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分子印迹膜-固相萃取-高效液相色谱法同时检测橙子中噻苯隆和氯吡脲

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食品科学 2025年第1期46卷 176-183页

作者：石雨王建豆瑞祁迎春董晓牛志睿任景俞黄华赵怡雪延安大学石油工程与环境工程学院延安市环境检测与修复重点实验室陕西延安716000 北京理工大学化学与化工学院北京100081

以聚多巴胺(polydopamine,PDA)修饰的聚偏氟乙烯(polyvinylidene fluoride,PVDF)膜为基膜,噻苯隆(thidiazuron,TDZ)为模板,甲基丙烯酸(methacrylic acid,MAA)为功能单体,乙二醇二甲基丙烯酸酯(ethylene glycol dimethacrylate,EGDMA)为交联剂,合成TDZ分子印迹膜(molecularly imprinted membrane,MIM),并将其应用于橙子中TDZ及其结构类似物氯吡脲(forchlorfenuron,CPPU)的高选择性同时提取。扫描电子显微镜表征结果表明,致密分子印迹聚合物通过PDA涂层固定在PDA@PVDF膜的三维网络结构表面;性能测试结果表明,MIM对TDZ和CPPU的吸附容量分别是相应非印迹膜的1.80、1.89倍,分别在20、30 min达到吸附平衡;MIM对干扰物质香豆素和3-叔丁基苯酚的特异性因子分别达到23.2和19.3。以MIM为固相萃取膜片,成功从橙子样品中高选择性同时提取TDZ和CPPU,在加标浓度为2.0、3.0、5.0μmol/L时,高效液相色谱法检测的加标回收率分别为90.3%~99.4%和88.2%~98.1%,相对标准偏差分别为0.9%~2.5%和1.2%~3.0%(n=3)。该方法能同时快速检测TDZ和CPPU,操作简单,具有较好的灵敏度、精密度及回收率,检测成本低,适用于果蔬中TDZ和CPPU残留的检测。

关键词：分子印迹膜固相萃取高效液相色谱法特异性识别噻苯隆氯吡脲

Fully autonomous flying: from collective motion in bird flocks to unmanned aerial vehicle autonomous swarms

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Science China Chemistry 2015年第12期58卷 207-209页

作者： QIU HuaXin WEI Chen dou rui ZHOU ZiWei Science and Technology on Aircraft Control Laboratory School of Automation Science and Electrical EngineeringBeihang University

1 IntroductionThe unmanned aerial vehicle （UAV）, an aircraft with no pilots on board, appeals to widespread appli- cations in military and civil fields [1]. In complex and dynamic mission environments, a single UAV will suffer from fatal drawbacks, such as the limitation in sensing range, computing capacity, and weapon pow- er. Therefore, the usage of UAV autonomous swarms for mission implementation will be a better choice for the dilemma single UAVs plunge in, which requires the capacity of precise real-time perception of emergency, autonomous decision making, and mission re-planning, based on pre-programmed flight plan or more complex dynamic automation system instead of remote control from ground control stations.

关键词：无人飞行器集体运动自主飞行自主性鸟

Tumor-Penetrating and Mitochondria-Targeted Drug Delivery Overcomes Doxorubicin Resistance in Lung Cancer

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Chinese Journal of Polymer Science 2023年第4期41卷 525-537,I0006页

作者： Meng-Xue Zhou Jia-Yu Zhang Xiao-Meng Cai rui dou Li-Fo Ruan Wen-Jiang Yang Wen-Chu Lin Jun Chen Yi Hu CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics and University of Chinese Academy of Sciences(UCAS)Chinese Academy of Sciences(CAS)Beijing100049China Key Laboratory of Tea Biology and Resource Utilization of Ministry of Agriculture Tea Research InstituteChinese Academy of Agricultural SciencesHangzhou310008China Division of Nuclear Technology and Applications Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing100049China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China University of Science and Technology of China Hefei230026China

As one of the major challenges in tumor chemotherapy,multidrug resistance typically correlates with the poor drug penetration within tumor tissues and drug efflux by the ATP-driven efflux pumps in tumor ***,we design a kind of near-infrared(NIR)light-and acidity-activated micellar i PUTDN nanoparticle for mitochondria-targeting doxorubicin(DOX)delivery to combat DOX resistance in small-cell lung *** the PEGylated i PUTDN nanoparticles can keep stealth in blood circulation,NIR irradiation at the tumor region can peel off the PEG shell from the nanoparticles,and the exposed i RGD can facilitate deep tumor penetration of the *** being internalized by DOX-resistant H69AR cells,the poly(β-aminoester)s(PAE)-based nanoparticles can release the triphenylphosphonium(TPP)-conjugated DOX(TDOX)into the cytosol,which can further accumulate in mitochondria with the aid of ***,the mitochondrial membrane potential and ATP content are both reduced in DOX-resistant H69AR *** in vivo therapeutic results show that TDOX-loaded nanoparticles with the aid of NIR light irradiation can effectively suppress the DOX-resistant small-cell lung cancer without noticeable adverse effects.

关键词： Doxorubicin NIR/p H-dual sensitive nanoparticles Tumor penetration Mitochondria Drug resistance

Effect of a poloxamer 407-based thermosensitive gel on minimization of thermal injury to diaphragm during microwave ablation of the liver

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World Journal of Gastroenterology 2017年第12期23卷 2141-2148页

作者： Li-Li Zhang Gui-Min Xia Yu-Jiang Liu rui dou John Eisenbrey Ji-Bin Liu Xiao-Wei Wang Lin-Xue Qian Department of Ultrasound Beijing Friendship Hospital Capital Medical University Department of Pharmaceutics Institute of Medicinal Biotechnology Chinese Academy of Medical Science and Peking Union Medical College Department of Radiology Thomas Jefferson University

AIM To assess the insulating effect of a poloxamer 407(P407)-based gel during microwave ablation of liver adjacent to the *** We prepared serial dilutions of P407, and 22.5%(w/w) concentration was identified as suitable for ablation procedures. Subsequently, microwave ablations were performed on the livers of 24 rabbits(gel, saline, control groups, n = 8 in each). The P407 solution and 0.9% normal saline were injected into the potential space between the diaphragm and liver in experimental groups. No barriers were applied to the controls. After microwave ablations, the frequency, size and degree of thermal injury were compared histologically among the three groups. Subsequently, another 8 rabbits were injected with the P407 solution and microwave ablation was performed. The levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), blood urea nitrogen(BUN) and creatinine(Cr) in serum were tested at 1 d before microwave ablation and 3 and 7 d after operation. RESULTS In vivo ablation thermal injury to the adjacent diaphragm was evaluated in the control, saline and 22.5% P407 gel groups(P = 0.001-0.040). However, there was no significant difference in the volume of ablation zone among the three groups(P > 0.05). Moreover, there were no statistical differences among the preoperative and postoperative gel groups according to the levels of ALT, AST, BUN and Cr in serum(all P > 0.05).CONCLUSION Twenty-two point five percent P407 gel could be a more effective choice during microwave ablation of hepatic tumors adjacent to the diaphragm. Further studies for clinical translation are warranted.

关键词： Microwave ablation Injury Hepatocellular carcinoma Poloxamer Hydrodissection

Bilateral macular edema secondary to nab-paclitaxel therapy for breast cancer

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1963-1966页

作者： Zi-Yi Zhou Ya-Ting Ye Jing-Ting Zhu Dong-Jie Sun Yu-Sheng Wang Guo-rui dou Department of Ophthalmology Eye Institute of Chinese PLAXijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina College of Life Sciences Northwestern UniversityXi’an 710032Shaanxi ProvinceChina

Dear Editor,Nanoparticle albumin bound(nab)–paclitaxel is a member of the taxane agents that has been proven efficient and widely applied in breast cancer as well as other kind of *** taxane-induced macular edema has been recognized as an uncommon side effect which might regress after the drug *** we presented our case as a rarely observed macular edema secondary to nab–paclitaxel therapy as *** consent from the patient was achieved and the research was approved by the Ethics Committee of Xijing Hospital(KY20202009-C-1).

关键词： edema breast macular

Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer

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Bioactive Materials 2022年第7期7卷 191-199页

作者： Lifo Ruan Jun Chen Chuanchao Du Huiru Lu Jiayu Zhang Xiaomeng Cai rui dou Wenchu Lin Zhifang Chai Guangjun Nie Yi Hu CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Multi-disciplinary Research DivisionInstitute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing100049PR China University of Chinese Academy of Sciences Beijing100049PR China Peking University Third Hospital Beijing100191PR China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031AnhuiPR China University of Science and Technology of China Hefei230026AnhuiPR China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190PR China

Reversal of cancer drug resistance remains a critical challenge in ***-targeted drug delivery has been suggested to mitigate drug resistance in *** overcome the intrinsic limitations in conventional mitochondrial targeting strategies,we develop mitochondrial temperature-responsive drug delivery to reverse doxorubicin(DOX)resistance in lung *** demonstrate that the thermoresponsive nanocarrier can prevent DOX efflux and facilitate DOX accumulation and mitochondrial targeting in DOX-resistant *** a consequence,thermoresponsive nanocarrier enhances the cytotoxicity of DOX and reverses the drug resistance in tumor-bearing *** work represents the first example of mitochondrial temperature-responsive drug delivery for reversing cancer drug resistance.

关键词： Mitochondrial temperature Thermoresponsive Drug delivery Drug resistance Nanomedicines

宪法基本权利和民事权利的连接与互动——以人格权为例

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政法论丛 2018年第3期 74-81页

作者：窦衍瑞山东政法学院民商法学院山东济南250014

宪法基本权利是构建民事权利体系的依据与基础,应根据宪法制定民法典。尊重和保障公民权利是宪法基本权利和民事权利共同的价值,连接宪法人格权与民法人格权共同的价值基础是人格尊严。人格权既是宪法权利,用以防范来自国家的侵犯,又是... 详细信息

宪法基本权利是构建民事权利体系的依据与基础,应根据宪法制定民法典。尊重和保障公民权利是宪法基本权利和民事权利共同的价值,连接宪法人格权与民法人格权共同的价值基础是人格尊严。人格权既是宪法权利,用以防范来自国家的侵犯,又是私法领域的民事权利,用以抵御来自私主体的妨害。建议民法典制定中人格权独立成编,将人格尊严置于高于一般人格权和具体人格权的地位。民法典人格权法应引入新兴人格权,如自己决定权、性自主权、性别权等,丰富宪法人身权利的内涵。

关键词：宪法基本权利民事权利人格尊严人格权

A modified laser-induced choroidal neovascularization animal model with intravitreal oxidized low-density lipoprotein

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1187-1194页

作者： Tong Wu Kuan-Rong Dang Ya-Fen Wang Bao-Zhen Lyu Wen-Qin Xu Guo-rui dou Jian Zhou Yan-Nian Hui Hong-Jun Du Department of Ophthalmology Xijing HospitalEye Institute of Chinese PLAFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Anatomy and Histology and Embryology Xi’an Health SchoolXi’an 710032Shaanxi ProvinceChina The Orbital Disease Institute of the Third Medical Center of PLA General Hospital Beijing100039China

AIM: To investigate whether intravitreal injection of oxidized low-density lipoprotein(OxLDL) can promote laserinduced choroidal neovascularization(CNV) formation in mice and the mechanism involved, thereby to develop a better animal ***: C57BL6/J mice were randomized into three groups. Immediately after CNV induction with 532 nm laser photocoagulation, 1.0 μL of OxLDL [100 μg/m L in phosphate-buffered saline(PBS)] was intravitreally injected, whereas PBS and the same volume low-density lipoprotein(LDL;100 μg/m L in PBS) were injected into the vitreous as controls. Angiogenic and inflammatory cytokines were measured by quantitative real-time polymerase chain reaction(q RT-PCR) and Western blotting(WB) after 5 d, and CNV severity was analyzed by choroid flat mount and immunofluorescence staining after 1wk. In vitro, retinal pigment epithelial(RPE) cell line(ARPE19) were treated with OxLDL(LDL as control) for 8 h. Angiogenic and inflammatory cytokine levels were measured. A specific inhibitor of lectin-like oxidized low-density lipoprotein receptor 1(LOX1) was used to evaluate the role of LOX1 in this ***: At 7 d after intravitreal injection of 1 μL(100 μg/mL) OxLDL, T15-labeled OxLDL was mainly deposited around the CNV area, and the F4/80-labeled macrophages, the CD31-labeled vascular endothelial cells number and CNV area were increased. Meanwhile, WB and qR T-PCR results showed that vascular endothelial growth factor(VEGF), CC chemokine receptor 2(CCR2), interleukin-6(IL-6), IL-1β, and matrix metalloproteinase 9(MMP9) expressions were increased, which was supported by in vitro experiments in RPE cells. LOX1 inhibitors significantly reduced expressions of inflammatory factors IL-1β and VEGF. CONCLUSION: A modified laser-induced CNV animal model is established with intravitreal injection of 1 μL(100 μg/mL) of OxLDL at 7 d, which at least partially through LOX1. This animal model can be used as a simple model for studying the role of OxLDL in age-

关键词： age-related macular degeneration choroidal neovascularization oxidized low-density lipoprotein animal model

深度学习算法在医学影像学中的应用及研究进展

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中国医学计算机成像杂志 2018年第5期24卷 369-372页

作者：窦瑞欣天津市南开医院放射科

在大数据时代背景下,医学影像数据也在迅速增加,同时,基于神经网络的深度学习算法日渐成熟,已经成为分析医学图像大数据的重要方法,为实现医学影像的自动分析及辅助诊断提供了新的契机。本文综述深度学习算法在医学影像学的最新研究进... 详细信息

在大数据时代背景下,医学影像数据也在迅速增加,同时,基于神经网络的深度学习算法日渐成熟,已经成为分析医学图像大数据的重要方法,为实现医学影像的自动分析及辅助诊断提供了新的契机。本文综述深度学习算法在医学影像学的最新研究进展。首先,介绍深度学习算法的模型及框架,及其在医学影像学中的应用,并从深度学习应用最多的几个类型及领域,具体分析其研究进展,总结研究动向,预测研究趋势,并提出深度学习在医学影像研究中可能存在的问题及建议。

关键词：深度学习神经网络医学影像辅助诊断