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中华疼痛学杂志 2020年第5期16卷 341-348页

作者： Raja SN.Carr DB Cohen m.Finnerup NB Flor H.Gibson S keefe FJ.mogil JS Ringkamp m.Sluka KA Song XJ.Stevens B Sullivan mD.Tutelman PR Ushida T.Vader K 程志祥(译) 许继军(译) 程建国(审校) 刘先国(审校) 刘延青(审校) 不详南京医科大学第二附属医院疼痛科南京市210011 美国克利夫兰医学中心疼痛科俄亥俄州克利夫兰市44101 中山大学疼痛研究中心广州市510275 首都医科大学附属北京天坛医院疼痛科北京市100070

现行国际疼痛研究协会(IASP)将疼痛定义为"与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验",该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研... 详细信息

现行国际疼痛研究协会(IASP)将疼痛定义为"与实际或潜在组织损伤,或描述的类似损伤相关的一种不愉快的感觉和情感体验",该定义是由一个分类小组委员会推荐,并于1979年被IASP理事会所采纳。这一定义已被疼痛领域的卫生保健专业人士和研究人员广泛接受,并被一些行业、政府及非政府组织(包括世界卫生组织)所采用。近年来,一些业内人士认为,随着对疼痛更深入的了解,有必要对这个定义重新审定,并提出了修改建议。因此,2018年,IASP成立了一个主席特别工作小组,该小组是由14名来自多个国家的在疼痛相关的临床和基础科学方面拥有广泛专业知识的人员组成,其任务是评估现行定义及其附带注释,并对其保留还是修改提出建议。本文提供了关键概念的摘要、对IASP会员和公众评论的分析以及两年内委员会对疼痛定义和注释的最终修订意见。特别工作小组最后建议将疼痛定义修改为"与组织损伤或潜在组织损伤相关或类似相关的一种不愉快的感觉和情感体验",并将原来的附带注释更新为一系列简要说明并提供相关词源。今年年初,IASP理事会一致接受了修订后的定义和注释。

关键词：定义术语分类法特别工作小组修订版 IASP

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Cumulative radiation exposure from diagnostic imaging in intensive care unit patients

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World Journal of Radiology 2016年第4期8卷 419-427页

作者： Fiachra moloney Daniel Fama maria Twomey Ruth O'Leary Conor Houlihane Kevin P murphy Siobhan B O'Neill Owen J O'Connor dorothy Breen michael m maher Department of Radiology Cork University Hospital Department of Anesthesia Cork University Hospital

AIm:To quantify cumulative effective dose of intensive care unit(ICU)patients attributable to diagnostic ***:This was a prospective,interdisciplinary study conducted in the ICU of a large tertiary referral and level 1 trauma *** and clinical data including age,gender,date of ICU admission,primary reason for ICU admission,APACHE Ⅱ score,length of stay,number of days intubated,date of death or discharge,and re-admission data was collected on all patients admitted over a 1-year *** overall radiation exposure was quantified by the cumulative effective radiation dose(CED)in millisieverts(mS v)and calculated using reference effective doses published by the United Kingdom National Radiation Protection *** patients were selected for ***:A total of 2737 studies were performedin 421 *** total CED was 1704 m Sv with a median CED of 1.5 mS v(IQR 0.04-6.6 mS v).Total CED in pediatric patients was 74.6 mS v with a median CED of 0.07 mS v(IQR 0.01-4.7 mS v).Chest radiography was the most commonly performed examination accounting for 83% of all studies but only 2.7% of total *** tomography(CT)accounted for 16% of all studies performed and contributed 97% of total *** patients received a statistically significant higher dose [median CED 7.7 mS v(IQR 3.5-13.8 mS v)] than medical [median CED 1.4 m Sv(IQR 0.05-5.4 m Sv)] and surgical [median CED 1.6 mS v(IQR 0.04-7.5 mS v)] *** of stay in ICU [OR = 1.12(95%CI:1.079-1.157)] was identified as an independent predictor of receiving a CED greater than 15 mS ***:Trauma patients and patients with extended ICU admission times are at increased risk of higher *** should be minimized where feasible,especially in young patients.

关键词： Cumulative effective dose Pediatric patients Computed tomography Radiation dose Intensive care unit

早产儿视网膜病激光治疗后功能与结构的远期预后

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世界核心医学期刊文摘(眼科学分册) 2006年第12期 25-25页

作者： mcLoone E. O’keefe m. mcLoone S. Lanigan B. 王永强 Prof. Children’s Hospital Temple Street Dublin 1 Ireland

Aims: To assess the long term functional and structural outcomes of premature babies who received diode laser photocoagulation for threshold retinopathy of prematurity (ROP). methods: 25 patients (43 eyes) treated with laser were recalled for assessment at a mean follow up of 11 years. A further seven patients (14 eyes) with subthreshold ROP, which had regressed spontaneously without laser treatment, were also examined. All children underwent distance acuity, near acuity, contrast sensitivity (CS), and colour vision assessments followed by a dilated fundal examination and cycloplegic autorefraction. Results: The laser treated eyes had a mean distance visual acuity of 0.37 logmAR, a mean near visual acuity of 0.39 logmAR, a mean contrast sensitivity of 1.49 log CS units, and a mean spherical equivalent of-2.10 D. An unfavourable distance visual acuity outcome occurred in five eyes (13.5%). An unfavourable near visual acuity outcome was also noted in the five eyes (13.5%) with poor distance visual outcome. 7%had an unfavourable structural outcome. On comparison with the control group, there was no significant difference in near acuity, CS, refraction, or colour vision between the two groups. However, there was a statistically significant difference in terms of distance visual acuity (p=0.03). Conclusions: Laser treated eyes with favourable structural outcome have a good visual outcome. The results show a long term benefit from diode laser photocoagulation in preserving distance and near vision in eyes with threshold ROP.

关键词：激光治疗视网膜病早产儿远期预后功能

菝葜科基于形态学证据的系统发育分析(英文)

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植物分类学报 2006年第2期44卷 113-125页

作者：陈士超邱英雄王艾丽 Kenneth m. CAmERON 傅承新浙江大学生命科学学院植物系统进化与生物多样性实验室 The Lewis B. and dorothy Cullman Program for molecular Systematics Studies

对全世界范围分布的菝葜科Smilacaceae的79个代表种(包括了全部的属和组), 以分布于南美洲的Philesia Comm. ex Juss.和Lapageria Ruiz & Pav.属为外类群, 选取包括花粉和染色体性状在内的47个广义的形态学性状进行了分支分类系统发育分... 详细信息

对全世界范围分布的菝葜科Smilacaceae的79个代表种(包括了全部的属和组), 以分布于南美洲的Philesia Comm. ex Juss.和Lapageria Ruiz & Pav.属为外类群, 选取包括花粉和染色体性状在内的47个广义的形态学性状进行了分支分类系统发育分析, 同时以表征分类的方法构建了距离树(NJ)辅助分析, 首次对世界分布的菝葜科各属间及属内的系统发育关系作了探讨。(1)Ripogonum与菝葜属Smilax +肖菝葜属Heterosmilax互为姐妹群, 但是距离较远, 支持将类菝葜属(新拟中文名)Ripogonum独立为科的观点; (2)肖菝葜属在菝葜科内处于较为进化的分支上, 并与菝葜属土茯苓组sect. Coilanthus的部分种组成一个具较高支持率(88%)的单系分支, 分析表明肖菝葜属并非是一个好属, 应归入菝葜属; (3)菝葜属6个组的划分大都没有得到支持, 只有东亚北美间断分布的草本菝葜组sect. Nemexia的单系得到很好的支持(93%); (4)分布于南美洲巴西的种类聚为一个单系类群, 表明它们可能有共同的起源, 但由于取样局限, 南美洲种类的系统地位有待进一步研究。

关键词：菝葜科菝葜属肖菝葜属类菝葜属形态学分支分析系统发育

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Levels and Patterns of Genetic Variation in the Endangered Species Changium smyrnioides (Umbelliferae) Using Inter-simple Sequence Repeats(ISSR) and Allozyme markers

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Levels and Patterns of Genetic Variation in the Endangered S...

Fungal dysbiosis predicts the diagnosis of pediatric Crohn's disease

第七届全国系统与进化植物学青年学术研讨会

作者： Kenneth m.CAmERON The Lewis B.and dorothy Cullman Program for molecular Systematics Studies TheNew York Botanical GardenBronxNew York 10458-5126 USA

Changium smyrnioids(Umbelliferae)is an endangered plant endemic to Eastern China. This study investigates the levels of genetic variation and patterns of population structure to provide genetic information for the development of suitable conservation strategies. Four of the seven known populations were sampled and analyzed using starch gel electrophoresis of ten enzymes coded by 19 interpretable loci. Population-level values for *** (means: P =33.0%, I=0.13, He = 0.07) are slightly exceeded mean values for endemic species. Values of GST tended to be high (mean GST= 0.578), indicating substantial divergence and limited gene flow among populations. We further investigated genetic variation among and within 7 populations with ISSRs profiles. Of the 196ISSR loci scored,

关键词： Changium smyrnioides. Conservation genetics Allozymes ISSRs

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World Journal of Gastroenterology 2018年第39期24卷 4510-4516页

作者： mohammad I El mouzan Kirill S Korolev mohammad A Al mofarreh Rajita menon Harland S Winter Ahmad A Al Sarkhy Scot E Dowd Ahmad m Al Barrag Asaad A Assiri Department of Pediatrics King Saud UniversityRiyadh 11461Saudi Arabia Department of Pediatrics Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research ChairKing Saud UniversityRiyadh 11461Saudi Arabia Bioinformatics Program Boston UniversityBostonMA 02215United States Al mofarreh PolyClinic Riyadh 11423Saudi Arabia massGeneral Hospital for Children BostonMA 02114United States mRDNA ShallowaterTX 79363United States Department of microbiology King Saud UniversityRiyadh 11461Saudi Arabia

AIm To investigate the accuracy of fungal dysbiosis inmucosa and stool for predicting the diagnosis of Crohn's disease(CD). mETHODS Children were prospectively enrolled in two medical centers: one university hospital and one private gastroenterology clinic in the city of Riyadh, Kingdom of Saudi Arabia. The children with confirmed diagnosis of CD by standard guidelines were considered cases, and the others were considered non-inflammatory bowel disease controls. mucosal and stool samples were sequenced utilizing Illumina miSeq chemistry following the manufacturer's protocols, and abundance and diversity of fungal taxa in mucosa and stool were analyzed. Sparse logistic regression was used to predict the diagnosis of CD. The accuracy of the classifier was tested by computing the receiver operating characteristic curves with 5-fold stratified cross-validation under 100 permutations of the training data partition and the mean area under the curve(AUC) was calculated. RESULTS All the children were Saudi nationals. There were 15 children with CD and 20 controls. The mean age was 13.9(range: 6.7-17.8) years for CD children and 13.9(3.25-18.6) years for controls, and 10/15(67%) of the CD and 13/20(65%) of the control subjects were boys. CD locations at diagnosis were ileal(L1) in 4 and colonic(L3) in 11 children, while CD behavior was non-stricturing and non-penetrating(B1) in 12 and stricturing(B2) in 3 children. The mean AUC for the fungal dysbiosis classifier was significantly higher in stools(AUC = 0.85 ± 0.057) than in mucosa(AUC = 0.71 ± 0.067)(P most fungal species were significantly more depleted in stools than mucosal samples, except for Saccharomyces cerevisiae and S. bayanus, which were significantly more abundant. Diversity was significantly more reduced in stools than in mucosa. CONCLUSION We found high AUC of fungal dysbiosis in fecal samples of children with CD, suggesting high accuracy in predicting diagnosis of CD.

关键词： Fungiome mycobiome Crohn’s disease Inflammation Saudi children

骨髓造血细胞来源的半乳糖苷凝集素导致细胞和系统胰岛素抵抗

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科学新闻 2017年第4期 40-40页

作者：李平平 Shuainan Liu min Lu Gautum Bandyopadhyay Dayoung Oh Takeshi Imamura Andrew m.F.Johnson dorothy Sears Zhufang Shen Bing Cui Lijuan Kong Shaocong Hou Xiao Liang Salvatore Iovino Steven m.Watkins Wei Ying Olivia Osborn Joshua Wollam martin Brenner Jerrold m.Olefsky 中国医学科学院药物研究所

文章简介肥胖时巨噬细胞与其他免疫细胞在胰岛素靶组织大量聚集,构成一种慢性炎症状态和胰岛素抵抗。半乳糖苷凝集素Galectin-3(Gal3)主要来源于巨噬细胞。无论在肥胖小鼠或者肥胖病人,Gal3水平明显增加。Gal3给药可让正常小鼠诱发胰岛... 详细信息

文章简介肥胖时巨噬细胞与其他免疫细胞在胰岛素靶组织大量聚集,构成一种慢性炎症状态和胰岛素抵抗。半乳糖苷凝集素Galectin-3(Gal3)主要来源于巨噬细胞。无论在肥胖小鼠或者肥胖病人,Gal3水平明显增加。Gal3给药可让正常小鼠诱发胰岛素抵抗和糖耐量异

关键词：胰岛素抵抗炎症病理凝集素细胞

Tet酶调控端粒和基因组稳定性的作用和机制

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科学新闻 2017年第4期 146-146页

作者： Jiao Yang Renpeng Guo Hua Wang Xiaoying Ye Zhongcheng Zhou Jiameng Dan Haiying Wang Peng Gong Wei Deng Yu Yin Shi Qing mao Lingbo Wang Junjun Ding Jinsong Li David L.keefe meelad m.Dawlaty Jianlong Wang Guo Liang Xu 刘林南开大学生命科学学院

文章简介Tets家族催化5-甲基胞嘧啶转变为5-羟甲基胞嘧啶。在小鼠胚胎干细胞中单独干扰Tet1或/和Tet2,伴随着端粒重组下降,导致端粒长度缩短和基因组稳定性异常。Tet1和Tet2同时敲除的细胞也表现出端粒长度缩短,但是缩短的程度没有干扰... 详细信息

文章简介Tets家族催化5-甲基胞嘧啶转变为5-羟甲基胞嘧啶。在小鼠胚胎干细胞中单独干扰Tet1或/和Tet2,伴随着端粒重组下降,导致端粒长度缩短和基因组稳定性异常。Tet1和Tet2同时敲除的细胞也表现出端粒长度缩短,但是缩短的程度没有干扰实验明显。更明显的是,Tet1/2/3同时敲除的细胞表现出端

关键词： Tet 敲除细胞基因组稳定性端粒

A NEW TEST mETHOD FOR FRP-TO-CONCRETE BOND BEHAVIOUR UNDER ImPACT LOADING 12th

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