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异步片上网络研究综述

计算机辅助设计与图形学学报 2012年第6期24卷 699-709页

作者：宋威 doug edwards School of Computer Science the University of ManchesterManchesterM13 9PL UK

异步片上网络具有低动态功耗、对延迟抖动的不敏感、统一的网络接口、较低的系统集成复杂度和较好的电磁兼容能力等众多特性,是下一代片上多核微处理器和多核片上系统的标准片上通信架构之一.在简单介绍异步电路的相关理论后,从多个方... 详细信息

异步片上网络具有低动态功耗、对延迟抖动的不敏感、统一的网络接口、较低的系统集成复杂度和较好的电磁兼容能力等众多特性,是下一代片上多核微处理器和多核片上系统的标准片上通信架构之一.在简单介绍异步电路的相关理论后,从多个方面概述了当前异步片上网络的研究成果,包括网络拓扑、同步?异步接口、流控制、服务质量、路由算法、低功耗设计、容错和可测性设计以及设计自动化;然后介绍并分析了一些具有代表性的异步片上网络设计案例.研究显示,异步片上网络具有众多同步片上网络所不具备的优点,大量的片上多核系统将使用异步片上网络作为其片上通信系统,但它们的易用性和网络性能亟待提高.

关键词：异步电路片上网络流控制低功耗容错

Understanding the initial use stage of cement mortar lining in drinking water distribution systems:Silicon and aluminum as stability indicators

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Journal of Environmental Sciences 2024年第1期135卷 495-505页

作者： Qiaozhi Liu Yuan Zhuang Guiwei Li Yao Zhang Marc A.edwards Baoyou Shi Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Civil and Environmental Engineering Virginia TechBlacksburgVA 24061USA

The cement mortar lining(CML)of commonly used ductile iron pipes can severely deteriorate the drinking water quality at the initial stage of use,but the behavioral characteristics of different elements release from the CML in this stage is still *** this study,dynamic immersion experiments with new cement mortar lined ductile iron pipe reactors were conducted under different feed water hardness and alkalinity *** results showed that the release of alkaline substances from the CML at the initial stage of use could strongly influence the pH of water,which consequently greatly impacted the release/precipitation behaviors of calcium,aluminum and *** pH and aluminum concentration of the effluent water could reach 11.5 and 700μg/L within 24 hr of hydraulic retention time,respectively,under conditions of relatively lower hardness and *** to the pH elevation,calcium carbonate precipitation could occur even at much lower feed water *** the aluminum and silicon could keep release from the CML in soluble form at different hardness and alkalinity levels,and their release rate depended on the amount of calcium carbonate ***,aluminum and silicon were more suitable as indicators of the corrosion intensity at the initial stage of CML use rather than the traditional calcium carbonate precipitation *** feed water hardness and alkalinity levels for mitigating the initial intense corrosion of CML were proposed:hardness>40 mg/L(CaCO_(3)),alkalinity>100 mg/L(CaCO_(3)).

关键词： Cement mortar lining Hardness Alkalinity Elemental release Drinking water supply

Learning from Neighbors and Differentiating Export Quality

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China & World Economy 2024年第4期32卷 1-32页

作者： Qiming Liu Bin Qiu Huw edwards Bo Gao School of Economics and Management Southeast UniversityChina Business school Loughborough UniversityUK

This paper explores how learning from neighboring firms affects new exporters' product quality. It builds a Bayesian learning model to study how new exporters revise their prior beliefs about foreign customers' preferences for product quality from neighboring pioneering exporters. The model shows that a new exporter improves its product quality when it receives a positive quality-preference signal from its neighbors. The learning process of a firm depends on the number of neighbors, the level and heterogeneity of their export quality, and its own prior knowledge of the market. Highly disaggregated firm–product–country level transaction data provide robust evidence for this. The results also suggest that the impact of neighboring signals on a new exporter's quality can be channeled through the importation of high-quality intermediate inputs and more fixed investment. Learning effects are heterogeneous across firms and learning can influence other aspects of export performance.

关键词： Bayesian learning export quality information spillovers uncertainty

Chronic effects of stretching on range of motion with consideration of potential moderating variables:A systematic review with meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 186-194页

作者： Andreas Konrad Shahab Alizadeh Abdolhamid Daneshjoo Saman Hadjizadeh Anvar Andrew Graham Ali Zahiri Reza Goudini Chris edwards Carina Scharf David George Behm Institute of Human Movement Science Sport and HealthGraz UniversityGraz A-8010Austria School of Human Kinetics and Recreation Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of Sport Injuries and Corrective Exercises Faculty of Sport SciencesShahid Bahonar University of KermanKerman 76169-13439Iran

Background:It is well known that stretch training can induce prolonged increases in joint range of motion(ROM).However,to date more information is needed regarding which training variables might have greater influence on improvements in ***,the purpose of this metaanalysis was to investigate the effects of stretch training on ROM in healthy participants by considering potential moderating variables,such as stretching technique,intensity,duration,frequency,and muscles stretched,as well as sex-specific,age-specific,and/or trained state-specific adaptations to stretch ***:We searched through PubMed,Scopus,Web of Science,and SportDiscus to find eligible studies and,finally,assessed the results from 77 studies and 186 effect sizes by applying a random-effect ***,by applying a mixed-effect model,we performed the respective subgroup *** find potential relationships between stretch duration or age and effect sizes,we performed a ***:We found a significant overall effect,indicating that stretch training can increase ROM with a moderate effect compared to the controls(effect size=-1.002;Z=-12.074;95%confidence interval:-1.165 to-0.840;p<0.001;I^(2)=74.97).Subgroup analysis showed a significant difference between the stretching techniques(p=0.01)indicating that proprioceptive neuromuscular facilitation and static stretching produced greater ROM than did ballistic/dynamic ***,there was a significant effect between the sexes(p=0.04),indicating that females showed higher gains in ROM compared to ***,further moderating analysis showed no significant relation or ***:When the goal is to maximize ROM in the long term,proprioceptive neuromuscular facilitation or static stretching,rather than ballistic/dynamic stretching,should be *** to consider in future research as well as sports practice is that neither volume,intensity,nor frequency of stretching were

关键词： Flexibility Long-term stretching Stretch training

利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa Elena V.Sviderskaya Masanobu Oshima Christopher edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiveness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of H_(2)O_(2)eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

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感恩记录

疯狂英语（初中天地） 2024年第1期 21-24页

作者： Richard edwards 不详

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享... 详细信息

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享受生命的美好,发现感恩的力量。

关键词：感恩享受生命用心记录

The Impact of Lifestyle Factors on Migraine Frequency and Severity in Neurology

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Journal of Biosciences and Medicines 2024年第7期12卷 301-313页

作者： Oluwatosin B. Iyun Okelue edwards Okobi Nneka P. Sams Eleni Asfaw Kebede Oboatarhe Blessing Ezie Department of Public Health and Family Medicine University of Cape Town Cape Town South Africa Larkin Community Hospital PSC Miami FL USA College of Health Sciences & Public Policy Walden University Minneapolis MN USA College of Health Sciences Addis Ababa University Addis Ababa Ethiopia Department of Family Medicine University of Benin Benin City Nigeria

Objective: This systematic review examines the impact of lifestyle factors on migraine frequency and severity through a comprehensive analysis of lifestyle factors such as diet, physical activity, sleep patterns, stress, mental health, and environmental influences. Methods: We thoroughly searched Google Scholar, PUBMED, Scopus, and Web of Science databases using keywords related to migraines and lifestyle factors. Keywords incorporated the Boolean operator “and” to narrow search results. Following the PRISMA guidelines, we identified, screened, and evaluated studies for inclusion, resulting in nine studies meeting the eligibility criteria. Results: A total of 4917 records were initially identified from Scopus (2786), PubMed (854), and Web of Science (1277). Following deduplication, 3657 records underwent title screening, with 382 additionally screened by abstract. Ultimately, 88 full-text articles were assessed, resulting in 9 studies meeting eligibility for qualitative synthesis: 7 prospective and 2 retrospective studies. Our findings highlight the multifaceted role of lifestyle factors in migraine pathophysiology and management. Dietary habits, such as high-calorie, high-fat, and gluten-containing diets were linked to migraine triggers. Moderate physical activity showed beneficial effects on migraine management, while intense exercise could exacerbate symptoms. Poor sleep hygiene and insomnia were strongly associated with increased migraine frequency and severity. Chronic stress and poor mental health significantly contributed to migraine exacerbation, with stress management techniques proving beneficial. Environmental factors, including light, sound, weather changes, and allergens, were also identified as significant migraine triggers. Conclusions: Personalized lifestyle modifications, tailored to individual patient profiles, are crucial in managing migraines. Evidence-based recommendations include balanced diets, moderate physical activity, improved sleep hygien

关键词： Migraine Lifestyle Factors Diet Physical Activity Sleep Patterns Stress Mental Health Environmental Factors Neurology

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尾矿的特性、灾害及其资源潜力

金属矿山 2024年第8期 216-227页

作者：王昆张峥 KAREN A.HUDSON-edwards 杨鹏诸利一杨修志陈志翔山东科技大学能源与矿业工程学院山东青岛266590 埃克塞特大学环境与可持续发展研究所英国康沃尔TR109FE 北京市信息服务工程重点实验室北京100010 北京科技大学土木与资源工程学院北京100083 山东省科技服务发展推进中心山东济南250101

尾矿是矿石磨细选别后残余的固体废弃物,尾矿物理化学特性及尾矿库的常规地表堆存共同导致尾矿库存在较大的安全与环境风险。低品位矿体高强度开采趋势下,我国尾矿年排放量维持在10亿t以上的高位,累计堆存规模超200亿t,细粒尾矿堆存方... 详细信息

尾矿是矿石磨细选别后残余的固体废弃物,尾矿物理化学特性及尾矿库的常规地表堆存共同导致尾矿库存在较大的安全与环境风险。低品位矿体高强度开采趋势下,我国尾矿年排放量维持在10亿t以上的高位,累计堆存规模超200亿t,细粒尾矿堆存方式、潜在灾害防治及综合利用面临新挑战,采选新技术装备及政策利好因素推动尾矿资源潜力亟待释放。因此,以尾矿物理化学特性、排放堆存方法、溃坝灾害、尾矿资源潜力为主线,综述了尾矿物理化学特性、尾矿堆存形式、尾矿溃坝灾害防治等方面的研究进展,系统梳理了尾矿空区充填、尾矿制备材料、尾矿二次利用、超积累植物提取金属元素、尾矿固碳等资源综合利用方法,可为研究者及工业界系统全面地重新审视尾矿废弃物特性、尾矿库灾害防治、矿产可持续开发利用提供启示。

关键词：尾矿库溃坝灾害环境危害尾矿综合利用

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy L.Barth Rodney J.Schlosser Thomas S.edwards Timothy L.Smith Zachary M.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(P<0.001,fold change 2.69).Reactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(P<0.05,FDR correction)including IL-4 and IL-13 signaling,IL-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing