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Perturbations in the earthworm metabolite profile during a two-week exposure to metformin

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Emerging Contaminants 2024年第3期10卷 221-229页

作者： J.D.Gillis G.w.Price s.O.Prasher Department of Bioresource Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada Department of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is among the most prescribed pharmaceuticals in many countries,and as a result has shown up in biosolids derived from municipal wastewater treatment that are destined for land *** humans taking metformin,the effects include reduced glucose uptake in the intestine,a reduction in gluconeogenesis,increased oxidation of fatty acids,and reduced fatty acid *** effects of metformin on soil-dwelling organisms are not well *** study tested the effects of metformin exposure(0,10,40,160,640μg g^(-1))on the earthworm(***)at four time points(6 h,2 d,7 d,and 14 d)using GC-Ms to reveal sub-lethal effects and elucidate potential modes of action for *** were no mortalities observed,and earthworms exposed to the highest concentrations(160 and 640μg g^(-1))gained weight relative to the control on days 7 and *** reductions on day 7 were observed for glucose and malic acid(consistent with a reduction in gluconeogenesis),and for palmitic and margaric acid(consistent with increased oxidation and reduced synthesis of fatty acids).Lactic acid ranked first and second among canonicals 1 and 2 respectively and led to significant differences in discriminant scores across concentration and *** levels increased to equal or greater than the control on day 14,likely caused by reduced exposure as metformin is reported to be readily transformed by microorganisms under aerobic *** observations were consistent with the known effects of metformin in humans,and suggests that a similar mode of action exists in earthworms.

关键词： Metabolites Toxicity Earthworms Metformin GC-Ms

Oil Palm Fiber Hybrid Composites: A recent review

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Journal of renewable Materials 2024年第10期12卷 1661-1689页

作者： H.A.Aisyah E.Hishamuddin A.w.Noorshamsiana Z.Ibrahim r.A.Ilyas Biomass Technology Unit Engineering and Processing DivisionMalaysian Palm Oil Board(MPOB)6Persiaran InstitusiBandar Baru BangiKajangSelangor43000Malaysia Department of Chemical Engineering Faculty of Chemical and Energy EngineeringUniversiti Teknologi MalaysiaJohor81310Malaysia

Composite materials from oil palmﬁber enhance sustainability by utilizing renewable resources,reducing depen-dence on non-renewable materials,and lessening environmental *** their mechanical and dimen-sional stability limitations,oil palmﬁber-based polymer composites offer signiﬁcant advantages,such as natural abundance,potential weight reduction,and cost-effectiveness due to local availability and *** growing interest in oil palm hybrid composites,made from blending differentﬁbers,is due to their custo-mizable mechanical and physical *** is one of the most effective methods to reinforce and improve the performance of oil palm-derived composite *** review investigates the structural qualities of hybrid composites made from oil palmﬁbers,their suitability for diverse applications,and recent advancements in theﬁ*** focusing on the availability,properties,applications,challenges,and future direc-tions of oil palmﬁber hybrid composites,this review highlights the potential of these materials to enhance mechanical and functional properties,thereby contributing to sustainable development and innovation in com-posite materials.

关键词： Oil palmﬁber empty fruit bunch mesocarpﬁber hybrid composite

rescattering of stimulated raman side scattering in nonuniform plasmas

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Matter and radiation at Extremes 2024年第5期9卷 68-76页

作者： s.Tan Q.wang Y.Chen w.B.Yao C.Z.Xiao J.F.Myatt school of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and Computational Mathematics Beijing 100094China school of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

rescattering of stimulated raman side scattering(srss)is observed for the first time via two-dimensional(2D)particle-in-cell(PIC)*** construct a theoretical model for the rescattering process,which can predict the region of occurrence of mth-order srss and estimate its *** rescattering process is identified by the 2D PIC simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order srss propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order srss,but there is no cascade acceleration to produce superhot *** studies for a wide range of ignition conditions show that srss and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

structural engineering of antimicrobials for optimal broad-spectrum activity

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Green Chemical Engineering 2024年第4期5卷 473-482页

作者： Arunmozhiarasi Armugam Diane s.w.Lim siti Nurhanna riduan shook Pui Chan Jerome Asugan Yugen Zhang Institute of Bioengineering and Bioimaging Institute of sustainability for Chemicals Energy and Environment(ISCE2) Agency for Science Technology and Research (A*STAR) Diploma in Biomedical science School of Chemical and Life SciencesSingapore Polytechnic

Antimicrobial materials are a crucial component in eradicating and managing the spread of infectious *** are expected to act on a broad-spectrum of microbes, including emerging pathogens which could cause the next Disease X. Herein, we reassessed a series of antimicrobial imidazolium polymers on our shelves and uncovered extended functionality through dual modes of action. By redesigning their structures, a truly broadspectrum antimicrobial material with optimized activity against bacteria(G +ve, G-ve) and fungi, as well as enveloped and non-enveloped viruses was developed. we demonstrated that the imidazolium polymer exhibits dual modes of function against microbes: targeting the microbial membrane and binding DNA. The latter DNA binding affinity was found to be key against non-enveloped viruses. with this insight, we designed small molecule compounds that exhibited optimum broad-spectrum antimicrobial activity and excellent efficacy against EsKAPE group of pathogens that are responsible for some of the deadliest nosocomial infections worldwide. Our results could also shed light on the design of broad-spectrum antimicrobial compounds against Disease X.

关键词： Broad-spectrum Antimicrobial Polyimidazolium structure-function Membrane active

Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

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Plasma science and Technology 2024年第4期26卷 52-60页

作者： V.A.KrUPIN M.r.NUrGALIEV A.r.NEMETs I.A.ZEMTsOV s.D.sUNTsOV T.B.MYALTON D.s.sErGEEV N.A.sOLOVEV D.V.sArYCHEV D.V.rYJAKOV s.N.TUGArINOV N.N.NAUMENKO National research Centre“Kurchatov Institute” Moscow 123182Russia Bauman Moscow state Technical University Moscow 105005Russia Institution“Project Center ITEr” Moscow 123098Russia JsC“sOLAr” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECrH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECrH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECrH power. The EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECrH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient r/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and r/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

spatiotemporal dynamics in butterfly hybrid zones

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Insect science 2024年第2期31卷 328-353页

作者： Ananda r.Pereira Martins Natalie B.warren w.Owen McMillan rowan D.H.Barrett redpath Museum McGill University859 Sherbrooke Street WestMontrealQuebecCanada smithsonian Tropical researchInstitute GamboaPanama CityPanama

Evaluating whether hybrid zones are stable or mobile can provide novelinsights for evolution and conservation biology. Butterflies exhibit high sensitivity to envi-ronmental changes and represent an important model system for the study of hybrid zoneorigins and maintenance. Here, we review the literature exploring butterfly hybrid zones,with a special focus on their spatiotemporal dynamics and the potential mechanisms thatcould lead to their movement or stability. we then compare different lines of evidenceused to investigate hybrid zone dynamics and discuss the strengths and weaknesses ofeach approach. Our goal with this review is to reveal general conditions associated withthe stability or mobility of butterfly hybrid zones by synthesizing evidence obtained us-ing different types of data sampled across multiple regions and spatial scales. Finally, wediscuss spatiotemporal dynamics in the context of a speciation/divergence continuum, therelevance of hybrid zones for conservation biology, and recommend key topics for futureinvestigation.

关键词： butterflies human impacts hybrid zones movement spatiotemporaldynamics stability

reproductive cycle of the oyster Crassostrea(Magallana)saidii(wong and sigwart,2021)from southeast Asia

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Aquaculture and Fisheries 2024年第4期9卷 653-662页

作者： Arun Chandra Barman Nur Leena w.s.wong Murni Marlina Abd Karim Department of Aquaculture Faculty of AgricultureUniversiti Putra MalaysiaSerdangSelangor43400Malaysia Bangladesh Fisheries research Institute(BFrI) Mymensingh2201Bangladesh International Institute of Aquaculture and Aquatic sciences(I-AQUAs) Universiti Putra MalaysiaSerdangSelangor43400Malaysia

Crassostrea(Magallana)saidii has been commercially ranched in Malaysia and consumed for more than 160 years,but it was only recently identified as a new species to *** study was conducted to evaluate the reproductive phenology of C.(M.)*** of 30 individual oysters were taken monthly for 15 months from the sole population at sungai Muar estuary in Johor,*** sex ratio was 1:1.64(male:female)for all examined specimens,with female numbers significantly *** was detected in 1.56%of all *** peaks in April(2019)and November(2018 and 2019),and were positively associated with the increased rainfall *** occurred throughout the research period with temporal *** highest values of maturity index(MI)were recorded in March,August and October 2019,when most oysters were in matured and maturing *** index(CI)ranged from 31.90±1.25(April 2019)to 70.03±3.23(October 2019),exhibiting two peaks(March and October 2019)and subsequently reduced in CI indicating spawning consistency with histological *** stressors such as heavy sedimentation and inland development are threatening the survival of this *** understanding of their reproductive biology is essential to ensure the survival and sustainability of C.(M.)saidii fishery.

关键词： Crassostrea(M.)saidii Gonad phenology sex ratio Maturity index Condition index Oyster

ranking environmental and edaphic attributes driving soil microbial community structure and activity with special attention to spatial and temporal scales

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mLife 2024年第1期3卷 21-41页

作者： Vadakattu V.s.r.Gupta James M.Tiedje CsIrO Agriculture&Food UrrbraeSouth AustraliaAustralia Centre for Microbial Ecology Michigan State UniversityEast LansingMichiganUSA

The incredibly complex soil microbial communities at small scales make their analysis and identification of reasons for the observed structures *** community structure is mainly a result of the inoculum(dispersal),the selective advantages of those organisms under the habitat-based environmental attributes,and the ability of those colonizers to sustain themselves over *** soil is protective,and its microbial inhabitants have long adapted to varied soil conditions,significant portions of the soil microbial community structure are likely ***,a substantial portion of the community will not correlate to often measured soil *** suggest that the drivers be ranked on the basis of their importance to the fundamental needs of the microbes:(i)those that supply energy,i.e.,organic carbon and electron acceptors;(i)environmental effectors or stressors,i.e.,pH,salt,drought,and toxic chemicals;(ii)macro-organism associations,i.e.,plants and their seasonality,animals and their fecal matter,and soil fauna;and(iv)nutrients,in order,N,P,and probably of lesser importance,other micronutrients,and *** relevance of drivers also varies with spatial and time scales,for example,aggregate to field to regional,and persistent to dynamic populations to transcripts,and with the extent of phylogenetic difference,hence phenotypic differences in organismal *** present a summary matrix to provide guidance on which drivers are important for particular studies,with special emphasis on a wide range of spatial and temporal scales,and illustrate this with genomic and population(rrNA gene)data from selected studies.

关键词： abundance community structure diversity functional microbiome microorganisms

superexchange and charge transfer in the nickelate superconductor La_(3)Ni_(2)O_(7) under pressure

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science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 1-8页

作者： wéi wú Zhihui Luo Dao-Xin Yao Meng wang Center for Neutron science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China

recently, a bulk nickelate superconductor La_(3)Ni_(2)O_(7) is discovered at pressures with a remarkable high transition temperature T_(c)~ 80 K. Here, we study a Hubbard model with tight-binding parameters derived from ab initio calculations of La_(3)Ni_(2)O_(7),by employing large scale determinant quantum Monte Carlo and cellular dynamical mean-field theory. Our result suggests that the superexchange couplings in this system are comparable to that of cuprates. The system is a charge transfer insulator as the hole concentration becomes four per site at large Hubbard U. Upon hole doping, two low-energy spin-singlet bands emerge in the system exhibiting distinct correlation properties: while the one composed of the out-of-plane Ni-d_(3z^(2)-r^(2)) and O-p_(z) orbitals demonstrates strong antiferromagnetic correlations and narrow effective bandwidth, the in-plane singlet band consisting of the Ni-d_(x^(2)-y^(2)) and O-p_(x)/p_(y) orbitals is in general more itinerant. Over a broad range of hole doping, the doped holes occupy primarily the d_(x^(2)-y^(2)) and p_(x)/p_(y) orbitals, whereas the d_(3z^(2)-r^(2)) and p_(z) orbitals retain underdoped. we propose an effective t-J model to capture the relevant physics and discuss the implications of our result for comprehending the La_(3)Ni_(2)O_(7) superconductivity.

关键词： superconductivity nickelate superconductors Hubbard model superexchange charge transfer insulator quantum Monte Carlo