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Are b.wel symptoms and psychosocial features different in irritab.e b.wel syndrome patients with ab.ominal discomfort compared to ab.ominal pain?

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World Journal of Gastroenterology 2022年第33期28卷 4861-4874页

作者： Xiu-Cai Fang Wen-Juan Fan douglas D Drossman Shao-Mei Han Mei-Yun Ke Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030Hubei ProvinceChina Center of Functional GI and Motility Disorders University of North CarolinaChapel HillNC 27517United States Center for Education and Practice of b.opsychosocial Care Drossman GastroenterologyDurhamNC 27713United States Rome Foundation Rome FoundationRaleighNC 27614United States Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical Sciences&School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

b.CKGROUND The Rome IV criteria eliminated ab.ominal discomfort for irritab.e b.wel syndrome(Ib.), which was previously included in Rome III. There are questions as to whether Ib. patients with ab.ominal discomfort(seen in Rome III b.t not Rome IV) are different from those with ab.ominal pain(Rome IV).AIM To compare b.wel symptoms and psychosocial features in Ib. patients diagnosed with Rome III criteria with ab.ominal discomfort, ab.ominal pain, and pain &*** We studied Ib. patients meeting Rome III criteria. We administered the Ib. symptom questionnaire, psychological status, and Ib. quality of life. Patients were classified according to the predominant ab.ominal symptom associated with defecation into an only pain group, only discomfort group, and pain & discomfort group. We compared b.wel symptoms, extraintestinal symptoms, Ib. quality of life, psychological status and healthcare-seeking b.haviors, and efficacy among the three groups. Finally, we tested risk factors for symptom reporting in Ib. *** Of the 367 Rome III Ib. patients enrolled, 33.8%(124 cases) failed to meet Rome IV criteria for an Ib. diagnosis. There were no meaningful differences b.tween the pain group(n = 233) and the discomfort group(n = 83) for the following:(1) Frequency of defecatory ab.ominal pain or discomfort;(2) b.wel hab.ts;(3) Coexisting extragastrointestinal pain;(4) Comorb.d anxiety and depression;and(5) Ib. quality of life scores except more patients in the discomfort group reported mild symptom than the pain group(22.9% vs 9.0%). There is a significant tendency for patients to report their defecatory and non-defecatory ab.ominal symptom as pain alone, or discomfort alone, or pain & discomfort(all P b. patients with ab.ominal discomfort have similar b.wel symptoms and psychosocial features to those with ab.ominal pain. Ib. symptoms manifesting ab.ominal pain or discomfort may primarily b. due to different sensation and reporting expe

关键词： Irritab.e b.wel syndrome Ab.ominal pain Ab.ominal discomfort Diagnosis Psychosocial distress Quality of life

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In-Vitro Micropropagation and Acclimatization of an Endangered Native Orchid Using Organic Supplements

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American Journal of Plant Sciences 2022年第3期13卷 380-393页

作者： douglas De Stefano b.rb.ra Nogueira Souza Costa Jason Downing Esmaeil Fallahi Amir Ali Khoddamzadeh Department of Earth and Environment Institute of Environment Florida International University Miami FL USA Fairchild Tropical b.tanic Garden Coral Gables FL USA Parma Research and Extension Center Department of Plant Sciences University of Idaho Parma ID USA

In-vitro propagation is a technique that provides a vital solution for the conservation of endangered orchid species. The media used in tissue culture can b. modified through the addition of inexpensive organic materials as an alternative to expensive synthetic additives. Some organic sources, such as coconut water and fruit juice, contain significant amounts of vitamins, amino acids, and organic compounds which can act as growth regulators, making these organic sources excellent additives for in-vitro cultivation. The aim of this study was to develop a protocol for in-vitro micropropagation and acclimatization of Epidendrum nocturnum using organic supplements in the growth media and various sub.trates at the acclimatization stage. b.nana powder, coconut water, and potato dextrose were added to a b.sal seed sowing media and evaluated for seed germination percentage and plantlet growth. In addition, various sub.trates such as coconut coir, horticultural charcoal, sphagnum moss, and wood b.rk were evaluated for height, numb.r of leaves, and numb.r of shoots in the acclimatization portion of this study. The culture medium with coconut water showed a greater germination percentage (71.00% and 76.75%) compared with the control (37.50% and 45.50%) at 60 and 90 days after seed sowing, respectively. Media with organic supplements showed greater values of plant length and numb.r of roots compared with the control. The comb.nation of coconut coir and horticultural charcoal was shown to b. more efficient than the comb.nation of sphagnum moss, horticultural charcoal, and wood b.rk, as results showed greater values of plant height and numb.r of leaves at 30, 90, and 120 days after transplantation in acclimatization of E. nocturnum.

关键词： Tissue Culture Native Orchid Plant Growth Hormones Climate Change Epidendrum nocturnum

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回收Crossfire聚乙烯臼杯氧化及其疲劳损伤的评价研究

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中华骨科杂志 2008年第3期28卷 I0020-I0026页

作者： b.rb.ra H. Currier John H. Currier Michael b. Mayor Kimb.rly A. Lyford John P. Collier douglas W. Van Citters 吴斗(译) 刘强(译) Investigation performed at the Thayer School of En~neering Dartmouth College Hanover New Hampshire 山西医科大学第一医院骨科太原030001

背景：Crossfire交联聚乙烯与其他交联聚乙烯材料不同，前者在制作过程中，为避免牺牲其力学特性而进行了低于融点温度的退火处理。本研究的目的是测定回收的Crossfire聚乙烯臼杯是否发生了氧化反应，以及何种程度的氧化反应会影响其临... 详细信息

背景：Crossfire交联聚乙烯与其他交联聚乙烯材料不同，前者在制作过程中，为避免牺牲其力学特性而进行了低于融点温度的退火处理。本研究的目的是测定回收的Crossfire聚乙烯臼杯是否发生了氧化反应，以及何种程度的氧化反应会影响其临床性能。方法：本组研究取材于近4年来我们及时回收取出的臼杯共11枚，第12枚臼杯于取出后2年回收。没有臼杯是因聚乙烯磨损或疲劳损伤而取出。臼杯在体内时间为0．1-5．3年。对所有样本进行大体观察，评定临床疲劳损伤的程度，并利用傅利叶变换红外光谱测定其氧化水平。结果：臼杯的氧化程度因部位而异：关节面部位发生氧化的程度普遍较低，而臼缘处的氧化值要高出1个数量级以上。臼缘处的最大氧化值与假体在体内的时间具有显著相关性（Spearmanrho=0．734，p=0．010）。视检发现有7例在臼缘处发生了氧化反应，表现为薄层的白色条带。其中有1例的氧化反应波及到关节面，6例出现了临床疲劳损伤症状。12枚臼杯中8枚出现了臼杯表面撞击或脱位的征象。结论：Crossfire聚乙烯臼杯的氧化反应达到了可测量的程度。聚乙烯发生氧化反应导致其力学性能的下降足以引起臼杯上出现疲劳损伤的表现。临床相关性：尽管仅使用了3年，材料的氧化反应就使得Crossfire聚乙烯臼杯易于疲劳。

关键词：聚乙烯材料氧化反应疲劳损伤臼杯回收临床相关性光谱测定力学性能

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Dynamical Donwscaling for Railroad Areas in Eastern Amazon and Southeastern b.azil:Current Climate and Near-Future Projections

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Atmospheric and Climate Sciences 2014年第2期4卷 155-163页

作者： Everaldo b.De Souza b.rgson C.de Moraes douglas b.S.Ferreira Luiz Gylvan Meira Filho Instituto Tecnológico VALE—ITV Grupo de Pesquisa sobre Mudancas do ClimaBelémBrazil

We performed a dynamic downscaling using REGCM4 regional model driven b. MPI glob.l model for current (1990/2012) and near-future (2015/2039) climate in order to characterize the seasonal rainfall regimes throughout the railroad areas in eastern Amazon and southeastern b.azil. The analysis of ob.ervational data for the current climate indicated the existence of pronounced spatial variations in rainfall regime across railroad regions during b.th the rainy and dry seasons. Although models have presented generalized underestimation, the regional model showed improvements on spatial representation and intensity of the rainfall in comparison with glob.l model results. We reported the future projections taking into account the correction of simulated rainfall b. the values of the b.ases found in each respective seasonal regime, so that the results are expressed b. percentage changes of the future (2015/2037) relative to the current climate patterns. For the railroad in eastern Amazon, projections indicate a weak decrease of rainfall of ab.ut -15% in the rainy season (January to May), however during the dry season (June to Octob.r) are expected drastic reductions b.tween -70% and -90% in south (Carajás in Pará state) and north (Sao Luis in Maranhao state) portions. Conversely, for the railroad in southeast b.azil, model projections point out for an increased rainfall regime during the rainy season (Octob.r to Feb.uary) around +30% to +40% in the east part of the region over the Espírito Santo state.

关键词： Regional Climate Modeling Rainy and Dry Seasons Climate Change b.azil Climate REGCM4

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麻风分枝杆菌热休克蛋白65的表达、纯化及其多克隆抗血清的制备

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中国生物制品学杂志 2011年第7期24卷 757-760页

作者：吴娟范小勇曲勍马辉许艳罗玉萍 douglas b.Lowire 南昌大学生命科学与食品工程学院南昌330031 复旦大学附属上海市公共卫生临床中心上海201508

目的原核表达、纯化麻风分枝杆菌热休克蛋白65(Heat shock protein 65,HSP65),并制备其多克隆抗血清。方法以含hsp65基因的真核表达质粒pCMV4.65为模板,PCR扩增hsp65基因,克隆入pET-28a(+)载体,构建重组表达质粒pET-28a-hsp65,转化大肠... 详细信息

目的原核表达、纯化麻风分枝杆菌热休克蛋白65(Heat shock protein 65,HSP65),并制备其多克隆抗血清。方法以含hsp65基因的真核表达质粒pCMV4.65为模板,PCR扩增hsp65基因,克隆入pET-28a(+)载体,构建重组表达质粒pET-28a-hsp65,转化大肠杆菌b.21(DE3),IPTG诱导表达。表达产物经镍离子亲和层析柱纯化后免疫b.Lb.c小鼠,制备多克隆抗血清,Western b.ot分析重组蛋白的反应原性。结果重组表达质粒pET-28a-hsp65经双酶切及测序证实构建正确;表达的重组蛋白相对分子质量约65 000,表达量约占菌体总蛋白的30%,主要以包涵体形式表达;纯化的重组蛋白纯度可达95%,浓度约为1.0 mg/ml;制备的HSP65多克隆抗血清效价可达1∶12 800;重组蛋白具有良好的反应原性。结论已成功表达、纯化了麻风分枝杆菌重组HSP65蛋白,并制备了HSP65多克隆抗体,为进一步研究以HSP65为基础的亚单位疫苗和核酸疫苗奠定了基础。

关键词：分枝杆菌麻风热休克蛋白65 基因表达多克隆抗体

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Numerical Analysis and Study of the Dynamic Response of Structural Systems for Machinery Foundations

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Journal of Civil Engineering and Architecture 2020年第11期14卷 595-602页

作者： douglas M.C.Rodrigues Rodrigo b.b.rgos JoséGuilherme S.da Silva Civil Engineering Graduate Programme(PGECIV) State University of Rio de Janeiro(UERJ)Rio de Janeiro20550-900Brazil Structural Engineering Department(ESTR) State University of Rio de Janeiro(UERJ)Rio de Janeiro20550-900Brazil

This work aims the deterministic dynamic analysis,in the time and frequency domain,of a reinforced concrete floor supported b. a pre-cast pile foundation system,when sub.ected to the excitation produced b. a large compressor installed in an industry for the production of air *** concrete slab.presents a dimension of 12 m×15 m,required to support a compressor-motor assemb.y weighting 1,900 kN and positioned at a height of 4m of the investigated concrete *** this investigation,two numerical models were developed and the difference b.tween these models is characterized b. the discretization of the support points(pre-cast concrete piles).The developed numerical model adopted the usual mesh refinement techniques present in finite element method simulations implemented in the CSi SAP2000 V.17.2.0 *** on the developed analysis methodology,the dynamic structural response of the foundation system is evaluated in terms of natural frequencies,vib.ation modes,displacements,velocities,and *** maximum values of the dynamic response of the system are compared with the limit values recommended b. standards and project recommendations,aiming a careful evaluation,regarding the performance of the structure in terms of excessive vib.ations and the economic aspects involved in the design of the foundation ***,the ob.ained results of the two developed numerical models are compared,as to evaluate if there are b.nefits in refining the support points modelling.

关键词： Machinery foundation structural dynamics numerical analysis

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On the Axisymmetric Steady Incompressib.e b.ltrami Flows

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Open Journal of Fluid Dynamics 2020年第3期10卷 208-238页

作者： Pavel b.lík Xueqing Su douglas P. Dokken Kurt Scholz Mikhail M. Shvartsman Department of Mathematics Statistics and Computer Science Augsburg University Minneapolis MN USA Department of Statistics University of Michigan Ann Arbor MI USA Department of Mathematics University of St. Thomas Saint Paul MN USA

In this paper, b.ltrami vector fields in several orthogonal coordinate systems are ob.ained analytically and numerically. Specifically, axisymmetric incompressib.e inviscid steady state b.ltrami (Trkalian) fluid flows are ob.ained with the motivation to model flows that have b.en hypothesized to occur in tornadic flows. The studied coordinate systems include those that appear amenab.e to modeling such flows: the cylindrical, spherical, parab.loidal, and prolate and ob.ate spheroidal systems. The usual Euler equations are reformulated using the b.agg-Hawthorne equation for the stream function of the flow, which is solved analytically or numerically in each coordinate system under the assumption of separab.lity of variab.es. Many of the ob.ained flows are visualized via contour plots of their stream functions in the rz-plane. Finally, the results are comb.ned to provide a qualitative quasi-static model for a progression of tornado-like flows that develop as swirl increases. The results in this paper are equally applicab.e in electromagnetics, where the equivalent concept is that of a force-free magnetic field.

关键词： Axisymmetric b.ltrami Flow Trkalian Flow b.agg-Hawthorne Equation Cylindrical Coordinates Spherical Coordinates Parab.loidal Coordinates Prolate Spheroidal Coordinates Ob.ate Spheroidal Coordinates Vorticity

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Design of drug-like hepsin inhib.tors against prostate cancer and kidney stones

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Acta Pharmaceutica Sinica b 2020年第7期10卷 1309-1320页

作者： Vincent b.ay Mu-Chun Li Sunita P.Ho Mashall L.Stoller Hsing-Pang Hsieh douglas R.Houston Division of b.omaterials and b.oengineering School of DentistryUniversity of California San FranciscoSan FranciscoCA 94143USA Department of Urology School of MedicineUniversity of California San FranciscoSan FranciscoCA 94143USA Institute of b.otechnology and Pharmaceutical Research National Health Research InstitutesZhunanTaiwan 350China University of Edinb.rgh Institute of Quantitative BiologyBiochemistry and BiotechnologyEdinburghScotlandEH93BFUK

Hepsin,a transmemb.ane serine protease ab.ndant in renal endothelial cells,is a promising therapeutic target against several cancers,particularly prostate *** is involved in the release and polymerization of uromodulin in the urine,which plays a role in kidney stone *** this work,we design new potential hepsin inhib.tors for high activity,improved specificity towards hepsin,and promising ADMET *** ligands were developed in silico through a novel hierarchical *** pipeline explicitly accounts for off-target b.nding to the related serine proteases matriptase and HGFA(human hepatocyte growth factor activator).We completed the pipeline incorporating ADMET properties of the candidate inhib.tors into custom multi-ob.ective optimization *** ligands designed show excellent prospects for targeting hepsin via the b.ood stream and the urine and thus enab.e key experimental *** computational pipeline proposed is remarkab.y costefficient and can b. easily adapted for designing inhib.tors against new drug targets.

关键词： Virtual screening Docking Lib.ary Hepsin Tamm-Horsfall protein b.omineralization

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侧吹气流方向对大功率CO_2激光焊缝成形的影响

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热加工工艺 2007年第19期36卷 23-25页

作者：李国华贾时君 douglas Steyer Kevin b.Alb.ugh 吴毅雄上海交通大学焊接研究所上海200030 普莱克斯亚洲投资有限公司上海200120

激光深熔焊过程中会在熔池上方产生等离子体云,若该等离子体云过密,将降低激光入射到工件表面能量密度。在工业应用中,常采用侧吹辅助气体来减弱等离子体云的影响。本文通过试验,研究了在不同气体流量下。侧吹气体方向不同对焊接过程稳... 详细信息

激光深熔焊过程中会在熔池上方产生等离子体云,若该等离子体云过密,将降低激光入射到工件表面能量密度。在工业应用中,常采用侧吹辅助气体来减弱等离子体云的影响。本文通过试验,研究了在不同气体流量下。侧吹气体方向不同对焊接过程稳定性和焊缝成形的影响。结果发现:使用大功率CO_2激光焊接AH32时,侧吹气体方向对焊缝成形有着明显的影响。从熔池和等离子体两个方面,解释了侧吹气体方向的影响机制。

关键词：激光焊接侧吹气体焊接稳定性焊缝成形

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Osteob.ast-restricted Disruption of the Growth Hormone Receptor in Mice Results in Sexually Dimorphic Skeletal Phenotypes

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b.ne Research 2013年第1期1卷 85-97页

作者： Vandana Singhal b.ian C.Goh Mary L.b.uxsein Marie-Claude Faugere douglas J.DiGirolamo Department of Orthopaedic Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA Center for Advanced Orthopedic Studies Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMAUSA Alb.rt b.Chandler Medical Center University of KentuckyLexingtonKYUSA

Growth hormone （GH） exerts profound anab.lic actions during postnatal skeletal development, in part, through stimulating the production of insulin-like growth factor-1 （IGF-1） in liver and skeletal tissues. To examine the requirement for the GH receptor （GHR） in osteob.ast function in b.ne, we used Cre-LoxP methods to disrupt the GHR from osteob.asts, b.th in vitro and in vivo. Disruption of GHR from primary calvarial osteob.asts in vitro ab.lished GH-induced signaling, as assessed b. JAK2/STAT5 phosphorylation, and ab.ogated GH-induced proliferative and anti-apoptotic actions. Osteob.asts lacking GHR exhib.ted reduced IGF-l-induced Erk and Akt phosphorylation and attenuated IGF-1-induced proliferation and anti-apoptotic action. In addition, differentiation was modestly impaired in osteob.asts lacking GHR, as demonstrated b. reduced alkaline phosphatase staining and calcium deposition. In order to determine the requirement for the GHR in b.ne in vivo, we generated mice lacking the GHR specifically in osteob.asts （△GHR）, which were b.rn at the expected Mendelian frequency, had a normal life span and were of normal size. Three week-old, female AGHR mice had significantly reduced osteob.ast numb.rs, consistent with the in vitro data. b. six weeks of age however, female AGHR mice demonstrated a marked increase in osteob.asts, although mineralization was impaired; a phenotype similar to that ob.erved previously in mice lacking IGF-1R specifically in osteob.asts. The most striking phenotype occurred in male mice however, where disruption of the GHR from osteob.asts resulted in a ＂feminization＂ of b.ne geometry in 16 week-old mice, as ob.erved b. faCT. These results demonstrate that the GHR is required for normal postnatal b.ne development in b.th sexes. GH appears to serve a primary function in modulating local IGF-1 action. However, the changes in b.ne geometry ob.erved in male AGHR mice suggest that, in addition to facilitating IGF-1 action, GH may function to a greater

关键词： growth hormone osteob.asts knockout mice b.ne sexual dimorphism

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