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Congenital Left Mesenteric-Parietal Hernia Associated to a Small Bowel Volvulus: About a Case

Open Journal of Pediatrics 2020年第3期10卷 404-410页

作者： Coulibaly Yacaria doumbia aliou Amadou Issa Coulibaly Oumar Moussa Kamaté Benoi Djiré Mohamed Kassoum Tanapo Kalifa Service of Pediatric Surgery Teaching Hospital Gabriel Toure Bamako Mali

Introduction: The left mesenterico-parietal hernia or left paraduodenal hernia is an anomaly of intestinal rotation which may be responsible for intestinal obstruction. It is rare. Observation: A 5-year-old boy was admitted for abdominal pain with episodes of vomiting and cessation of matters and gases. After clinical and paraclinical investigations, the diagnosis of occlusion was accepted and the child was operated. Exploration revealed a mesenterico-parietal hernia with a retrocolic sac measuring 11 cm of collar and a deep of 18 cm containing a twisted bowel. After reduction of the content, we untwisted the small intestine and released adhesions. The hernial sac was partially resected and the defect was closed. Operating outcomes were simple. Conclusion: The mesenterico-parietal hernia is a cause of organic intestinal obstruction. Although of congenital origin, it can have a late clinical manifestation. It should be considered in case of episodes of repetitive abdominal pain and vomiting to avoid complications.

关键词： Mesenterico-Parietal Hernia Small Bowel Volvulus Child Mali

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Factors of Nephroblastomas’ Relapse in Children at the Academic Hospital Gabriel Toure, Bamako, Mali

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Open Journal of Pediatrics 2020年第1期10卷 131-136页

作者： Djénèba Konaté Coulibaly Yacaria doumbia Abdoul Karim doumbia aliou Amadou Issa Oumar M. Coulibaly Traoré Fousseyni K. Traoré Kamaté Bénoi Djiré Mamadou Kassoum Coulibaly Youssouf Traoré Abdramane Togo Pierre Koné Oumou Togo Boubacar Service of Pediatrics Teaching Hospital Gabriel Touré Bamako Mali Service of Pediatric Surgery Teaching Hospital Gabriel Touré Bamako Mali National Public Health Research Institute Bamako Mali

Introduction:?The factors of nephroblastomas’ relapse are a set of elements playing a role in the reappearance of cancer cells in the same place of the kidney or in other regions of the body after a 5-year remission.?Objectives:?To determine the frequency and the factors of nephroblastomas’ relapse in the pediatric oncology unit and pediatric surgery of the academic hospital Gabriel Touré. Materials and methods:?This was a retrospective study carried out from January 1, 2005 to December 31, 2019 in all children treated for nephroblastoma relapses in the pediatric oncology unit and in the pediatric surgery service.?Results:?In 15 years, we have managed 182 cases of nephroblastoma, of which 128 cases were declared in complete remission after 5 years and 12 cases presented a recurrence. The relapses factors were: capsular break, intraoperative tumor rupture, presence of an associated malformation, surgery without neoadjuvant chemotherapy and tumor surgical stage (p??0.05). Patients’ age at diagnosis, sex, number of neoadjuvant and adjuvant chemotherapy sessions and histological type were not decisive (p?> 0.05).?Conclusion:?Relapses are more and more frequent in cases of nephroblastoma. The correct use of the protocol would avoid these recurrences.

关键词： Nephroblastoma Relapse Factors Children Mali

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Mutations in Spike Gene of SARS-CoV-2 that Are Associated with a Higher Viral Load: A Clinical Case Study

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Case Reports in Clinical Medicine 2022年第11期11卷 474-486页

作者： Ibrahim Keita Garan Dabo Lassina doumbia Youssouf Diarra Ibrahim Traoré Mariam Traoré Lansana Sangaré Yacouba Toloba Mahamadou Alpha Diallo Djeneba Sy Andres H. Gutierrez aliou Sissako Ibrahim Guindo Mohamed Diallo Akory Ag Iknane Anne S. De Groot Ousmane aliou Koita Laboratoire de Biologie Moléculaire Appliquée Université des Sciences Techniques et des Technologies de Bamako Bamako Mali Hô pital du Mali Ministère de la Santé Publique et du Développement Social Bamako Mali Centre Hospitalo-Universitaire du Point G Ministère de la Santé Publique et du Développement Social Bamako Mali EpiVax Inc. Providence USA Institut National de Santé Publique Ministère de la Santé Publique et du Développement Social Bamako Mali Center for Vaccines and Immunology College of Veterinary Medicine University of Georgia Athens USA

Background: Quantitative PCR (qPCR) can be used to detect and quantify a load of a pathogen. It is a good indicator of the degree of transmissibility. While performing routine qPCR, we observed an unusually short cycle threshold (Ct) value of SARS-CoV-2 for a clinical specimen obtained in Bamako, Mali. This prompted us to sequence the short-cycle SARS-CoV-2 sample to identify potential mutations in the Spike gene (S gene) gene. Methods: Post-infection, Quantitative Reverse Transcription (qRT-PCR) was performed over a defined time course to estimate the Ct of the SARS-CoV-2 specimen collected from the patient. Sanger sequencing was done on the entire fragment of the S gene to identify mutations. Findings: Sanger sequencing revealed mutations in the lineage of interest, designated B.1.525 by Pango, and also known as “Eta” using the nomenclature defined by WHO. This variant was originally found in Nigeria and Italy. The four novel mutations identified in Eta (D228N, Y451N, I1172M, and C1250F) were otherwise observed with a low frequency worldwide. Although the initial Ct was 10 in the case study patient, he did not exhibit severe symptoms of SARS-CoV-2, for example, pneumonia. However, we observed a longer viral clearance period than usual, of 3 weeks. We note that as compared to SARS-CoV-2 samples obtained during the first peaks of SARS-CoV-2 infection in Mali, when the infection was at its peak in March 2020 (Ct = 30.4), circulating strains evaluated at the time the Eta sample was obtained demonstrated a lower mean Ct (Ct = 24). Conclusions: The short cycle threshold associated with this variant, and the temporal association with a decrease in the mean Ct in the region of Bamako, may indicate higher levels of transmissibility due to a circulating variant. This variant is a lineage of interest designated B.1.525 by Pango or Eta by WHO.

关键词： SARS-CoV-2 Variant Eta Ct Value Mali

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Development of a data collection and management system in West Africa:challenges and sustainability

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Infectious Diseases of Poverty 2018年第1期7卷 1300-1313页

作者： Jeffrey G.Shaffer Seydou O.doumbia Daouda Ndiaye Ayouba Diarra Jules F.Gomis Davis Nwakanma Ismaela Abubakar Abdullahi Ahmad Muna Affara Mary Lukowski Clarissa Valim James C.Welty Frances J.Mather Joseph Keating Donald J.Krogstad Departments of Biostatistics(1440 Canal St. Suite 1610)and Tropical Medicine(#83171430 Tulane AvenueJ.B.Johnston BuildingRoom 510)New OrleansLA 70112-2699USA University of the Sciences Techniques and Technologies of BamakoBamakoMali University Cheikh Anta Diop DakarSenegal Medical Research Council Unit FajaraThe Gambia ScienceTRAX LLC MaconGAUSA Harvard T.H.Chan School of Public Health BostonMAUSA

Background:Developing and sustaining a data collection and management system(DCMS)is difficult in malariaendemic countries because of limitations in internet bandwidth,computer resources and numbers of trained *** premise of this paper is that development of a DCMS in West Africa was a critically important outcome of the West African International Centers of Excellence for Malaria *** purposes of this paper are to make that information available to other investigators and to encourage the linkage of DCMSs to international research and Ministry of Health data systems and ***:We designed and implemented a DCMS to link study sites in Mali,Senegal and The *** system was based on case report forms for epidemiologic,entomologic,clinical and laboratory aspects of plasmodial infection and malarial disease for a longitudinal cohort study and included on-site training for Principal Investigators and Data *** on this experience,we propose guidelines for the design and sustainability of DCMSs in environments with limited resources and ***:From 2012 to 2017,we performed biannual thick smear surveys for plasmodial infection,mosquito collections for anopheline biting rates and sporozoite rates and year-round passive case detection for malarial disease in four longitudinal cohorts with 7708 individuals and 918 households in Senegal,The Gambia and *** challenges included the development of uniform definitions and reporting,assessment of data entry error rates,unstable and limited internet access and software and technology *** included entomologic collections linked to longitudinal cohort studies,on-site data centres and a cloud-based data ***:At a time when research on diseases of poverty in low and middle-income countries is a global priority,the resources available to ensure accurate data collection and the electronic availability of those data remain severely limited.

关键词： Data collection Data(database)management system Diseases of poverty Malaria Plasmodium falciparum

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