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Leaves Aqueous Extract of <i>boerhavia coccinea</i>Induces Antinociceptive Effect but Increases Nitric Oxide Production in Macrophages

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Journal of biosciences and Medicines 2020年第10期8卷 90-103页

作者： basile N. Piegang douglas A. M. Ngangoum Sorelle M. Ngassam Pius P. Tseuguem bibiane A. Wandji Desiré F. T. bomba Aliance R. Fokoua Télesphore b. Nguelefack Research Unit of Neuro-Inflammatory and Cardiovascular Pharmacology Laboratory of Animal Physiology and Phytopharmacology Faculty of Science University of Dschang Dschang Cameroon Institut Universitaire du Golf de Guinée (IUG) Institut Supérieur des Sciences Appliquées (ISA) Douala Cameroun

Pain treatment is one of the most challenging situations of the modern medicine. To overcome the actual limitations, new strategies should be developed and phytotherapy represents a promising alternative. boerhavia coccinea is a medicinal plant used for the treatment of pain. The present work was undertaken to evaluate the antinociceptive effects of crude aqueous extract of the leaves of boerhavia coccinea (AE) on acute pain and examine its mechanism of action. The analgesic effect of AE was evaluated at doses 50, 100, 200 and 400 mg/kg using the formalin-induced nociception in mice. The specific analgesic effect of AE was verified by testing its effect of AE on the sleep induced by diazepam. The anti-inflammatory effects of AE were also tested in vivo (100 and 200 mg/kg) on CFA-induced inflammation and in vitro (1 to 300 μg/ml) on the production of NO by non-activated or activated (LPS, 1 μg/l) macrophages. The effect of AE in non-stimulated macrophages was evaluated in absence and in presence of L-NAME (100 μg/ml) or dexathetasone (30 μg/ml). AE administered orally significantly (p bited both neurogenic and inflammatory phases of the formalin pain with a maximum inhibition percentage of 81% at the 1st phase and 90% at the 2nd phase, but did not show any anti-inflammatory effect. AE at 50 mg/kg increased the latency to sleep and reduced sleep duration. AE drastically (p by non-activated or activated macrophages by up to 5654%. L-NAME and dexamethasone potentiated the activation effect of AE on NO production. In conclusion, AE possess potent antinociceptive effect that is not related to any anti-inflammatory activity. Instead, this extract increases the nitric oxide production by an unknown mechanism.

关键词： boerhavia coccinea Aqueous Extract Analgesic Macrophage Nitric Oxide

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祁连山东段河流阶地的形成时代与机制探讨

地理科学 2005年第2期25卷 197-202页

作者：高红山潘保田邬光剑李吉均李炳元 douglas burbank 业渝光兰州大学西部环境教育部重点实验室和地理科学系甘肃兰州730000 中国科学院寒区旱区环境与工程研究所冰芯与寒区环境重点实验室甘肃兰州730000 中国科学院地理科学与资源研究所北京100101 Department of Geological Sciences 国土资源部青岛海洋地质研究所山东青岛266071

第四纪期间祁连山东段发育了多级洪积台地与河流阶地,它们是研究区域构造活动与气候变化良好的载体。对该区主要河流阶地序列的野外考察,利用ESR、TL、IRSL以及14C等测年方法,研究表明,第四纪期间石羊河上游的各大支流普遍发育了5-6级阶... 详细信息

第四纪期间祁连山东段发育了多级洪积台地与河流阶地,它们是研究区域构造活动与气候变化良好的载体。对该区主要河流阶地序列的野外考察,利用ESR、TL、IRSL以及14C等测年方法,研究表明,第四纪期间石羊河上游的各大支流普遍发育了5-6级阶地,其中南营村附近金塔河五级河流阶地的形成时代大致为1.24Mab.P.(T5)、0.78Mab.P.(T4)、0.14Mab.P.(T3)、0.06Mab.P.(T2)和0.01Mab.P.(T1),完全可以与该区沙沟河、黄河兰州段以及长江三峡段的阶地序列相对比。从各级阶地砾石层的堆积时代以及阶地的沉积特征分析,我们认为,即使在构造活动区域,气候变化在河流地貌演化过程之中起着重要的控制作用。

关键词：形成时代成因河流阶地祁连山东段

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老年胃肠道感染和粘膜免疫

国外医学(老年医学分册) 1987年第3期 97-100页

作者： douglas L 郝先刚

虽然老年对免疫活性的影响已有很多研究,但对分泌性或者粘膜免疫系统尚未引起足够重视。监于该系统起着防卫许多抗原和病原体第一线的关键作用,因此不能忽视。许多研究资料表明,老年人粘膜表面如呼吸道和胃肠道显示对感染性疾病的易感... 详细信息

虽然老年对免疫活性的影响已有很多研究,但对分泌性或者粘膜免疫系统尚未引起足够重视。监于该系统起着防卫许多抗原和病原体第一线的关键作用,因此不能忽视。许多研究资料表明,老年人粘膜表面如呼吸道和胃肠道显示对感染性疾病的易感性增加,这反映分泌性免疫系统分泌的主要免疫球蛋白A(lgA)与衰老相关的下降。除流行病学资料证实免疫反应降低、呼吸和胃肠道感染性疾病的发病率增高与衰老相关之外,分泌性免疫系统与衰老相关的资料则不多见。许多研究者报告,人类和啮齿动物抗体形成能力、总抗体和/或特异性抗体滴度与衰老呈相关性降低。但其他一些研究者报告,不同种类动物血清lgA水平随年龄增长

关键词：粘膜免疫肠道分泌性浆细胞抗体效应b细胞 b-淋巴细胞集合淋巴结老年

Australian tertiary care outcomes of entecavir monotherapy in treatment naive patients with chronic hepatitis b

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World Journal of Gastroenterology 2013年第5期19卷 721-726页

作者： Farzan Fahrtash-bahin Viraj C Kariyawasam Timothy Gray Karen byth Jacob George Mark W douglas Storr Liver Unit Westmead Millennium InstituteUniversity of Sydney at Westmead Hospital2145 SydneyAustralia Centre for Infectious Diseases and Microbiology and Sydney Emerging Infections and biosecurity Institute University of Sydney at Westmead Hospital2145 SydneyAustralia Department of biostatistics School of Public HealthUniversity of Sydney2145 SydneyAustralia

AIM:To evaluate the long-term treatment outcomes of entecavir monotherapy in treatment naive patients in an Australian tertiary care setting. METHODS:A retrospective analysis of treatment naive patients receiving entecavir monotherapy through Westmead Hospital was *** were excluded if they had received previous treatment with another nucleoside or nucleotide analogue,were pregnant or less than 18 years old. RESULTS:Out of 336 patients,163 patients fulfilled the selection *** of follow up was 3-46 mo (mean 26 mo).134 patients(82.2%)had pre-treatment biopsies,with 26 patients(16.0%)demonstrating F3-4 *** total,153 patients(93.9%)achieved at least Partial Virological Suppression(PVS),with 134 patients (82.2%)achieving complete virological suppression. The cumulative CVS and PVS rates at 36 mo were 82.1%and 96.4%,respectively.3 patients(1.8%)failed to achieve PVS,while 5 patients(3.0%)developed virological rebound.128 patients(78.5%)maintained CVS throughout follow *** of CVS included lower baseline DNA level(P=0.001),hepatitis b virus e antigen negative status(P=0.001)and increasing age at treatment(log rank 0.001).No significant adverse effects were reported necessitating cessation of entecavir. CONCLUSION:Entecavir monotherapy is efficacious and safe in an Australian tertiary care *** and rebound rates are very *** is similar to data from controlled and uncontrolled trials around the world.

关键词： Chronic hepatitis b Entecavir Australia Asia-Pacific Monotherapy Hepatitis b virus Antivirals

basic statistics for business and economics / 3rd ed.

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Comissioning of the lEA-R1 Nuclear Reactor New Heat Exchanger

2000年

作者： douglas A. Lind Robert D. Mason William G. March

Includes index.

ISBN: (数字)0073660620

ISBN: (纸本)0073660620

Includes index.

关键词： Social sciences

来源：畅想之星图书光盘版（南... 评论

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Journal of Energy and Power Engineering 2013年第6期7卷 1058-1065页

作者： Alfredo Jose Alvim de Castro Pedro Ernesto Umbehaun Marcos Rodrigues de Carvalho Roberto Frajndlich douglas Alves Cassiano Nuclear Engineering Center Nuclear and Energy Research Institute (IPEN-CNEN/SP) Sao Paulo 05508-000 Brazil Engineering Modeling and Applied Social Sciences Center ABC Federal University (UFABC) S6o Bernardo do Campo09606-070 Brazil

This work presents results on the commissioning of the new heat exchanger of the IEA-R1 nuclear reactor in the occasion of its operational power upgrade from 2 MW to 5 MW, in comparison to the values calculated in the project of IESA Design and Equipments Company. This reactor is a swimming pool type, light water moderated and with graphite reflectors, used for research purposes and medical radioisotopes production. During monitoring procedures, issues were observed on the reactor operation at 5 MW mainly due to the ageing of the reactor＇s oldest heat exchanger （TC-A） and excessive vibrations at high flow rates on the other installed heat exchanger （TC-b）. So it was decided to provide a new IESA heat exchanger with 5 MW capacity to definitely substitute the TC-A heat exchanger. The results show that the IEA-R1 nuclear reactor can be operated safely and continuously at 5 MW with the new IESA heat exchanger.

关键词： Heat exchangers IEA-RI nuclear reactor research nuclear reactors radioisotope production.

Molecular evolution,virology and spatial distribution of HCV genotypes in Pakistan:A meta-analysis

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Infectious Medicine 2023年第4期2卷 324-333页

作者： Arslan Habib Nadiya Habib Khalid Mahmood Anjum Riffat Iqbal Zeeshan Ashraf Muhammad Usman Taj Muhammad Asim Kanwal Javid Faezeh Idoon Saeid Dashti Cassio Rocha Medeiros Ana Pavla Almeida Diniz Gurgel Henrique douglas Melo Coutinho Laboratory of Molecular Immunology School of Life SciencesFudan UniversityShanghai 200433China Department of Zoology University of GujratGujratPunjab 50700Pakistan Department of Zoology University of Veterinary and Animal SciencesLahore 54000Pakistan Department of Zoology Government College UniversityLahore 54000Pakistan Department of Fisheries and Aquaculture University of Veterinary and Animal SciencesLahore 54000Pakistan Department of Zoology University of NarowalNarowal 51600Pakistan Department of Geography Government College UniversityLahore 54000Pakistan Department of Surgical Technology Ferdows School of Allied Medicine and Public HealthBirjand University of Medical SciencesBirjand 97178Iran Ferdows School of Paramedical and Health Birjand University of Medical SciencesBirjand 97178Iran CECAPE College Juazeiro do Norte 63024-015Brazil Department of Engineering and Environment Federal University of ParaibaJoão Pessoa 58051-900Brazil Laboratory of Microbiology and Molecular biology(LMbM) Department of Biological ChemistryRegional University of CaririCrato 63105-000Brazil

background:Hepatitis C,caused by the Hepatitis C Virus(HCV),is the second most common form of viral *** geographical distribution of HCV genotypes can be quite complex,making it challenging to ascertain the most prevalent genotype in a specific ***:To address this,a review was conducted to determine the prevalence of HCV genotypes across various provinces and as a whole in *** scientific literature regarding the prevalence,distribution,genotyping,and epidemiology of HCV was gathered from published articles spanning the years ***:Genotype 1 accounted for 5.1%of the patients,with its predominant subtype being 1a at 4.38%.The frequencies of its other subtypes,1b and 1c,were observed to be 1.0%and 0.31%*** 2 had a frequency of 2.66%,with the most widely distributed subtype being 2a at 2.11%of the *** other subtypes,2b and 2c,had frequencies of 0.17%and 0.36%*** most prevalent genotype among all isolates was 3(65.35%),with the most frequent subtype being 3a(55.15%),followed by 3b(7.18%).The prevalence of genotypes 4,5,and 6 were scarce in Pakistan,with frequencies of 0.97%,0.08%,and 0.32%*** prevalence of untypeable and mixed genotypes was 21.34%and 3.53%*** genotypes proves to be a productive method in assisting with the duration and selection of antiviral *** HCV genotypes can exhibit variations in their response to specific antiviral *** genotypes may have distinct natural histories,including variations in disease progression and *** genotypes may lead to more rapid liver damage,while others progress more ***:This information can guide screening and testing strategies,helping to identify individuals at higher risk of developing severe *** the distribution of HCV genotypes in a population can provide valuable insights into the transmission dynamics of the virus.

关键词： Genotypes HCV Molecular evolution Pakistan Spatial distribution

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早晨光照和晚上光照对鸡产蛋大小的影响

家畜生态学报 1990年第4期23卷 44-46页

作者： C.R.douglas T.b.CHAILLE A.S.ARAFA R.H.HARMS 郭创业山西省农科院

导言许多养鸡场都有这样的经验,即在炎热的季节鸡产蛋比较小,5、6、7、8月产蛋量接近高峰。据 Hays(1930)。Funk 和 Kempstor(1934)报道,最大的蛋产于冬季,春季和夏季比较小。蛋重也受产蛋时辰影响。据 Roland 和 Harms(1974)报道。

关键词：蛋重光照处理产蛋时间蛋产量蛋鸡饲料冷季气候炎热喂鸡消化能进食量

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Microsoft Windows CE程序设计 G

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