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The Use of Triancinolone for the Treatment of Keloid Scars

Journal of Cosmetics, dermatological Sciences and Applications 2024年第3期14卷 270-275页

作者： José Humberto Cardoso Resende Luís Otávio Torres Anderson Alves Brandão delma dos Santos Assis Mercadante Jessyka oliveira Barbosa Batista William Felix de oliveira Pacheco Elisangelo Aparecido Costa Da Silva douglas henrique farias de oliveira Nébia Maria Almeida de Figueiredo UNIFAN-Centro Universitrio Alfredo Nasser Aparecida de Goinia Brazil UNIRIO Rio de Janeiro Brazil

Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.

关键词： Keloid Scar Hypertrophy Collagen Affection

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Albumin administration in patients with cirrhosis: Current role and novel perspectives

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World Journal of Gastroenterology 2022年第33期28卷 4773-4786页

作者： Angelo Zambam de Mattos douglas Alano Simonetto Carlos Terra Alberto Queiroz farias Paulo Lisboa Bittencourt Tales henrique Soares Pase Marlon Rubini Toazza Angelo Alves de Mattos Alliance of Brazilian Centers for Cirrhosis Care-the ABC Group Graduate Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55902United States department of Gastroenterology State University of Rio de JaneiroRio de Janeiro 20550-170Brazil department of Gastroenterology University of São PauloSão Paulo 01246-903Brazil Gastroenterology and Hepatology Unit Hospital PortuguêsSalvador 40130-030Brazil Internal Medicine Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil 不详

Mortality in cirrhosis is mostly associated with the development of clinical decompensation,characterized by ascites,hepatic encephalopathy,variceal bleeding,or ***,it is important to prevent and manage such ***,the pathophysiology of decompensated cirrhosis was explained by the peripheral arterial vasodilation hypothesis,but it is currently understood that decompensation might also be driven by a systemic inflammatory state(the systemic inflammation hypothesis).Considering its oncotic and nononcotic properties,albumin has been thoroughly evaluated in the prevention and management of several of these decompensating *** are formal evidence-based recommendations from international medical societies proposing that albumin be administered in individuals with cirrhosis undergoing large-volume paracentesis,patients with spontaneous bacterial peritonitis,those with acute kidney injury(even before the etiological diagnosis),and those with hepatorenal ***,there are a few randomized controlled trials and meta-analyses suggesting a possible role for albumin infusion in patients with cirrhosis and ascites(long-term albumin administration),individuals with hepatic encephalopathy,and those with acute-on-chronic liver failure undergoing modest-volume *** studies are necessary to elucidate whether albumin administration also benefits patients with cirrhosis and other complications,such as individuals with extraperitoneal infections,those hospitalized with decompensated cirrhosis and hypoalbuminemia,and patients with hyponatremia.

关键词： Cirrhosis Albumin Paracentesis Spontaneous bacterial peritonitis Acute kidney injury Hepatorenal syndrome

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Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 405-413页

作者： Patrícia Gonçalves Pinheiro Gilvandete Maria Pinheiro Santiago Francisco Erivaldo Freitas da Silva Ana Carolina Justino de Araújo Cícera Rejane Tavares de oliveira Priscilla Ramos Freitas Janaína Esmeraldo Rocha JoséBezerra de Araújo Neto Maria Milene Costa da Silva Saulo Relison Tintino Irwin Rose Alencar de Menezes henrique douglas Melo Coutinho JoséGalberto Martins da Costa departamento de Química Biológica Programa de Pos-Graduação em Química BiológicaUniversidade Regional do Cariri–URCACrato–CEBrazil Programa de Pós-Graduação em Química Centro de CiênciasUniversidade Federal do Ceará–UFCFortaleza–CEBrazil

Objective:To evaluate the inhibitory activity of ferulic acid and four of its esterified derivatives(methyl,ethyl,propyl,and butyl)against resistance mechanisms in Staphylococcus aureus ***:Ferulic acid derivatives were obtained by esterification with methanol,ethanol,propanol,and butanol,and then characterized by hydrogen and carbon-13 nuclear magnetic resonance *** minimum inhibitory concentrations(MIC)of ferulic acid and its esterified derivatives,ethidium bromide,and norfloxacin were obtained using the microdilution test,while the efflux pump inhibition test was conducted by examining reduction in the MICs of norfloxacin and ethidium *** docking was also carried out using the Schrodinger Suite 2015 molecular modeling software.A three-dimensional model of NorA efflux pump was generated using *** best scoring model was used as a receptor for ligand-receptor ***:The methyl and butyl ester derivatives did not demonstrate significant antimicrobial ***,a significant synergic effect was evidenced when norfloxacin was combined with the ethyl and propyl esterified *** docking study demonstrated favorable energy of interaction between ferulate derivatives and NorA,and amino acid residues TYR57,TYR58,and LEU255 were present commonly in stabilizing all *** PCA analysis corroborated the docking hypothesis that the lipophilic character and hydrogen bond interactions were the most relevant characteristics involved with NorA *** pharmacokinetic parameters of ferulic acid derivatives showed good ADMET properties,demonstrating that they can be easily absorbed and have no effect or inhibit the cytochrome P450 enzyme complex,revealing their potential as drug ***:This study provides strong evidence that the molecular basis for this activity is potentially due to the NorA efflux pump.

关键词： Ferulic acid Esterified derivatives Efflux pump Staphylococcus aureus Resistance mechanisms

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Mean and Interannual Variability of Maize and Soybean in Brazil under Global Warming Conditions

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American Journal of Climate Change 2013年第4期2卷 237-253页

作者： Flávio Justino Evandro Chaves oliveira Rafael de Avila Rodrigues Paulo henrique Lopes Goncalves Paulo Jorge oliveira Ponte Souza Frode Stordal José Marengo Thieres G.da Silva Rafael Coll delgado douglas da Silva Lindemann Luiz Claudio Costa departamento de Engenharia Agrícola Universidade Federal de ViçosaVicosaBrazil Universidade Federal Rural da Amazônia Instituto Sócio-Ambiental e dos Recursos HídricosBelémBrazil department of Geosciences University of OsloOsloNorway Instituto Nacional de Pesquisas Espaciais Cachoeira PaulistaBrazil Universidade Federal Rural de Pernambuco Unidade Academica de Serra TalhadaSerra TalhadaBrazil Universidade Federal Rural do Rio de Janeiro Instituto de Florestas/Departamento de Ciencias AmbientaisSeropédicaBrazil

Brazil is responsible for 27% of the world production of soybeans and 7% of maize. Mato Grosso and Para states in Brazil are among the largest producer. The viability to the cultivation of maize (Zea mays) and soybeans (Glycine max), for future climate scenarios (2070-2100, GHG) is evaluated based on crop modeling (DSSAT) forced by observational data and regional climate simulations (HadRM3). The results demonstrated that a substantial reduction in the yield in particular for maize may be expected for the end of the 21st century. Distinct results are found for soybeans. By applying the A2 climate changes scenario, soybean yield rises by up top 60% assuming optimum soil treatment and no water stress. However, by analyzing the inter-annual variability of crop yields for both maize and soybean, could be demonstrated larger year-to-year fluctuations under greenhouse warming conditions as compared to current conditions, leading to very low productivity by the end of the 21st century. Therefore, these Brazilian states do not appear to be economically suitable for a future cultivation of maize and soybeans. Improved adaptation measures and soil management may however partially alleviate the negative climate change effect.

关键词： Climate Changes Soybeans Maize

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Virulence Factors and Biofilm Formation in Vancomycin Resistant Enterococcus faecalis and Enterococcus faecium Isolates in Brazil

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Advances in Microbiology 2023年第6期13卷 299-314页

作者： Bárbara de Azevedo Ramos Marília Manta Manta Sivoneide Maria da Silva Rafael Artur Queiroz Cavalcanti de Sá Natália Lira de Souza henrique douglas Melo Coutinho Márcia Vanusa da Silva Túlio Diego da Silva Maria Tereza dos Santos Correia Maria Betânia Melo de oliveira Universidade Federal de Pernambuco Pernambuco Brazil Universidade Regional do Cariri Ceará Brazil Instituto de Tecnologia de Pernambuco Pernambuco Brazil

In this work, we evaluated biofilm formation of Vancomycin Resistant of E. faecalis and E. faecium (VRE) in different culture media and adhesion substrate, as well as cellular hydrophobicity and presence of virulence genes. For this, 35 isolates were collected from a public hospital in Recife, Pernambuco, Brazil and identified by the Matrix-Assisted Laser desorption Ionization - Time-of-flight - Mass Spectrometry (MALDI-TOF-MS) technique. Biofilm formation was analyzed by the Crystal Violet (CV) method and fluorescence microscopy, cellular hydrophobicity by hydrocarbon interaction and the presence of gelE, esp and asa1 genes by Polymerase Chain Reaction (PCR). 12 isolates were identified as E. faecalis and 23 as E. faecium. Most were obtained in Coronary Units (40.0%) and Intensive Care Unit (31.4%). E. faecium isolates were more resistant to the antibiotics tested than E. faecalis;however, E. faecalis stood out as a biofilm producer. Regarding the presence and gene frequency, it was observed that gelE (54.3%) and esp (54.3%) were the most prevalent, followed by asa1 (22.9%). When comparing the gene frequency, it was observed that gelE and esp were predominant (48.6% for both species), while asa1 was more frequent in E. faecalis (20.0%). The data presented here are worrying, because they reveal the virulence potential of isolates VRE, which contributes to the dissemination and persistence of these pathogens in the hospital environment.

关键词： Biofilm Cellular Hydrophobicity Gram-Positive Hospital Environment Virulence Genes

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