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Radiofrequency ablation is an inferior option to liver resection for solitary hepatocellular carcinoma≤5 cm without cirrhosis:A population-based study with stratification by tumor size

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 605-614页

作者： Song-Chen Dong dou-sheng bai Fu-An Wang sheng-Jie Jin Chi Zhang Bao-Huan Zhou Guo-Qing Jiang Department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhou 225001China Department of Hepatobiliary Surgery The First Clinical CollegeDalian Medical UniversityDalian 116000China Department of Interventional Radiology Clinical Medical CollegeYangzhou UniversityYangzhou 225001China

Background:About 10%-20%of all individuals who develop hepatocellular carcinoma(HCC)do not have *** are rarely reported regarding the effectiveness of radiofrequency ablation(RFA)and liver resection(LR)in survival of HCC without cirrhosis and stratification by tumor size≤5 ***:We used the Surveillance,Epidemiology,and End Results(SEER)database and identified 1505 patients with a solitary HCC tumor≤5 cm who underwent RFA or LR during *** were classified into non-cirrhosis and cirrhosis groups and each group was categorized into three subgroups,according to tumor size(≤30 mm,31-40 mm,41-50 mm).Results:In patients without cirrhosis,LR showed better 5-year HCC cancer-specific survival than RFA in all tumor size subgroups(≤30 mm:82.51%vs.56.42%;31-40 mm:71.31%vs.46.83%;41-50 mm:74.7%vs.37.5%;all P0.05).However,in those with tumor size 41-50 mm,LR showed significantly better 5-year HCC cancer-specific survival than RFA in both univariate(54.72%vs.23.06%;P<0.001)and multivariate analyses(HR=0.297;95%CI:0.136-0.648;P=0.002).Conclusions:RFA is an inferior treatment option to LR for patients without cirrhosis who have a solitary HCC tumor≤5 cm.

关键词： Cirrhosis Liver resection Radiofrequency ablation Hepatocellular carcinoma Tumor size

Perioperative advantages of modified laparoscopic vs open splenectomy and azygoportal disconnection

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World Journal of Gastroenterology 2014年第27期20卷 9146-9153页

作者： Guo-Qing Jiang Ping Chen Jian-Jun Qian Jie Yao Xiao-Dong Wang sheng-Jie Jin dou-sheng bai Department of Hepatobiliary Surgery Clinical Medical College of Yangzhou University

AIM: To investigate perioperative outcomes in patients undergoing modified laparoscopic splenectomy or open splenectomy and azygoportal disconnection for portal hypertension.

关键词： Portal hypertension Laparoscopy Splenectomy Azygoportal disconnection Inflammatory response

Modified laparoscopic splenectomy and azygoportal disconnection combined with cell salvage is feasible and might reduce the need for blood transfusion

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World Journal of Gastroenterology 2014年第48期20卷 18420-18426页

作者： Guo-Qing Jiang dou-sheng bai Ping Chen Jian-Jun Qian sheng-Jie Jin Jie Yao Xiao-Dong Wang Department of Hepatobiliary Surgery Clinical Medical College of Yangzhou University

AIM: To investigate perioperative outcomes in patients undergoing modified laparoscopic splenectomy and azygoportal disconnection (MLSD) with intraoperative autologous cell salvage.

关键词： Portal hypertension Laparoscopy Splenectomy Azygoportal disconnection Cell salvage

Review of preoperative transarterial chemoembolization for resectable hepatocellular carcinoma

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World Journal of Hepatology 2015年第1期7卷 40-43页

作者： Zhi-Hui Gao dou-sheng bai Guo-Qing Jiang sheng-Jie Jin Hepato-bilio-pancreatic Surgery Department Subei People’s HospitalYangzhou University

Hepatocellular carcinoma(HCC) is one of the few cancers whose incidence has been continually increasing over recent *** of HCC offers the only hope for ***,recurrences are common in patients who have undergone *** our opinion,the effectiveness with which transarterial chemoembolization(TACE) as a neoadjuvant therapy for resectable HCC prevents recurrence and prolongs survival has not been conclusively *** published meta-analyses have consistently failed to demonstrate that preoperative TACE improves the prognosis of resectable *** believe that these published articles have several limitations and have our own views about the results of *** is very important that the scientific community shed more light on the pathogenesis of HCC and relate this to choice of *** review mainly concerns our understanding of preoperative TACE for resectable HCC and briefly addresses desirable directions for future studies.

关键词： Hepatocellular carcinoma Surgical resection Transarterial chemoembolization Preoperative Review

Individualized peri-operative fluid therapy facilitating early-phase recovery after liver transplantation

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World Journal of Gastroenterology 2012年第16期18卷 1981-1986页

作者： Guo-Qing Jiang Ping Chen dou-sheng bai Jing-Wang Tan Hao Su Min-Hao Peng Departmentof Hepatobiliary Surgery Clinical Medical College of Yangzhou University Yangzhou 225000 Jiangsu Province China Department of Hepatobiliary Surgery First Affiliated Hospital Guangxi Medial University Nanning 530021 Guangxi Zhuang Autonomous Region China

AIM:To investigate the correlation between peri-operative fluid therapy and early-phase recovery after liver transplantation(LT) by retrospectively reviewing 102 consecutive ***:Based on whether or not the patients had pulmonary complications,the patients were categorized into non-pulmonary and pulmonary *** peri-operative variables were analyzed in both groups to screen for the factors related to the occurrence of early pulmonary ***:The starting hemoglobin(Hb) value,an intra-operative transfusion > 100 mL/kg,and a fluid balance ≤-14 mL/kg on the first day and the second or third day post-operatively were significant factors for early pulmonary *** extubation time,time to initial passage of flatus,or intensive care unit length of stay were significantly prolonged in patients who had not received an intra-operative transfusion ≤ 100 mL/kg or a fluid balance ≤-14 mL/kg on the first day and the second or the third day ***,these patients had poorer results in arterial blood gas ***:It is important to offer a precise and individualized fluid therapy during the peri-operative period to the patients undergoing LT for cirrhosis-associated hepatocellular carcinoma.

关键词： Fluid therapy Liver transplantation Earlyphase recovery Pulmonary complications Hemoglobin

Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming bai Jia-sheng Rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

Effect of magnetic flow and external forcing current on mixed bursting in the pre-Botzinger complex

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Chinese Physics B 2019年第11期28卷 120-128页

作者： dou-dou Guo Zhuo-sheng Lu School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China

The pre-B?tzinger complex(pre-B?tC) in mammalian brainstem is essential for the generation of respiratory *** dynamic studies on the pre-B?tC neuron have been focused on its firing activities modulated by the ion conductances rather than that by the electromagnetic radiation or the external forcing current. In this paper, by adding the electromagnetic radiation and external forcing current to Park and Rubin’s model, we mainly investigate the influences of those two factors on the mixed bursting(MB) of single pre-B?tC neuron. First, we explore how the variation of external forcing current affects the MB patterns of the system with non-vanishing magnetic flux. We classify the MB patterns and show their dynamic mechanism through fast-slow decomposition and bifurcation analysis. Then, by modifying the feedback coefficient, we further analyze the sole effect of electromagnetic radiation on the firing activities of the system. Our results may be instructive in understanding the dynamical behavior of pre-B?tC neuron.

关键词： pre-Botzinger complex mixed bursting magnetic flow dynamical analysis

Molecular calculations for HeH^+ with two-center correlated orbitals

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Science China Chemistry 2009年第12期52卷 2249-2256页

作者： dou Yusheng TANG Hong bai MingZe Institute of Computational Chemistry Chongqing University of Posts and TelecommunicationsChongqing 400065China Department of Physical Sciences Nicholls State UniversityThibodaux 70310USA

A two-center correlated orbital approach was used to calculate the electronic ground state energy for the HeH+ molecular ion. The wavefunctions were constructed from the exact solution of the Schrdinger equation for the HeH++ problem in prolate-spheroidal coordinates taken together with a Hylleraas type correlation factor. With a simple single term wavefunction,we obtained ground state energy of -2.95308691 hartree without any variational parameters in the calculation. When a two-configuration-state wavefunction was used and effective charges were allowed to be adjusted,we found an energy of -2.97384868 hartree,which is to be compared with -2.97869074 hartree obtained by an 83 term configuration interaction wavefunction or -2.97364338 hartree by an ab initio calculation (at the MP4(SDQ)/6-311++G(3df,3dp) level) using the well-known "canned" code.

关键词： HeH+ two-center orbitals prolate-spheroidal coordinates correlation function

Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages

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World Journal of Gastroenterology 2017年第45期23卷 7978-7988页

作者： yan-wei li chong zhang qiu-ju sheng han bai yang ding xiao-guang dou department of infectious diseases shengjing hospital of china medical university

AIM To investigate whether M1 or M2 polarization contributes to the therapeutic effects of mesenchymal stem cells(MSCs) in acute hepatic failure(AHF).METHODS MSCs were transfused into rats with AHF induced by D-galactosamine(DGal N). The therapeutic effects of MSCs were evaluated based on survival rate and hepatocyte proliferation and apoptosis. Hepatocyte regeneration capacity was evaluated by the expression of the hepatic progenitor surface marker epithelial cell adhesion molecule(Ep CAM). Macrophage polarization was analyzed by M1 markers [CD68,tumor necrosis factor alpha(TNF-α),interferon-γ(IFN-γ),inducible nitric oxide synthase(INOS)] and M2 markers [CD163,interleukin(IL)-4,IL-10,arginase-1(Arg-1)] in the survival and death groups after MSC *** The survival rate in the MSC-treated group was increased compared with the DPBS-treated control group(37.5% vs 10%). MSC treatment protected rats with AHF by reducing apoptotic hepatocytes and promoting hepatocyte regeneration. Immunohistochemical analysis showed that MSC treatment significantly increased the expression of Ep CAM compared with the control groups(P < 0.001). Expression of Ep CAM in the survival group was significantly up-regulated compared with the death group after MSC transplantation(P = 0.003). Transplantation of MSCs significantly improved the expression of CD163 and increased the gene expression of IL-10 and Arg-1 in the survival group. IL-4 concentrations were significantly increased compared to the death group after MSC transplantation(88.51 ± 24.51 pg/m L vs 34.61 ± 6.6 pg/m L,P < 0.001). In contrast,macrophages showed strong expression of CD68,TNF-α,and INOS in the death group. The concentration of IFN-γ was significantly increased compared to the survival group after MSC transplantation(542.11 ± 51.59 pg/m L vs 104.07 ± 42.80 pg/m L,P < 0.001).CONCLUSION M2 polarization contributes to the therapeutic effects of MSCs in AHF by altering levels of anti-inflammatory and pro-infla

关键词： Acute hepatic failure Mesenchymal stem cells Macrophages Polarization Inflammation