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Bayesian inf.rence-based wear prediction method f.r plain bearings under stationary mixed-f.iction conditions

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f.iction 2024年第6期12卷 1272-1282页

作者： f.orian KÖNIG f.orian WIRSING Georg jacobs Rui HE Zhigang TIAN Ming J.ZUO Institute f.r Machine Elements and Systems Engineering RWTH Aachen UniversityAachen 52062Germany Department of.Mechanical Engineering University of AlbertaEdmonton T6G1H9Canada Qingdao International Academician Park Research Institute Qingdao 266000China

This study introduces a method to predict the remaining usef.l lif.(RUL)of.plain bearings operating under stationary,wear-critical *** this method,the transient wear data of.a coupled elastohydrodynamic lubrication(mixed-EHL)and wear simulation approach is used to parametrize a statistical,linear degradation *** method incorporates Bayesian inf.rence to update the linear degradation model throughout the runtime and thereby consider the transient,system-dependent wear progression within the RUL prediction.A case study is used to show the suitability of.the proposed *** results show that the method can be applied to three distinct types of.post-wearing-in behavior:wearing-in with subsequent hydrodynamic,stationary wear,and progressive wear *** hydrodynamic operation leads to an inf.nite lif.time,the method is successf.lly applied to predict RUL in cases with stationary and progressive wear.

关键词： plain bearings wear modeling remaining usef.l lif. prediction Bayesian inf.rence

A brief.history of.the Compendium of.Physical Activities

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Journal of.Sport and Health Science 2024年第1期13卷 3-5页

作者： Barbara E.Ainsworth Stephen D.Herrmann David R.jacobs Jr. Melicia C.Whitt-Glover Catrine Tudor-Locke School of.Exercise and Health Shanghai University of SportShanghai 200438China College of.Health Solutions Arizona State UniversityPhoenixAZ 85003USA Kansas Center f.r Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of.Epidemiology and Community Health University of MinnesotaMinneapolisMN 55455USA Gramercy Research Group KnightdaleNC 27545USA College of.Health and Human Services University of North Carolina at CharlotteCharlotteNC 28223USA

The Compendium of.Physical Activities(Compendium)was developed to address consistent assignment of.physical activity(PA)intensity values used in PA epidemiology research of.the association between PA and health outcomes.1The known protective ef.ects of.PA on incident health outcomes traces to the mid-1900s,with over 50 studies examining coronary heart disease(CHD)as the outcome of.interest.

关键词： epidemiology Activities protective

Hepatic angiotensin-converting enzyme 2 expression in metabolic dysf.nction-associated steatotic liver disease and in patients with f.tal COVID-19

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World Journal of.Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K jacobs Steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A f.llowf.eld Peter C Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transf.sion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute f.r Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUND Metabolic dysf.nction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inf.ammation and oxidative stress accompanied by cell damage and *** injury(LI)is also f.equently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of.LI and the development of.COVID-19-associated *** of.injury at the cellular level remain unclear,but it may be signif.cant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of.the‘anti-inf.ammatory’arm of.the renin-angiotensin system,f.r viral attachment and host cell *** To determine if.hepatic ACE2 levels are altered during progression of.MASLD and in patients who died with severe *** ACE2 protein levels and localisation,and histological f.brosis and lipid droplet accumulation as markers of.MASLD were determined in f.rmalin-f.xed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysf.nction-associated steatohepatitis(MASH)+/-f.brosis,end-stage cirrhosis)and in post-mortem tissues f.om patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of.total collagen and lipid droplet areas,f.llowed by quantif.cation using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of.centrilobular hepatocytes and apical membranes of.bile duct ***,ACE2 protein levels are elevated in non-f.brotic MASH compared to healthy controls but not in the progression to MASH with f.brosis and in ***2 protein levels and histological f.brosis are not associated,but ACE2 and liver lipid droplet content are signif.cantly correlated across the MASLD *** A

关键词： Metabolic dysf.nction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVID-19 COVID-19-associated cholangiopathy

CD4^(+)T cells produce If.-I to license cDC1s f.r induction of.cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij J.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel f.C.C.de Miranda Heinz jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao Department of.Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of.Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of.Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of.Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of.Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of.Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identif.ed cDC1s with a transcriptomic imprint of.CD4^(+)T-cell help,specif.cally in T-cell-inf.ltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of.cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce If.βvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),If.βalso optimizes the costimulatory and other f.nctions of.cDC1s required f.r CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-inf.ltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic prof.le and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of.If.-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing If.-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

Development of.cork oak (Quercus suber L.) seedlings in response to tree shelters and mulching in northwestern Tunisia

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Journal of.f.restry Research 2013年第2期24卷 193-204页

作者： Taher Mechergui Marta Pardos Naceur Boussaidi Brahim Hasnaoui dougl.ss f. jacobs f.culté des Sciences de Bizerte (f.B) Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA). Centro de Investigacion f.restal. Ctra. de La Coruňa Institut Sylvo-Pastoral de Tabarka Department of.f.restry and Natural Resources Purdue University

The need f.r ref.restation in cork oak （Quercus suber L.） areas is challenged by dif.iculties. Principal among these is herbivory of.young plants, vegetative competition, and slow growth rates of.cork oak seedlings. We evaluated the early development of.cork oak seedlings treated using tree shelters and mulching in northwestern Tunisia. We tested three tree shelter treatments （non-vented, vented, and control） to shield seedlings f.om animal damage and f.ve mulch types to control competing vegetation （Italian Stone Pine, Lentisk, combination of.Italian Stone Pine and Lentisk （organic mulches）, gravel （inorganic mulch） and no mulch）. At the end of.the two-year experiment, sheltered seedlings were 89-99% taller than unshelteredseedlings and had higher numbers and lengths of.shoot growth f.ushes. In contrast, both stem diameter growth and dry weight biomass （f.om samples extracted af.er two years） were signif.cantly reduced inside tree shelters. Root-to-shoot ratio was not signif.cantly dif.erent in sheltered vs. unsheltered seedlings, suggesting that tree shelters do not adversely af.ect this parameter. Mulching alone did not f.vour growth, but could be benef.cial when combined with tree shelters. The combination of.vented tree shelters and gravel mulch was the most ef.ective treatment f.r promoting diameter, height and stem volume growth.

关键词： Quercus suber L. af.orestation tree shelter mulching seedling growth polycyclism

2024 Adult Compendium of.Physical Activities:A third update of.the energy costs of.human activities

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Journal of.Sport and Health Science 2024年第1期13卷 6-12页

作者： Stephen D.Herrmann Erik A.Willis Barbara E.Ainsworth Tiago V.Barreira Mary Hastert Chelsea L.Kracht John M.Schuna Jr. Zhenghui Cai Minghui Quan Catrine Tudor-Locke Melicia C.Whitt-Glover David R. jacobs Jr. Kansas Center f.r Metabolism and Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA Division of.Physical Activity and Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA Center f.r Health Promotion and Disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA College of.Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of.Exercise and Health Shanghai University of SportShanghai 200438China Exercise Science Department Syracuse UniversitySyracuseNY 13244USA Clinical Sciences Division Pennington Biomedical Research CenterBaton RougeLA 70808USA School of.Exercise and Sport Science Oregon State UniversityCorvallisOR 97331USA College of.Health and Human Services University of North Carolina at CharlotteCharlotteNC 28223USA Gramercy Research Group KnightdaleNC 27545USA Division of.Epidemiology and Community Health School of Public HealthUniversity of MinnesotaMinneapolisMN 55454USA

Background:The Compendium of.Physical Activities was published in 1993 to improve the comparability of.energy expenditure values assigned to self.reported physical activity(PA)across *** original version was updated in 2000,and again in 2011,and has been widely used to support PA research,practice,and public health ***:This 2024 update was tailored f.r adults 19-59 years of.age by removing data f.om those≥60 *** a systematic review and supplementary searches,we identif.ed new activities and their associated measured metabolic equivalent(MET)values(using indirect calorimetry)published since *** replaced estimated METs with measured values when ***:We screened 32,173 abstracts and 1507 f.ll-text papers and extracted 2356 PA energy expenditure values f.om 701 *** added303 new PAs and adjusted 176 existing MET values and descriptions to ref.ect the addition of.new data and removal of.METs f.r older *** added a Major Heading(Video Games).The 2024 Adult Compendium includes 1114 PAs(912 with measured and 202 with estimated values)across 22 Major ***:This comprehensive update and ref.nement led to the creation of.The 2024 Adult Compendium,which has utility across research,public health,education,and healthcare domains,as well as in the development of.consumer health *** new website with the complete lists of.PAs and supporting resources is available at https://***.

关键词： Adults Energy expenditure Exercise MET Physical Activities

Inf.uence of.lanthanum level and interactions with nitrogen source on early development of.Juglans nigra

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Journal of.Rare Earths 2009年第2期27卷 270-279页

作者： Nicodemus Michael A Salif. K f.ancis jacobs dougl.ss f Department of.f.restty and Natural Resources Hardwood Tree Improvement and Regeneration Center Purdue University West Lafayette IN 47907 USA

Rare earth elements have been used f.r 30 years in Chinese agriculture to improve growth and yield. Numerous scientif.c studies have shown improvements in physiology, mineral nutrition, and growth, though deleterious ef.ects may also occur. Very f.w studies have been perf.rmed on woody species. We exponentially f.rtilized one-year old black walnut （Juglans nigra L.） seedlings with 0, 0.1, 1, 10, or 100 mg lanthanum （La） and 800 mg nitrogen （N） as NaNO3, （NH4）2SO4, NH4NO3, or no N. One month f.llowing f.nal f.rtilization, growth, mineral nutrition, photosynthesis, chlorophyll, and nitrate reductase activity were assessed. Plants f.rtilized with the highest level of.La had reduced f.ne root growth, concentrations of.magnesium, calcium, nickel, and phosphorus, photosynthesis levels, and chlorophyll a content. f.liar La concentration showed an interaction ef.ect, with three to f.ur times greater concentration in plants f.d at 100 mg La to those given 10 mg La f.r （NH4）2SO4 and NHaNO3 treatments. The results suggested no benef.cial ef.ects of.La addition at levels used in this study and interactions between N source and La levels did not have an important impact on the growth, mineral nutrition, or physiology of.black walnut seedlings.

关键词： lanthanum nitrate reductase chlorophyll photosynthesis Jugians nigra rare earths

Inf.uence of.mulching and tree shelters on 4-year survival and growth of.zeen oak (Quercus canariensis) seedlings

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Journal of.f.restry Research 2019年第1期30卷 129-141页

作者： Taher Mechergui Marta Pardos dougl.ss f.jacobs f.cultédes Sciences de Bizerte Laboratoire des Ressources Sylvo-Pastorales (Institut Sylvo-Pastoral de Tabarka) Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA) Centro de Investigacion Forestal Department of.f.restry and Natural Resources Hardwood Tree Improvement and Regeneration Center Purdue University

We assessed the ef.ect of.mulching and tree shelters on the establishment and early growth of.zeen oak(Quercus canariensis Willd.) during the f.rst 4 years af.er planting in Northwestern Tunisia. f.ve mulch types(Italian Stone Pine(Pinus pinea L.), Lentisk(Pistacia lentiscus L.),and a combination of.Italian Stone Pine and Lentisk(organic mulches), gravel(inorganic mulch) and control), and three tree shelter types(non-vented and vented tree shelters, and control) were tested. An increase in the number of.internodes occurred under the gravel mulch, while a reduction in survival was f.und f.r the lentisk mulch. Tree shelters had no ef.ect on survival, but increased mean height growth and reduced mean diameter growth during the 4 years(excepting a non-signif.cant ef.ect f.r vented tree shelter at year f.ur). Comparison of.the annual shoots and growth units(GU) between sheltered and unsheltered plants according to year of.f.rmation revealed two growth phases. In f.rst phase, shoots were totally or partially inside the shelters; mean length of.annual shoots and GU were greater f.r sheltered plants. The second phase was characterized by shoots emerging f.om shelters; mean length of.annual shoots and GU were similar f.r all plants, with or without tree shelters. Results suggest that the use of.tree shelters, particularly vented shelters, could contribute to the improvement of.the artif.cial regeneration of.zeen *** use of.mulching alone or in combination with tree shelters did not improve zeen oak perf.rmance in the f.eld.

关键词： Zeen oak Mulching Tree shelters Plantation Survival rate Growth

10 Tips f.r College Students Looking f.r a Job in a Tough Market

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考试与评价（大学英语四级考试版） 2010年第6期 34-36,59页

作者： Lynn f. jacobs

找工作同做其他事情一样，需要一定的方法和技巧。很多人找不到工作并不是因为他们没有做事的能力，而是因为他们在找工作过程中没有运用正确的方法和一定的技巧。让我们听听资深专家Susan Schell的建议吧。

关键词：英语学习学习方法英语考试阅读