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Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage:roles of microglia/macrophages

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Stroke & Vascular Neurology 2023年第6期8卷 486-502,I0073-I0080页

作者： Ruiyi Zhang Yifei Dong Yang Liu dorsa moezzi Samira Ghorbani Reza Mirzaei Brian M Lozinski Jeff F Dunn V Wee Yong Mengzhou Xue Department of Cerebrovascular Diseases The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Academy of Medical Science Zhengzhou UniversityZhengzhouHenanChina Hotchkiss Brain Institute and Department of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada Department of Biochemistry Microbiology&ImmunologyCollege of MedicineUniversity of SaskatchewanSaskatoonSaskatchewanCanada Department of Radiology University of CalgaryCalgaryAlbertaCanada

background Inflammation-exacerbated secondary brain injury and limited tissue regeneration are barriers to favourable prognosis after intracerebral haemorrhage(ICH).As a regulator of inflammation and lipid metabolism,Liver X receptor(LXR)has the potential to alter microglia/macrophage(M/M)phenotype,and assist tissue repair by promoting cholesterol efflux and recycling from *** support potential clinical translation,the benefits of enhanced LXR signalling are examined in experimental *** Collagenase-induced ICH mice were treated with the LXR agonist GW3965 or *** tests were conducted at multiple time *** and haematoma volume,and other brain parameters were assessed using multimodal MRI with T2-weighted,diffusion tensor imaging and dynamic contrast-enhanced MRI *** fixed brain cryosections were stained and confocal microscopy was applied to detect LXR downstream genes,M/M phenotype,lipid/cholesterol-laden phagocytes,oligodendrocyte lineage cells and neural stem *** blot and real-time qPCR were also ***3CR1^(CreER):Rosa26^(iDTR) mice were employed for M/M-depletion *** GW3965 treatment reduced lesion volume and white matter injury,and promoted haematoma *** mice upregulated LXR downstream genes including ABCA1 and Apolipoprotein E,and had reduced density of M/M that apparently shifted from proinflammatory interleukin-1β+to Arginase1+CD206+regulatory *** cholesterol crystal or myelin debris-laden phagocytes were observed in GW3965 *** activation increased the number of Olig2+PDGFRα+precursors and Olig2+CC1+mature oligodendrocytes in perihaematomal regions,and elevated SOX2+or nestin+neural stem cells in lesion and subventricular *** results supported better lesion recovery by GW3965,and this was corroborated by return to pre-ICH values of functional rotarod *** therapeutic effects of GW3965 were abrogated by M/M depletion in CX3CR1^(CreER):Ros

关键词： metabolism injury depletion

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Propane-1,2,3-triyl tris(hydrogen sulfate): A mild and efficient recyclable catalyst for the synthesis of biscoumarin derivatives in water and solvent-free conditions

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Chinese Chemical Letters 2014年第1期25卷 183-186页

作者： Ramin Rezaei Fatemeh moezzi Mohammad Mahdi Doroodmand Department of Chemistry Firoozabad BranchIslamic Azad University Department of Chemistry College of Sciences& Nanotechnology Research CenterShiraz University

A simple, efficient, and ecofriendly procedure has been developed using propane-l,2,3-triyl tris（hydrogen sulfate） as a catalyst for the synthesis of biscoumarin derivatives in water and solvent-free conditions. The significant features of the present protocol are simplicity, environmentally benign, high yields, no chromatographic separation, and recyclability of the catalyst.

关键词： Biscoumarin Aldehyde4-Hydroxycoumarin Propane-1 2 3-triyl tris(hydrogen sulfate)Homogeneous catalyst

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