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Risk factors, surgical complications and graft survival in liver transplant recipients with early allograft dysfunction

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 423-429页

作者： doug.as bastos-neves Paolo Rogerio de Oliveira Salvalaggio Marcio Dias de Almeida Digestive and Hepatobiliary Surgery Hospital Sao Vicente de PauloRio de JaneiroBrazil Liver Transplant Unit Hospital Israelita Albert EinsteinSao PauloBrazil

Background: Early allograft dysfunction (EAD) is a severe complication after liver transplantation. The associated risk factors and complications have re-gained recent interest. This study investigated risk factors, survival and complications associated with EAD in a large liver transplant center in Latin America. Methods: Retrospective, unicenter, cohort, based on data from adult patients undergoing first deceaseddonor liver transplant from January 2009 to December 2013. EAD was defined by one or more of the following:(i) bilirubin ≥10 mg/dL on postoperative day 7;(ii) international normalized ratio ≥1.6 on postoperative day 7, and (iii) alanine aminotransferase or aspartate aminotransferase > 2000 IU/L within the first seven days after transplant. Results: A total of 602 patients were included;of these 34.2% developed EAD. Donor risk factors were male ( P = 0.007), age between 50 and 59 years ( P = 0.034), overweight ( P = 0.028) or grade I obesity ( P = 0.012), sodium > 157 mmol/L ( P = 0.002) and grade IV ischemia/reperfusion injury ( P = 0.002). Cold ischemia time ≥10 h ( P = 0.008) and warm ischemia time ≥40 min ( P = 0.013) were the surgical factors. Male ( P 157 mmol/L and grade Ⅳ ischemia/reperfusion injury. Cold ischemia time ≥10 h and warm ischemia time ≥40 min were the surgical risk factors. Male was the only recipient protective factor. Patients with EAD had higher reoperations and graft loss rates.

关键词： Graft survival Liver transplantation Primary graft dysfunction Donor evaluation

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Liver transplantation in patients with SARS-CoV-2:Two case reports

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World Journal of Clinical Infectious Diseases 2021年第1期11卷 27-34页

作者： Camilla Bezerra bastos Limeira Camila Monteiro Veras JoséHicaro Hellano Gonçalves Lima Paiva Marina Seixas Studart e neves Themístocles Mesquita Teles de Carvalho Natália Stefani de Assunção Ferreira Alessandra Maria Mont`Alverne Pierre Ivelise Regina Canito Brasil Transplantation Division Hospital Geral de FortalezaFORTALEZA 60175742CEBrazil UECE UeceFORTALEZA 60175742CearaBrazil

BACKGROUND Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19).This disease was declared a worldwide health problem with the characteristics of a *** patients have mild symptoms and a good *** on the evolution and prognosis of COVID-19 in solid organ recipients is *** SUMMARY We describe two patients who underwent liver transplantation with a positive test result for detection of the viral sequence for COVID-19,using reversetranscription polymerase chain reaction(RT-PCR),immediately before *** patients showed good evolution in the postoperative period,without signs of graft *** immunosuppressive therapy was not *** patients were discharged for subsequent outpatient *** In conclusion,it is expected that the experience at this center can be used as an example,aimed at the continuation of transplantations by other services and,thus,the morbidity and mortality of patients with liver disease on the transplantation waiting list can be *** centers must be able to readjust daily to the evolution of the COVID-19 pandemic.

关键词： COVID-19 Liver transplantation Coronavirus Pneumonia Immunosuppressed patients Case report Infection diseases

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Evaluation of the toxic effect of insecticide chlorantraniliprole on the silkworm Bombyx mori(Lepidoptera:Bombycidae)

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Open Journal of Animal Sciences 2013年第4期3卷 343-353页

作者： Roxelle Ethienne Ferreira Munhoz Thais Souto Bignotto Naiara Climas Pereira Claudia Regina das neves Saez Rafaela Bespalhuk Veronica Aureliana Fassina Graziele Milani Pessini Mayarha Patricia Dequigiovanni Baggio Lucineia de Fatima Chasko Ribeiro Rose Meire Costa Brancalhao Shunsuke Mizuno Willian Shigeaki Aita Maria Aparecida Fernandez Departamento de Biotecnologia Genetica e Biologia CelularUniversidade Estadual de MaringaMaringaBrasil Universidade Estadual do Oeste do Parana CascavelBrasil Fiacao de Seda Bratac S.A.bastos Sao PauloBrasil

The silkworm Bombyx mori feeds exclusively on mulberry leaves and is highly sensitive to pesticides in general. Although mulberry plantations are free of agrochemicals, pesticide drift can occur. Chlorantraniliprole, a novel insecticide of the anthranilic diamides class, has been used to control pests in field crops. In this study, we investigated the biological effects of different concentrations of chlorantraniliprole on B. mori silkworm commercial Brazilian hybrids. To evaluate the toxicity of chlorantraniliprole, bioassays were carried out and data on the lethal concentrations, symptomatology, morphology and variables of silk production were collected. Results indicated that B. mori is extremely sensitive to chlorantraniliprole, even in low concentrations. The highest silkworm mortality rates were observed in the two highest chlorantraniliprole concentrations, 0.2 and 0.1 ppm. Although lower chlorantraniliprole concentrations did not cause death of all the silkworm larvae, various symptoms of toxicity were observed: feeding cessation, regurgitation, late development and incomplete ecdysis. Such symptoms reflect the morphological changes we observed in the midgut epithelium, which affected nutrient uptake and metabolism, and even the production of cocoons. Exposed larvae also produced?thin-shelled cocoons, which constitutes a serious economic problem because this type of cocoon is not useful for the silk industry. The results provided herein confirm the toxicity of chlorantraniliprole in silkworm larvae. Therefore, we strongly suggest that, competent authorities of the National Health Surveillance Agency, in pesticide management should take measures to reduce or eliminate the use of chlorantraniliprole in areas nearest to silkworm cultivation.

关键词： Silkworm Pesticide Drift Mortality Symptomatology Chlorantraniliprole

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