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Levels and Patterns of Genetic Variation in the Endangered Species Changium.sm.rnioides (Um.elliferae) Using Inter-sim.le Sequence Repeats(ISSR) and Allozym. m.rkers

Levels and Patterns of Genetic Variation in the Endangered S...

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第七届全国系统与进化植物学青年学术研讨会

作者： Kenneth m.CAm.RON The Lewis B.and dorothy Cullm.n Program.for m.lecular System.tics Studies TheNew York Botanical GardenBronxNew York 10458-5126 USA

Changium.sm.rnioids(Um.elliferae)is an endangered plant endem.c to Eastern China. This study investigates the levels of genetic variation and patterns of population structure to provide genetic inform.tion for the developm.nt of suitable conservation strategies. Four of the seven known populations were sam.led and analyzed using starch gel electrophoresis of ten enzym.s coded by 19 interpretable loci. Population-level values for *** (m.ans: P =33.0%, I=0.13, He = 0.07) are slightly exceeded m.an values for endem.c species. Values of GST tended to be high (m.an GST= 0.578), indicating substantial divergence and lim.ted gene flow am.ng populations. We further investigated genetic variation am.ng and within 7 populations with ISSRs profiles. Of the 196ISSR loci scored,

关键词： Changium.sm.rnioides. Conservation genetics Allozym.s ISSRs

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Fungal dysbiosis predicts the diagnosis of pediatric Crohn's disease

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World Journal of Gastroenterology 2018年第39期24卷 4510-4516页

作者： m.ham.ad I El m.uzan Kirill S Korolev m.ham.ad A Al m.farreh Rajita m.non Harland S Winter Ahm.d A Al Sarkhy Scot E Dowd Ahm.d m.Al Barrag Asaad A Assiri Departm.nt of Pediatrics King Saud UniversityRiyadh 11461Saudi Arabia Departm.nt of Pediatrics Supervisor of Prince Abdullah Bin Khalid Celiac Disease Research ChairKing Saud UniversityRiyadh 11461Saudi Arabia Bioinform.tics Program Boston UniversityBostonMA 02215United States Al m.farreh PolyClinic Riyadh 11423Saudi Arabia m.ssGeneral Hospital for Children BostonMA 02114United States m.DNA ShallowaterTX 79363United States Departm.nt of m.crobiology King Saud UniversityRiyadh 11461Saudi Arabia

AIm.To investigate the accuracy of fungal dysbiosis inm.cosa and stool for predicting the diagnosis of Crohn's disease(CD). m.THODS Children were prospectively enrolled in two m.dical centers: one university hospital and one private gastroenterology clinic in the city of Riyadh, Kingdom.of Saudi Arabia. The children with confirm.d diagnosis of CD by standard guidelines were considered cases, and the others were considered non-inflam.atory bowel disease controls. m.cosal and stool sam.les were sequenced utilizing Illum.na m.Seq chem.stry following the m.nufacturer's protocols, and abundance and diversity of fungal taxa in m.cosa and stool were analyzed. Sparse logistic regression was used to predict the diagnosis of CD. The accuracy of the classifier was tested by com.uting the receiver operating characteristic curves with 5-fold stratified cross-validation under 100 perm.tations of the training data partition and the m.an area under the curve(AUC) was calculated. RESULTS All the children were Saudi nationals. There were 15 children with CD and 20 controls. The m.an age was 13.9(range: 6.7-17.8) years for CD children and 13.9(3.25-18.6) years for controls, and 10/15(67%) of the CD and 13/20(65%) of the control subjects were boys. CD locations at diagnosis were ileal(L1) in 4 and colonic(L3) in 11 children, while CD behavior was non-stricturing and non-penetrating(B1) in 12 and stricturing(B2) in 3 children. The m.an AUC for the fungal dysbiosis classifier was significantly higher in stools(AUC = 0.85 ± 0.057) than in m.cosa(AUC = 0.71 ± 0.067)(P m.st fungal species were significantly m.re depleted in stools than m.cosal sam.les, except for Saccharom.ces cerevisiae and S. bayanus, which were significantly m.re abundant. Diversity was significantly m.re reduced in stools than in m.cosa. CONCLUSION We found high AUC of fungal dysbiosis in fecal sam.les of children with CD, suggesting high accuracy in predicting diagnosis of CD.

关键词： Fungiom. m.cobiom. Crohn’s disease Inflam.ation Saudi children

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骨髓造血细胞来源的半乳糖苷凝集素导致细胞和系统胰岛素抵抗

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科学新闻 2017年第4期 40-40页

作者：李平平 Shuainan Liu m.n Lu Gautum.Bandyopadhyay Dayoung Oh Takeshi Im.m.ra Andrew m.F.Johnson dorothy Sears Zhufang Shen Bing Cui Lijuan Kong Shaocong Hou Xiao Liang Salvatore Iovino Steven m.Watkins Wei Ying Olivia Osborn Joshua Wollam.m.rtin Brenner Jerrold m.Olefsky 中国医学科学院药物研究所

文章简介肥胖时巨噬细胞与其他免疫细胞在胰岛素靶组织大量聚集,构成一种慢性炎症状态和胰岛素抵抗。半乳糖苷凝集素Galectin-3(Gal3)主要来源于巨噬细胞。无论在肥胖小鼠或者肥胖病人,Gal3水平明显增加。Gal3给药可让正常小鼠诱发胰岛... 详细信息

文章简介肥胖时巨噬细胞与其他免疫细胞在胰岛素靶组织大量聚集,构成一种慢性炎症状态和胰岛素抵抗。半乳糖苷凝集素Galectin-3(Gal3)主要来源于巨噬细胞。无论在肥胖小鼠或者肥胖病人,Gal3水平明显增加。Gal3给药可让正常小鼠诱发胰岛素抵抗和糖耐量异

关键词：胰岛素抵抗炎症病理凝集素细胞

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A NEW TEST m.THOD FOR FRP-TO-CONCRETE BOND BEHAVIOUR UNDER Im.ACT LOADING 12th

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The Twelfth International Sym.osium.on Structural Engineering

作者： J.F.Chen X.Q.Li Y.Lu I.m.m.y T.J.Stratford R.O'Sullivan A.Sheil School of the Built Environm.nt Heriot Watt UniversityEdinburghUK

ISBN: (纸本)9787030357878

External bonding of fibre reinforced polym.r(FRP) com.osites has becom. a popular technique worldwide for strengthening reinforced concrete(RC) structures since *** of the technique have been typically for static loading and seism.c retrofitting,but m.ny studies on strengthening concrete and m.sonry structures with externally bonded FRP for im.roved blast and im.act resistance in protective engineering have also been *** bond behaviour between FRP and concrete plays a critical role in a strengthening system.with externally bonded *** to the dynam.c characteristics of blast and im.act loading,the bond behaviour between FRP and concrete under such loading could be very different from.that under static *** paper presents a prelim.ary study using a new test m.thod for exam.ning this bond behaviour under im.act *** m.in test results of the first batch of specim.ns are reported.

关键词： FRP-to-Concrete bond im.act loading

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运用ELISPOT研究1型糖尿病病人胰岛特异性肽诱导的T细胞功能

运用ELISPOT研究1型糖尿病病人胰岛特异性肽诱导的T细胞功能

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2007年浙江省儿科学、小儿外科学学术年会

作者：傅君芬 L.Petrich de m.rquesini A.J.Bishop C.Baker F.S.Wong S.Arif C.Van Krinks m.Peakm.n C.m.Dayan 浙江大学医学院附属儿童医院内分泌科 Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol Hertry Wellcom. Laboratory for Integrated Neuroscience and Endocrinology dorothy Hodgldn Building University of Bristol

研究背景：1型糖尿病是 T 细胞介导的以破坏β细胞为目标的自身免疫性疾病。胰岛素的治疗虽能延缓,但不能阻止并发症的出现。抗胰岛的自身抗体在糖尿病发病前10余年就已出现,所以在糖尿病出现前有一段很长时间的干预窗,这为糖尿病的免... 详细信息

研究背景：1型糖尿病是 T 细胞介导的以破坏β细胞为目标的自身免疫性疾病。胰岛素的治疗虽能延缓,但不能阻止并发症的出现。抗胰岛的自身抗体在糖尿病发病前10余年就已出现,所以在糖尿病出现前有一段很长时间的干预窗,这为糖尿病的免疫治疗提供空间。但是由于体内 T 细胞数量甚少,因此对其研究受到了技术上的限制。我们最近建立了一套新的方法(ELISPOT)用于研究

关键词：糖尿病病人细胞功能 ELISPOT

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