerative colitis histological evaluation dysplasia differential diagnosis

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Analytical and technological aspects of amylose inclusion complexes for potential applications in functional foods

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Food Bioscience 2022年第3期47卷 17-31页

作者： Andrea E.Di Marco Vanesa Y.Ixtaina Mabel c.tomás centro de Investigación y Desarrollo en criotecnología de Alimentos cIDcA CCT La Plata CONICETFacultad de Ciencias Exactas FCE-UNLPCICPBAcalle 47 y 1161900La PlataArgentina Facultad de ciencias Agrarias y Forestales FcAyF-UNLP calle 60 y 1191900La PlataArgentina

The linear component of starch,amylose,has the ability to interact with hydrophobic molecules forming inclusion complexes(Ics).These structures have gained a particular interest for potential food applications,either as dietary fiber or as delivery systems of bioactive *** the second case,the complexation of sensitive molecules is directed to protect them from processing,storage and stom.ch conditions and to guarantee a sustained release in the gastrointestinal *** present review covers the analytical and technological aspects of inclusion complexes,with focus on their potential application in the development of functional *** was addressed by first explaining the methodologies used for the analytical assessment of their structural,thermal,and functional properties,followed by the study of the functionality of Ics as carrier agents of different bioactive compounds and food ingredients,including alpha-lipoic acid,α-linolenic and linoleic fatty acids,conjugated linoleic acid,ascorbyl palmitate,phenolic compounds,and *** also covers the application of Ics in food products and the analysis of the potential industrial scalability of the formation *** analytical methodologies allowed a complete characterization of the *** structures have shown suitable functional properties as delivery systems of the bioactive compounds and flavors covered in this *** incorporation of Ics in food has led to the development of products with improved nutritional and/or functional *** successful formation of complexes using methods suitable for an industrial scale represents promising preliminary results to achieve the scalability of the Ics production in the near future.

关键词： Amylose inclusion complex Delivery system Bioactive compound V-type structure

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Experimental Investigation of Effects of Reynolds Number and Incidence Angle on Secondary Flow within a Linear Blade cascade

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Journal of Thermal Science 2021年第6期30卷 2122-2136页

作者： FLÍDR Erik JELÍNEK tomáš KLADRUBSKÝMilan Laboratory of High Speed Aerodynamics Czech Aerospace Research CenterBeranovych 130Prague 19905Czech Republic

The kinetic energy loss and the secondary loss downstream of a high turning nozzle cascade were *** of the incidence angle(i=-25°,0°and 25°)and Reynolds number(Re_(2,is)=0.8×10^(5),1.2×10^(5),2.5×10^(5) and 4.5×10^(5))were studied on two cascade configurations defined by different pitch to chord ratio(t/c=0.6 and 0.9),*** at the cascade inlet were performed by means of Preston tube,while at the cascade outlet by means of miniature pyramid five-hole pressure *** effect of studied parameters on the flow field at the cascade outlet was shown by the distribution of the kinetic energy loss,secondary loss,mix-out loss and streamwise vorticity.

关键词： linear blade cascade secondary loss pressure measurement

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Decomposition of labile and recalcitrant coniferous litter fractions affected by temperature during the growing season

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Journal of Forestry Research 2020年第4期31卷 1115-1121页

作者： Veronika Jílková Kristyna Dufková tomás cajthaml Na Sádkách 7CeskéBudějovice 37005Czech Republic Faculty of Science Masaryk UniversityKotlárská267/2Brno 61137Czech Republic Institute for Environmental Studies Charles University in PragueBenátská2Prague 12801Czech Republic Institute of Microbiology Czech Academy of SciencesVídeňská1083Prague 14220Czech Republic

Temperate coniferous forest soils are considered important sinks of soil organic carbon(c).Fresh c inputs may,however,affect soil microbial activity,leading to increased organic matter decomposition and carbon dioxide *** consists of labile and recalcitrant fractions which are thought to be utilized by distinct microbial communities and at different rates during the growing *** this study,we incubated the whole litter(Lc+Rc),the labile(Lc)and the recalcitrant(Rc)fractions with the coniferous soil at two temperatures representing spring/autumn(10℃)and summer(20℃)for one *** respiration and microbial community composition were regularly determined using phospholipid fatty acids as *** Lc fraction greatly increased soil respiration at the beginning of the incubation period but this effect was rather *** effect of the Rc fraction persisted longer and,together with the Lc+Rc fraction,respiration increased during the whole incubation *** of the Rc fraction was more strongly affected by higher temperatures than decomposition of the more labile fractions(Lc and Lc+Rc).However,when we consider the relative increase in soil respiration compared to the dH2 O treatment,respiration increased more at a lower temperature,suggesting that available c is more important for microbial metabolism at lower *** c was added only once in our study,no changes in microbial community composition were detected,possibly because the microbial community is adapted to relatively low amounts of additional c such as the amounts naturally found in litter.

关键词： Temperate forest Picea abies Soil respiration Hot water-extractable carbon PLFA (phospholipid fatty acids)

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Assembly of a parts list ofthe human mitotic cell cycle machinery

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Journal of Molecular cell Biology 2019年第8期11卷 703-718页

作者： Bruno Giott Sz-Hau chen Mark W.Barnett Tim Regan Tony Ly Stefan Wiemann David A.Hume tom.c.Freeman The Roslin Institute University of Edinburgh Easter Bush Midlothian EH25 9RG Scotland UK Biosciences and Biotechnology Institute EDyP Department CEA Grenoble 17 rue des Martyrs 38054 Grenoble France Wellcome centre for cell Biology University of Edinburgh Swann Building Edinburgh EH9 3BF Scotland UK Molecular Genome Analysis (B050) Deutsches Krebsforschungszentrum Im Neuenheimer Feld 580 69120 Heidelberg Germany Mater Research Institute University of Queensland Level 3 Aubigny Place Raymond Terrace South Brisbane Qld 4101 Australia

The set of proteins required for mitotic division remains poorly characterized. Here, an extensive series of correlation analyses of human and mouse transcriptom.cs data were performed to identify genes strongly and reproducibly associated with cells undergoing S/G2-M phases of the cell cycle. In so doing, 701 cell cycle-associated genes were defined and while it was shown that many are only expressed during these phases, the expression of others is also driven by alternative promoters. Of this list, 496 genes have known cell cycle functions, whereas 205 were assigned as putative cell cycle genes, 53 of which are functionally uncharacterized. Among these, 27 were screened for subcellular localization revealing many to be nuclear localized and at least three to be novel centrosomal proteins. Furthermore, 10 others inhibited cell proliferation upon siRNA knockdown. This study presents the first comprehensive list of human cell cycle proteins, identifying many new candidate proteins.

关键词： cell cycle systems biology gene expression transcriptome network analysis

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Importance of the Development of Veterinary Toxicology in Argentina

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Biomedical and Environmental Sciences 1989年第1期2卷 7-16页

作者： tomáS A.LóPEZ Instituto

The different types of toxic substances that affect farm animals in Argentina are described. These substances include (a) toxic plants, such as Solanum glaucophyllum. Baccharis coridifolia, Festuca arundinacea; (b) mycotoxins, such as zearalenone, tremorgenic mycotoxins, and ergoalkaloid; (c) trace elements, such as fluorine, copper, molybdenum, and arsenic; and (d) others, such as toxic algae and pesticides. The direct and indirect economic loss of farm animals associated with these toxic substances in Argentina is roughly estimated at 50 million dollars a year. A number of recommendations are made to ameliorate the situation. 1989 Academic Press, Inc.

关键词： In Importance of the Development of Veterinary Toxicology in Argentina

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