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Promotion of reactive oxygen species activated by nanosilver surface engineering for resistant bacteria-infected skin tissue therapy

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Rare Metals 2023年第12期42卷 4167-4183页

作者： Pei-Pei Li Yu Zhang Chao Wang Shu-Jie Wang Wen-Qing Yan dou-xin xiao Jing Kang De-Zhi Yang Hai-Xia Wu Alideertu Dong College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhot 010021China International Mongolia Hospital of Inner Mongolia Hohhot 010065China

Nanosilver has been regarded as a promising alternative to traditional antibiotics for fighting pathogenassociated infections due to its efficacy toward a broad spectrum of ***,bacterial resistance to nanosilver has emerged *** this contribution,a surface engineering strategy based on N-halamine chemistry to address bacterial resistance to nanosilver was *** 1,3-dichloro-5,5-dimethylhydantoin(DCDMH)as an N-halamine source,AgCI nanodots were deposited on the surface of Ag nano wires(Ag NWs)via in situ redox reaction to prepare AgCl-on-Ag *** in vitro and in vivo tests,AgCl-on-Ag NWs effectively inactivated two antibiotic-resistant bacteria,ampicillinresistant Escherichia coli(AREC)and methicillin-resistant Staphylococcus aureus(MRSA)with the minimum bactericidal concentration(MBC)as low as 10μg·ml~(-1)and exhibited good biosafety against normal *** experimental and theoretical tests demonstrated that AgCl-onAg NWs worked on AREC and MAS A by generating high level of reactive oxygen species under visible light irradiation,coupled with the sustained Ag ion ***,the antibacterial mechanism of AgCl-on-Ag NWs against MRSA was verified at the gene level by transcriptome analysis(RNA sequencing).Moreover,the fullthickness defect model verified that AgCl-on-Ag NWs reduced inflammatory cell infiltration and dramatically accelerated wound *** work provides a synergistic mechanism based on nanosilver surface engineering to eradicate the resistant bacteria that can alleviate drug resistance and develop an innovative approach for the treatment of bacterial infections.

关键词： Surface engineering Nanosilver N-halamine Reactive oxygen species(ROS) Antibiotic resistance

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PTA输送异常分析及处理

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聚酯工业 2017年第4期30卷 34-35页

作者：窦鑫龙祁晓娇中国石油化工股份有限公司天津分公司化工部

对PET装置原料PTA输送过程中所遇到的异常问题如压缩机异常、过滤器异常、输送介质异常、原料指标异常进行了分析,并从加强设备和工艺控制方面提出了解决方法。

关键词： PTA 输送异常处理

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区域经济提质增效升级统计监测指标体系研究——以陕西省为例

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科技和产业 2017年第7期17卷 37-41页

作者：陈红亚施蕾谢铭窦筱欣陕西省科学技术情报研究院西安710054

全面促进经济提质增效已成为各地区经济新常态下的一项基本任务。以陕西省为例,根据陕西经济发展现状和特征,在充分考虑地区层面差异的基础上,提出陕西省经济提质增效升级统计监测指标体系,以准确地反映地区提质增效进程。监测指标体系... 详细信息

全面促进经济提质增效已成为各地区经济新常态下的一项基本任务。以陕西省为例,根据陕西经济发展现状和特征,在充分考虑地区层面差异的基础上,提出陕西省经济提质增效升级统计监测指标体系,以准确地反映地区提质增效进程。监测指标体系由6个一级指标、28个二级指标构成,运用准确的数据和科学的方法,开展实证分析,形成监测结果,为陕西经济"提质增效升级"战略提供决策参考。

关键词：提质增效升级产业转型统计监测指标体系

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Declining diagnostic accuracy of non-invasive fibrosis tests is associated with elevated alanine aminotransferase in chronic hepatitis B

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World Journal of Clinical Cases 2018年第12期6卷 521-530页

作者： Lin Wang Yao-xin Fan xiao-Guang dou Department of Infectious Diseases Shengjing Hospital of China Medical Uni-versity

AIM To explore the effect of alanine aminotransferase(ALT) on the performance of non-invasive fibrosis tests in chronic hepatitis B(CHB) patients. METHODS A total of 599 treatment-naive and biopsy-proven CHB patients were included in the study. The cohort was divided into the following three groups: Normal ALT(ALT ≤ 40), slightly elevated ALT(40 80). The diagnostic performance of five common non-invasive fibrosis tests for liver fibrosis(stages S2-4), including the aspartate aminotransferase(AST)-to-platelet(PLT) ratio index(APRI), fibrosis index based on 4 factors(FIB-4), King's score, Forns index and gamma-glutamyl transpeptidase(GGT)-to-PLT ratio(GPR), were evaluated for each group. RESULTS Higher ALT levels were associated with higher non-invasive fibrosis test scores. Patients with the same fibrosis stage but higher ALT levels showed higher noninvasive test scores. The areas under the receiver operating characteristics curves(AUROCs) of the noninvasive tests for prediction of ≥ S2 were higher for patients with ALT ≤ 40 U/L(range 0.705-0.755) and 40 80 U/L(range 0.604-0.701). The AUROCs for predicting ≥ S3 and S4 were higher in patients with ALT ≤ 40 U/L(range 0.736-0.814 for ≥ S3, 0.79-0.833 for S4) than in patients with 40 80 U/L(range 0.7-0.784 for ≥ S3, range 0.662-0.719 for S4). The diagnostic accuracy of the non-invasive tests decreased in a stepwise manner with the increase in *** ALT has a significant effect on the diagnostic performance of non-invasive fibrosis tests. The ALT level should be considered before performing these noninvasive tests.

关键词： Chronic hepatitis B Non-invasive tests Liver fibrosis Alanine aminotransferase Inflammation

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Exploration of the structural and optical properties of a red-emitting phosphor K_2TiF_6:Mn^(4+)

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Chinese Physics B 2019年第1期28卷 544-549页

作者： Xi-Long dou xiao-Yu Kuang xin-xin Xia Meng Ju Institute of Atomic and Molecular Physics Sichuan University School of Physical Science and Technology Southwest University

The exploration of the appropriate red phosphor with good luminescence properties is an important issue in the development of current white light-emitting diode(WLED) devices. Transition metal Mn-doped compounds are fascinating luminescent materials. Herein, we performed a systematic theoretical study of the microstructure and optical properties of K_2TiF_6:Mn^(4+) using the CALYPSO structure search method in combination with first-principles calculations. We uncovered a novel structure of K_2TiF_6:Mn^(4+) with space group P-3m1 symmetry, where the impurity Mn_(4+) ions are accurately located at the center of the MnF_6 octahedra. Based on our developed complete energy matrix diagonalization(CEMD)method, we calculated transition lines for ~2E_g →~4A_2,~4A_2→~4T_2, and^4A_2→T2at 642 nm, 471 nm, and 352 nm,respectively, which are in good agreement with the available experimental data. More remarkably, we also found another transition(~4A_2→~2T_2) that lies at 380 nm, which should be a promising candidate for laser action.

关键词： crystal structures first-principles calculations K2TiF6

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基于微信的校医院师生服务小程序设计

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电脑知识与技术 2021年第33期17卷 49-52页

作者：欧阳斌陈瑞志冯子洋林声伟窦晓欣湛江科技学院广东湛江524094

针对高校师生对校内线上医疗的需求以及人工记录信息耗时长、传统医疗程序冗杂等问题,研究设计一种基于微信平台的校医院师生服务小程序,提供在线预约及问诊、防疫打卡、BMI指数自测等功能。该小程序为校医院配套使用,优化校医院就诊流... 详细信息

针对高校师生对校内线上医疗的需求以及人工记录信息耗时长、传统医疗程序冗杂等问题,研究设计一种基于微信平台的校医院师生服务小程序,提供在线预约及问诊、防疫打卡、BMI指数自测等功能。该小程序为校医院配套使用,优化校医院就诊流程,为校园的疫情防控工作提供有力支持。

关键词：微信小程序线上医疗校医院健康大学生

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Theoretical and numerical simulation study on jet formation and penetration of different liner structures driven by electromagnetic pressure

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Defence Technology（防务技术） 2021年第3期17卷 846-858页

作者： Jian-hao dou xin Jia Zheng-xiang Huang xiao-hui Gu Ying-min Zheng Bin Ma Qiang-qiang xiao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094JiangsuChina

The use of a shaped liner driven by electromagnetic force is a new means of forming jets. To study the mechanism of jet formation driven by electromagnetic force, we considered the current skin effect and the characteristics of electromagnetic loading and established a coupling model of "ElectriceMagnetic eForce" and the theoretical model of jet formation under electromagnetic force. The jet formation and penetration of conical and trumpet liners have been calculated. Then, a numerical simulation of liner collapse under electromagnetic force, jet generation, and the stretching motion were performed using an ANSYS multiphysics processor. The calculated jet velocity, jet shape, and depth of penetration were consistent with the experimental results, with a relative error of less than 10%. In addition, we calculated the jet formation of different curvature trumpet liners driven by the same loading condition and obtained the influence rule of the curvature of the liner on jet formation. Results show that the theoretical model and the ANSYS multiphysics numerical method can effectively calculate the jet formation of liners driven by electromagnetic force, and in a certain range, the greater the curvature of the liner is, the greater the jet velocity is.

关键词： Electromagnetic field Shaped charge jet formation Theoretical calculation Numerical simulation

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Multi-Objective Cooperative Salvo Attack Against Group Target

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Journal of Systems Science & Complexity 2018年第1期31卷 244-261页

作者： ZENG Jie dou Lihua xin Bin School of Automation State Key Laboratory of Intelligent Control and Decision of Complex SystemsBeijing Advanced Innovation Center for Intelligent Robots and Systems Beijing Institute of Technology

This paper proposes a solution for the problem of cooperative salvo attack of multiple cruise missiles against targets in a group. Synchronization of the arrival time of missiles to hit their common target, minimizing the time consumption of attack and maximizing the expected damage to group targets are taken into consideration simultaneously. These operational objectives result in a hierarchical mixed-variable optimization problem which includes two types of subproblems, namely the multi-objective missile-target assignment（MOMTA） problem at the upper level and the time-optimal coordinated path planning（TOCPP） problems at the lower level. In order to solve the challenging problem, a recently proposed coordinated path planning method is employed to solve the TOCPP problems to achieve the soonest salvo attack against each target. With the aim of finding a more competent solver for MOMTA, three state-of-the-art multi-objective optimization methods（MOMs）,namely NSGA-II, MOEA/D and DMOEA-εC, are adopted. Finally, a typical example is used to demonstrate the advantage of the proposed method. A simple rule-based method is also employed for comparison. Comparative results show that DMOEA-εC is the best choice among the three MOMs for solving the MOMTA problem. The combination of DMOEA-εC for MOMTA and the coordinated path planning method for TOCPP can generate obviously better salvo attack schemes than the rule-based method.

关键词： Coordinated path planning missile-target assignment multi-missile salvo attack multiobjective optimization

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A joint mid-course and terminal course cooperative guidance law for multi-missile salvo attack

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Chinese Journal of Aeronautics 2018年第6期31卷 1311-1326页

作者： Jie ZENG Lihua dou Bin xin School of Automation Beijing Institute of Technology Beijing 100081 China State Key Laboratory of Intelligent Control and Decision of-Complex Systems Beijing 100081 China

Salvo attacking a surface target by multiple missiles is an effective tactic to enhance the lethality and penetrate the defense system. However, existing cooperative guidance laws in the midcourse or terminal course are not suitable for long-and medium-range missiles or stand-off attacking. Because the initial conditions of cooperative terminal guidance that are generally generated from the mid-course flight may not lead to a successful cooperative terminal guidance without proper mid-course flight adjustment. Meanwhile, cooperative guidance in the mid-course cannot solely guarantee the accuracy of a simultaneous arrival of multiple missiles. Therefore, a joint mid-course and terminal course cooperative guidance law is developed. By building a distinct leader-follower framework, this paper proposes an efficient coordinated Dubins path planning method to synchronize the arrival time of all engaged missiles in the mid-course flight. The planned flight can generate proper initial conditions for cooperative terminal guidance, and also benefit an earliest simultaneous arrival. In the terminal course, an existing cooperative proportional navigation guidance law guides all the engaged missiles to arrive at a target accurately and *** integrated guidance law for an intuitive application is summarized. Simulations demonstrate that the proposed method can generate fast and accurate salvo attack.

关键词： Cooperative systems Dubins path Mid-course flight Missile guidance Salvo attack

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CO_(2) corrosion of X80 steel welded joints under micro-turbulence induced by welding reinforcement height

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Journal of Iron and Steel Research International 2024年第4期31卷 1015-1032页

作者： xiao-hui dou Bin Li Zong-hao He xin-wei Zhang Da-lei Zhang Yan Li School of Materials Science and Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

Corrosion failure accidents owing to flow erosion and pipeline corrosion frequently occur during *** welding reinforcement height(WRH)can induce locally micro-turbulent flow field,which aggravates local corrosion of welded joints.A high wall shear stress(WsS)experimental setup was established to conduct the online electrochemical corrosion *** influence of WRH sizes on local corrosion of welded joints was studied at different flow *** electrochemical signals of the local corrosion of X80 welded joints at different flow rates were monitored in real time using electrochemical impedance spectroscopy and wire beam *** addition,the corrosion products composition and properties were *** results show that the micro-turbulent flow fields induced by the WRHs can enhance ion mass transfer near the welded *** corrosion products on the WRH surface also present different microscopic morphologies at different flow *** strong flow fields,the locally enhanced wsS can peel off the dense corrosion product partially,leading to the electrochemical distribution of large cathode and small anode,which accelerates the occurrence and development processes of the local corrosion of welded *** scientific guidelines for the corrosion protection of long-distance oil and gas pipelines can be potentially provided.

关键词： X80 steel welded joint Welding reinforcement height Micro-turbulence CO_(2)corrosion-Ion mass transfer

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