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Breast cancer resistance protein(BCRP/ABCG2):its role in multidrug resistance and regulation of its gene expression

Chinese Journal of Cancer 2012年第2期31卷 73-99页

作者： Takeo Nakanishi douglas D.Ross Department of Membrane Transport and Biopharmaceutics Kanazawa University School of Pharmaceutical SciencesKanazawa 920-1192Japan University of Maryland Greenebaum Cancer Center the Departments of Medicine Pathology and Pharmacology and Experimental TherapeuticsUniversity of Maryland School of Medicineand the Baltimore VA Medical CenterBaltimoreMaryland 21201USA

Breast cancer resistance protein(BCRP)/ATP-binding cassette subfamily G member 2(ABCG2) is an ATP-binding cassette(ABC) transporter identified as a molecular cause of multidrug resistance(MDR) in diverse cancer *** physiologically functions as a part of a self-defense mechanism for the organism;it enhances elimination of toxic xenobiotic substances and harmful agents in the gut and biliary tract,as well as through the blood-brain,placental,and possibly blood-testis *** recognizes and transports numerous anticancer drugs including conventional chemotherapeutic and targeted small therapeutic molecules relatively new in clinical ***,BCRP expression in cancer cells directly causes MDR by active efflux of anticancer *** BCRP is also known to be a stem cell marker,its expression in cancer cells could be a manifestation of metabolic and signaling pathways that confer multiple mechanisms of drug resistance,self-renewal(stemness),and invasiveness(aggressiveness),and thereby impart a poor ***,blocking BCRP-mediated active efflux may provide a therapeutic benefit for *** the precise molecular mechanisms for BCRP gene expression may lead to identification of a novel molecular target to modulate BCRP-mediated *** evidence suggests that BCRP gene transcription is regulated by a number of trans-acting elements including hypoxia inducible factor 1α,estrogen receptor,and peroxisome proliferator-activated ***,alternative promoter usage,demethylation of the BCRP promoter,and histone modification are likely associated with drug-induced BCRP overexpression in cancer ***,PI3K/AKT signaling may play a critical role in modulating BCRP function under a variety of *** biological events seem involved in a complicated *** the events would be an essential first step to developing a method to modulate BCRP function to aid patients with *** review will present a sy

关键词：多重耐药性基因表达调控组蛋白修饰乳腺癌过氧化物酶体增殖物激活受体分子机制多药耐药肿瘤细胞

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Unconformity structures controlling stratigraphic reservoirs in the north-west margin of Junggar basin, North-west China

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Frontiers of Earth Science 2013年第1期7卷 55-64页

作者： Kongyou WU douglas PATON Ming ZHA School of Geoscience China University of Petroleum Qingdao 266555 China School of Earth and Environment University of Leeds Leeds LS2 9JT UK

Tectonic movements formed several unconfor- mities in the north-west margin of the Junggar basin. Based on data of outcrop, core, and samples, the unconformity is a structural body whose formation associates with weath- ering, leaching, and onlap. At the same time, the structural body may be divided into three layers, including upper layer, mid layer, and lower layer. The upper layer with good primary porosity serves as the hydrocarbon migration system, and also accumulates the hydrocarbon. The mid layer with compactness and ductility can play a role as cap rock, the strength of which increases with depth. The lower layer with good secondary porosity due to weathering and leaching can form the stratigraphic truncation traps. A typical stratigraphie reservoir lying in the unconformity between the Jurassic and Triassic in the north-west margin of the Junggar basin was meticulously analyzed in order to reveal the key controlling factors. The results showed that the hydrocarbon distribution in the stratigraphic onlap reservoirs was controlled by the onlap line, the hydro- carbon distribution in the stratigraphic truncation reser- voirs was confined by the truncation line, and the mid layer acted as the key sealing rock. So a conclusion was drawn that ＂two lines （onlap line and truncation line） and a body （unconformity structural body）＂ control the formation and distribution of stratigraphic reservoirs.

关键词： unconformity structural body stratigraphicreservoir key controlling factors Jurassic bottom north-west margin of the Junggar basin

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Texture-based latent space disentanglement for enhancement of a training dataset for ANN-based classification of fruit and vegetables

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Information Processing in Agriculture 2023年第1期10卷 85-105页

作者： Khurram Hameed douglas Chai Alexander Rassau School of Engineering Edith Cowan University270 Joondalup DriveJoondalup WA 6027PerthAustralia

The capability of Convolutional Neural Networks(CNNs)for sparse representation has significant application to complex tasks like Representation Learning(RL).However,labelled datasets of sufficient size for learning this representation are not easily *** unsupervised learning capability of Variational Autoencoders(VAEs)and Generative Adversarial Networks(GANs)provide a promising solution to this issue through their capacity to learn representations for novel data samples and classification *** this research,a texture-based latent space disentanglement technique is proposed to enhance learning of representations for novel data samples.A comparison is performed among different VAEs and GANs with the proposed approach for synthesis of new data *** different VAE architectures are considered,a single layer dense VAE and a convolution based VAE,to compare the effectiveness of different architectures for learning of the *** GANs are selected based on the distance metric for disjoint distribution divergence estimation of complex representation learning *** proposed texture-based disentanglement has been shown to provide a significant improvement for disentangling the process of representation learning by conditioning the random noise and synthesising texture rich images of fruit and vegetables。

关键词： Information Maximisation(IM) Fruit and vegetables classification Representation Learning(RL) Variational Autoencoder(VAE) Generative Adversarial Network (GAN) Latent space disentanglement

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Heading control strategy assessment for coaxial compound helicopters

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Chinese Journal of Aeronautics 2019年第9期32卷 2037-2046页

作者： Ye YUAN douglas THOMSON Renliang CHEN Richard DUNLOP National Key Laboratory of Rotorcraft Aeromechanics Nanjing University of Aeronautics&AstronauticsNanjing 210016China University of Glasgow Glasgow G12 8QQUnited Kingdom

The coaxial compound helicopter has two possible strategies for heading control: collective differential and rudder deflection. A flight dynamics model is developed to assess the effect of different heading control strategies. This includes the trim characteristics, steady flight performance,controllability, and manoeuvrability. The trim study demonstrates that heading control strategies are less influential on trim results, and the steady flight performance is also not significantly affected by the heading control strategy adopted. The controllability analysis shows although heading bandwidth and phase delay results at various speeds with different heading control strategies are all satisfied, the control derivative of the collective differential decreases as speed increases, and its heading aggressive agility is degraded into Level 3 in high-speed flight. In addition, using collective differential would lead to severe heading-rolling coupling as forward speed increases. On the contrary, the control derivative and aggressive agility of the rudder deflection is improved with forward speed, and there is no evidence of heading-rolling coupling. Finally, the transient turn MissionTask-Element(MTE) is utilized to investigate the heading manoeuvre characteristics in different heading control strategies, which indicates that the collective differential would add the amplitude of control input and the power consumption during this MTE.

关键词： Coaxial compound helicopter Control strategy Handling qualities Helicopter flight dynamics Helicopter performance

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Indian medicinal plants are effective in the treatment and management of COVID-19

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BIOCELL 2023年第4期47卷 677-695页

作者： SUBHASH CHANDRA SANTWANA PALAI EDINARDO FAGNER ferreira-MATIAS IVO CAVALCANTE PITA-NETO CÍCERO LUCAS GOMES-RAMALHO EDLANE MARTINS DE ANDRADE RAY SILVA DE ALMEIDA MARCELLO IRITI HENRIQUE douglas MELO-COUTINHO Department of Pharmaceutical Chemistry SGRR UniversityUttarakhand248001India Department of Pharmaceutical Chemistry HNB Garhwal UniversitySrinagar246174India Department of Veterinary Pharmacology&Toxicology College of Veterinary Science and Animal HusbandryBhubaneswar751003India CECAPE—College of Dentistry Juazeiro do Norte63050-203Brazil Department of Biological Chemistry Regional University of CaririCrato63105-000Brazil Department of Biomedical Surgical and Dental SciencesUniversitàdegli Studi di MilanoMilan20133Italy National Interuniversity Consortium of Materials Science and Technology Florence50121Italy

Indian medicinal plants are referred to as the“nectar of life”owing to their phytochemicals and bioactive complexes that are beneficial in treating *** disease 2019(COVID-19)is a global health issue without any proper *** indigenous plants of India can be exploited to control the precise signs of *** Ministry of AYUSH(Ayurveda,Yoga and Naturopathy,Unani,Siddha,and Homeopathy)has advised routine usage of medicinal plants for *** plants like Zingiber officinalis,Azadirachta indica,Ocimum sanctum,Nigella sativa,Withania somnifera,Curcuma longa,Piper nigrum,Allium sativum,Tinospora cordifolia,*** immunity-boosting,antiviral,antibacterial,antioxidant and anti-inflammatory actions that can suppress and treat symptoms of *** vitro,in vivo as well as in silico validation,these phytochemicals can help us to manage and treat COVID-19 *** integration of traditional knowledge in the prophylaxis of corona infection and current skills validating it for the development of precise and powerful therapeutic approaches will more efficiently resolve different clinical aspects of *** review focuses on both traditional and emergent methods to prevent and treat COVID-19 with various Indian medicinal plants along with their phytochemicals.

关键词： Antiviral Corona virus Diagnosis Immunity Herbs

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Honour and Kingship in Herodotus: Status, Role, and the Limits of Self-Assertion

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Frontiers of Philosophy in China 2019年第1期14卷 75-93页

作者： douglas Cairns Department of Classics University of Edinburgh EH8 9AG Scotland UK

The notion of time(Tiμη, normally translated "honour") is a key concept when it comes to thinking about virtues, roles, and duties in ancient Greek ethics and society, both in popular and in philosophical terms. This discussion concentrates on the work of the fifth-century historian, Herodotus, where the idea of time as the fulfilment of a specific role in society takes on particular and interesting inflections. In Herodotus, as in Greek generally, time covers both the esteem that one receives from others and the claim to esteem that the individual him- or herself brings to bear in social interaction. Thus time is both "deference" and "demeanour"(to use Goflman's terminology). As a quality of an individual that commands others' respect, time also encompasses the roles that are bound up with one's status. Roles and offices express, attract, and demand time, but such demands are normally constrained by reciprocal respect for the time of others. The office of the Persian king, however, appears at first sight to involve unconditional claims to recognition respect, powerful drives towards appraisal respect (in DarwalPs terminology), and only limited acknowledgement of either ethical norms or others claims as potential limitations to regal self-assertion. Closer inspection, however, reveals that the values of mutual respect that underpin the freedom enjoyed by citizens of Greek poleis are also felt by Herodotus to ground claims to freedom and in dependence on the part of those poleis themselves, claims that the historian9s narrative suggests are ultimately upheld by the gods and embedded in the structure of the cosmos itself.

关键词： Herodotus honour time Persian wars Xerxes

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Donald Trump, Globalization, and Modernity

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Fudan Journal of the Humanities and Social Sciences 2018年第3期11卷 265-284页

作者： douglas Kellner UCLA Los Angeles CA USA

The election of Donald Trump can be partially understood in the context of the rise of authoritarian populist, nationalist, and anti-globalist movements throughout the world. Unlike previous American presidents in the modern era, however, Donald Trump had no previous political experience and emerged from media culture and the business world, rather than the world of party politics. In this paper, I will focus on the assault on globalization in the Trump campaign, look at his administration and actions as president, and raise questions concerning whether or not he has betrayed his anti-globalist followers and is pursing business-as-usual for global, corporate capitalism---or something else. This investigation also leads us into engaging the Trump campaign/administration connections with Russia and the role of Russia and global computer networks in Election 2016, making Election 2016 the first US election deeply shaped by global political forces and the Interuet, new media, and social networking.

关键词： Donald Trump Authoritarian populism US presidentialelection Globalization Modernity

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Donald *** memoir—exceptional seismologist,teacher,mentor,friend

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Earthquake Science 2022年第1期35卷 26-28页

作者： douglas Dreger University of California BerkeleyCA 94720USA

Donald *** was an unparalleled observational seismologist,and *** pioneering work in seismic waveform modeling,and the numerical methods he developed to simulate seismograms to study the structure of the Earth and the... 详细信息

关键词： seism earthquake Earth

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The paternal epigenome and embryogenesis： poising mechanisms for development

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Asian Journal of Andrology 2011年第1期13卷 76-80页

作者： Timothy G Jenkins douglas T Carrell Andrology and IVF Laboratories Department of Surgery University of Utah Salt Lake City UT 84108 USA Department of Obstetrics and Gynecology University of Utah School of Medicine Salt Lake City UT 84108 USA Department of Physiology University of Utah School of Medicine Salt Lake City UT 84108 USA

The scope of paternal contributions during early embryonic development has long been considered limited. Dramatic changes in chromatin structure throughout spermatogenesis have been thought to leave the sperm void of complex layers of epigenetic regulation over the DNA blueprint, thus leaving the balance of that regulation to the oocyte. However, recent work in the fields of epigenetics and male factor infertility has placed this long-held, and now controversial dogma, in a new light. Elegant studies investigating chromatin and epigenetic modifications in the developing sperm cell have provided new insights that may establish a more critical role for the paternal epigenome in the developing embryo. DNA methylation, histone tail modifications, targeted histone retention and protamine incorporation into the chromatin have great influence in the developing sperm cell. Perturbations in the establishment and/or maintenance of any of these epigenetic marks have been demonstrated to affect fertility status, ranging in severity from mild to catastrophic. Sperm require this myriad of chromatin structural changes not only to serve a protective role to DNA throughout spermatogenesis and future delivery to the egg, but also, it appears, to contribute to the developmental program of the future embryo. This review will focus on our current understanding of the epigenetics of sperm. We will discuss sperm-specific chromatin modifications that result in genes essential to development being poised for activation early in embryonic development, the disruption of which may result in reduced fecundity.

关键词： chromatin DNA methylation embryogenesis epigenetics histone modification male infertility

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Arthropods and biofuel production systems in North America

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Insect Science 2010年第3期17卷 220-236页

作者： douglas A. Landis Benjamin P. Werling Department of Entomology and Great Lakes Bioenergy Research Center 204 Center for Integrated Plant Systems Michigan State University East Lansing Michigan USA

Biomass harvest may eventually be conducted on over 100 000 000 ha of US crop and forest lands to meet federally-mandated targets for renewable biofuels. Such largescale land use changes could profoundly impact working landscapes and the arthropod communities that inhabit them. We review the literature on dedicated biofuel crops and biomass harvest from forests to look for commonalities in arthropod community responses. With expanded biofuel production, existing arthropod pests of biofuel crops will likely become more important and new pests will emerge. Beneficial arthropods will also be influenced by biofuel crop habitats, potentially altering the distribution of pollination and pest control services to the surrounding landscape. Production of biofuel crops including initial crop selection, genetic improvement, agronomic practices, and harvest regimes will also influence arthropod communities. In turn, arthropods will impact the productivity and species composition of biomass production systems. Some of these processes have the potential to cause landscape-level changes in arthropod community dynamics and insect- vectored plant diseases. Finally, changes in arthropod populations and their spatiotemporal distribution in the landscape will have impacts on consumers of insects at higher trophic levels, potentially influencing their population and community dynamics and producing feedbacks to arthropod communities. Given that dedicated biofuel crops and intensified biomass harvest from forests are still relatively uncommon in North America, as they increase, we anticipate ＇predictably unpredictable＇ shifts in arthropod communities and the ecosystem services and functions they support. We suggest that research on arthropod dynamics within biofuel crops, their spillover into adjacent habitats, and implications for the sustainability of working landscapes are critical topics for both basic and applied investigations.

关键词： biodiversity land use change pest management

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