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Optical redox imaging of ANT1-de-cient muscles

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 135-140页

作者： He N.Xu Ryan M.Morrow Min Feng Huaqing Zhao douglas Wallace Lin Z.Li Britton Chance Laboratory of Redox Imaging Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA 19104USA Center for Mitochondrial and Epigenomic Medicine Children's Hospital of Philadelphia Research Institute Philadelphia PA 19104USA Center for Biostatistics and Epidemiology Lewis Katz School of Medicine at Temple University Philadelphia PA 19140USA

Adenine nucleotide translocator(ANT)is a mitochondrial protein involved in the exchange of ADP and ATP across the mitochondrial inner *** plays a crucial role in cellular energy metabolism by facilitating the transport of ATP synthesized within the mitochondria to the *** isoform ANT1 predominately expresses in cardiac and skeletal *** or dysregulation in ANT1 have been implicated in various mitochondrial disorders and neuromuscular *** aimed to examine whether ANT1 deletion may affect mitochondrial redox state in our established ANT1-de-cient *** and quadriceps resected from age-matched wild type(WT)and ANT1-de-cient mice were snap-frozen in liquid *** Chance redox scanner was utilized to perform 3D optical redox *** sample underwent scanning across 3–5 *** averaging analysis showed no signi-cant differences in the redox indices(NADH,flavin adenine dinucleotide containing-flavoproteins Fp,and the redox ratio Fp/(NADH+Fp)between WT and ANT1-de-cient ***,quadriceps had higher Fp than hearts in both groups(p¼0:0004 and 0.01,respectively).Furthermore,the quadriceps were also more oxidized(a higher redox ratio)than hearts in WT group(p¼0:004).NADH levels were similar in all *** data suggest that under non-stressful physical condition,the ANT1-de-cient muscle cells were in the same mitochondrial state as WT ones and that the signi-cant difference in the mitochondrial redox state between quadriceps and hearts found in WT might be diminished in ANT1-de-cient *** imaging of muscles under physical stress can be conducted in future.

关键词： ANT1 redox ratio flavoproteins

The unregulated commercialization of stem cell treatments:a global perspective

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Frontiers of Medicine 2011年第4期5卷 348-355页

作者： douglas Sipp Research Unit for Science Policy and Ethics Studies RIKEN Center for Developmental Biology2-2-3 Minatojima MinamimachiChuo-kuKobe 650-0047Japan

Research into the biological properties and clinical potential of stem cells has spurred strong public investment,industry development,media coverage,and patient interest in recent *** date,however,few clinical applications of demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stem cells in the treatment of diseases of the blood and immune *** lack of an evidence basis notwithstanding,hundreds of companies and private clinics around the world now sell putative stem cell treatments for an enormously broad range of medical and quality-of-life *** represents a major challenge for legitimate scientists working in the field,for authorities seeking to protect their constituencies,and for patients and consumers targeted by such companies’marketing *** this review,I provide an overview of the global industry in pseudomedical stem cell treatments,with an investigation of claims in a single disease area(amyotrophic lateral sclerosis),and make recommendations for the introduction and enforcement of appropriate regulatory responses to this problem.

关键词： stem cell tourism medical ethics stem cell policy and regulation alternative medicine

Hermitian geometry on the resolvent set(Ⅱ)

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Science China Mathematics 2021年第2期64卷 385-398页

作者： Ronald G.douglas Rongwei Yang Department of Mathematics Texas A&M UniversityCollege StationTX 77843USA School of Mathematical Sciences Tianjin Normal UniversityTianjin 300387China Department of Mathematics and Statistics State University of New York at AlbanyAlbanyNY 12222USA

For an element A in a unital C^(*)-algebra B,the operator-valued 1-formωA(z)=(z-A)^(-1) dz is analytic on the resolvent setρ(A),which plays an important role in the functional calculus of *** paper defines a class of Hermitian metrics onρ(A)through the coupling of the operator-valued(1,1)-formΩA=-ωA^(*)∧ωA with tracial and vector *** main goal is to study the connection between A and the properties of the metric concerning curvature,arc length,completeness and singularity.A particular example is when A is quasi-nilpotent,in which case the metric lives on the punctured complex plane C\{0}.The notion of the power set is defined to gauge the"blow-up"rate of the metric at 0,and examples are given to indicate a likely link with A’s hyper-invariant subspaces.

关键词： C^(*)-algebra Hermitian metric curvature arc length Fuglede-Kadison determinant quasi-nilpotent operator power set

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Generalized Algorithms of Discrete Optimization and Their Power Engineering Applications

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Engineering（科研） 2015年第8期7卷 530-543页

作者： Roberto Berredo Petr Ekel Helder ferreira Reinaldo Palhares douglas Penaforte Advanced System Optimization Technologies—ASOTECH Belo Horizonte Brazil Graduate Program in Electrical Engineering Pontifical Catholic University of Minas Gerais Belo Horizonte Brazil CEMIG Distribution Belo Horizonte Brazil Graduate Program in Electrical Engineering Federal University of Minas Gerais Belo Horizonte Brazil CEMIG Generation and Transmission Belo Horizonte Brazil

Generalized algorithms for solving problems of discrete, integer, and Boolean programming are discussed. These algorithms are associated with the method of normalized functions and are based on a combination of formal and heuristic procedures. This allows one to obtain quasi-optimal solutions after a small number of steps, overcoming the NP-completeness of discrete optimization problems. Questions of constructing so-called “duplicate” algorithms are considered to improve the quality of discrete problem solutions. An approach to solving discrete problems with fuzzy coefficients in objective functions and constraints on the basis of modifying the generalized algorithms is considered. Questions of applying the generalized algorithms to solve multicriteria discrete problems are also discussed. The results of the paper are of a universal character and can be applied to the design, planning, operation, and control of systems and processes of different purposes. The results of the paper are already being used to solve power engineering problems.

关键词： Discrete Optimization Method of Normalized Functions Duplicate Algorithms Fuzzy Coefficients Interrelated Models Multiobjective Decision Making

High surface area biocarbon monoliths for methane storage

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Green Energy & Environment 2023年第5期8卷 1308-1324页

作者： Elizabeth Michaelis Renfeng Nie douglas Austin Yanfeng Yue Department of Chemistry Delaware State UniversityDoverDE 19901United States College of Chemical Engineering Zhengzhou UniversityZhengzhouHenan450001China

New energy sources that reduce the volume of harmful gases such as SO_(x)and NO_(x)released into the atmosphere are in constant *** gas,primarily made up of methane,is being widely used as one reliable energy source for heating and electricity generation due to its high combustion ***,natural gas accounts for a large portion of electricity generation and chemical feedstock in manufacturing plastics and other commercially important organic *** the near future,natural gas will be widely used as a fuel for ***,a practical storage device for its storage and transportation is very beneficial to the deployment of natural gas as an energy source for new *** this tutorial review,biomaterials-based carbon monoliths(CMs),one kind of carbonaceous material,was reviewed as an adsorbent for natural gas(methane)adsorption and storage.

关键词： Activated carbon Carbon monolith Methane storage High surface area Activation agent

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Comparison of Principal Components Analysis,Independent Components Analysis and Common Components Analysis

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Journal of Analysis and Testing 2018年第3期2卷 235-248页

作者： douglas N.Rutledge INRA UMR GENIALAgroParisTechUniversitéParis-SaclayMassyFrance

The aim of this work is to describe and compare three exploratory chemometrical tools,principal components analysis,independent components analysis and common components analysis,the last one being a modification of the multi-block statistical method known as common components and specific weights *** three methods were applied to a set of data to show the differences and similarities of the results obtained,highlighting their complementarity.

关键词： Exploratory data analysis Chemometrics Principal components analysis Independent components analysis Common components analysis Common components and specific weights analysis

ANALYSIS OF THE IMPACT OF SAMPLE SIZE, ATTRIBUTE VARIANCE AND WITHIN-SAMPLE CHOICE DISTRIBUTION ON THE ESTIMATION ACCURACY OF MULTINOMIAL LOGIT MODELS USING SIMULATED DATA

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Journal of Systems Science and Systems Engineering 2018年第6期27卷 771-789页

作者： Minhui Zeng Ming Zhong John douglas Hunt Engineering Research Center for Transportation safety ofMOE Wuhan University of Technology Wuhan China School of Traffic and Transportation Engineering Changsha University of Science & Technology China National Engineering Research Center for Water Transportation Safety China Department of Civil and Environmental Engineering University of Waterloo Ontario Canada Department of Civil Engineering University of Calgary Alberta Canada

Literature review indicates that sample size, attribute variance and within-sample choice distribution of alternatives are important considerations in the estimation of multinomial logit （MNL） models, but their impacts on the estimation accuracy have not been systematically studied. Therefore, the objective of this paper is to provide an empirical examination to the above issues through a set of simulated discrete choice preference and rank ordered preference datasets. In this paper, the utility coefficients, alternative specific constants （ASCs）, and the mean and standard deviation of the four attributes for a set of seven hypothetical alternatives are specified as a priori. Then, synthetic datasets, with varying sample size, attribute variance and within-sample choice distribution are simulated. Based on these datasets, the utility coefficients and ASCs of the specified MNLs are re-estimated and compared with the original values specified as the priori. It is found that （1） the estimation accuracy of utility parameters increases as the sample size increases; （2） the utility coefficients can be re-estimated with reasonable accuracy, but the estimates of the ASCs are confronted with much larger errors; （3） as the variances of the alternative attributes increase, the estimation accuracy improves significantly; and （4） as the distribution of chosen choices becomes more balanced across alternatives within sample datasets, the hit-ratio decreases. The results indicate that （a） under a similar setting presented in this paper, a large sample consisting of a few thousand observations （3000 - 4000） may be needed in order to provide reasonable estimates for utility coefficients, particularly for ASCs; （b） a larger, but realistic attribute space is preferred in the stated preference survey design; and （c） choice datasets with unbalanced ＂chosen＂ choice frequency distribution is preferred, in order to better capture the elasticity between the ＂perceived utility＂ associated wit

关键词： Sample size attribute variance within-sample choice distribution simulated data

Redefining the possibility of digital Earth and geosciences with spatial cloud computing

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International Journal of Digital Earth 2013年第4期6卷 297-312页

作者： Chaowei Yang Yan Xu douglas Nebert Center of Intelligent Spatial Computing for Water/Energy Sciences George Mason UniversityFairfaxVAUSA Microsoft Research RedmondWAUSA Federal Geographic Data Committee RestonVAUSA

Global challenges(such as economy and natural hazards)and technology advancements have triggered international leaders and organizations to rethink geosciences and Digital Earth in the new *** next generation visions pose grand challenges for infrastructure,especially computing *** gradual establishment of cloud computing as a primary infrastructure provides new capabilities to meet the *** paper reviews research conducted using cloud computing to address geoscience and Digital Earth needs within the context of an integrated Earth *** also introduce the five papers selected through a rigorous review process as exemplar research in using cloud capabilities to address the *** literature and research demonstrate that spatial cloud computing provides unprecedented new capabilities to enable Digital Earth and geosciences in the twenty-first century in several aspects:(1)virtually unlimited computing power for addressing big data storage,sharing,processing,and knowledge discovering challenges,(2)elastic,flexible,and easy-to-use computing infrastructure to facilitate the building of the next generation geospatial cyberin-frastructure,CyberGIS,CloudGIS,and Digital Earth,(3)seamless integration environment that enables mashing up observation,data,models,problems,and citizens,(4)research opportunities triggered by global challenges that may lead to breakthroughs in relevant fields including infrastructure building,GIScience,computer science,and geosciences,and(5)collaboration supported by cloud computing and across science domains,agencies,countries to collectively address global challenges from policy,management,system engineering,acquisition,and operation aspects.

关键词： EarthCube CloudGIS eScience Earthscience interoperability

Comment on “A numerical investigation of the acoustic mode waves in a deviated borehole penetrating a transversely isotropic formation”

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Science China(Physics,Mechanics & Astronomy) 2016年第8期59卷 89-90页

作者： Steve A.Horne douglas Miller CanYun Wang Chevron Energy Technology Corporation London El4 4HA UK Massachusetts Institute of Technology Boston 02139 USA CNPC Logging Company Ltd Beijing 102206 China

In the paper"A numerical investigation of the acoustic mode waves in a deviated borehole penetrating a transversely isotropic formation"by Liu et al.[1]numerical experiments are reported for a dipole sonic logging scenario with a deviated borehole penetrating a VTI anisotropic *** such a situation it is important to clearly define the meaning of group and phase velocities as this has led to much confusion in the literature as discussed by Miller,Horne and Walsh[2].

关键词： penetrating Comment on isotropic borehole logging sonic confusion dipole deviation clearly

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