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Maternal hyperthyroidism increases the synthesis activity and the osteogenic markers expression of calvarial osteoblasts from offspring in a murine model

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BIOCELL 2023年第2期47卷 423-430页

作者： FABIANA ROCHA ARAÚJO BRUNO MACHADO BERTASSOLI ISABELLA CRISTINA SOUZA FÉLIX douglas MARINHO ABREU NATÁLIA MELO OCARINO AMANDA MARIA SENA REIS JUNEO FREITAS SILVA ROGÉRIA SERAKIDES Núcleo de Células Tronco e Terapia Celular Animal(NCT-TCA) Veterinay SchoolUniversidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil Universidade de Uberaba(UNIUBE) UberabaMinas Gerais38065-300Brasil Instituto de Ciências Biológicas Universidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil Universidade Estadual de Santa Cruz Campus Soane Nazare de AndradeIlheusBahiaBrasil

To evaluate the characteristics and synthesis activity of osteoblasts extracted from the calvaria of offspring of rats exposed to maternal *** adult Wistar rats were divided into two groups,one control and one treated with daily administration of L-thyroxine by an orogastric tube(50μg/animal/day)during *** days after delivery and confirmation of the mothers’hyperthyroidism,the offspring were euthanized for the extraction of osteoblasts from the *** 7,14,and 21 days,proliferation activity was assessed using MTT assay,while alkaline phosphatase(ALP)activity was assessed by the BCIP/NBT *** 21 days,the total area of the mineralized matrix stained by von Kossa was evaluated by *** expression of gene transcripts for Runx2,Bmp2,Fgfr1,collagen type 1(Col1),osteocalcin(Oc),and osteopontin(op)were evaluated by real-time *** were compared using the Student’s *** activity was significantly higher at 14 and 21 days in cultures of osteoblasts extracted from offspring exposed to maternal hyperthyroidism,while MTT conversion was significantly lower at 21 days in this *** cultures of neonates exposed to maternal hyperthyroidism also showed a larger total area of mineralized matrix and greater expression of gene transcripts for Oc and *** hyperthyroidism increases the activity of matrix synthesis,alkaline phosphatase activity,and expression of gene transcripts for osteocalcin and osteopontin in the osteoblasts,extracted from the calvaria of the offspring,which may be one of the mechanisms of premature fusion of cranial sutures.

关键词： Craniosynostosis Intramembranous growth Ossification Rat Thyroid dysfunction

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Is clinically measured knee range of motion after total knee arthroplasty‘good enough?’:A feasibility study using wearable inertial measurement units to compare knee range of motion captured during physical therapy versus at home

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Medicine in Novel Technology and Devices 2021年第3期11卷 195-204页

作者： Ryan M.Chapman Wayne E.Moschetti douglas W.Van Citters Dartmouth College Thayer School of Engineering14 Engineering DriveHanoverNH03755USA Dartmouth Hitchcock Medical Center Department of Orthopaedics1 Medical Center DriveLebanonNH03766USA University of Rhode Island Department of Kinesiology25 W Indendence WayKingstonRI02881USA

Total knee arthroplasty is highly successful,in part due to range of motion(RoM)*** is typically estimated goniometrically/visually by physical therapists(PTs)in the clinic,which is ***,a validated inertial measurement unit(IMU)method for capturing knee RoM was deployed assessing postoperative RoM both in and outside of the clinical *** study's objectives were to evaluate the feasibility of continuously capturing knee RoM pre-/post-op via IMUs,dividing data into PT/non-PT portions of each day,and comparing PT/non-PT *** hypothesized IMU-based clinical knee RoM would differ from IMU-based knee RoM captured outside clinical settings.10 patients(3 M,69±13 years)completed informed consent documents following ethics board approval.A validated IMU method captured long duration(8–12 h/day,~50 days)knee RoM pre-/***-op metrics were subdivided(PT versus non-PT).Clinical RoM and patient reported outcome measures were also *** and clinical disruption were *** compared post-op PT and non-PT means and change *** flexion during PT was less than outside *** stance/swing RoM and activity level were greater than outside *** temporal variable differences were found PT versus *** RoM measurements capture richer information than clinical *** PT flexion was likely less than non-PT due to the exercises completed(*** passive RoM *** RoM gait).PT gait flexion likely exceed non-PT because of‘white coat effects’wherein patients are closely monitored *** implies data captured clinically represents optimum performance whereas data captured non-clinically represents realistic performance.

关键词： Knee replacement Postoperative rehabilitation Wearable Inertial measurement unit Total joint arthroplasty Range of motion

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