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Risk factors, surgical complications and graft survival in liver transplant recipients with early allograft dysfunction

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 423-429页

作者： douglas bastos-neves Paolo Rogerio de Oliveira Salvalaggio Marcio Dias de Almeida Digestive and Hepatobiliary Surgery Hospital Sao Vicente de PauloRio de JaneiroBrazil Liver Transplant Unit Hospital Israelita Albert EinsteinSao PauloBrazil

Background: Early allograft dysfunction (EAD) is a severe complication after liver transplantation. The associated risk factors and complications have re-gained recent interest. This study investigated risk factors, survival and complications associated with EAD in a large liver transplant center in Latin America. Methods: Retrospective, unicenter, cohort, based on data from adult patients undergoing first deceaseddonor liver transplant from January 2009 to December 2013. EAD was defined by one or more of the following:(i) bilirubin ≥10 mg/dL on postoperative day 7;(ii) international normalized ratio ≥1.6 on postoperative day 7, and (iii) alanine aminotransferase or aspartate aminotransferase > 2000 IU/L within the first seven days after transplant. Results: A total of 602 patients were included;of these 34.2% developed EAD. Donor risk factors were male ( P = 0.007), age between 50 and 59 years ( P = 0.034), overweight ( P = 0.028) or grade I obesity ( P = 0.012), sodium > 157 mmol/L ( P = 0.002) and grade IV ischemia/reperfusion injury ( P = 0.002). Cold ischemia time ≥10 h ( P = 0.008) and warm ischemia time ≥40 min ( P = 0.013) were the surgical factors. Male ( P 157 mmol/L and grade Ⅳ ischemia/reperfusion injury. Cold ischemia time ≥10 h and warm ischemia time ≥40 min were the surgical risk factors. Male was the only recipient protective factor. Patients with EAD had higher reoperations and graft loss rates.

关键词： Graft survival Liver transplantation Primary graft dysfunction Donor evaluation

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Effect of Environmental Factors on Rock-inhabiting Fungal Communities from Brazilian Soapstone Samples

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Journal of Environmental Science and Engineering(B) 2017年第2期6卷 55-71页

作者： douglas Boniek Lorena Vivien neves de Oliveira Noelly de Queiroz Ribeiro Christiane Abreu Oliveira Paiva Ubiraci Gomes de Paula Lana Antonio Femando Batista dos Santos Maria Aparecida de Resende Stoianoff Post-Graduate Program in Microbiology Institute of Biological Sciences Federal University of Minas Gerais UFMG BeloHorizonte 31270-901 Brazil Embrapa Milho Sorgo Brazilian Agricultural Research Corporation Sete Lagoas 35701-970 Brazil Faculty of Engineering and Architecture Foundation of Education and Culture of Minas Gerais Belo Horizonte 30310-190Brazil Department of Microbiology Institute of Biological Sciences Federal University of Minas Gerais UFMG Belo Horizonte31270-901 Brazil

The present study aims to evaluate the environmental effect on fungal community composition associated with biodeterioration occurring in stones （soapstone） at two distinct locations in Minas Gerais State, Brazil： Congonhas city and Sanctuary of Cara^a. Four collections of fungal communities over one year were obtained from both research sites from the soapstone block surfaces exposed for over two decades. The molecular diversity profile of the fungal community at the two localities was obtained by DGGE （Denaturing Gradient Gel Electrophoresis）, and the genomes of the most representative population were sequenced. DGGE showed the formation of two clusters with filamentous fungal communities. Sequencing of the most representative bands revealed the presence of fungi associated with the biodeterioration of soapstone. In addition, many of the identified species were associated with photobionts that could generate lichens, indicating that environmental characteristics affect the occurrence of filamentous fungi, which leads to biodeterioration of stones. Authors＇ study focused on an environmental variation of an extreme habitat for fungi associated with soapstone in the state of Minas Gerais, Brazil and identified the presence of interesting rock-inhabiting fungal communities including species related to lichens, which can accelerate the deterioration of stones by the production of organic acids.

关键词： Fungal community biodeterioration soapstone cultural heritage Minas Gerais state.

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