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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural regeneration research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel refai Gerald r.rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Analysis and Optimization of Operational and Pollutant Attributes of Diesel Engine with CNT-Infused Orange Peel Biodiesel-Diesel Blend Fuel

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Journal of Thermal Science 2024年第2期33卷 761-778页

作者： ranjeet rAI r.r.SAHOO Mechanical Engineering Department GLA UniversityMathura281406India Mechanical Engineering Department IIT(BHU)Varanasi221005India

The current study is performed to find sustainable solutions for the future of transportation and environmental *** conventional methods and experimental design table(L16 Orthogonal Array)techniques have been employed to examine and optimize a diesel-powered engine's operational and pollutant *** L16 Orthogonal Array is obtained through Taguchi's experimental design approach using Minitab 16 *** experimental design incorporated three control variables,namely engine speed,fuel type,and engine load,each with four *** operational parameters,namely brake thermal efficiency(BTE)and brake specific fuel consumption(BSFC),as well as the emission characteristics,including hydrocarbon(HC),carbon monoxide(CO),nitrogen oxide(NO),and smoke emissions,were acquired using the L16 orthogonal array(OA) and subsequently *** utilization of methodologies such as signal-to-noise(S/N) ratio and grey analysis was employed to determine the optimal operational state of the engine to achieve maximum performance while minimizing *** engine's ideal state of operation,in terms of BTE and BSFC,was determined to be at 75% engine load,1000 r/min engine speed,and using 10^(-4)(in vol) carbon nanotube incorporated 20% orange peel biodiesel(OPB20CNT100) blended fuel(A3-B1-C4).The study indicated that engine load significantly influenced BTE and BSFC,with 84.05% and 87.79% contribution factors,*** 25% engine load,1000 r/min,and OPB20CNT100 fuel(A1-B1-C4) CO,smoke,NO,and HC emissions were the *** load affects emissions the *** BSFC increased 3.10% and NO emissions 1.77%.BTE,CO,smoke,and HC emissions decreased by 1.9%,12.29%,47.05%,and 47.22%,respectively,at optimal operating conditions concerning diesel *** study shows that Taguchi-Grey's experimental design optimizes diesel engine operational and pollutant *** outcomes revealed that orange peel biodiesel infused with CNT can replace diesel fuel in a

关键词： Taguchi-Grey method OPB20CNT100 transesterification S/N ratio GrG HC CO and NO

Investigation of quality factor frequency content in vertical seismic profile for gas reservoirs

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Petroleum research 2021年第1期6卷 57-65页

作者： Ehsan Larki Abbas Ayatizadeh Tanha Amirhossein Parizad Bahram Soltani Soulgani dr Hassan Bagheri National Iranian drilling Company Well Logging DepartmentAhwazIran Petroleum University of Technology Ahwaz Faculty of Petroleum EngineeringAhwazIran Sahand University of Technology Petroleum Exploration EngineeringTabrizIran Department of Petroleum Engineering Ahwaz Faculty of Petroleum EngineeringPetroleum University of Technology(PUT)AhwazIran

Since long ago, indirect study of the underground layers properties has been interesting to *** method for this study was seismography which gained great interest besides other tools due to thedifferent identity of waves and energy attraction phenomena in different layers. Vertical seismic profiling(VSP) is considered as a valuable method in oil and gas exploration. This method is used to estimate therock properties in a well. In seismic operations elastic waves are sent down to the underground. Part ofthe waves’ energy is reflected after passing through the earth layers and are received by receivers on theground level. The received data determine the situation of the underneath layers after being processed,and one of the most important applications of seismic data is in the oil and gas exploration field. Qualityfactor is one of the most important seismic detectors that shows itself apparently in VSP data results. Themost substantial purpose of this study is to investigate the frequency content of the quality factor.

关键词： Vertical seismic profiling(VSP) Sonic log Seismic waves Quality factor rock properties Gas reservoir

AlMgSi 0.5挤压坯料的质量要求(1)

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轻合金加工技术 1991年第8期19卷 16-20,33页

作者： dr.r.AKErET A.rIED dr.J-J.THELEr 徐文艳

AlMgSi0.5挤压坯料的组织参数会以多种形式影响目前已达到的挤压速度以及挤压状态的和阳极氧化状态的型材表面质量。为了说明相互之间的关系,研究了型材表面的形成,挤压时铸锭表层的运动过程和挤压时铸造组织的变化。采用隔热模铸造、... 详细信息

AlMgSi0.5挤压坯料的组织参数会以多种形式影响目前已达到的挤压速度以及挤压状态的和阳极氧化状态的型材表面质量。为了说明相互之间的关系,研究了型材表面的形成,挤压时铸锭表层的运动过程和挤压时铸造组织的变化。采用隔热模铸造、热顶铸造、油气模或电磁铸造可获得均匀的铸造组织,以保证最佳的挤压性能和优良的表面质量。均匀化处理的温度和保温时间以及随后的冷却速度同样很重要。质量控制的任务首先是对产品中肉眼能观察到的组织参数的差别进行统计并做出评价。

关键词：铝镁合金挤压坯料质量要求

AlMgSi0.5挤压坯料的质量要求(2)

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轻合金加工技术 1991年第11期19卷 19-24,38页

作者： dr.r.AKErET A.rIED dr.J.-J.THELEr 徐文艳

关键词： AlMgSi合金挤压坯料铸造质量

The effect of initial geometric imperfection on the nonlinear resonance of functionally graded carbon nanotube-reinforced composite rectangular plates

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Applied Mathematics and Mechanics(English Edition) 2018年第9期39卷 1219-1238页

作者： r.GHOLAMI r.ANSArI Department of Mechanical Engineering Lahijan Branch Islamic Azad University Department of Mechanical Engineering University of Guilan

The purpose of the present study is to examine the impact of initial geometric imperfection on the nonlinear dynamical characteristics of functionally graded carbon nanotube-reinforced composite(FG-CNTrC) rectangular plates under a harmonic excitation transverse load. The considered plate is assumed to be made of matrix and single-walled carbon nanotubes(SWCNTs). The rule of mixture is employed to calculate the effective material properties of the plate. Within the framework of the parabolic shear deformation plate theory with taking the influence of transverse shear deformation and rotary inertia into account, Hamilton’s principle is utilized to derive the geometrically nonlinear mathematical formulation including the governing equations and corresponding boundary conditions of initially imperfect FG-CNTrC plates. Afterwards, with the aid of an efficient multistep numerical solution methodology, the frequency-amplitude and forcing-amplitude curves of initially imperfect FG-CNTrC rectangular plates with various edge conditions are provided, demonstrating the influence of initial imperfection,geometrical parameters, and edge conditions. It is displayed that an increase in the initial geometric imperfection intensifies the softening-type behavior of system, while no softening behavior can be found in the frequency-amplitude curve of a perfect plate.

关键词： nonlinear dynamical characteristics imperfect functionally graded carbon nanotube-reinforced composite(FG-CNTrC) rectangular plate geometric imperfection sensitivity

A rEVIEW OF HIGH FrEQUENCY THIN FILM FErrOELECTrIC ACOUSTIC rESONATOrS FOr MOBILE PHONE APPLICATIONS

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A REVIEW OF HIGH FREQUENCY THIN FILM FERROELECTRIC ACOUSTIC ...

第8届国际材联电子材料国际研讨会

作者： dr.P.B. Kirby dr.Q.Zhang dr.Z Huang dr.C. Williams Professor r.W. Whatmore Nanotechnology group School of Industrial Manufacturing Sciences Cranfield University Cranfield Bedford MK43 0AL UK Nanotechnology group School of Industrial Manufacturing Sciences Cranfield University Cranfield Bedford MK43 0AL UK Nanotechnology group School of Industrial Manufacturing Sciences Cranfield University Cranfield Bedford MK43 0AL UK Nanotechnology group School of Industrial Manufacturing Sciences Cranfield University Cranfield Bedford MK43 0AL UK Nanotechnology group School of Industrial Manufacturing Sciences Cranfield University Cranfield Bedford MK43 0AL UK

＜正＞ A Thin Film Bulk Acoustic wave resonator （FBAr） is a resonant piezoelectric device, similar to the more familiar bulk acoustic resonators, which typically use thin quartz plates but scaled down in thickness so as to operate at higher frequency. Usually a membrane of thin film piezoelectric material is supported on a silicon structure that is created by silicon micromachining techniques. Combining piezoelectric thin films with micromechanical silicon structures offers a means of producing resonant structures whose impedance varies

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技术对经济发展的推动作用——回顾和展望

高分子通报 1989年第3期 1-8页

作者： dr.r.G.Arnold 管志斌孙燕慧美国杜邦公司高分子产品部北京大学化学系

罗伯特·阿诺德博士是美国杜邦公司高分子部的研究主任,主要负责高分子材料研究的长远规划、研究工作及实验中心的管理。阿诺德博士在工业界工作了近40年时间,在高分研究工作、产品开发等方面积累了丰富的经验。在本文中,作者精辟阐述... 详细信息

罗伯特·阿诺德博士是美国杜邦公司高分子部的研究主任,主要负责高分子材料研究的长远规划、研究工作及实验中心的管理。阿诺德博士在工业界工作了近40年时间,在高分研究工作、产品开发等方面积累了丰富的经验。在本文中,作者精辟阐述了自工业革命以来技术对经济发展的促进作用,分析了材料科学,特别是高分子材料对经济发展的贡献,总结了作为有效技术的必要条件,提供了许多有价值的意见。

关键词：高分子材料

Three Key Variables in China-EU Economic and Trade relations:Strategic Foundation,reciprocity and Institutions

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International Understanding 2012年第1期 14-20页

作者： dr.Zhang Xiaotong Yu Jie Ministry of Commerce, P.r.China.

Following the American Subprime Crisis,the sovereign debt crisis in Europe is another major event that has profound repercussions on the world *** each other's major trading partner,China and the EU have inevitably su... 详细信息

关键词：经贸关系中国欧盟基础机构互惠世界经济贸易伙伴