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Dried blood spots,valid screening for viral hepatitis and human immunodeficiency virus in real-life

World Journal of Gastroenterology 2016年第33期22卷 7604-7612页

作者： Belinda K Mossner Benjamin Staugaard Janne Jensen Soren Thue Lillevang Peer B Christensen dorte kinggaard holm Department of Infectious Diseases Odense University Hospital Department of Medicine Lillebaelt Hospital Department of Clinical Immunology Odense University Hospital Department of Clinical Research University of Southern Denmark

AIM To detect chronic hepatitis B(CHB),chronic hepatitis C(CHC) and human immunodeficiency virus(HIV) infections in dried blood spot(DBS) and compare these samples to venous blood sampling in *** We included prospective patients with known viral infections from drug treatment centers,a prison and outpatient clinics and included blood donors as negative controls. Five drops of finger capillary blood were spotted on filter paper,and a venous blood sample was obtained. The samples were analyzed for HBs Ag,antiHBc,anti-HBs,anti-HCV,and anti-HIV levels as well as subjected to a combined nucleic acid test(NAT) for HBV DNA,HCV RNA and HIV *** Samples from 404 subjects were screened(85 CHB,116 CHC,114 HIV and 99 blood donors). DBS had a sensitivity of > 96% and a specificity of > 98% for the detection of all three infections. NAT testing did not improve sensitivity,but correctly classified 95% of the anti-HCV-positive patients with chronic and past infections. Anti-HBc and anti-HBS showed low sensitivity in DBS(68% and 42%).CONCLUSION DBS sampling,combined with an automated analysis system,is a feasible screening method to diagnose chronic viral hepatitis and HIV infections outside of the health care system.

关键词： Dried blood spot Real-life Screening Hepatitis B Hepatitis C Human immunodeficiency virus People who inject drugs Drug-users Prisoners

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