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Re-Challenge with Clozapine after Neuroleptic Malignant Syndrome and Seizure in a Patient with Di-George Syndrome: Case Report and Review of Literature

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Open Journal of Psychiatry 2020年第1期10卷 9-14页

作者： Geetha Chandrashekar Ganesh Gopalakrishna Austin Campbell Katherine edwards Muaid Ithman Department of Psychiatry University of Missouri Columbia USA Department Psychiatry University of Arizona Tucson USA Department of Pharmacy University of Missouri Health Care Columbia USA

Background: Individuals with 22q11.2DS, a genetic subtype of Schizophrenia, respond as well to clozapine as those with other forms of Schizophrenia. It has been reported that serious and rare adverse events like seizures, and myocarditis have been associated with clozapine treatment in this population. To the best of our knowledge, the incidence of neuroleptic malignant syndrome (NMS) as an adverse effect of antipsychotic use in patients with this disorder has not yet been reported. Aim: In this article, we discuss a case of clozapine-induced NMS and subsequent re-challenge in a patient with 22q11.2DS-associated schizophrenia. The aim of this study is to accumulate scientific data about rare presentations, and serve as a major educational tool, and highlight the unique challenges faced when using clozapine in a patient with DiGeorge Syndrome. Methods: This is a descriptive case report of a patient encountered in the inpatient unit which includes retrospective review of the patient’s electronic medical record and a literature review of antipsychotic medications-induced NMS. Conclusion: This study demonstrates a successful re-challenge with clozapine after the patient developed NMS and seizures during the initial treatment and also highlights how, in addition to drug level monitoring, considering pharmacogenetic testing early in treatment might help minimize adverse drug reactions in individuals with known genetic disorders such as 22q11.2DS.

关键词： Clozapine DiGeorge Syndrome 22q11.2 Deletion Syndrome Neuroleptic Malignant Syndrome (NMS) Seizure Re-Challenge

Viscosity Effects of the Precursor Solution and Surface Structure of Gadolinium Oxide (Gd2O3) and Gadolinium Oxide Europium Doped (Gd2O3:Eu3+) Sol-Gel Films

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Materials Sciences and Applications 2014年第14期5卷 1027-1033页

作者： Quianna S. Johnson Matthew edwards Josh Herring Michael Curley Department of Physics Chemistry and Mathematics Alabama A & M University Normal AL USA Department of Food and Animal Sciences Alabama A & M University Normal AL USA

The sol-gel method is a novel technique for the preparation of thin films. In this research, gadolinium oxide (Gd2O3) and gadolinium oxide europium doped (Gd2O3:Eu3+) films prepared via the sol-gel and dip coating methods were investigated. In addition to the elaboration on the sol-gel preparation routes and additional observations of the films’ surface morphology as characterized by scanning electron microscope (SEM), we determined via viscosity measurements that the sols were stable for 398 days. FTIR analysis of the Gd2O3 and Gd2O3:Eu3+ dip coated films was made to monitor the decomposition and oxidation reactions that occurred during processing as well as process stability.

关键词： Gadolinium Oxide Thin Film Sol-Gel Dip Coating Viscosity SEM FTIR

东亚季风MIS3早期DO事件的亚旋回及全球意义

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第四纪研究 2008年第1期28卷 169-176页

作者：刘殿兵汪永进陈仕涛程海 R．L．edwards 南京师范大学地理科学学院南京210097 Department of Geology and Geophysics University of Minnesota Minneapolis MN 55455 USA

根据湖北永兴洞石笋（YX51）10个U／Th年龄，470组氧、碳同位素数据建立了深海氧同位素3阶段（MIS3）早期57．7～35．6kaB．P．期间东亚夏季风演化时间序列。在发育时段，千年尺度δ^18O峰谷变化与高纬冰芯记录的Dansgaard-Oeschger（D... 详细信息

根据湖北永兴洞石笋（YX51）10个U／Th年龄，470组氧、碳同位素数据建立了深海氧同位素3阶段（MIS3）早期57．7～35．6kaB．P．期间东亚夏季风演化时间序列。在发育时段，千年尺度δ^18O峰谷变化与高纬冰芯记录的Dansgaard-Oeschger（D0）事件一致；δ^18C呈现出与δ^18O正相关同步演化特征，但受区域环境影响，在事件内部细节上存在差异。区域对比表明，同一季风区的永兴洞和葫芦洞石笋δ^18O指示的季风降水同位素组成具有本质上一致性；高低纬记录对比显示，千年尺度的峰谷变化一一对应，反映热带辐合带（ITCZ）水汽传输能力、平均位置变化对东亚季风和高北纬气候具有重要影响。在DO13至DO15事件内部，永兴洞石笋δ^18O记录了显著的双峰特征，说明低纬季风强度变化和格陵兰冰芯δ^18O揭示的次级暖峰具有一致对应关系，指示大气快速传输机制在高低纬环境突变中起着重要作用。

关键词： MIS 3阶段石笋 DO事件亚旋回

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赣北石笋记录的新仙女木事件

第四纪研究 2019年第4期39卷 994-1005页

作者：张海伟程海蔡演军 Kathayat Gayatri 宁有丰 edwards R Lawrence 孟秉霖西安交通大学全球变化研究院陕西西安710054 Department of Earth Sciences University of Minnesota Minneapolis MN 55455 USA 中国科学院地球环境研究所黄土与第四纪地质国家重点实验室陕西西安710061

新仙女木事件(Younger Dryas,简称YD)是末次冰消期升温过程中发生的一次北半球急剧降温事件,目前全球范围多个地区的地质记录中均有发现该事件的印记.然而,受限于定年误差或采样分辨率等因素,关于YD事件的精确起止时间、精细内部结构和... 详细信息

新仙女木事件(Younger Dryas,简称YD)是末次冰消期升温过程中发生的一次北半球急剧降温事件,目前全球范围多个地区的地质记录中均有发现该事件的印记.然而,受限于定年误差或采样分辨率等因素,关于YD事件的精确起止时间、精细内部结构和触发机制仍存在争议.本研究利用江西北部神农宫溶洞内一支文石石笋SN29(总长度426 mm,其中距离顶部220~388 mm用于本研究),通过高精度 230Th定年和氧、碳稳定同位素测试分析,建立了13614~10811 a B. P.期间平均分辨率12年的石笋氧同位素(δ18O)变化序列.该记录最为显著的特征是δ18O值在12851~11575 a B. P.时段偏正1. 7‰,指示了一次显著的弱季风突变事件,响应于北大西洋YD事件. SN29为高铀含量文石石笋且生长速率较快,精确界定了响应于YD事件的东亚弱季风事件的起止时间和精细内部结构.结果表明: YD期间, SN29记录的东亚弱夏季风事件的开始时间为 12851±16 a B. P.,经历了约249年;结束过程开始于11575±19 a B. P.,经历了约146年;整个YD弱季风事件共持续了 1276±35年.东亚季风区各石笋δ18O记录的YD弱季风事件在误差范围内基本一致,且与格陵兰冰芯δ18O记录和低纬度其他记录的发生时间一致,支持YD时期东亚夏季风减弱事件可能是对大量淡水进入北大西洋导致径向翻转流减弱、北半球变冷、ITCZ南移的快速响应的假说.

关键词：新仙女木事件(Younger Dryas) 石笋氧同位素东亚季风神农宫

Micromolded honeycomb scaffold design to support the generation of a bilayered RPE and photoreceptor cell construct

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Bioactive Materials 2023年第12期30卷 142-153页

作者： In-Kyu Lee Ruosen Xie Agustin Luz-Madrigal Seunghwan Min Jingcheng Zhu Jiahe Jin Kimberly L.edwards M.Joseph Phillips Allison L.Ludwig David M.Gamm Shaoqin Gong Zhenqiang Ma Department of Electrical and Computer Engineering University of Wisconsin-MadisonMadisonWI53706USA Wisconsin Institute for Discovery University of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI53706USA McPherson Eye Research Institute University of Wisconsin-MadisonMadisonWI53705USA Waisman Center University of Wisconsin-MadisonMadisonWI53705USA Department of Comparative Biomedical Sciences University of Wisconsin–MadisonMadisonWI53706USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI53706USA Department of Engineering Physics University of Wisconsin-MadisonMadisonWI53706USA Grainger Institute for Engineering University of Wisconsin-MadisonMadisonWI53706USA

Age-related macular degeneration(AMD)causes blindness due to loss of retinal pigment epithelium(RPE)and photoreceptors(PRs),which comprise the two outermost layers of the *** the small size of the macula and the importance of direct contact between RPE and PRs,the use of scaffolds for targeted reconstruction of the outer retina in later stage AMD and other macular dystrophies is particularly *** developed microfabricated,honeycomb-patterned,biodegradable poly(glycerol sebacate)(PGS)scaffolds to deliver organized,adjacent layers of RPE and PRs to the subretinal ***,an optimized process was developed to photocure PGS,shortening scaffold production time from days to *** resulting scaffolds robustly supported the seeding of human pluripotent stem cell-derived RPE and PRs,either separately or as a dual celllayered *** advanced,economical,and versatile scaffolds can accelerate retinal cell transplantation efforts and benefit patients with AMD and other retinal degenerative diseases.

关键词： Microfabrication Retina Scaffolds Stem cells Tissue engineering

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心理研究中的实验设计第5版

心理研究中的实验设计第5版

用热脉冲速度记录仪(HPVR)测定树干液流

1996年

作者：（美）（爱德华兹）A.L.edwards原毛正中等译

来源：汇雅图书（南通市图书馆... 评论

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植物生理学通讯 1993年第2期29卷 110-115页

作者：刘奉觉郑世锴巨关升 edwards WRN 中国林业科学研究院林业研究所北京100091 新西兰科学与工业研究部

树木蒸腾耗水是环境生态平衡(水分)的重要因素。由于树体高大,环境、时间、空间变异因素复杂,测定工作十分困难。在林木生态系统中,水分运动的途径是,树木根部吸收土壤水分,通过树干(木质部上升液流)输送到树冠部,从叶表面蒸腾散失到大... 详细信息

树木蒸腾耗水是环境生态平衡(水分)的重要因素。由于树体高大,环境、时间、空间变异因素复杂,测定工作十分困难。在林木生态系统中,水分运动的途径是,树木根部吸收土壤水分,通过树干(木质部上升液流)输送到树冠部,从叶表面蒸腾散失到大气中,即所谓“土壤-植物-大气连续系统”。在此过程中,树干是水流通道的咽喉部位,树干液流量的大小制约着冠部蒸腾量的变化。因此。

关键词：树干液流热脉冲记录仪

Histopathological Investigation of the Stomach of Rats Fed a 60% Genetically Modified Corn Diet

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Food and Nutrition Sciences 2018年第6期9卷 763-796页

作者： Irena M. Zdziarski Judy A. Carman John W. edwards Discipline of Anatomy and Pathology School of Medicine University of Adelaide Australia The Institute of Health and Environmental Research (IHER) Kensington Park Australia Health and Environment College of Science and Engineering Flinders University Bedford Park Australia

Genetic modification (GM) represents new opportunities for enhanced crop features such as improved insect resistance and herbicide tolerance. The technology allows for cross-species alterations, therefore potentially allowing a vast array of novel traits. Many GM crops have been developed and approved for human and animal consumption. The present study investigated a triple-stacked GM corn variety containing modifications for insect resistance (via cry1Ab and cry3Bb1 genes) and herbicide tolerance (via an EPSPS gene), which was fed to rats for six months. The study investigated the mucosa of the stomach. Alterations to tight junction apposition, gland dilatations with epithelial elongation and dysplasia in the GM-fed rats were observed. These results indicate that GM-corn may have an effect on rat stomach mucosa, which may have health implications.

关键词： Genetically Modified Corn Rat Feeding Study Long-Term Feeding Study Histopathology Stomach

Measurements and Visualization of the Fluid Field of the Plume from an Animal Housing Ventilation Fan

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Journal of Environmental Protection 2017年第11期8卷 1296-1311页

作者： Manqing Ying Lingjuan Wang-Li Larry F. Stikeleather Jack edwards Department of Biological and Agricultural Engineering North Carolina State University Raleigh USA Department of Mechanical and Aerospace Engineering North Carolina State University Raleigh USA

Various dispersion models have been developed to simulate the fate and transport of air emissions from animal housing systems to meet the increasing need for knowledge in this area. However, the accuracy of the models may be challenged due to the unknown plume rise and plume shape. This paper reports a combination of theoretical and field study of the plum rise and shape of air flow from a ventilation fan commonly used in mechanically ventilated animal houses. The theoretical modeling of the plume shape was conducted using a commercial Computational Fluid Dynamics (CFD) package named FloEFD;the field measurements of the plume field was conducted using five 3D ultrasonic anemometers to simultaneously measure the air flow in the plume at various locations (four heights and five downwind distances). The TECPLOT package was used to visualize the plume flow field based upon anemometer measurements. While the plume shapes were found to be left-shifted by the CFD model and TECPLOT visualization, the magnitudes of the 3D wind velocities from field measurement were found to be significantly larger than those from CFD model. The plume field measurements indicated that the plume of a 0.6 m (24-inch) ventilation fan had a depth about 9 m, a width about ±6 m, and a rise (lifting) beyond the highest measurement point, 4.88 m (16 ft).

关键词： Computational Fluid Dynamics (CFD) Plume Fluid Field Measurement Plume Rise Animal Housing