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血清心肌损伤标志物及炎症因子与新生儿窒息严重程度的相关性

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医学临床研究 2024年第2期41卷 273-275,279页

作者：沈洁张卫星武俊宝新乡市中心医院/新乡医学院第四临床学院新生儿重症监护室河南新乡453000

【目的】探讨血清心肌损伤标志物及炎症因子与新生儿窒息严重程度的相关性。【方法】选择2019年9月至2022年9月在本院出生的120例新生儿窒息患儿(观察组)及50例健康新生儿(对照组)。比较两组研究对象血清心肌损伤标志物[肌钙蛋白I(cTnI... 详细信息

【目的】探讨血清心肌损伤标志物及炎症因子与新生儿窒息严重程度的相关性。【方法】选择2019年9月至2022年9月在本院出生的120例新生儿窒息患儿(观察组)及50例健康新生儿(对照组)。比较两组研究对象血清心肌损伤标志物[肌钙蛋白I(cTnI)、肌酸激酶(CK)及肌酸激酶同工酶(CK-MB)]及炎症因子[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)],并分析血清cTnI、CK、CK-MB、CRP、IL-6、TNF-α水平与新生儿窒息严重程度关系。【结果】观察组患儿血清cTnI、CK、CK-MB、CRP、IL-6、TNF-α水平均高于对照组,差异有统计学意义(P<0.05)。重度窒息组患儿出生第1天及第7天血清cTnI、CK、CK-MB水平高于轻度窒息组(P<0.05),两组出生第7天血清cTnI、CK、CK-MB水平低于出生第1天,差异有统计学意义(P<0.05)。重度窒息组患儿出生第1天及第7天血清CRP、IL-6、TNF-α水平均明显高于轻度窒息组(P<0.05),两组患儿出生第7天血清CRP、IL-6、TNF-α水平低于出生第1天,差异有统计学意义(P<0.05)。Spearman相关性分析显示,血清cTnI、CK、CK-MB、CRP、IL-6、TNF-α水平与新生儿窒息严重程度均呈正相关(均P<0.05)。【结论】新生儿窒息患儿的心肌损伤标志物及炎症因子水平异常升高,且心肌损伤标志物及炎症因子水平与新生儿窒息严重程度呈正相关。

关键词：新生儿窒息肌钙蛋白/血液肌酸激酶,MB型/血液炎症趋化因子类/血液

Microstructure and nano-mechanical property of cold spray Co-base refractory alloy coating

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 190-194页

作者： Vongli LIANG Bi SHI Xiaoping YANG junbao zhang Xianming MENG Advanced Technology Institute Baosteel Technology Center Baoshan Iron & Steel Co. Shanghai 201900 China School of Materials Science and Engineering Dalian University of Technology Dalian 116024 China

Co-base refractory alloy coating was prepared on carbon steel substrate by cold spray technology; microstructure and nano-mechenieal property were examined by scanning electron microscope （SEM） and nano indenter individually. The results showed that about 250 μm Co-base refractory alloy coating could be deposited o11 steel substrate by cold spray technique, interface between coating and substrate was combined well, and the refractory alloy particle had a significant plastic deformation during deposition process; mixing Ni powders into Co-base refractory alloy powders could increase the density and decrease the nano-hardness of coating, the nano-hardness and elastic modulus of refractory alloy coating was higher than 6 GPa and 160 GPa, respectively.

关键词： Cold spray Co-base refractory alloy Microstructure Nano-mechanical property

Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury

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Neural Regeneration Research 2012年第24期7卷 1866-1872页

作者： Haomei Tian Hong zhang junbao Zhu Juan zhang Hening Cai Yuchen zhang Chutao Chen Key Laboratory of Meridians and Viscera Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Liuzhou Hospital of Traditional Chinese Medicine Liuzhou 545001Guangxi Zhuang Autonomous RegionChina Ningxiang Hospital of Traditional Chinese Medicine Ningxiang 410600Hunan ProvinceChina Postgraduate College Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina Laboratory of Acupuncture Bioinformatics Hunan University of Traditional Chinese MedicineChangsha 410007Hunan ProvinceChina

A middle cerebral artery occlusion-model was established in rats using the improved thread embolism *** were treated with acupuncture at either Dazhui（DU14）,Renzhong（DU26）, Baihui（DU20）,or a non-meridian *** with protein-chip technology showed that the level of protein phosphorylation in both groups was upregulated or downregulated depending on the signaling pathway compared with the model group that did not receive *** of proteins showing downregulated phosphorylation revealed that five signaling pathways were activated in the acupuncture-treatment group,while only two were activated in the acupuncture-control *** contrast,analysis of proteins showing upregulated phosphorylation revealed only one pathway was activated in the acupuncture-treatment group,whereas four pathways were activated in the acupuncture-control ***,the number of activated proteins in the acupuncture-treatment group was not only higher than the acupuncture-control group,but unlike the acupuncture-control group,the majority of activated proteins were key proteins in the signaling *** findings indicate that acupuncture at specific points can activate multiple signaling pathways to promote the restoration of brain tissue following ischemic injury,and that this is based on a combination of effects resulting from multiple pathways,targets,and means.

关键词： acupuncture cerebral ischemia Dazhui Baihui Renzhong protein-chip technology signal-transduction pathways nerve injury brain injury ischemic injury neural regeneration

Progress in bionic information processing techniques for an electronic nose based on olfactory models

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Chinese Science Bulletin 2009年第4期54卷 521-534页

作者： LI Guang FU Jun zhang Jia ZHENG junbao State Key Laboratory of Industrial Control Technology Zhejiang University Hangzhou 310027 China Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China Sir Run Run Shaw Hospital Affiliated with the School of Medicine Zhejiang University Hangzhou 310016 China Faculty of Informatics and Electronics Zhejiang Sci-Tech University Hangzhou 310018 China

As a novel bionic analytical technique, an electronic nose, inspired by the mechanism of the biological olfactory system and integrated with modern sensing technology, electronic technology and pattern recognition technology, has been widely used in many areas. Moreover, recent basic research findings in biological olfaction combined with computational neuroscience promote its development both in methodology and application. In this review, the basic information processing principle of biological olfaction and artificial olfaction are summarized and compared, and four olfactory models and their applications to electronic noses are presented. Finally, a chaotic olfactory neural network is detailed and the utilization of several biologically oriented learning rules and its spatiotemporal dynamic propties for electronic noses are discussed. The integration of various phenomena and their mechanisms for biological olfaction into an electronic nose context for information processing will not only make them more bionic, but also perform better than conventional methods. However, many problems still remain, which should be solved by further cooperation between theorists and engineers.

关键词：电子鼻子嗅觉系统嗅觉模型图像识别仿生学

不同防护措施对早熟朱柿抽条的防护效果及其生理机制

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干旱地区农业研究 2024年第4期42卷 62-69页

作者：刘格格侯锐王宁宁黄军保张拥兵王林吕英忠山西农业大学林学院山西太谷030801 山西农业大学果树研究所山西太谷030801

选取定植1 a的早熟朱柿幼树为研究对象,设置树干缠防寒布+反光膜、树干培土、树干涂白、树干缠防寒布、枝条喷涂水果保鲜剂、枝条喷涂高脂膜、枝条喷涂石蜡乳化剂共7个防抽条处理,测定不同处理的抽条率以及一年生枝的水分状况、细胞活... 详细信息

选取定植1 a的早熟朱柿幼树为研究对象,设置树干缠防寒布+反光膜、树干培土、树干涂白、树干缠防寒布、枝条喷涂水果保鲜剂、枝条喷涂高脂膜、枝条喷涂石蜡乳化剂共7个防抽条处理,测定不同处理的抽条率以及一年生枝的水分状况、细胞活力和非结构性碳水化合物(NSC)含量。结果表明:防寒布+反光膜处理和培土处理抽条率为0,水果保鲜剂、高脂膜、石蜡乳化剂处理抽条率介于30%~60%之间,涂白、防寒布处理及对照的抽条率为100%。石蜡乳化剂、防寒布+反光膜处理和培土处理的凌晨水势显著高于水果保鲜剂处理和高脂膜处理(P<0.05),两组差值为0.5 MPa左右。培土处理的枝条导水损失率(PLC)较水果保鲜剂处理和高脂膜处理显著降低,分别降低10.95%和11.24%(P<0.05);韧皮部细胞活力显著高于其他处理,增幅为13.53%~34.87%(P<0.05)。培土处理的韧皮部可溶性糖含量、淀粉含量和NSC含量显著高于其他处理,分别提高13.79%~28.80%、9.15%~39.65%和14.87%~29.61%(P<0.05),培土处理的木质部可溶性糖含量、淀粉含量和NSC含量显著高于其他处理,分别提高20.59%~35.27%、14.19%~37.90%和17.40%~37.00%(P<0.05)。相关性分析结果表明,不同防抽条技术措施下的抽条率与枝条PLC呈显著正相关关系(P<0.05),与枝条凌晨水势、木质部相对含水量、韧皮部细胞活力、木质部淀粉含量、木质部NSC含量呈显著负相关关系(P<0.05)。可见,防寒布+反光膜处理和培土处理对柿树冬春季抽条有较好的防护效果,能维持枝条水分状况和韧皮部细胞活力,并促进NSC向枝条运输。

关键词：柿树防抽条措施抽条率水分状况细胞活力非结构性碳水化合物含量

三代核电反应堆压力容器低合金钢焊缝性能对比分析

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压力容器 2024年第2期41卷 1-6页

作者：梅乐张俊宝王永东黄逸峰王秉熙郑明光上海核工程研究设计院股份有限公司上海200233

通过模拟国内三代核电压水堆反应堆压力容器环焊缝,分别采用国产焊接材料和进口焊接材料,在焊接工艺性能、焊缝金属化学成分、拉伸、冲击韧性、落锤和低周疲劳试验等方面进行了对比分析。结果表明,国产和进口焊接材料的焊接工艺性能和... 详细信息

通过模拟国内三代核电压水堆反应堆压力容器环焊缝,分别采用国产焊接材料和进口焊接材料,在焊接工艺性能、焊缝金属化学成分、拉伸、冲击韧性、落锤和低周疲劳试验等方面进行了对比分析。结果表明,国产和进口焊接材料的焊接工艺性能和焊缝金属力学性能均相当;焊接试件不同厚度取样位置的焊缝金属-28.3℃冲击吸收能量平均值都大于90 J,有较大的设计裕量。该国产焊接材料已应用于国内某三代核电机组反应堆压力容器,为进一步推广应用提供技术支撑。

关键词：反应堆压力容器 SA-508 Gr.3 Cl.1钢国产焊材焊缝性能

老年自发性脑出血病人早期神经功能恶化的危险因素研究

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实用老年医学 2024年第6期38卷 568-571页

作者：张要田周勇王军宝马昌宝淮安市中医院脑外科江苏省淮安市223000

目的探讨老年自发性脑出血(SICH)病人早期神经功能恶化(END)的危险因素。方法回顾性分析2019年1月至2022年9月本院收治的100例老年SICH病人的临床资料,根据NIHSS评估结果分为非END组(n=60)与END组(n=40)。比较2组一般资料及实验室指标Hc... 详细信息

目的探讨老年自发性脑出血(SICH)病人早期神经功能恶化(END)的危险因素。方法回顾性分析2019年1月至2022年9月本院收治的100例老年SICH病人的临床资料,根据NIHSS评估结果分为非END组(n=60)与END组(n=40)。比较2组一般资料及实验室指标Hcy、CRP水平,采用多因素Logistic回归分析各指标与END的相关性。结果100例SICH病人中END发生率为40.00%(40/100)。非END组高血压、出血破入脑室占比以及血肿体积、CRP、Hcy水平低于END组(P<0.05)。多因素Logistic回归分析结果显示,高血压、血肿体积、出血破入脑室、CRP、Hcy是老年SICH病人发生END的危险因素(P<0.05)。结论老年SICH病人发生END受较多因素影响,当血肿体积、CRP、Hcy增高时,需注意END的发生。

关键词：自发性脑出血早期神经功能恶化同型半胱氨酸 C反应蛋白

EAOdr.id: Andr.id Malware Detection Based on Enhanced API Order

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Chinese Journal of Electronics 2023年第5期32卷 1169-1178页

作者： HUANG Lu XUE Jingfeng WANG Yong QU Dacheng CHEN junbao zhang Nan zhang Li School of Computer Science and Technology Beijing Institute of Technology Department of Media Engineering Communication University of Zhejiang

The development of smart mobile devices brings convenience to people’s lives, but also provides a breeding ground for Andr.id malware. The sharp increasing malware poses a disastrous threat to personal privacy in the information age. Based on the fact that malware heavily resorts to system application programming interfaces(APIs) to perform its malicious actions,there has been a variety of API-based detection *** of them do not consider the relationship between APIs. We contribute a new approach based on the enhanced API order for Andr.id malware detection, named EAOdr.id, which learns the similarity of system APIs from a large number of API sequences and groups similar APIs into clusters. The extracted API clusters are further used to enhance the original API calls executed by an app to characterize behaviors and perform classification. We perform multi-dimensional experiments to evaluate EAOdr.id on three datasets with ground truth. We compare with many state-of-the-art works, showing that EAOdr.id achieves effective performance in Andr.id malware detection.

关键词： Performance evaluation Privacy Programming Information age Malware Mobile handsets Behavioral sciences

Ferroelastic domain identification and toughening mechanism for yttrium tantalate–zirconium oxide

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Journal of Materials Science & Technology 2022年第32期127卷 78-88页

作者： Cheng Luo Cong Li Ke Cao junbao Li Junhui Luo Qinghua zhang QianQian Zhou Fan zhang Lin Gu Li Yang Yichun Zhou School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710126China Frontier Research Center of Thin Films and Coatings for Device Applications Academy of Advanced Interdisciplinary ResearchXidian UniversityXi’an 710126China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China College of Engineering BIC-ESATPeking UniversityBeijing 100871China

Yttrium tantalate(YTaO_(4))is the next generation of higher service temperature thermal barrier coatings(TBCs)materials due to its smaller volume effect in phase change,lower thermal conductivity and unique ferroelastic domain ***,the low fracture toughness limits its *** first characterized the diffraction patterns of variants,and two variants(M_(1)and M_(2))observed in transmission electron microscopy(TEM)results were determined from four possible variants by mechanical *** role of Zr^(4+)doping in ferroelastic toughening was explained in *** the increase of Zr^(4+)doping concentration,the monoclinic angle β and the domain rotation angleαdecrease,*** spontaneous strain component and the principal strain in the main space also have a similar decreasing *** decrease of the ferroelastic domain inversion energy barrier is beneficial to the improvement of fracture *** the results of Vickers indentation,we found that Zr^(4+)could be enriched at the domain boundary to inhibit the generation of *** appropriate amount of Zr^(4+)is conducive to the improvement of fracture toughness,and the excessive Zr^(4+)will reduce the fracture toughness due to the generation of by-product t-ZrO_(2).So,the optimal composition is Y_(0.44)Ta_(0.44)Zr_(0.12)O_(2) and the best fracture toughness(2.9–3.8MPa m^(1/2))is equivalent to the commercial *** result will promote the application of a new generation of TBCs.

关键词： Ferroelastic domain Variants Domain switch TBCs Fracture toughness