检索结果-南通市图书馆

Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

引用

Cellular & Molecular Immunology 2019年第1期16卷 65-74页

作者： Vanessa Lamontain Tobias Schmid dorothea weber-steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H Straub Daniela N Männel Institute of Immunology University of Regensburg93042 RegensburgGermany Laboratory of Experimental Rheumatology and Neuroendocrine Immunology Department of Internal MedicineUniversity Hospital Regensburg93042 RegensburgGermany Division of Molecular Internal Medicine Department of Internal Medicine IIUniversity Hospital Würzburg97070 WürzburgGermany

Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory *** TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory *** this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced *** with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second *** days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were *** were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by *** with TNCscTNF80 increased arthritis-induced *** effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid *** treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph *** addition,the expression of TNFR2 on Treg cells was *** clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of *** histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control *** of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis.

关键词： collagen type II-induced arthritis regulatory T cells TNF TNF receptor type 2 TNFR2-specific agonist TNCscTNF80

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：